C4orf27 Gene
protein-coding GIFtS: 45
GCID: GC04M170650
|
|
chromosome 4 open reading frame 27
| |
Aliases
for C4orf27 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 4 Open Reading Frame 271 2 | | FLJ205341 | | UPF0609 Protein C4orf272 |
Export aliases for C4orf27 gene to outside databasesPrevious GC identifers: GC04M170887 GC04M166405 |
Summaries
for C4orf27 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C4orf27 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C4orf27 gene promoter:
AML1a ATF-2 MIF-1 E47 Meis-1b E2F-1 E2F Hand1 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C4orf27
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4orf27 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q33 Ensembl cytogenetic band: 4q33 HGNC cytogenetic band: 4q33C4orf27 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M170650: view genomic region
(about GC identifiers)
Start:
|
170,650,616 bp from pter |
End:
|
170,679,104 bp from pter |
Size:
|
28,489 bases |
Orientation:
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minus strand |
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Proteins
for C4orf27 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CD027_HUMAN, Q9NWY4 (See
protein sequence)Recommended Name: UPF0609 protein C4orf27 Size: 346 amino acids; 39436 DaExplore the universe of human proteins at neXtProt for C4orf27: NX_Q9NWY4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NWY4
C4orf27 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060337.2
ENSEMBL proteins: ENSP00000406598
Human Recombinant Protein Products for C4orf27:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
C4orf27 for ontologies About GeneDecksing
C4orf27 Antibody Products:
Assay Products for C4orf27: |
Protein
Domains /
Families
for C4orf27 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C4orf27 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NWY4ProtoNet protein and cluster: Q9NWY4 UniProtKB/Swiss-Prot: CD027_HUMAN, Q9NWY4Similarity: Belongs to the UPF0609 family |
Function
for C4orf27 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for C4orf27:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf27 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf27 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: C4orf27 (NM_017867) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C4orf27 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf27 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf27 |
|
Pathways & Interactions
for C4orf27 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C4orf27
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/13 Interacting proteins for C4orf27 (Q9NWY42, 3 ENSP000004065984) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
|
Drugs & Compounds
for C4orf27 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C4orf27
Search CenterWatch for drugs/clinical trials and news about C4orf27 / CD027
|
Transcripts
for C4orf27 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C4orf27 gene: NM_017867.2 Unigene Cluster for C4orf27: Chromosome 4 open reading frame 27 Hs.406756 [show with all ESTs]Unigene Representative Sequence: BM4580193 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393381(uc003isl.4) ENST00000515204 ENST00000506125
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf27 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf27 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C4orf27 (NM_017867) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C4orf27 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf27 |
Additional cDNA sequence: AK000541.1 AL136673.1 BC010367.1 7 DOTS entries: DT.441269 DT.102825693 DT.95373029 DT.92426705 DT.92426704 DT.95373034 DT.91743572 24/121 AceView cDNA sequences (see all 121): AI589724 BQ011514 CB105134 BU630734 BU689800 CB164621 AK124036 BQ774188 BM667452 CR623533 CA944509 AA418905 W95882 AJ707079 CR606119 AI337885 CK823967 AA810170 BM905677 CB242862 CB162264 BQ015910 AI963737 CR607563
GeneLoc Exon Structure
|
Expression
for C4orf27 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C4orf27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTAAGGTGG
About this image
See C4orf27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C4orf27
SOURCE GeneReport for Unigene cluster: Hs.406756
SABiosciences Custom PCR Arrays for C4orf27
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C4orf27
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C4orf27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4orf27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4orf27 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf27 |
Orthologs
for C4orf27 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C4orf27 gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
2700029M09Rik1 , 5 |
RIKEN cDNA 2700029M09 gene1, 5 |
89.76(n)1
89.57(a)1 |
|
8 (30.90 cM)5
726121 NM_028299.11 NP_082575.11
608904185 |
chicken
(Gallus gallus) |
Aves |
C4H4orf271 |
chromosome 4 open reading frame, human C4orf27 |
74.68(n)
75.66(a) |
|
422431 XM_420399.2 XP_420399.2 |
lizard
(Anolis carolinensis) |
Reptilia |
C4orf276 |
-- |
74(a) |
1 ↔ 1 |
GL343216.1(807705-813184) |
African clawed frog
(Xenopus laevis) |
Amphibia |
AW645483.12 |
-- |
75.56(n) |
|
AW645483.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb44b082 |
Danio rerio cDNA clone IMAGE3816913, partial cds |
77.44(n) |
|
BC055260.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG12181 |
CG1218 |
45.24(n)
36.69(a) |
|
40718 NM_141332.3 NP_649589.1 |
ENSEMBL Gene Tree for C4orf27 (if available)
TreeFam Gene Tree for C4orf27 (if available) |
Paralogs
for C4orf27 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C4orf27 gene
C4orf27 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for C4orf27
PGOHUM00000235155 PGOHUM00000235277 PGOHUM00000235483 PGOHUM00000236392
|
Genomic Variants
for C4orf27 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C4orf27 (170650616 - 170679104 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C4orf27: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C4orf27 |
|
Disorders
/ Diseases
for C4orf27 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C4orf27 for disorders About GeneDecksing
2  diseases for C4orf27: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma
Human Genome Epidemiology (HuGE) Navigator: C4orf27 (1 document)
Export disorders for C4orf27 gene to outside databases
|
Publications
for C4orf27 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C4orf27 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with C4orf27) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Complementary quantitative proteomics reveals that tr anscription factor AP-4 mediates E-box-dependent complex formation for transcri ptional repression of HDM2. (PubMed id 19505873)1 Ku W.C....Chen Y.J. (2009)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
|
External Searches for C4orf27 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C4orf27 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C4orf27 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C4orf27 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C4orf27 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C4orf27 gene:
Search GeneIP for patents involving C4orf27
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C4orf27 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C4orf27 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C4orf27 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C4orf27 | | | OriGene Protein Over-expression Lysate for C4orf27 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C4orf27 | | OriGene 3'-UTR Clone for C4orf27 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf27 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf27 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C4orf27 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C4orf27 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4orf27 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C4orf27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4orf27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4orf27 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for C4orf27 |
| |  |  |  |  | | | | |
 |
 |
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 | | | C4orf27 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf27 |
|  |  |  |  | | | | ThermoFisher Antibodies for C4orf27 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf27 |
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