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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C4orf29 Gene

protein-coding   GIFtS: 37
GCID: GC04P128886

chromosome 4 open reading frame 29
  Search for C4orf29
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C4orf29    

Aliases
for C4orf29 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 4 Open Reading Frame 291 2
FLJ211061
Uncharacterized Protein C4orf292

External Ids:    HGNC: 261111   Entrez Gene: 801672   Ensembl: ENSG000001640747   UniProtKB: Q0P6513   

Export aliases for C4orf29 gene to outside databases

Previous GC identifers: GC04P129105 GC04P124618


Summaries
for C4orf29 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C4orf29 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C4orf29 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C4orf29

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4orf29


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.2   Ensembl cytogenetic band:  4q28.2   HGNC cytogenetic band: 4q28.2

C4orf29 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C4orf29 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P128886:  view genomic region     (about GC identifiers)

Start:
 128,886,461 bp from pter      End:
 128,960,866 bp from pter
Size:
 74,406 bases      Orientation:
 plus strand

Proteins
for C4orf29 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD029_HUMAN, Q0P651 (See protein sequence)
Recommended Name: Uncharacterized protein C4orf29 precursor  
Size: 414 amino acids; 46954 Da
Subcellular location: Secreted (Potential)
Secondary accessions: A1A4W8 A1A4W9 Q9H7A7
Alternative splicing: 4 isoforms:  Q0P651-1   Q0P651-2   Q0P651-3   Q0P651-4   (No experimental confirmation available. Ref.1 (BAB14990) sequence is in conflict in position: 36:S->P)

Explore the universe of human proteins at neXtProt for C4orf29: NX_Q0P651

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q0P651

    • C4orf29 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001034806.1  
    ENSEMBL proteins: 
     ENSP00000425434   ENSP00000397229   ENSP00000423570   ENSP00000373447   ENSP00000421129  
     ENSP00000381937  

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    Uscn Proteins for C4orf29

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    C4orf29 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for C4orf29 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    C4orf29 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019149 DUF2048

    Graphical View of Domain Structure for InterPro Entry Q0P651

    ProtoNet protein and cluster: Q0P651


    Function
    for C4orf29 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for C4orf29 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C4orf29

    1 Interacting protein for C4orf29 (Q0P6513) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C12orf4Q9NQ893I2D: score=3 
    About this table

    Drugs & Compounds
    for C4orf29 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for C4orf29
    Search CenterWatch for drugs/clinical trials and news about C4orf29 / CD029 

    Transcripts
    for C4orf29 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for C4orf29 gene (2 alternative transcripts): 
    NM_001039717.1  NM_025097.1  

    Unigene Cluster for C4orf29:

    Chromosome 4 open reading frame 29
    Hs.445817  [show with all ESTs]
    Unigene Representative Sequence: BC075793
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473040(uc003ift.3) ENST00000444616(uc003ifu.3) ENST00000480407(uc010inz.3)
    ENST00000388795(uc003ifv.3) ENST00000513371 ENST00000398965(uc021xrs.1 uc003ifq.2 uc021xrt.1)


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK024759.1 BC034253.1 BC058847.1 BC058898.1 BC075793.1 BC111400.1 BC128142.1 BC128143.1 

    10 DOTS entries:

    DT.97814789  DT.75147537  DT.40197433  DT.97803541  DT.91860193  DT.121272844  DT.40265407  DT.207104 
    DT.95154397  DT.121272860 

    24/68 AceView cDNA sequences (see all 68):

    BU784363 CK823517 BU788029 BC058898 NM_025097 AI911428 BC034253 CR597196 
    BF794563 AI269668 BM967305 AK024759 BX350600 BM052868 BC058847 AW673838 
    AI434783 CA444257 BC075793 BM804070 BI757221 AA824457 BX500590 BM893960 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for C4orf29    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12
    SP1:                                                                                                
    SP2:                          -                                                                     
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for C4orf29

    Expression
    for C4orf29 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C4orf29 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See C4orf29 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C4orf29

    SOURCE GeneReport for Unigene cluster: Hs.445817
        SABiosciences Custom PCR Arrays for C4orf29
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    In Situ
    Assay Products:     
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    Orthologs
    for C4orf29 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for C4orf29 gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 3110057O12Rik1 , 5 RIKEN cDNA 3110057O12 gene1, 5 88.81(n)1
    90.58(a)1    		   3 (19.58 cM)5
    2694231  NM_026622.31  NP_080898.21 
     408941455 
    chicken
    (Gallus gallus)    		 Aves C4H4orf291 chromosome 4 open reading frame, human C4orf29 75.65(n)
    76.46(a)    		   422499  NM_001031134.2  NP_001026305.2 
    lizard
    (Anolis carolinensis)    		 Reptilia C4orf296
    		 --
    		 69(a)
    		 1 ↔ 1
    		 5(136346022-136356070)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC688532 hypothetical protein MGC68853 78.67(n)    BC057712.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufk51f042 Transcribed sequence with moderate similarity to protein more 74.7(n)    BG306982.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG321121 CG32112 53.28(n)
    51.58(a)    		   317860  NM_168507.2  NP_729820.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea C54G4.71 Protein C54G4.7 48.26(n)
    39.83(a)    		   3565589  NM_059805.3  NP_492206.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G121501 hypothetical protein 48.08(n)
    39.03(a)    		   820392  NM_112050.2  NP_187822.2 
    rice
    (Oryza sativa)    		 Liliopsida Os02g01950001 hypothetical protein 45.74(n)
    39.05(a)    		   4328606  NM_001052718.1  NP_001046183.1 


    ENSEMBL Gene Tree for C4orf29 (if available)
    TreeFam Gene Tree for C4orf29 (if available) 

    Paralogs
    for C4orf29 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C4orf29 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C4orf29
    DNA2.0 Custom Variant and Variant Library Synthesis for C4orf29

    Disorders / Diseases
    for C4orf29 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C4orf29 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C4orf29 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C4orf29)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for C4orf29 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C4orf29 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80167 HGNC: 26111 AceView: FLJ21106 Ensembl:ENSG00000164074 euGenes: HUgn80167
    ECgene: C4orf29 H-InvDB: C4orf29

    Other Databases showing C4orf29 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C4orf29 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C4orf29 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C4orf29 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C4orf29 gene:
    Search GeneIP for patents involving C4orf29

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C4orf29 gene

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    About This Section

     
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