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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C4orf19 Gene

protein-coding   GIFtS: 40
GCID: GC04P037455

chromosome 4 open reading frame 19
 Explore 1 disease affiliated with
C4orf19 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C4orf19    

Aliases
for C4orf19 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 4 Open Reading Frame 191 2
FLJ110171
Uncharacterized Protein C4orf192

External Ids:    HGNC: 256181   Entrez Gene: 552862   Ensembl: ENSG000001542747   UniProtKB: Q8IY423   

Export aliases for C4orf19 gene to outside databases

Previous GC identifers: GC04P037131 GC04P036779


Summaries
for C4orf19 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C4orf19 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016297.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C4orf19 gene promoter:
         STAT1beta   Olf-1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   LCR-F1   STAT1alpha   YY1   MZF-1   ZIC2/Zic2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C4orf19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4orf19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

C4orf19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C4orf19 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P037455:  view genomic region     (about GC identifiers)

Start:
 37,455,552 bp from pter      End:
 37,625,117 bp from pter
Size:
 169,566 bases      Orientation:
 plus strand

Proteins
for C4orf19 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD019_HUMAN, Q8IY42 (See protein sequence)
Recommended Name: Uncharacterized protein C4orf19  
Size: 314 amino acids; 33742 Da
Secondary accessions: Q9NV03

Explore the universe of human proteins at neXtProt for C4orf19: NX_Q8IY42

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IY42

    • C4orf19 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001098099.1  NP_060772.2  

    ENSEMBL proteins: 
     ENSP00000371408   ENSP00000421537   ENSP00000284437  

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    Protein Domains /
    Families
    for C4orf19 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8IY42


    Function
    for C4orf19 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for C4orf19 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C4orf19

    Drugs & Compounds
    for C4orf19 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for C4orf19
    Search CenterWatch for drugs/clinical trials and news about C4orf19 / CD019 

    Transcripts
    for C4orf19 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for C4orf19 gene (2 alternative transcripts): 
    NM_001104629.1  NM_018302.2  

    Unigene Cluster for C4orf19:

    Chromosome 4 open reading frame 19
    Hs.107527  [show with all ESTs]
    Unigene Representative Sequence: NM_001104629
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381980(uc003gsw.4) ENST00000508175 ENST00000284437(uc003gsy.4)


    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate C4orf19 (see all 32):
    hsa-miR-548j hsa-miR-30c hsa-miR-125a-5p hsa-miR-4328 hsa-miR-548i hsa-miR-330-5p hsa-miR-219-5p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: C4orf19 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK001879.1 AK225192.1 BC037906.1 

    6 DOTS entries:

    DT.210915  DT.100750282  DT.75101089  DT.95260912  DT.121241275  DT.91735232 

    24/49 AceView cDNA sequences (see all 49):

    AW028005 Z39499 CR611641 AI283126 BX483152 BX107974 AU136005 AW271563 
    BG285847 BE392777 NM_018302 BF211670 H17472 BI838315 BG485704 BV197734 
    BQ684955 BE395684 CF995148 Z43422 CD245832 BC037906 BF509178 BQ685158 

    GeneLoc Exon Structure


    Expression
    for C4orf19 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C4orf19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACATTCGGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C4orf19 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndBone
    BrainHypothalamusBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C4orf19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C4orf19

    SOURCE GeneReport for Unigene cluster: Hs.107527
        SABiosciences Custom PCR Arrays for C4orf19
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf19

    Orthologs
    for C4orf19 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C4orf19 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 0610040J01Rik1 , 5 RIKEN cDNA 0610040J01 gene1, 5 72.06(n)1
    60.07(a)1    		   5 (32.80 cM)5
    762611  NM_029554.41  NP_083830.31 
     638124955 
    chicken
    (Gallus gallus)    		 Aves C4orf196
    		 Uncharacterized protein
    		 33(a)
    		 1 ↔ 1
    		 4(71956023-71958065)
    lizard
    (Anolis carolinensis)    		 Reptilia C4orf196
    		 --
    		 49(a)
    		 1 ↔ 1
    		 GL343361.1(767684-770353)


    ENSEMBL Gene Tree for C4orf19 (if available)
    TreeFam Gene Tree for C4orf19 (if available) 

    Paralogs
    for C4orf19 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C4orf19 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for C4orf19
         7 CNVs: 80249 80248 92046 80251 92045 92047 80250
         5 Indels: 92044 46641 92043 80247 63803
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for C4orf19 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    C4orf19 for disorders           About GeneDecksing

    1 disease for C4orf19:    About MalaCards
    multiple sclerosis

    Human Genome Epidemiology (HuGE) Navigator: C4orf19 (1 document)

    Export disorders for C4orf19 gene to outside databases

    Publications
    for C4orf19 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C4orf19 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C4orf19)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    4. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. (PubMed id 20802204)1 Baranzini S.E....Pelletier D. (2010)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    External Searches for C4orf19 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C4orf19 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55286 HGNC: 25618 AceView: FLJ11017 Ensembl:ENSG00000154274 euGenes: HUgn55286
    ECgene: C4orf19 H-InvDB: C4orf19

    Other Databases showing C4orf19 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C4orf19 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C4orf19 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C4orf19 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C4orf19 gene:
    Search GeneIP for patents involving C4orf19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    for C4orf19 gene

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    About This Section

     
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