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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C4orf45 Gene

protein-coding   GIFtS: 37
GCID: GC04M159814

Chromosome 4 Open Reading Frame 45

  Search for C4orf45
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 4 Open Reading Frame 451 2
Uncharacterized Protein C4orf452

External Ids:    HGNC: 263421   Entrez Gene: 1529402   Ensembl: ENSG000001641237   UniProtKB: Q96LM53   

Export aliases for C4orf45 gene to outside databases

Previous GC identifers: GC04M160035 GC04M155564


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C4orf45 Gene: 
C4orf45 (chromosome 4 open reading frame 45) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C4orf45 gene promoter:
         HNF-1A   AREB6   S8   FOXJ2 (long isoform)   HNF-1   FOXO1a   Sox9   FOXJ2   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C4orf45

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4orf45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.1   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q32.1

C4orf45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C4orf45 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M159814:  view genomic region     (about GC identifiers)

Start:
159,814,286 bp from pter      End:
159,959,912 bp from pter
Size:
145,627 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD045_HUMAN, Q96LM5 (See protein sequence)
Recommended Name: Uncharacterized protein C4orf45  
Size: 186 amino acids; 21723 Da
Sequence caution: Sequence=BAB71665.1; Type=Frameshift; Positions=178;
Secondary accessions: A8MPU3 C9J0T8

Explore the universe of human proteins at neXtProt for C4orf45: NX_Q96LM5

Explore proteomics data for C4orf45 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LM5

  • C4orf45 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C4orf45 Protein Expression
    REFSEQ proteins: NP_689756.2  
    ENSEMBL proteins: 
     ENSP00000412215  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96LM5


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for C4orf45:
     Increased cell number in G2M,  

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C4orf45

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C4orf45 (CD045)

    Search CenterWatch for drugs/clinical trials and news about C4orf45 / CD045

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C4orf45 gene: 
    NM_152543.2  

    Unigene Cluster for C4orf45:

    Chromosome 4 open reading frame 45
    Hs.415576  [show with all ESTs]
    Unigene Representative Sequence: AK307319
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434826(uc003iqf.1 uc010iqt.1) ENST00000508011 ENST00000505647

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    Additional mRNA sequence: 

    AK058100.1 AK307319.1 

    3 DOTS entries:

    DT.40284307  DT.121239078  DT.100745220 

    10 AceView cDNA sequences:

    AA992028 AA621199 NM_152543 AK058100 BP369394 AI808320 BG186198 AW182411 
    BG212472 AW269030 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See C4orf45 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C4orf45

    SOURCE GeneReport for Unigene cluster: Hs.415576
        SABiosciences Custom PCR Arrays for C4orf45
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf45

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C4orf45 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm173591 , 5 predicted gene, 173591, 5 73.6(n)1
    65.17(a)1
      3 (34.91 cM)5
    1002332071  NM_001142953.11  NP_001136425.11 
     793453765 
    chicken
    (Gallus gallus)
    Aves C4H4orf451 chromosome 4 open reading frame, human C4orf45 53.28(n)
    43.31(a)
      769822  XM_001233137.2  XP_001233138.2 
    zebrafish
    (Danio rerio)
    Actinopterygii C14H4orf456
    chromosome 4 open reading frame 45
    20(a)
    1 ↔ 1
    14(50968942-50975026)


    ENSEMBL Gene Tree for C4orf45 (if available)
    TreeFam Gene Tree for C4orf45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2500 SNPs in C4orf45 are shown (see all 2500)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs76989871,2
    C--159828600(+) ATCCCC/TGCTTG 1 -- int10--------
    rs1388510611,2
    --159828689(+) AGGTTC/GTTCAC 1 -- int10--------
    rs1857502681,2
    --159829099(+) ATAGAC/TACCAA 1 -- int10--------
    rs21624231,2
    C,A,H--159829235(-) ATTAAC/ATATAA 1 -- int112Minor allele frequency- A:0.01NA WA CSA EA 374
    rs1420288121,2
    --159829268(+) AATAAC/TTCGTG 1 -- int10--------
    rs1463125601,2
    --159829325(+) TTTTGA/GAAATG 1 -- int10--------
    rs729713621,2
    C,F--159829351(+) TTAGCG/ATAATG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1905255891,2
    --159829391(+) TGGGGC/GCTCAG 1 -- int10--------
    rs76588311,2
    C,F,A--159829523(+) ttataA/Gttaag 1 -- int12Minor allele frequency- G:0.19CSA WA 119
    rs1924552221,2
    --159829607(+) ATGCAA/GTTGTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for C4orf45 (159814286 - 159959912 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C4orf45:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4571CNV Loss18451855
    nsv830127CNV Loss17160897
    nsv830128CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C4orf45 for disorders           About MalaCards

    C4orf45 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C4orf45
    Human Genome Epidemiology (HuGE) Navigator: C4orf45 (1 document)

    Export disorders for C4orf45 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C4orf45 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C4orf45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 152940 HGNC: 26342 AceView: FLJ25371 Ensembl:ENSG00000164123 euGenes: HUgn152940
    ECgene: C4orf45 H-InvDB: C4orf45

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C4orf45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C4orf45 gene:
    Search GeneIP for patents involving C4orf45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     SwitchGear 3'UTR luciferase reporter plasmids for C4orf45
     Browse SwitchGear Promoter luciferase reporter plasmids for C4orf45
     Search ThermoFisher Antibodies for C4orf45
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf45
     inGenious Targeting Laboratory - Custom generated mouse model solutions for C4orf45
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C4orf45
    Customized:
     lentivirus for stable overexpression of C4orf45
     lentivirus expression plasmids for stable overexpression of C4orf45
     adenovirus for overexpression of C4orf45
     LSBio Antibodies in human, mouse, rat for C4orf45
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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