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C4orf22 Gene

protein-coding   GIFtS: 43
GCID: GC04P081256

Chromosome 4 Open Reading Frame 22

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 4 Open Reading Frame 221 2
Uncharacterized Protein C4orf222

External Ids:    HGNC: 285541   Entrez Gene: 2551192   Ensembl: ENSG000001978267   UniProtKB: Q6V7023   

Export aliases for C4orf22 gene to outside databases

Previous GC identifers: GC04P081475 GC04P077000


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C4orf22 Gene:
C4orf22 (chromosome 4 open reading frame 22) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C4orf22 gene promoter:
         STAT5B   CUTL1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   STAT5A   POU3F2   MEF-2A   POU2F1   POU2F1a   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C4orf22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C4orf22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21.21

C4orf22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C4orf22 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P081256:  view genomic region     (about GC identifiers)

Start:
81,256,874 bp from pter      End:
81,884,910 bp from pter
Size:
628,037 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD022_HUMAN, Q6V702 (See protein sequence)
Recommended Name: Uncharacterized protein C4orf22  
Size: 233 amino acids; 26869 Da
Secondary accessions: E7EQ13 Q6ZQY4 Q8N4G9
Alternative splicing: 3 isoforms:  Q6V702-2   Q6V702-1   Q6V702-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for C4orf22: NX_Q6V702

Explore proteomics data for C4orf22 at MOPED


See C4orf22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001193926.1  NP_689983.2  

ENSEMBL proteins: 
 ENSP00000350818   ENSP00000426308   ENSP00000422569   ENSP00000425786  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR027887 DUF4464

Graphical View of Domain Structure for InterPro Entry Q6V702

ProtoNet protein and cluster: Q6V702


Find genes that share domains with C4orf22           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for C4orf22:
 Actin fiber cells 

     1 MGI phenotypic allele for 1700007G11Rik (no phenotypes)

Find genes that share phenotypes with C4orf22           About GenesLikeMe

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2
cytoskeleton1
extracellular1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C4orf22
Interactions:

    Search GeneGlobe Interaction Network for C4orf22

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C4orf22 (CD022)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C4orf22 gene (2 alternative transcripts): 
NM_001206997.1  NM_152770.2  

Unigene Cluster for C4orf22:

Chromosome 4 open reading frame 22
Hs.527104  [show with all ESTs]
Unigene Representative Sequence: BC034296
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000358105(uc010ijp.3 uc003hmf.3) ENST00000512931 ENST00000514249
ENST00000502497 ENST00000513920 ENST00000508675 ENST00000503883 ENST00000508314

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Additional mRNA sequence: 

AY349359.1 BC034296.1 

4 DOTS entries:

DT.406504  DT.121247319  DT.100743962  DT.75130543 

Selected AceView cDNA sequences (see all 29):

AI932395 AI651145 AI919149 BE502517 AA709187 AI650567 BG183737 AI247339 
AI149611 CD103403 CF995638 BG220137 AW183314 AW118140 BM979645 AI218635 
AK128642 AA412289 BI827593 BG181665 BG198747 AW340087 BE856735 BC034296 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C4orf22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTAATTTCCT
C4orf22 Expression
About this image


C4orf22 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
         Epiblast Stem Cell line 5
C4orf22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C4orf22 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.527104
    Custom PCR Arrays for C4orf22
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for C4orf22 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 1700007G11Rik1 , 5 RIKEN cDNA 1700007G11 gene1, 5 83.83(n)1
84.55(a)1
  5 (47.77 cM)5
757841  NM_001024614.11  NP_001019785.11 
 983293545 
lizard
(Anolis carolinensis)
Reptilia C4orf226
chromosome 4 open reading frame 22
68(a)
1 ↔ 1
GL343425.1(470915-775664)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004980451 chromosome unknown open reading frame, human C4orf22 70.98(n)
71.55(a)
  100498045  XM_002933999.2  XP_002934045.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.124932 Transcribed sequences 74.06(n)    BQ074897.1 
fruit fly
(Drosophila melanogaster)
Insecta CG81386
CG35286
(see all 4)
--
30(a)
28(a)
(see all 4)
many → 1
many → 1
(see all 4)
3R(9007026-9007876)
2L(2517102-2518037)


ENSEMBL Gene Tree for C4orf22 (if available)
TreeFam Gene Tree for C4orf22 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for C4orf22 gene
Selected SIMAP similar genes for C4orf22 using alignment to 3 protein entries:     CD022_HUMAN (see all proteins) (see all similar genes):
LINC00596    MPP4    AURA2    EDRF1    MYB    NF2
LAMB4    RUFY1    ZNF564    TSEN2    BTBD2    HMGA2
ERBB2    HKR1    FAM175A    SH3PXD2A    TMEM14B    LEPROTL1

Find genes that share paralogs with C4orf22           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C4orf22 (see all 12323)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs345387081,2
C--81168408(+) TTTTT-/G/TG  
        
TTTGT
2 -- int10--------
rs1875497541,2
--81254909(+) GGGATC/TGGTGC 2 -- us2k10--------
rs1920256051,2
--81255013(+) TGCAAC/TGAAAA 2 -- us2k10--------
rs1464580411,2
--81255136(+) TTATAC/TGCACT 2 -- us2k10--------
rs1398428721,2
C--81255179(+) TAAGTG/TTATGA 2 -- us2k10--------
rs1849918171,2
--81255184(+) TTATGA/GATTTT 2 -- us2k10--------
rs1895663781,2
C--81255197(+) TGATAA/G/TTAATA 2 -- us2k10--------
rs1820221281,2
--81255198(+) GATATC/TAATAG 2 -- us2k10--------
rs1431662041,2
--81255316(+) GATTAC/TTTCAT 2 -- us2k10--------
rs1846334901,2
--81255405(+) ATATAA/TAGCCA 2 -- us2k10--------

HapMap Linkage Disequilibrium report for C4orf22 (81256874 - 81506874 bp, first 250kb of C4orf22)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for C4orf22 (see all 30):    About this table    
Variant IDTypeSubtypePubMed ID
esv2727872CNV Deletion23290073
esv2557088CNV Deletion19546169
esv1003054CNV Deletion20482838
esv2668568CNV Deletion23128226
esv2660580CNV Deletion23128226
esv2458804CNV Deletion19546169
esv2727868CNV Deletion23290073
esv1772075CNV Deletion17803354
esv2659472CNV Deletion23128226
esv2661892CNV Deletion23128226

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with C4orf22           About GenesLikeMe

Genetic Association Database (GAD): C4orf22
Human Genome Epidemiology (HuGE) Navigator: C4orf22 (2 documents)

Export disorders for C4orf22 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C4orf22 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with C4orf22)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  6. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
  7. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
  8. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
  9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 255119 HGNC: 28554 AceView: MGC35043 Ensembl:ENSG00000197826 euGenes: HUgn255119
ECgene: C4orf22 H-InvDB: C4orf22

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C4orf22 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C4orf22 gene:
Search GeneIP for patents involving C4orf22

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Block miRNA regulation of human, mouse, rat C4orf22 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing C4orf22
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 Search Tocris compounds for C4orf22 (CD022)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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 Browse ESI BIO Cell Lines and PureStem Progenitors for C4orf22
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 SwitchGear 3'UTR luciferase reporter plasmids for C4orf22
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 Search ThermoFisher Antibodies for C4orf22
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf22
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C4orf22
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 LSBio Antibodies in human, mouse, rat for C4orf22
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 Search Addgene for plasmids for C4orf22
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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