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Aliases for C4orf50 Gene

Aliases for C4orf50 Gene

  • Chromosome 4 Open Reading Frame 50 2 3 5

External Ids for C4orf50 Gene

Previous GeneCards Identifiers for C4orf50 Gene

  • GC04M006009
  • GC04M005899
  • GC04M005958

Summaries for C4orf50 Gene

GeneCards Summary for C4orf50 Gene

C4orf50 (Chromosome 4 Open Reading Frame 50) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4orf50 Gene

Genomics for C4orf50 Gene

Regulatory Elements for C4orf50 Gene

Enhancers for C4orf50 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G005955 0.7 ENCODE 12 +62.1 62051 1.4 PKNOX1 NFIB ZMYM3 ZIC2 RELA YY1 POLR2A ZNF143 SMARCA5 NR2F1 C4orf50 GC04P005940 PIR44557
GH04G006019 0.5 ENCODE 0.7 -1.3 -1342 0.2 CTCF TEAD4 TRIM22 ZNF143 RAD21 C4orf50 GC04M006100
GH04G006087 0.6 ENCODE 0.2 -69.3 -69342 0.2 ZNF263 CTCF CEBPB CEBPG REST RAD21 CEBPA SMC3 GC04M006100 C4orf50
GH04G006105 0.5 ENCODE 0.2 -87.0 -87022 0.2 RNF2 TEAD4 MAX KDM1A GC04M006100 C4orf50
GH04G006110 0.6 ENCODE 0.1 -91.9 -91902 0.2 CTCF PKNOX1 ESRRA CEBPA HLF CEBPB CEBPG GC04M006100 C4orf50
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C4orf50 on UCSC Golden Path with GeneCards custom track

Genomic Location for C4orf50 Gene

5,897,373 bp from pter
6,018,507 bp from pter
121,135 bases
Minus strand

Genomic View for C4orf50 Gene

Genes around C4orf50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf50 Gene

Proteins for C4orf50 Gene

  • Protein details for C4orf50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C4orf50
    Protein Accession:

    Protein attributes for C4orf50 Gene

    276 amino acids
    Molecular mass:
    30622 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C4orf50 Gene

Post-translational modifications for C4orf50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C4orf50 Gene

Domains & Families for C4orf50 Gene

Protein Domains for C4orf50 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C4orf50: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C4orf50 Gene

Function for C4orf50 Gene

Phenotypes for C4orf50 Gene

genes like me logo Genes that share phenotypes with C4orf50: view

Animal Model Products

miRNA for C4orf50 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C4orf50 Gene

Localization for C4orf50 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C4orf50 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C4orf50 Gene

Pathways & Interactions for C4orf50 Gene

SuperPathways for C4orf50 Gene

No Data Available

Interacting Proteins for C4orf50 Gene

Gene Ontology (GO) - Biological Process for C4orf50 Gene


No data available for Pathways by source and SIGNOR curated interactions for C4orf50 Gene

Drugs & Compounds for C4orf50 Gene

No Compound Related Data Available

Transcripts for C4orf50 Gene

mRNA/cDNA for C4orf50 Gene

(13) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C4orf50 Gene

Chromosome 4 open reading frame 50:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf50 Gene

No ASD Table

Relevant External Links for C4orf50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C4orf50 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C4orf50 Gene

mRNA differential expression in normal tissues according to GTEx for C4orf50 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x11.4), Brain - Frontal Cortex (BA9) (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Caudate (basal ganglia) (x5.2), Brain - Cortex (x4.9), and Brain - Putamen (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for C4orf50 Gene

This gene is overexpressed in Lung (61.7) and CD4 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C4orf50 Gene

Protein tissue co-expression partners for C4orf50 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C4orf50 Gene:


SOURCE GeneReport for Unigene cluster for C4orf50 Gene:

genes like me logo Genes that share expression patterns with C4orf50: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C4orf50 Gene

Orthologs for C4orf50 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C4orf50 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC750617 34
  • 98.87 (n)
C4orf50 35
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC102553825 34
  • 65.35 (n)
(Canis familiaris)
Mammalia C4orf50 35
  • 64 (a)
(Mus musculus)
Mammalia Gm1043 34 16 35
  • 63.81 (n)
(Bos Taurus)
Mammalia C4orf50 35
  • 60 (a)
(Monodelphis domestica)
Mammalia C4orf50 35
  • 13 (a)
Species where no ortholog for C4orf50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C4orf50 Gene

Gene Tree for C4orf50 (if available)
Gene Tree for C4orf50 (if available)

Paralogs for C4orf50 Gene

(1) SIMAP similar genes for C4orf50 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C4orf50: view

No data available for Paralogs for C4orf50 Gene

Variants for C4orf50 Gene

Sequence variations from dbSNP and Humsavar for C4orf50 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_042681 A breast cancer sample
rs1000000289 -- 5,918,678(+) TGCAT(C/T)CAAGC intron-variant
rs1000010262 -- 5,951,775(+) CGTTC(C/G)CTCTC intron-variant
rs10000138 -- 5,949,970(+) ggcaa(C/T)aagag intron-variant
rs1000028695 -- 6,016,751(+) CAATC(A/C)CATAG intron-variant

Variation tolerance for C4orf50 Gene

Gene Damage Index Score: 11.89; 93.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C4orf50 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C4orf50 Gene

Disorders for C4orf50 Gene

Relevant External Links for C4orf50

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C4orf50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf50 Gene

Publications for C4orf50 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans D.M. … Whitfield J.B. (Hum. Mol. Genet. 2013) 3 64
  3. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C4orf50 Gene

Sources for C4orf50 Gene

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