C4orf21 Gene
protein-coding GIFtS: 43
GCID: GC04M113483
|
|
chromosome 4 open reading frame 21
| |
Aliases
for C4orf21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 4 Open Reading Frame 211 2 | | FLJ113311 | | Prematurely Terminated MRNA Decay Factor-Like2 |
Export aliases for C4orf21 gene to outside databasesPrevious GC identifers: GC04M113730 GC04M109192 |
Summaries
for C4orf21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C4orf21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C4orf21 gene promoter:
E2F-3a E2F-4 E2F-5 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) E2F-2 Cdc5 POU3F2 E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for C4orf21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4orf21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q25 Ensembl cytogenetic band: 4q25 HGNC cytogenetic band: 4q25C4orf21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M113483: view genomic region
(about GC identifiers)
Start:
|
113,460,489 bp from pter |
End:
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113,558,151 bp from pter |
Size:
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97,663 bases |
Orientation:
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minus strand |
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Proteins
for C4orf21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CD021_HUMAN, Q86YA3 (See
protein sequence)Recommended Name: Uncharacterized protein C4orf21 Size: 1062 amino acids; 119347 Da
Secondary accessions: Q9NUJ4Alternative splicing: 2 isoforms: Q86YA3-1 Q86YA3-2 Explore the universe of human proteins at neXtProt for C4orf21: NX_Q86YA3
Post-translational modifications:
View modification sites using PhosphoSitePlus2 (C4orf21)View neXtProt modification sites for NX_Q86YA3
C4orf21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060862.3
ENSEMBL proteins: ENSP00000424737 ENSP00000404365 ENSP00000426938 ENSP00000309095 ENSP00000424946 ENSP00000424995 ENSP00000424429 ENSP00000390505
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
C4orf21 for ontologies About GeneDecksing
C4orf21 Antibody Products:
Assay Products for C4orf21: |
Protein
Domains /
Families
for C4orf21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C4orf21 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86YA3ProtoNet protein and cluster: Q86YA3 |
Function
for C4orf21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf21 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf21 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C4orf21 (NM_018392) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C4orf21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf21 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf21 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
C4orf21 for ontologies About GeneDecksing
|
Pathways & Interactions
for C4orf21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C4orf21
|
Drugs & Compounds
for C4orf21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C4orf21
Search CenterWatch for drugs/clinical trials and news about C4orf21 / CD021
|
Transcripts
for C4orf21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C4orf21 gene (3 alternative transcripts): NM_001099776.1 NM_138698.2 NM_018392.4 Unigene Cluster for C4orf21: Chromosome 4 open reading frame 21 Hs.380346 [show with all ESTs]Unigene Representative Sequence: NM_01839211 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000505019(uc003iav.3 uc003iau.3) ENST00000445413 ENST00000506675(uc003iat.3)
ENST00000473015 ENST00000309071(uc003iaw.3) ENST00000264370 ENST00000514770
ENST00000503172 ENST00000512075 ENST00000502805 ENST00000445203
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf21 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf21 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C4orf21 (NM_018392) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C4orf21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf21 |
Additional cDNA sequence: AF075091.1 AK002193.1 AK090556.1 AK126054.1 AK299831.1 AK302613.1 AL137700.1 BC028584.2 BC044799.1 BX647594.1 14 DOTS entries: DT.97771568 DT.300709 DT.104187 DT.97790559 DT.40278041 DT.97763250 DT.100730059 DT.100693104 DT.40222313 DT.65285408 DT.100811375 DT.91647074 DT.75106326 DT.97777216 24/74 AceView cDNA sequences (see all 74): AW169469 AI733193 BE217866 BX647594 AW292966 BP369240 AK090556 AA972753 AA683145 AK002193 AI733385 AL137700 AW021355 NM_018392 AX746508 CN484639 BC028584 AA931632 AK126054 BE327659 NM_138698 BX279541 BP350173 BC044799
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for C4orf21 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 |
|---|
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| SP1: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C4orf21
|
Expression
for C4orf21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C4orf21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAAATTTT
About this image
See C4orf21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C4orf21
SOURCE GeneReport for Unigene cluster: Hs.380346
SABiosciences Custom PCR Arrays for C4orf21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C4orf21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C4orf21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4orf21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4orf21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf21 |
Orthologs
for C4orf21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for C4orf21 gene from 7/25 species (see all 25) About this table
ENSEMBL Gene Tree for C4orf21 (if available)
TreeFam Gene Tree for C4orf21 (if available) |
Paralogs
for C4orf21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C4orf21 gene
- ZNFX12 AQR2 UPF12
18/23 SIMAP similar genes for C4orf21 using alignment to 8 protein entries: CD021_HUMAN (see all proteins)
(see all similar genes):RNF217 NF2 USP38 ZDHHC20 PLEKHH2 CATSPERG
ZNF527 CRCP DNMT1 NPLOC4 ZNF585B TCF4
NRAMP1 WARS GCDH EML2 TMEM135 VPS33A
C4orf21 for paralogs About GeneDecksing
|
Genomic Variants
for C4orf21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for C4orf21
2 CNVs: 23071 98850
6 Indels: 12526 40675 62251 12525 46481 41858 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C4orf21 |
|
Disorders
/ Diseases
for C4orf21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C4orf21 for disorders About GeneDecksing
2  diseases for C4orf21: About MalaCardsalcohol dependence alcoholism
Human Genome Epidemiology (HuGE) Navigator: C4orf21 (1 document)
Export disorders for C4orf21 gene to outside databases
|
Publications
for C4orf21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C4orf21 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with C4orf21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)1 Bechtel S.... Schupp I. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for C4orf21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C4orf21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C4orf21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C4orf21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C4orf21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C4orf21 gene:
Search GeneIP for patents involving C4orf21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C4orf21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C4orf21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C4orf21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C4orf21 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C4orf21 | | OriGene 3'-UTR Clone for C4orf21 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C4orf21 | | OriGene Custom Protein Services for C4orf21 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C4orf21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C4orf21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4orf21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C4orf21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4orf21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4orf21 |
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| | | | Search Tocris compounds for C4orf21 |
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 | | | C4orf21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf21 |
|  |  |  | | | | Search ThermoFisher Antibodies for C4orf21 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf21 |
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