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Aliases for C4orf17 Gene

Aliases for C4orf17 Gene

  • Chromosome 4 Open Reading Frame 17 2 3 5

External Ids for C4orf17 Gene

Previous GeneCards Identifiers for C4orf17 Gene

  • GC04P100790
  • GC04P100651
  • GC04P100432
  • GC04P096170

Summaries for C4orf17 Gene

GeneCards Summary for C4orf17 Gene

C4orf17 (Chromosome 4 Open Reading Frame 17) is a Protein Coding gene.

Additional gene information for C4orf17 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4orf17 Gene

Genomics for C4orf17 Gene

Regulatory Elements for C4orf17 Gene

Enhancers for C4orf17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H099944 1.2 ENCODE 11.8 +437.1 437148 6 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LINC01218 LINC01216 PCNAP1 FAM177A1P1 DNAJB14 C4orf17 LAMTOR3 DAPP1 LOC256880
GH04H099535 0.6 ENCODE 11.5 +25.5 25509 1 SOX5 SOX13 FOXA2 RARA POLR2A NR2F6 BCL6 RXRB MTTP C4orf17
GH04H099539 0.2 ENCODE 10.8 +29.2 29208 1 MTTP TRMT10A C4orf17 ADH1B
GH04H099561 1.1 Ensembl ENCODE 0.2 +50.3 50297 0 PKNOX1 ATF1 RAD21 CHAMP1 GTF3C2 POLR3A FOS RCOR1 CREM SMARCA5 MTTP LOC100507053 C4orf17
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C4orf17 on UCSC Golden Path with GeneCards custom track

Genomic Location for C4orf17 Gene

Chromosome:
4
Start:
99,511,004 bp from pter
End:
99,542,303 bp from pter
Size:
31,300 bases
Orientation:
Plus strand

Genomic View for C4orf17 Gene

Genes around C4orf17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf17 Gene

Proteins for C4orf17 Gene

  • Protein details for C4orf17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53FE4-CD017_HUMAN
    Recommended name:
    Uncharacterized protein C4orf17
    Protein Accession:
    Q53FE4
    Secondary Accessions:
    • Q6FI84
    • Q6IS77
    • Q8NA78
    • Q9H0D9

    Protein attributes for C4orf17 Gene

    Size:
    359 amino acids
    Molecular mass:
    39644 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C4orf17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C4orf17 Gene

Post-translational modifications for C4orf17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C4orf17 Gene

No data available for DME Specific Peptides for C4orf17 Gene

Domains & Families for C4orf17 Gene

Gene Families for C4orf17 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C4orf17 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C4orf17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C4orf17: view

No data available for UniProtKB/Swiss-Prot for C4orf17 Gene

Function for C4orf17 Gene

Phenotypes From GWAS Catalog for C4orf17 Gene

genes like me logo Genes that share phenotypes with C4orf17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C4orf17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C4orf17 Gene

Localization for C4orf17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C4orf17 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C4orf17 Gene

Pathways & Interactions for C4orf17 Gene

SuperPathways for C4orf17 Gene

No Data Available

Interacting Proteins for C4orf17 Gene

Gene Ontology (GO) - Biological Process for C4orf17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C4orf17 Gene

Drugs & Compounds for C4orf17 Gene

No Compound Related Data Available

Transcripts for C4orf17 Gene

Unigene Clusters for C4orf17 Gene

Chromosome 4 open reading frame 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C4orf17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3:
SP4: - -

Relevant External Links for C4orf17 Gene

GeneLoc Exon Structure for
C4orf17
ECgene alternative splicing isoforms for
C4orf17

Expression for C4orf17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C4orf17 Gene

mRNA differential expression in normal tissues according to GTEx for C4orf17 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for C4orf17 Gene

This gene is overexpressed in Liver, secretome (66.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C4orf17 Gene



Protein tissue co-expression partners for C4orf17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C4orf17 Gene:

C4orf17

SOURCE GeneReport for Unigene cluster for C4orf17 Gene:

Hs.97501
genes like me logo Genes that share expression patterns with C4orf17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C4orf17 Gene

Orthologs for C4orf17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C4orf17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C4H4orf17 33
  • 99.26 (n)
C4orf17 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C6H4orf17 33
  • 84.58 (n)
C4orf17 34
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C32H4orf17 33
  • 84.37 (n)
C4orf17 34
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309170 33
  • 73.12 (n)
mouse
(Mus musculus)
Mammalia 4930579F01Rik 33 16 34
  • 70.85 (n)
oppossum
(Monodelphis domestica)
Mammalia C4orf17 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C4orf17 34
  • 28 (a)
OneToOne
Species where no ortholog for C4orf17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C4orf17 Gene

ENSEMBL:
Gene Tree for C4orf17 (if available)
TreeFam:
Gene Tree for C4orf17 (if available)

Paralogs for C4orf17 Gene

No data available for Paralogs for C4orf17 Gene

Variants for C4orf17 Gene

Sequence variations from dbSNP and Humsavar for C4orf17 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000018 -- 99,537,291(+) GGTGC(A/G)CAGGC intron-variant
rs1000064080 -- 99,525,759(+) GCCAC(C/T)GCACT intron-variant
rs1000079019 -- 99,519,715(+) AAGTG(A/G)AAGAT intron-variant
rs1000102870 -- 99,516,605(+) ACAAC(C/G)GGGTT intron-variant
rs1000157121 -- 99,535,156(+) CTCTG(A/G)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C4orf17 Gene

Variant ID Type Subtype PubMed ID
dgv51e213 CNV gain 24956385
dgv5345n100 CNV gain 25217958
esv3584519 CNV gain 24956385

Variation tolerance for C4orf17 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C4orf17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C4orf17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C4orf17 Gene

Disorders for C4orf17 Gene

Relevant External Links for C4orf17

Human Genome Epidemiology (HuGE) Navigator
C4orf17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C4orf17

No disorders were found for C4orf17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf17 Gene

Publications for C4orf17 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60
  5. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PMID: 23319000) Luykx JJ … Ophoff RA (Molecular psychiatry 2014) 3 60

Products for C4orf17 Gene

Sources for C4orf17 Gene

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