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Aliases for C4orf22 Gene

Aliases for C4orf22 Gene

  • Chromosome 4 Open Reading Frame 22 2 3 5

External Ids for C4orf22 Gene

Previous GeneCards Identifiers for C4orf22 Gene

  • GC04P081475
  • GC04P081256
  • GC04P077000

Summaries for C4orf22 Gene

GeneCards Summary for C4orf22 Gene

C4orf22 (Chromosome 4 Open Reading Frame 22) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4orf22 Gene

Genomics for C4orf22 Gene

Regulatory Elements for C4orf22 Gene

Enhancers for C4orf22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C4orf22 on UCSC Golden Path with GeneCards custom track

Promoters for C4orf22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C4orf22 Gene

Chromosome:
4
Start:
80,335,326 bp from pter
End:
80,963,756 bp from pter
Size:
628,431 bases
Orientation:
Plus strand

Genomic View for C4orf22 Gene

Genes around C4orf22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf22 Gene

Proteins for C4orf22 Gene

  • Protein details for C4orf22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6V702-CD022_HUMAN
    Recommended name:
    Uncharacterized protein C4orf22
    Protein Accession:
    Q6V702
    Secondary Accessions:
    • E7EQ13
    • Q6ZQY4
    • Q8N4G9

    Protein attributes for C4orf22 Gene

    Size:
    233 amino acids
    Molecular mass:
    26869 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C4orf22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C4orf22 Gene

Post-translational modifications for C4orf22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C4orf22 Gene

No data available for DME Specific Peptides for C4orf22 Gene

Domains & Families for C4orf22 Gene

Protein Domains for C4orf22 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C4orf22: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C4orf22 Gene

Function for C4orf22 Gene

genes like me logo Genes that share phenotypes with C4orf22: view

Animal Models for C4orf22 Gene

MGI Knock Outs for C4orf22:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C4orf22 Gene

Localization for C4orf22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C4orf22 Gene COMPARTMENTS Subcellular localization image for C4orf22 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2
cytoskeleton 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C4orf22 Gene

Pathways & Interactions for C4orf22 Gene

SuperPathways for C4orf22 Gene

No Data Available

Interacting Proteins for C4orf22 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000425786%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000425786 Q6V702-CD022_HUMAN for C4orf22 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C4orf22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C4orf22 Gene

Drugs & Compounds for C4orf22 Gene

No Compound Related Data Available

Transcripts for C4orf22 Gene

Unigene Clusters for C4orf22 Gene

Chromosome 4 open reading frame 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf22 Gene

No ASD Table

Relevant External Links for C4orf22 Gene

GeneLoc Exon Structure for
C4orf22
ECgene alternative splicing isoforms for
C4orf22

Expression for C4orf22 Gene

mRNA expression in normal human tissues for C4orf22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C4orf22 Gene

This gene is overexpressed in Testis (x23.9).

NURSA nuclear receptor signaling pathways regulating expression of C4orf22 Gene:

C4orf22

SOURCE GeneReport for Unigene cluster for C4orf22 Gene:

Hs.527104
genes like me logo Genes that share expression patterns with C4orf22: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C4orf22 Gene

Orthologs for C4orf22 Gene

This gene was present in the common ancestor of animals.

Orthologs for C4orf22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C6H4orf22 34
  • 88.89 (n)
  • 87.45 (a)
C4orf22 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C32H4orf22 34
  • 88.67 (n)
  • 85.2 (a)
C4orf22 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700007G11Rik 34
  • 83.83 (n)
  • 84.55 (a)
1700007G11Rik 16
1700007G11Rik 35
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C4H4orf22 34
  • 99.2 (n)
  • 98 (a)
C4orf22 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC685158 34
  • 74.64 (n)
  • 71.74 (a)
oppossum
(Monodelphis domestica)
Mammalia C4orf22 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C4orf22 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C4orf22 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498045 34
  • 70.98 (n)
  • 71.55 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12493 34
si:ch211-57h10.1 34
  • 63.62 (n)
  • 60.43 (a)
C5H4orf22 35
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.274 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006170 34
  • 45.83 (n)
  • 35.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14013 35
  • 25 (a)
OneToMany
CG14017 35
  • 28 (a)
OneToMany
CG3528 35
  • 28 (a)
OneToMany
CG8138 35
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 63 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8131 34
Species where no ortholog for C4orf22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C4orf22 Gene

ENSEMBL:
Gene Tree for C4orf22 (if available)
TreeFam:
Gene Tree for C4orf22 (if available)

Paralogs for C4orf22 Gene

genes like me logo Genes that share paralogs with C4orf22: view

No data available for Paralogs for C4orf22 Gene

Variants for C4orf22 Gene

Sequence variations from dbSNP and Humsavar for C4orf22 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs11947742 - 80,870,072(+) AAAGA(C/T)GGAAG downstream-variant-500B, reference, missense
rs1052325 - 80,963,568(+) TCTAC(A/G)TACAA reference, missense, utr-variant-3-prime
rs374274 -- 80,701,573(+) AGGCA(C/T)GAAAT intron-variant
rs396273 -- 80,711,765(-) AAATA(C/G)GGTAC intron-variant
rs410848 -- 80,697,505(-) TTGTT(G/T)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C4orf22 Gene

Variant ID Type Subtype PubMed ID
dgv155n6 CNV deletion 16902084
dgv2834n106 CNV deletion 24896259
dgv2835n106 CNV deletion 24896259
dgv2836n106 CNV deletion 24896259
esv1003054 CNV deletion 20482838
esv1761835 CNV deletion 17803354
esv1772075 CNV deletion 17803354
esv2012478 CNV deletion 18987734
esv22804 CNV loss 19812545
esv2287638 CNV deletion 18987734
esv2437571 CNV deletion 19546169
esv2458804 CNV deletion 19546169
esv2557088 CNV deletion 19546169
esv2659472 CNV deletion 23128226
esv2660580 CNV deletion 23128226
esv2661892 CNV deletion 23128226
esv2668568 CNV deletion 23128226
esv2727868 CNV deletion 23290073
esv2727869 CNV deletion 23290073
esv2727870 CNV deletion 23290073
esv2727871 CNV deletion 23290073
esv2727872 CNV deletion 23290073
esv2763370 CNV gain 21179565
esv29813 CNV loss 19812545
esv3564134 CNV deletion 23714750
esv3564135 CNV deletion 23714750
esv3564136 CNV deletion 23714750
esv3564138 CNV deletion 23714750
esv3569534 CNV loss 25503493
esv3569535 CNV loss 25503493
esv3575755 CNV gain 25503493
esv3601136 CNV loss 21293372
esv3601138 CNV loss 21293372
esv3601139 CNV loss 21293372
esv3601140 CNV gain 21293372
esv3601141 CNV gain 21293372
esv3601142 CNV loss 21293372
esv3601143 CNV gain 21293372
esv3707 CNV loss 18987735
esv3893966 CNV loss 25118596
esv4973 CNV loss 18987735
esv8483 CNV loss 19470904
esv996118 CNV deletion 20482838
nsv1013945 CNV loss 25217958
nsv1073346 CNV deletion 25765185
nsv1073347 CNV deletion 25765185
nsv1114548 CNV deletion 24896259
nsv1121628 CNV deletion 24896259
nsv1125818 CNV tandem duplication 24896259
nsv1139275 CNV deletion 24896259
nsv1141810 CNV insertion 24896259
nsv1143098 CNV tandem duplication 24896259
nsv1145996 CNV insertion 26484159
nsv1147567 CNV deletion 26484159
nsv293578 CNV deletion 16902084
nsv4401 CNV insertion 18451855
nsv472244 CNV novel sequence insertion 20440878
nsv517072 CNV loss 19592680
nsv517603 CNV loss 19592680
nsv525865 CNV loss 19592680
nsv528410 CNV loss 19592680
nsv955663 CNV deletion 24416366
nsv955669 CNV deletion 24416366

Variation tolerance for C4orf22 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C4orf22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C4orf22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C4orf22 Gene

Disorders for C4orf22 Gene

Relevant External Links for C4orf22

Genetic Association Database (GAD)
C4orf22
Human Genome Epidemiology (HuGE) Navigator
C4orf22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C4orf22

No disorders were found for C4orf22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf22 Gene

Publications for C4orf22 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3 65
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 65
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 65
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 65

Products for C4orf22 Gene

Sources for C4orf22 Gene

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