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Aliases for C4orf22 Gene

Aliases for C4orf22 Gene

  • Chromosome 4 Open Reading Frame 22 2 3

External Ids for C4orf22 Gene

Previous GeneCards Identifiers for C4orf22 Gene

  • GC04P081475
  • GC04P081256
  • GC04P077000

Summaries for C4orf22 Gene

GeneCards Summary for C4orf22 Gene

C4orf22 (Chromosome 4 Open Reading Frame 22) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4orf22 Gene

Genomics for C4orf22 Gene

Regulatory Elements for C4orf22 Gene

Genomic Location for C4orf22 Gene

Start:
80,335,707 bp from pter
End:
80,963,756 bp from pter
Size:
628,050 bases
Orientation:
Plus strand

Genomic View for C4orf22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C4orf22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf22 Gene

Proteins for C4orf22 Gene

  • Protein details for C4orf22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6V702-CD022_HUMAN
    Recommended name:
    Uncharacterized protein C4orf22
    Protein Accession:
    Q6V702
    Secondary Accessions:
    • E7EQ13
    • Q6ZQY4
    • Q8N4G9

    Protein attributes for C4orf22 Gene

    Size:
    233 amino acids
    Molecular mass:
    26869 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C4orf22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C4orf22 Gene

Proteomics data for C4orf22 Gene at MOPED

Post-translational modifications for C4orf22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C4orf22 Gene

No data available for DME Specific Peptides for C4orf22 Gene

Domains for C4orf22 Gene

Protein Domains for C4orf22 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C4orf22: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C4orf22 Gene

Function for C4orf22 Gene

Phenotypes for C4orf22 Gene

GenomeRNAi human phenotypes for C4orf22:
genes like me logo Genes that share phenotypes with C4orf22: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C4orf22

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C4orf22 Gene

Localization for C4orf22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C4orf22 Gene COMPARTMENTS Subcellular localization image for C4orf22 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C4orf22 Gene

Pathways for C4orf22 Gene

SuperPathways for C4orf22 Gene

No Data Available

Interacting Proteins for C4orf22 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000425786%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000425786 for C4orf22 Gene via STRING

Symbol External ID(s) Details
BAG3

Gene Ontology (GO) - Biological Process for C4orf22 Gene

None

No data available for Pathways by source for C4orf22 Gene

Transcripts for C4orf22 Gene

Unigene Clusters for C4orf22 Gene

Chromosome 4 open reading frame 22:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C4orf22

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf22 Gene

No ASD Table

Relevant External Links for C4orf22 Gene

GeneLoc Exon Structure for
C4orf22
ECgene alternative splicing isoforms for
C4orf22

Expression for C4orf22 Gene

mRNA expression in normal human tissues for C4orf22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C4orf22 Gene

This gene is overexpressed in Testis (23.9).

SOURCE GeneReport for Unigene cluster for C4orf22 Gene Hs.527104

genes like me logo Genes that share expressions with C4orf22: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for C4orf22 Gene

Orthologs for C4orf22 Gene

This gene was present in the common ancestor of animals.

Orthologs for C4orf22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C4H4orf22 35
  • 99.2 (n)
  • 98 (a)
C4orf22 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C4orf22 36
  • 87 (a)
OneToOne
C6H4orf22 35
  • 88.89 (n)
  • 87.45 (a)
dog
(Canis familiaris)
Mammalia C32H4orf22 35
  • 88.67 (n)
  • 85.2 (a)
C4orf22 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700007G11Rik 35
  • 83.83 (n)
  • 84.55 (a)
1700007G11Rik 16
1700007G11Rik 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C4orf22 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C4orf22 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC685158 35
  • 74.64 (n)
  • 71.74 (a)
lizard
(Anolis carolinensis)
Reptilia C4orf22 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498045 35
  • 70.98 (n)
  • 71.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.274 35
zebrafish
(Danio rerio)
Actinopterygii C5H4orf22 36
  • 49 (a)
OneToOne
Dr.12493 35
si:ch211-57h10.1 35
  • 63.62 (n)
  • 60.43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006170 35
  • 45.83 (n)
  • 35.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14013 36
  • 25 (a)
OneToMany
CG14017 36
  • 28 (a)
OneToMany
CG3528 36
  • 28 (a)
OneToMany
CG8138 36
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8131 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for C4orf22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C4orf22 Gene

ENSEMBL:
Gene Tree for C4orf22 (if available)
TreeFam:
Gene Tree for C4orf22 (if available)

Paralogs for C4orf22 Gene

genes like me logo Genes that share paralogs with C4orf22: view

No data available for Paralogs for C4orf22 Gene

Variants for C4orf22 Gene

Sequence variations from dbSNP and Humsavar for C4orf22 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs184513 -- 80,706,536(+) ATTGA(C/T)ACATG intron-variant
rs191295 -- 80,706,382(+) TCCAG(A/C)TAGAA intron-variant
rs329392 -- 80,715,257(-) TCCAA(C/T)CAAAT intron-variant
rs329393 -- 80,714,733(-) TTTTG(C/T)AGTTT intron-variant
rs329394 -- 80,714,478(-) TATTT(C/T)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C4orf22 Gene

Variant ID Type Subtype PubMed ID
esv2660580 CNV Deletion 23128226
esv2437571 CNV Deletion 19546169
esv2012478 CNV Deletion 18987734
esv3707 CNV Deletion 18987735
dgv155n6 CNV Loss 16902084
esv2727868 CNV Deletion 23290073
esv996118 CNV Deletion 20482838
esv1772075 CNV Deletion 17803354
esv8483 CNV Loss 19470904
nsv4401 CNV Insertion 18451855
nsv528410 CNV Loss 19592680
esv2727869 CNV Deletion 23290073
esv2287638 CNV Deletion 18987734
esv4973 CNV Deletion 18987735
esv1003054 CNV Deletion 20482838
esv2557088 CNV Deletion 19546169
esv2727870 CNV Deletion 23290073
esv1761835 CNV Deletion 17803354
esv29813 CNV Loss 19812545
esv2668568 CNV Deletion 23128226
esv2727871 CNV Deletion 23290073
esv2661892 CNV Deletion 23128226
esv2659472 CNV Deletion 23128226
esv22804 CNV Loss 19812545
esv2458804 CNV Deletion 19546169
esv2727872 CNV Deletion 23290073
nsv517603 CNV Loss 19592680
nsv517072 CNV Loss 19592680
nsv293578 CNV Loss 16902084
nsv525865 CNV Loss 19592680

Relevant External Links for C4orf22 Gene

HapMap Linkage Disequilibrium report
C4orf22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C4orf22 Gene

Disorders for C4orf22 Gene

Relevant External Links for C4orf22

Genetic Association Database (GAD)
C4orf22
Human Genome Epidemiology (HuGE) Navigator
C4orf22
genes like me logo Genes that share disorders with C4orf22: view

No data available for UniProtKB/Swiss-Prot for C4orf22 Gene

Publications for C4orf22 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for C4orf22 Gene

Sources for C4orf22 Gene

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