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Aliases for C4orf45 Gene

Aliases for C4orf45 Gene

  • Chromosome 4 Open Reading Frame 45 2 3 5

External Ids for C4orf45 Gene

Previous GeneCards Identifiers for C4orf45 Gene

  • GC04M160035
  • GC04M159814
  • GC04M155564

Summaries for C4orf45 Gene

GeneCards Summary for C4orf45 Gene

C4orf45 (Chromosome 4 Open Reading Frame 45) is a Protein Coding gene.

Additional gene information for C4orf45 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4orf45 Gene

Genomics for C4orf45 Gene

GeneHancer (GH) Regulatory Elements for C4orf45 Gene

Promoters and enhancers for C4orf45 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I159035 Promoter 0.5 EPDnew 550.2 +47.6 47637 0.1 C4orf45 GC04P159027 GC04M159065 ENSG00000206978 GC04P158864
GH04I159046 Enhancer 1.2 Ensembl ENCODE 47.6 +35.3 35252 2.4 HDGF PKNOX1 FOXA2 MLX ARID4B FEZF1 YY1 ZNF766 FOS SP5 C4orf45 RAPGEF2 C4orf46 ENSG00000206978 GC04M159065 GC04P159027 GC04P158864
GH04I159041 Enhancer 1 ENCODE 49.9 +40.7 40662 2.2 PKNOX1 SMAD1 ARNT FEZF1 ZNF2 NCOA2 TCF12 POLR2B ZNF766 GATA2 C4orf45 RAPGEF2 GC04P159027 ENSG00000206978 GC04M159065 GC04P158864
GH04I159102 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 18.9 -22.3 -22327 5.9 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 POLR2B RAPGEF2 C4orf46 C4orf45 ENSG00000271817 ETFDH MIR3688-2 GC04P158864
GH04I158996 Enhancer 1.1 Ensembl ENCODE 17.1 +85.7 85717 1.8 PKNOX1 FEZF1 YY1 ZNF121 ZNF213 FOS RXRA TSHZ1 ATF4 MAFF C4orf45 PSME2P3 ENSG00000274535 GC04P158864
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C4orf45 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C4orf45 gene promoter:

Genomic Locations for C4orf45 Gene

Genomic Locations for C4orf45 Gene
chr4:158,893,134-159,082,867
(GRCh38/hg38)
Size:
189,734 bases
Orientation:
Minus strand
chr4:159,814,286-159,959,912
(GRCh37/hg19)

Genomic View for C4orf45 Gene

Genes around C4orf45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf45 Gene

Proteins for C4orf45 Gene

  • Protein details for C4orf45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LM5-CD045_HUMAN
    Recommended name:
    Uncharacterized protein C4orf45
    Protein Accession:
    Q96LM5
    Secondary Accessions:
    • A8MPU3
    • C9J0T8

    Protein attributes for C4orf45 Gene

    Size:
    186 amino acids
    Molecular mass:
    21723 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71665.1; Type=Frameshift; Positions=178; Evidence={ECO:0000305};

neXtProt entry for C4orf45 Gene

Post-translational modifications for C4orf45 Gene

No Post-translational modifications

Other Protein References for C4orf45 Gene

No data available for DME Specific Peptides for C4orf45 Gene

Domains & Families for C4orf45 Gene

Gene Families for C4orf45 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C4orf45 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C4orf45: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C4orf45 Gene

Function for C4orf45 Gene

Phenotypes From GWAS Catalog for C4orf45 Gene

Phenotypes for C4orf45 Gene

genes like me logo Genes that share phenotypes with C4orf45: view

Animal Models for C4orf45 Gene

MGI Knock Outs for C4orf45:

miRNA for C4orf45 Gene

miRTarBase miRNAs that target C4orf45

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C4orf45 Gene

Localization for C4orf45 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C4orf45 gene
Compartment Confidence
nucleus 2
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C4orf45 Gene

Pathways & Interactions for C4orf45 Gene

SuperPathways for C4orf45 Gene

No Data Available

Interacting Proteins for C4orf45 Gene

Selected Interacting proteins: Q96LM5-CD045_HUMAN for C4orf45 Gene via UniProtKB

Symbol External ID(s) Details
MDFI

Gene Ontology (GO) - Biological Process for C4orf45 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C4orf45 Gene

Drugs & Compounds for C4orf45 Gene

No Compound Related Data Available

Transcripts for C4orf45 Gene

mRNA/cDNA for C4orf45 Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C4orf45 Gene

Chromosome 4 open reading frame 45:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf45 Gene

No ASD Table

Relevant External Links for C4orf45 Gene

GeneLoc Exon Structure for
C4orf45
ECgene alternative splicing isoforms for
C4orf45

Expression for C4orf45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C4orf45 Gene

mRNA differential expression in normal tissues according to GTEx for C4orf45 Gene

This gene is overexpressed in Testis (x36.9).

NURSA nuclear receptor signaling pathways regulating expression of C4orf45 Gene:

C4orf45

SOURCE GeneReport for Unigene cluster for C4orf45 Gene:

Hs.415576

Evidence on tissue expression from TISSUES for C4orf45 Gene

  • Heart(2.5)
  • Nervous system(2.4)
  • Muscle(2.2)
  • Stomach(2.2)
  • Liver(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with C4orf45: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C4orf45 Gene

Orthologs for C4orf45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C4orf45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C4H4orf45 33
  • 98.82 (n)
C4orf45 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C15H4orf45 33
  • 80.54 (n)
C4orf45 34
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm17359 33 16 34
  • 75.61 (n)
cow
(Bos Taurus)
Mammalia C17H4orf45 33 34
  • 74.71 (n)
rat
(Rattus norvegicus)
Mammalia LOC499643 33
  • 74.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C4orf45 34
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C4orf45 34
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves C4H4ORF45 33
  • 52.67 (n)
C4orf45 34
  • 28 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493543 33
  • 52.31 (n)
Species where no ortholog for C4orf45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C4orf45 Gene

ENSEMBL:
Gene Tree for C4orf45 (if available)
TreeFam:
Gene Tree for C4orf45 (if available)

Paralogs for C4orf45 Gene

No data available for Paralogs for C4orf45 Gene

Variants for C4orf45 Gene

Sequence variations from dbSNP and Humsavar for C4orf45 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000041316 -- 159,030,748(-) C/T intron_variant
rs1000058781 -- 158,906,575(-) TTAATTTAAT/TTAAT intron_variant
rs1000062822 -- 159,067,939(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000066555 -- 159,069,943(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000067171 -- 159,023,236(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C4orf45 Gene

Variant ID Type Subtype PubMed ID
esv3569768 CNV loss 25503493
nsv4571 CNV deletion 18451855
nsv830127 CNV loss 17160897
nsv830128 CNV gain 17160897
nsv966332 CNV duplication 23825009
nsv967806 CNV duplication 23825009

Variation tolerance for C4orf45 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C4orf45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C4orf45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C4orf45 Gene

Disorders for C4orf45 Gene

Additional Disease Information for C4orf45

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C4orf45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf45 Gene

Publications for C4orf45 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y … Sugano S (Genome research 2004) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for C4orf45 Gene

Sources for C4orf45 Gene

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