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Aliases for C4orf3 Gene

Aliases for C4orf3 Gene

  • Chromosome 4 Open Reading Frame 3 2 3 5
  • HCV F-Transactivated Protein 1 2 3 4
  • Hepatitis C Virus F Protein-Transactivated Protein 1 3 4
  • Uncharacterized Protein C4orf3 3
  • HCVFTP1 3

External Ids for C4orf3 Gene

Previous GeneCards Identifiers for C4orf3 Gene

  • GC04M120437
  • GC04M120217
  • GC04M115939

Summaries for C4orf3 Gene

GeneCards Summary for C4orf3 Gene

C4orf3 (Chromosome 4 Open Reading Frame 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4orf3 Gene

Genomics for C4orf3 Gene

Regulatory Elements for C4orf3 Gene

Enhancers for C4orf3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F119572 0.5 FANTOM5 3.8 -267.7 -267657 0.1 C4orf3 ENSG00000221245 GC04P119639
GH04F119319 0.2 ENCODE 0.3 -16.8 -16833 4.0 PKNOX1 GATA3 FEZF1 MNT ZNF843 SP7 LOC645513 FABP2 KLHL2P1 ENSG00000260091 C4orf3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C4orf3 on UCSC Golden Path with GeneCards custom track

Genomic Location for C4orf3 Gene

119,296,419 bp from pter
119,304,445 bp from pter
8,027 bases
Minus strand

Genomic View for C4orf3 Gene

Genes around C4orf3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf3 Gene

Proteins for C4orf3 Gene

  • Protein details for C4orf3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C4orf3
    Protein Accession:
    Secondary Accessions:
    • Q6J203

    Protein attributes for C4orf3 Gene

    66 amino acids
    Molecular mass:
    7604 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C4orf3 Gene


neXtProt entry for C4orf3 Gene

Post-translational modifications for C4orf3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C4orf3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C4orf3 Gene

Domains & Families for C4orf3 Gene

Protein Domains for C4orf3 Gene


Suggested Antigen Peptide Sequences for C4orf3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C4orf3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C4orf3 Gene

Function for C4orf3 Gene

Phenotypes for C4orf3 Gene

genes like me logo Genes that share phenotypes with C4orf3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C4orf3 Gene

Localization for C4orf3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C4orf3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for C4orf3 Gene COMPARTMENTS Subcellular localization image for C4orf3 gene
Compartment Confidence
cytosol 3
plasma membrane 3
extracellular 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C4orf3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C4orf3: view

Pathways & Interactions for C4orf3 Gene

SuperPathways for C4orf3 Gene

No Data Available

Interacting Proteins for C4orf3 Gene

Selected Interacting proteins: Q8WVX3-CD003_HUMAN for C4orf3 Gene via IID

Gene Ontology (GO) - Biological Process for C4orf3 Gene


No data available for Pathways by source and SIGNOR curated interactions for C4orf3 Gene

Transcripts for C4orf3 Gene

mRNA/cDNA for C4orf3 Gene

Unigene Clusters for C4orf3 Gene

Chromosome 4 open reading frame 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf3 Gene

No ASD Table

Relevant External Links for C4orf3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C4orf3 Gene

mRNA expression in normal human tissues for C4orf3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C4orf3 Gene

This gene is overexpressed in Nasal epithelium (58.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C4orf3 Gene

NURSA nuclear receptor signaling pathways regulating expression of C4orf3 Gene:


SOURCE GeneReport for Unigene cluster for C4orf3 Gene:

genes like me logo Genes that share expression patterns with C4orf3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C4orf3 Gene

Orthologs for C4orf3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C4orf3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC461458 34
  • 98.83 (n)
C4orf3 35
  • 98 (a)
(Bos Taurus)
Mammalia C4orf3 35
  • 72 (a)
C6H4orf3 34
  • 67.66 (n)
(Mus musculus)
Mammalia 1810037I17Rik 35
  • 69 (a)
(Canis familiaris)
Mammalia C4orf3 35
  • 66 (a)
Species where no ortholog for C4orf3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C4orf3 Gene

Gene Tree for C4orf3 (if available)
Gene Tree for C4orf3 (if available)

Paralogs for C4orf3 Gene Pseudogenes for C4orf3 Gene

genes like me logo Genes that share paralogs with C4orf3: view

No data available for Paralogs for C4orf3 Gene

Variants for C4orf3 Gene

Sequence variations from dbSNP and Humsavar for C4orf3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs11098500 -- 119,298,084(-) AACCT(A/T)TTTTT utr-variant-3-prime
rs111306236 -- 119,300,040(+) AATAA(C/T)TTCTC intron-variant
rs111393001 -- 119,297,619(+) TTTGT(A/T)TTTTT utr-variant-3-prime
rs111722934 -- 119,298,120(+) GAGGC(C/T)CAAGA utr-variant-3-prime
rs111741197 -- 119,301,296(+) GCAGG(C/G)GCCTG intron-variant, upstream-variant-2KB

Variation tolerance for C4orf3 Gene

Gene Damage Index Score: 0.88; 18.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C4orf3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C4orf3 Gene

Disorders for C4orf3 Gene

Relevant External Links for C4orf3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C4orf3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf3 Gene

Publications for C4orf3 Gene

  1. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 64
  2. Screening and cloning target genes transactivated by hepatitis C virus F protein using suppression subtractive hybridization technique. (PMID: 16174453) Guo J. … Wu S.H. (Zhonghua Gan Zang Bing Za Zhi 2005) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64

Products for C4orf3 Gene

Sources for C4orf3 Gene

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