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C4orf45 Gene

protein-coding   GIFtS: 39
GCID: GC04M159814

Chromosome 4 Open Reading Frame 45

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 4 Open Reading Frame 451 2
Uncharacterized Protein C4orf452

External Ids:    HGNC: 263421   Entrez Gene: 1529402   Ensembl: ENSG000001641237   UniProtKB: Q96LM53   
ORGUL members:         

Export aliases for C4orf45 gene to outside databases

Previous GC identifers: GC04M160035 GC04M155564


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C4orf45 Gene:
C4orf45 (chromosome 4 open reading frame 45) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the C4orf45 gene promoter:
         HNF-1A   AREB6   S8   FOXJ2 (long isoform)   HNF-1   FOXO1a   Sox9   FOXJ2   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C4orf45

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C4orf45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.1   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q32.1

C4orf45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C4orf45 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M159814:  view genomic region     (about GC identifiers)

Start:
159,814,286 bp from pter      End:
159,959,912 bp from pter
Size:
145,627 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CD045_HUMAN, Q96LM5 (See protein sequence)
Recommended Name: Uncharacterized protein C4orf45  
Size: 186 amino acids; 21723 Da
Sequence caution: Sequence=BAB71665.1; Type=Frameshift; Positions=178;
Secondary accessions: A8MPU3 C9J0T8

Explore the universe of human proteins at neXtProt for C4orf45: NX_Q96LM5

Explore proteomics data for C4orf45 at MOPED


See C4orf45 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689756.2  
ENSEMBL proteins: 
 ENSP00000412215  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR027814 DUF4562

Graphical View of Domain Structure for InterPro Entry Q96LM5

ProtoNet protein and cluster: Q96LM5


Find genes that share domains with C4orf45           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for C4orf45:
 Increased cell number in G2M,  

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for C4orf45

miRNA
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miRTarBase miRNAs that target C4orf45:
hsa-mir-335-5p (MIRT017095)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus2
cytosol1
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C4orf45
Interactions:

    Search GeneGlobe Interaction Network for C4orf45

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C4orf45 (CD045)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C4orf45 gene: 
NM_152543.2  

Unigene Cluster for C4orf45:

Chromosome 4 open reading frame 45
Hs.415576  [show with all ESTs]
Unigene Representative Sequence: AK307319
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000434826(uc003iqf.1 uc010iqt.1) ENST00000508011 ENST00000505647

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Additional mRNA sequence: 

AK058100.1 AK307319.1 

3 DOTS entries:

DT.40284307  DT.121239078  DT.100745220 

10 AceView cDNA sequences:

AA992028 AA621199 AK058100 BP369394 NM_152543 AI808320 AW182411 BG186198 
BG212472 AW269030 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

C4orf45 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C4orf45 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.415576
    Custom PCR Arrays for C4orf45
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for C4orf45 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gm173591 , 5 predicted gene, 173591, 5 75.61(n)1
67.07(a)1
  3 (34.91 cM)5
1002332071  NM_001142953.11  NP_001136425.11 
 793453765 
chicken
(Gallus gallus)
Aves C4H4ORF451 chromosome 4 open reading frame, human C4orf45 52.67(n)
41.98(a)
  769822  XM_001233137.3  XP_001233138.3 
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004935431 chromosome unknown open reading frame, human C4orf45 52.31(n)
40.97(a)
  100493543  XM_002934741.2  XP_002934787.1 


ENSEMBL Gene Tree for C4orf45 (if available)
TreeFam Gene Tree for C4orf45 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C4orf45 (see all 2500)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs76989871,2
C--159828600(+) ATCCCC/TGCTTG 1 -- int10--------
rs1388510611,2
--159828689(+) AGGTTC/GTTCAC 1 -- int10--------
rs1857502681,2
--159829099(+) ATAGAC/TACCAA 1 -- int10--------
rs21624231,2
C,A,H--159829235(-) ATTAAC/ATATAA 1 -- int112Minor allele frequency- A:0.01NA WA CSA EA 374
rs1420288121,2
--159829268(+) AATAAC/TTCGTG 1 -- int10--------
rs1463125601,2
--159829325(+) TTTTGA/GAAATG 1 -- int10--------
rs729713621,2
C,F--159829351(+) TTAGCG/ATAATG 1 -- int11Minor allele frequency- A:0.50WA 2
rs1905255891,2
--159829391(+) TGGGGC/GCTCAG 1 -- int10--------
rs76588311,2
C,F,A--159829523(+) ttataA/Gttaag 1 -- int12Minor allele frequency- G:0.19CSA WA 119
rs1924552221,2
--159829607(+) ATGCAA/GTTGTT 1 -- int10--------

HapMap Linkage Disequilibrium report for C4orf45 (159814286 - 159959912 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for C4orf45:    About this table    
Variant IDTypeSubtypePubMed ID
nsv4571CNV Loss18451855
nsv830127CNV Loss17160897
nsv830128CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with C4orf45           About GenesLikeMe

Genetic Association Database (GAD): C4orf45
Human Genome Epidemiology (HuGE) Navigator: C4orf45 (1 document)

Export disorders for C4orf45 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C4orf45 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C4orf45)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 152940 HGNC: 26342 AceView: FLJ25371 Ensembl:ENSG00000164123 euGenes: HUgn152940
ECgene: C4orf45 H-InvDB: C4orf45

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C4orf45 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C4orf45 gene:
Search GeneIP for patents involving C4orf45

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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