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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C4B_2 Gene

protein-coding   GIFtS: 28
GCID: GC06P031985

Complement Component 4B (Chido Blood Group), Copy 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Complement Component 4B (Chido Blood Group), Copy 21 2     Basic Complement C43
Complement C4-B-Like2     C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 33
CO43     EC 2.1.1.1448
CPAMD33     EC 2.7.118

External Ids:    HGNC: 423981   Entrez Gene: 1002935342   Ensembl: ENSG000002243897   UniProtKB: P0C0L53   

Export aliases for C4B_2 gene to outside databases

Previous GC identifer: GC06Po31872


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for C4B_2 Gene:
This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is
expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma
chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and
other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local
inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to
the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene
cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a
long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
This GeneID and its associated RefSeq record represent a second copy of C4B found on ALT_REF_LOCI_7. (provided by
RefSeq, Jul 2011)

GeneCards Summary for C4B_2 Gene: 
C4B_2 (complement component 4B (Chido blood group), copy 2) is a protein-coding gene. Diseases associated with C4B_2 include systemic lupus erythematosus, and lupus erythematosus, and among its related super-pathways are Initial triggering of complement and Immune System. An important paralog of this gene is A2M.

UniProtKB/Swiss-Prot: CO4B_HUMAN, P0C0L5
Function: Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the
classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the
solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is
responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B
isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate
antigens
Function: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local
inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes
histamine release from mast cells and basophilic leukocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for C4B_2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C4B_2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4B_2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3 ALT_REF_LOCI_7

C4B_2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C4B_2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031985:  view genomic region     (about GC identifiers)

Start:
31,982,539 bp from pter      End:
32,003,195 bp from pter
Size:
20,657 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,ALT_REF_LOCI_3 31,964,725-31,979,014      Chr6+,NT_167249 3,282,544-3,303,168      Chr6+,ALT_REF_LOCI_7 31,974,391-31,995,048     
Chr6+,ALT_REF_LOCI_7 31,941,653-31,962,310      Chr6+,ALT_REF_LOCI_2 31,937,353-31,951,642      Chr6+,ALT_REF_LOCI_5 32,026,249-32,026,275     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CO4B_HUMAN, P0C0L5 (See protein sequence)
Recommended Name: Complement C4-B precursor  
Size: 1744 amino acids; 192751 Da
Subunit: Circulates in blood as a disulfide-linked trimer of alpha, beta and gamma chains
Subcellular location: Secreted
Sequence caution: Sequence=AAA99717.1; Type=Erroneous gene model prediction;
Secondary accessions: A2BHY4 P01028 P78445 Q13160 Q13906 Q14033 Q14835 Q6U2E9 Q6U2G1 Q6U2I5
Q6U2L1 Q6U2L7 Q6U2L9 Q6U2M5 Q6VCV8 Q96SA7 Q9NPK5 Q9UIP5

Explore the universe of human proteins at neXtProt for C4B_2: NX_P0C0L5

Explore proteomics data for C4B_2 at MOPED 

Post-translational modifications:

  • UniProtKB: Prior to secretion, the single-chain precursor is enzymatically cleaved to yield non-identical chains alpha, beta
    and gamma. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta
    and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation
    of C3 convertase. The proteolytic cleavages often are incomplete so that many structural forms can be found in
    plasma
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0C0L5

  • 2 DME Specific Peptides for C4B_2 (P0C0L5)
     DLGCGPG  GPGGGDS 

    C4B_2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C4B_2 Protein Expression
    REFSEQ proteins: NP_001229752.1  
    ENSEMBL proteins: 
     ENSP00000415941   ENSP00000391933  
    Reactome Protein details: P0C0L5
    Human Recombinant Protein Products for C4B_2: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space ----
    GO:0005886plasma membrane ----

    C4B_2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/14 InterPro protein domains (see all 14):
     IPR008993 TIMP-like_OB-fold
     IPR019742 MacrogloblnA2_CS
     IPR001599 Macroglobln_a2
     IPR000020 Anaphylatoxin/fibulin
     IPR011626 A2M_comp

    Graphical View of Domain Structure for InterPro Entry P0C0L5

    ProtoNet protein and cluster: P0C0L5

    5 Blocks protein domains:
    IPB001134 Netrin
    IPB001599 Alpha-2-macroglobulin
    IPB001840 Anaphylatoxin domain signature
    IPB002890 Alpha-2-macroglobulin
    IPB009048 Alpha-macroglobulin


    UniProtKB/Swiss-Prot: CO4B_HUMAN, P0C0L5
    Similarity: Contains 1 anaphylatoxin-like domain
    Similarity: Contains 1 NTR domain


    C4B_2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CO4B_HUMAN, P0C0L5
    Function: Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the
    classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the
    solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is
    responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B
    isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate
    antigens
    Function: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local
    inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes
    histamine release from mast cells and basophilic leukocytes

         Enzyme Numbers (IUBMB): EC 2.1.1.1442 EC 2.7.112

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity ----
    GO:0005515protein binding ----
         
    C4B_2 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for C4B_2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Classical antibody-mediated complement activation
    Initial triggering of complement0.86
    Complement cascade0.76
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3Immune response Lectin induced complement pathway
    Regulation of Complement cascade0.50
    4Activation of C3 and C5
    Activation of C3 and C50.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for C4B_2 (see all 6)
        Regulation of Complement cascade
    Activation of C3 and C5
    Complement cascade
    Immune System
    Initial triggering of complement



    C4B_2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C4B_2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/22 Interacting proteins for C4B_2 (P0C0L53 ENSP000004159414) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206372P066813, ENSP000003728534I2D: score=1 STRING: ENSP00000372853
    ENSG00000231543P066813, ENSP000004079614I2D: score=1 STRING: ENSP00000407961
    C2P066813, ENSP000002993674I2D: score=1 STRING: ENSP00000299367
    ENSG00000204364P066813I2D: score=1 
    ENSG00000226560P066813I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response ----
    GO:0006956complement activation ----
    GO:0006958complement activation, classical pathway ----
    GO:0030449regulation of complement activation ----
    GO:0045087innate immune response ----

    C4B_2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C4B_2 (CO4B)

    Search CenterWatch for drugs/clinical trials and news about C4B_2 / CO4B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C4B_2 gene: 
    NM_001242823.2  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435363(uc011dpd.2 uc011dpe.2) ENST00000490071 ENST00000485543
    ENST00000461632 ENST00000478438 ENST00000474912 ENST00000486992 ENST00000485263
    ENST00000478388 ENST00000468936 ENST00000463249 ENST00000468237(uc003nzd.4)
    ENST00000496065 ENST00000473957 ENST00000496560 ENST00000425700(uc021yvg.1 uc011dpf.1)

    miRNA
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    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4B_2

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See C4B_2 Protein Expression from SPIRE MOPED and PaxDB

    UniProtKB/Swiss-Prot: CO4B_HUMAN, P0C0L5
    Tissue specificity: Complement component C4 is expressed at highest levels in the liver, at moderate levels in the
    adrenal cortex, adrenal medulla, thyroid gland,and the kidney, and at lowest levels in the heart, ovary, small
    intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local
    protection and inflammatory response

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for C4B_2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for C4B_2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves C46
    --
    --
    39(a)
    37(a)
    1 ↔ many
    possible ortholog
    16(44245-58599)
    1(170575659-170618202)
    lizard
    (Anolis carolinensis)
    Reptilia --
    C56
    Uncharacterized protein
    45(a)
    15(a)
    1 ↔ many
    possible ortholog
    2(198340313-198430254)
    AAWZ02038773(1221-8229)
    zebrafish
    (Danio rerio)
    Actinopterygii c46
    C4A6
    complement component 4A (Rodgers blood group)
    34(a)
    33(a)
    possible ortholog
    1 ↔ many
    15(31598256-31629790)
    16(18720425-18754319)
    fruit fly
    (Drosophila melanogaster)
    Insecta TepII6
    TepI6
    (see all 6)
    Thiolester containing protein I
    (see all 6)
    20(a)
    19(a)
    (see all 6)
    possible ortholog
    possible ortholog
    (see all 6)
    2L(7693800-7701585)
    2L(15888639-15893811)
            Species with no ortholog for C4B_2

    ENSEMBL Gene Tree for C4B_2 (if available)
    TreeFam Gene Tree for C4B_2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C4B_2 gene
    A2M2  C52  C32  A2ML12  C4A2  PZP2  CPAMD82  CD1092  
    4 SIMAP similar genes for C4B_2 using alignment to 1 protein entry:     CO4B_HUMAN:
    C4A    C4B    C3    OVOS2

    C4B_2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CO4B_HUMAN, P0C0L5
    Polymorphism: The complement component C4 is the most polymorphic protein of the complement system. It is the
    product of 2 closely linked and highly homologous genes, C4A and C4B. Once polymorphic variation is discounted,
    the 2 isotypes differ by only 4 amino acids at positions 1120-1125: PCPVLD for C4A and LSPVIH for C4B. The 2
    isotypes bear several antigenic determinants defining Chido/Rodgers blood group system [MIM:614374]. Rodgers
    determinants are generally associated with C4A allotypes, and Chido with C4B. Variations at these loci involve
    not only nucleotide polymorphisms, but also gene number and gene size. The second copy of C4B gene present in
    some individuals has been called C4B_2 by the HUGO Gene Nomenclature Committee (HGNC). Some individuals may lack
    either C4A, or C4B gene. Partial deficiency of C4A or C4B is the most commonly inherited immune deficiency known
    in humans with a combined frequency over 31% in the normal Caucasian population (PubMed:11367523)

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UniProtKB/Swiss-Prot: CO4B_HUMAN, P0C0L5
  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile
    multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints,
    kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory
    mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated
    erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry. Interindividual
    copy-number variation (CNV) of complement component C4 and associated polymorphisms result in different
    susceptibilities to SLE. The risk of SLE susceptibility has been shown to be significantly increased among
    subjects with only two copies of total C4. A high copy number is a protective factor against SLE
  • Complement component 4B deficiency (C4BD) [MIM:614379]: A rare defect of the complement classical pathway
    associated with the development of autoimmune disorders, mainly systemic lupus with or without associated
    glomerulonephritis. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for C4B_2:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    acute myocardial infarction    myocardial infarction


    C4B_2 for disorders           About GeneDecksing


    Export disorders for C4B_2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C4B_2 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with C4B_2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Linkage analysis of the C4A/C4B copy number variation and polymorphisms of the adjacent steroid 21-hydroxylase gene in a healthy population. (PubMed id 19505723)1, 3 Blasko B.... Szilagyi A. (2009)
    2. Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. (PubMed id 17503323)1, 2 Yang Y....Yu C.Y. (2007)
    3. Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity. (PubMed id 2431902)1, 2 Yu C.Y.... Porter R.R. (1986)
    4. The structural basis of the multiple forms of human complement component C4. (PubMed id 6546707)1, 2 Belt K.T.... Porter R.R. (1984)
    5. A review of the Chido/Rodgers blood group. (PubMed id 20795316)1 Mougey R. (2010)
    6. Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction. (PubMed id 18032375)1 Blasko B....Arason G.J. (2008)
    7. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)2 Ramachandran P....Loo J.A. (2006)
    8. C4d DNA sequence of complement C4B93 and recombination mechanisms for its generation. (PubMed id 14989716)2 Lopez-Goyanes A.... Paz-Artal E. (2004)
    9. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)2 Bunkenborg J.... Wisniewski J.R. (2004)
    10. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)2 Zhang H.... Aebersold R. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100293534 HGNC: 42398 Ensembl:ENSG00000224389 euGenes: HUgn100293534 ECgene: C4B_2
    H-InvDB: C4B_2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C4B_2 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=chrg

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C4B_2 gene:
    Search GeneIP for patents involving C4B_2

    GeneCards and IP:
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