C4orf45 Gene
protein-coding GIFtS: 36
GCID: GC04M159814
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chromosome 4 open reading frame 45
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Aliases
for C4orf45 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 4 Open Reading Frame 451 2 | | FLJ253711 | | Uncharacterized Protein C4orf452 |
Export aliases for C4orf45 gene to outside databasesPrevious GC identifers: GC04M160035 GC04M155564 |
Summaries
for C4orf45 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C4orf45 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C4orf45 gene promoter:
HNF-1A AREB6 S8 FOXJ2 (long isoform) HNF-1 FOXO1a Sox9 FOXJ2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C4orf45
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4orf45 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q32.1 Ensembl cytogenetic band: 4q32.1 HGNC cytogenetic band: 4q32.1C4orf45 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M159814: view genomic region
(about GC identifiers)
Start:
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159,814,286 bp from pter |
End:
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159,959,912 bp from pter |
Size:
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145,627 bases |
Orientation:
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minus strand |
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Proteins
for C4orf45 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CD045_HUMAN, Q96LM5 (See
protein sequence)Recommended Name: Uncharacterized protein C4orf45 Size: 186 amino acids; 21723 Da
Sequence caution: Sequence=BAB71665.1; Type=Frameshift; Positions=178;
Secondary accessions: A8MPU3 C9J0T8Explore the universe of human proteins at neXtProt for C4orf45: NX_Q96LM5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96LM5
C4orf45 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689756.2
ENSEMBL proteins: ENSP00000412215
Human Recombinant Protein Products:
C4orf45 Antibody Products:
Assay Products for C4orf45: |
Protein
Domains /
Families
for C4orf45 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96LM5 |
Function
for C4orf45 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf45 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf45
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C4orf45 (NM_152543) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C4orf45 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf45 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf45 |
1 GenomeRNAi human phenotype for C4orf45:
|
Pathways & Interactions
for C4orf45 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C4orf45
|
Drugs & Compounds
for C4orf45 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C4orf45
Search CenterWatch for drugs/clinical trials and news about C4orf45 / CD045
|
Transcripts
for C4orf45 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C4orf45 gene: NM_152543.2 Unigene Cluster for C4orf45: Chromosome 4 open reading frame 45 Hs.415576 [show with all ESTs]Unigene Representative Sequence: AK3073193 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000434826(uc003iqf.1 uc010iqt.1) ENST00000508011 ENST00000505647
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf45 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf45
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C4orf45 (NM_152543) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C4orf45 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf45 |
Additional cDNA sequence: AK058100.1 AK307319.1 3 DOTS entries: DT.40284307 DT.121239078 DT.100745220 10 AceView cDNA sequences: AA992028 AA621199 NM_152543 AK058100 BP369394 BG186198 AW182411 AI808320 BG212472 AW269030
GeneLoc Exon Structure
|
Expression
for C4orf45 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C4orf45 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C4orf45 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C4orf45
SOURCE GeneReport for Unigene cluster: Hs.415576
SABiosciences Custom PCR Arrays for C4orf45
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C4orf45
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C4orf45 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4orf45 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4orf45 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf45 |
Orthologs
for C4orf45 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C4orf45 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for C4orf45 (if available)
TreeFam Gene Tree for C4orf45 (if available) |
Paralogs
for C4orf45 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C4orf45 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C4orf45
1 CNV: 4420 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C4orf45 |
|
Disorders
/ Diseases
for C4orf45 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C4orf45 for disorders About MalaCards
C4orf45 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: C4orf45 (1 document)
Export disorders for C4orf45 gene to outside databases
|
Publications
for C4orf45 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C4orf45 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C4orf45) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for C4orf45 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C4orf45 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C4orf45 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C4orf45 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C4orf45 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C4orf45 gene:
Search GeneIP for patents involving C4orf45
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C4orf45 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C4orf45 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C4orf45 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C4orf45 | | | OriGene Protein Over-expression Lysate for C4orf45 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C4orf45 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf45 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf45 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C4orf45 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C4orf45 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4orf45 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C4orf45 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4orf45 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4orf45 |
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 |  |  |  | |
| | | | Search Tocris compounds for C4orf45 |
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 | | | C4orf45 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf45 |
|  |  |  | | | | Search ThermoFisher Antibodies for C4orf45 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf45 |
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