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Aliases for C4orf46 Gene

Aliases for C4orf46 Gene

  • Chromosome 4 Open Reading Frame 46 2 3 5
  • RCDG1 3 4
  • Renal Cancer Differentiation Gene 1 2

External Ids for C4orf46 Gene

Previous GeneCards Identifiers for C4orf46 Gene

  • GC04M159808
  • GC04M159587
  • GC04M155337

Summaries for C4orf46 Gene

Entrez Gene Summary for C4orf46 Gene

  • This gene encodes a small, conserved protein of unknown function that is expressed in a variety of tissues. There are pseudogenes for this gene on chromosomes 6, 8, 16, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

GeneCards Summary for C4orf46 Gene

C4orf46 (Chromosome 4 Open Reading Frame 46) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4orf46 Gene

Genomics for C4orf46 Gene

Regulatory Elements for C4orf46 Gene

Enhancers for C4orf46 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C4orf46 on UCSC Golden Path with GeneCards custom track

Promoters for C4orf46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C4orf46 on UCSC Golden Path with GeneCards custom track

Genomic Location for C4orf46 Gene

Chromosome:
4
Start:
158,666,675 bp from pter
End:
158,672,255 bp from pter
Size:
5,581 bases
Orientation:
Minus strand

Genomic View for C4orf46 Gene

Genes around C4orf46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf46 Gene

Proteins for C4orf46 Gene

  • Protein details for C4orf46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q504U0-CD046_HUMAN
    Recommended name:
    Renal cancer differentiation gene 1 protein
    Protein Accession:
    Q504U0
    Secondary Accessions:
    • B3KNH7

    Protein attributes for C4orf46 Gene

    Size:
    113 amino acids
    Molecular mass:
    11899 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C4orf46 Gene

Proteomics data for C4orf46 Gene at MOPED

Post-translational modifications for C4orf46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C4orf46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C4orf46 Gene

Domains & Families for C4orf46 Gene

Protein Domains for C4orf46 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C4orf46: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C4orf46 Gene

Function for C4orf46 Gene

genes like me logo Genes that share phenotypes with C4orf46: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C4orf46 Gene

Localization for C4orf46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C4orf46 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C4orf46 Gene COMPARTMENTS Subcellular localization image for C4orf46 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for C4orf46 Gene

Pathways & Interactions for C4orf46 Gene

SuperPathways for C4orf46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C4orf46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C4orf46 Gene

Drugs & Compounds for C4orf46 Gene

No Compound Related Data Available

Transcripts for C4orf46 Gene

mRNA/cDNA for C4orf46 Gene

Unigene Clusters for C4orf46 Gene

Chromosome 4 open reading frame 46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf46 Gene

No ASD Table

Relevant External Links for C4orf46 Gene

GeneLoc Exon Structure for
C4orf46
ECgene alternative splicing isoforms for
C4orf46

Expression for C4orf46 Gene

mRNA expression in normal human tissues for C4orf46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C4orf46 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C4orf46 Gene



SOURCE GeneReport for Unigene cluster for C4orf46 Gene Hs.380920

mRNA Expression by UniProt/SwissProt for C4orf46 Gene

Q504U0-CD046_HUMAN
Tissue specificity: Expressed in the kidney, in epithelial cells in both proximal tubules and distal convoluted tubules.
genes like me logo Genes that share expression patterns with C4orf46: view

Protein tissue co-expression partners for C4orf46 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for C4orf46 Gene

Orthologs for C4orf46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C4orf46 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C17H4orf46 35
  • 88.79 (n)
  • 88.5 (a)
C17H4orf46 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C15H4orf46 35
  • 87.61 (n)
  • 84.07 (a)
C4orf46 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930579G24Rik 35
  • 88.75 (n)
  • 91.25 (a)
4930579G24Rik 16
4930579G24Rik 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C4H4orf46 35
  • 99.71 (n)
  • 100 (a)
C4orf46 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560010 35
  • 89.17 (n)
  • 91.25 (a)
oppossum
(Monodelphis domestica)
Mammalia C4orf46 36
  • 60 (a)
OneToOne
Species with no ortholog for C4orf46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C4orf46 Gene

ENSEMBL:
Gene Tree for C4orf46 (if available)
TreeFam:
Gene Tree for C4orf46 (if available)

Paralogs for C4orf46 Gene

Pseudogenes.org Pseudogenes for C4orf46 Gene

genes like me logo Genes that share paralogs with C4orf46: view

No data available for Paralogs for C4orf46 Gene

Variants for C4orf46 Gene

Sequence variations from dbSNP and Humsavar for C4orf46 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3210748 -- 158,667,514(+) CAAAA(A/T)ATGTA nc-transcript-variant, utr-variant-3-prime
rs3210749 -- 158,667,579(+) ctgta(A/C)tccca nc-transcript-variant, utr-variant-3-prime
rs7697479 -- 158,667,632(+) CAAGT(C/T)TAAGG nc-transcript-variant, utr-variant-3-prime
rs10024549 -- 158,666,828(+) caaga(C/T)gaagg nc-transcript-variant, utr-variant-3-prime
rs11544037 -- 158,667,824(-) TGGTG(G/T)TCATG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C4orf46 Gene

Variant ID Type Subtype PubMed ID
esv2728610 CNV Deletion 23290073

Variation tolerance for C4orf46 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C4orf46 Gene

Disorders for C4orf46 Gene

Relevant External Links for C4orf46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C4orf46

No disorders were found for C4orf46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf46 Gene

Publications for C4orf46 Gene

  1. Expression and clinical significance of RCDG1 in renal cell carcinoma: a novel renal cancera89associated gene. (PMID: 25059753) Yu Z. … Lai Y. (Mol Med Rep 2014) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for C4orf46 Gene

Sources for C4orf46 Gene

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