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C4BPB Gene

protein-coding   GIFtS: 61
GCID: GC01P207262

Complement Component 4 Binding Protein, Beta

(Previous names: complement component 4-binding protein, beta)
(Previous symbol: C4BP)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Complement Component 4 Binding Protein, Beta1 2     Complement Component 4 Binding Protein1
C4BP1 2     Complement Component 4-Binding Protein, Beta1
Beta Chain1     C4b-Binding Protein Beta Chain2
C4b Binding Protein1     

External Ids:    HGNC: 13281   Entrez Gene: 7252   Ensembl: ENSG000001238437   OMIM: 1208315   UniProtKB: P208513   

Export aliases for C4BPB gene to outside databases

Previous GC identifers: GC01P205922 GC01P202972 GC01P203905 GC01P204346 GC01P203650 GC01P205328 GC01P177959


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for C4BPB Gene:
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus
repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven
identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls
activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in
the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein
that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located
adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative
splicing gives rise to multiple transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for C4BPB Gene:
C4BPB (complement component 4 binding protein, beta) is a protein-coding gene.

UniProtKB/Swiss-Prot: C4BPB_HUMAN, P20851
Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator
(C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a
complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein
S and with serum amyloid P component. The beta chain binds protein S




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C4BPB gene promoter:
         C/EBPbeta   GATA-3   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): C4BPB promoter sequence
   Search Chromatin IP Primers for C4BPB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C4BPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32

C4BPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C4BPB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207262:  view genomic region     (about GC identifiers)

Start:
207,262,187 bp from pter      End:
207,273,338 bp from pter
Size:
11,152 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: C4BPB_HUMAN, P20851 (See protein sequence)
Recommended Name: C4b-binding protein beta chain precursor  
Size: 252 amino acids; 28357 Da
Subunit: Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha
chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta
chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at
the end
Secondary accessions: A5JYP8 D3DT81 Q5VVR0 Q9BS25
Alternative splicing: 2 isoforms:  P20851-1   P20851-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C4BPB: NX_P20851

Explore proteomics data for C4BPB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn64, Asn71, Asn98, Asn117, Asn154

  • See C4BPB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000707.1  NP_001017364.1  NP_001017365.1  NP_001017366.1  NP_001017367.1  

    ENSEMBL proteins: 
     ENSP00000356045   ENSP00000392237   ENSP00000243611   ENSP00000356043   ENSP00000375790  
     ENSP00000405649  
    Reactome Protein details: P20851

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry P20851

    ProtoNet protein and cluster: P20851

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: C4BPB_HUMAN, P20851
    Similarity: Contains 3 Sushi (CCP/SCR) domains


    Find genes that share domains with C4BPB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C4BPB_HUMAN, P20851
    Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator
    (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a
    complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein
    S and with serum amyloid P component. The beta chain binds protein S

         Genatlas biochemistry entry for C4BPB:
    complement component 4,binding protein beta,45kDa,regulator of C3 convertase of classical pathway,see RCA@

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C4BPB
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    hsa-mir-124-3p (MIRT022824), hsa-mir-142-3p (MIRT021565)

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    Sino Biological Human cDNA Clone for C4BPB
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    C4BPB_HUMAN, P20851: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytosol1
    lysosome1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with C4BPB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for C4BPB About    
    See pathways by source

    SuperPathContained pathways About
    1Complement Pathway
    Immune response Lectin Induced complement pathway0.56
    Regulation of Complement cascade0.48
    Immune response Classic complement pathway0.56
    2Complement and coagulation cascades
    Complement and coagulation cascades0.71
    3Creation of C4 and C2 activators
    Complement cascade0.68
    4Pertussis
    Pertussis
    5FOXA1 transcription factor network
    FOXA1 transcription factor network


    Find genes that share SuperPaths with C4BPB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for C4BPB
        Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    1 BioSystems Pathway for C4BPB
        FOXA1 transcription factor network


    1 Reactome Pathway for C4BPB
        Regulation of Complement cascade


    2 Kegg Pathways  (Kegg details for C4BPB):
        Complement and coagulation cascades
    Pertussis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C4BPB
    Interactions:

        GeneGlobe Interaction Network for C4BPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for C4BPB (P208513 ENSP000002436114) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PROS1P072253, ENSP000003777834I2D: score=1 STRING: ENSP00000377783
    C4BPAENSP000003560374STRING: ENSP00000356037
    CFIENSP000003781304STRING: ENSP00000378130
    NFIAENSP000003845234STRING: ENSP00000384523
    NFICENSP000003968434STRING: ENSP00000396843
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006958complement activation, classical pathway IEA--
    GO:0007596blood coagulation TAS8325877
    GO:0030449regulation of complement activation TAS--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with C4BPB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C4BPB

    6 Novoseek inferred chemical compound relationships for C4BPB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylserine 39.4 5 15096498 (1), 12570163 (1), 17699521 (1)
    phospholipid 21.2 3 2144523 (2), 19878975 (1)
    heparin 16 6 9626699 (3), 10408373 (1), 15179322 (1)
    calcium 0 3 9132028 (2), 2144524 (1)
    alanine 0 1 12431388 (1)
    serine 0 1 11090879 (1)



    Find genes that share compounds with C4BPB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C4BPB gene (5 alternative transcripts): 
    NM_000716.3  NM_001017364.1  NM_001017365.1  NM_001017366.1  NM_001017367.1  

    Unigene Cluster for C4BPB:

    Complement component 4 binding protein, beta
    Hs.99886  [show with all ESTs]
    Unigene Representative Sequence: AK315137
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367078(uc001hfj.3 uc001hfi.3) ENST00000492730 ENST00000452902
    ENST00000243611(uc001hfl.3 uc001hfm.3) ENST00000367076(uc001hfk.3 uc009xcd.3)
    ENST00000469326 ENST00000470767 ENST00000391923 ENST00000451804(uc010pse.1)

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    GenScript: all cDNA clones in your preferred vector (see all 5): C4BPB (NM_000716)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C4BPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4BPB
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat C4BPB
      QuantiTect SYBR Green Assays in human, mouse, rat C4BPB
      QuantiFast Probe-based Assays in human, mouse, rat C4BPB

    Additional mRNA sequence: 

    AK293379.1 AK315137.1 BC005378.1 L11245.1 M29964.1 

    9 DOTS entries:

    DT.456049  DT.91703213  DT.40131808  DT.91703225  DT.100741677  DT.91703220  DT.100741678  DT.101979475 
    DT.95122434 

    Selected AceView cDNA sequences (see all 72):

    BQ650658 BE545748 CR598788 BM987840 AA969142 BC005378 T41035 CD013941 
    M29964 CR625432 CB163639 CD013942 H78142 CD013943 T40922 BG568220 
    BG618669 BG618718 AA677687 T41007 BX362549 AA779336 AK092427 H63461 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for C4BPB (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                                            -     -     -           -                                 
    SP2:                                            -     -     -           -                                 
    SP3:                                      -     -     -     -           -                                 
    SP4:                                      -     -     -     -     -     -                                 
    SP5:                                            -     -     -     -     -                                 


    ECgene alternative splicing isoforms for C4BPB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C4BPB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAATGGAGG
    C4BPB Expression
    About this image

    C4BPB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C4BPB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99886
        Custom PCR Arrays for C4BPB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4BPB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for C4BPB gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C4bp-ps15 complement component 4 binding protein, pseudogene more   --   1 (56.89 cM) 130670202 


    ENSEMBL Gene Tree for C4BPB (if available)
    TreeFam Gene Tree for C4BPB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C4BPB gene
    Selected SIMAP similar genes for C4BPB using alignment to 3 protein entries:     C4BPB_HUMAN (see all proteins) (see all similar genes):
    ATL2    ZNF564    COQ5    SH2B3    SUMO1    TBCB
    UBXN4    FAM175A    FLJ00047    SNRPF    GBGT1    PFKFB3
    RQCD1    GALK2    CASC4    HC6    MST132    RBP7

    Find genes that share paralogs with C4BPB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C4BPB (see all 324)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1493146241,2
    --177970018(+) TTTCAC/TGCTCT 5 -- int10--------
    rs1882420831,2
    --177970043(+) GCCACC/TTCTGA 5 -- int10--------
    rs563303031,2
    C,F--177970120(+) CTTTGC/TTTGCC 5 -- int11Minor allele frequency- T:0.03NA 120
    rs796536511,2
    C,F--177970130(+) CTGCCC/TGCTGC 5 -- int11Minor allele frequency- T:0.03WA 118
    rs1926801161,2
    --177970184(+) GGTACC/TGGTCT 5 -- int10--------
    rs1147640711,2
    C,F--177970194(+) TGTGGC/TCCTGG 5 -- int11Minor allele frequency- T:0.01NA 120
    rs1847277651,2
    --177970243(+) CAATGC/TGTGAG 5 -- int10--------
    rs1435622821,2
    --177970251(+) GAGAAC/TTGGAA 5 -- int10--------
    rs1891058511,2
    --177970377(+) TATTTA/GAGCCA 5 -- int10--------
    rs2004032101,2
    C--177970584(+) CCATGG/AAGAAC 10 /K /E mis11Minor allele frequency- A:0.00EU 1323

    HapMap Linkage Disequilibrium report for C4BPB (207262187 - 207273338 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C4BPB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832426CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C4BPB
    DNA2.0 Custom Variant and Variant Library Synthesis for C4BPB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 120831    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for C4BPB:
    Protein S deficiency

    Find genes that share disorders with C4BPB           About GenesLikeMe

    4 Novoseek inferred disease relationships for C4BPB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    response acute phase 29.5 6 7561114 (2), 8598458 (1)
    inflammation 3.06 2 19563958 (1), 12907438 (1)
    necrosis 0 2 19563958 (2)
    thrombosis 0 1 9169428 (1)

    Genetic Association Database (GAD): C4BPB
    Human Genome Epidemiology (HuGE) Navigator: C4BPB (9 documents)

    Export disorders for C4BPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C4BPB gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with C4BPB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human C4b-binding protein beta-chain gene. (PubMed id 8325877)1, 2, 3, 9 Hillarp A.... Dahlback B. (J. Biol. Chem. 1993)
    2. Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: sequence homology with the alpha chain. (PubMed id 2300577)1, 2, 3 Hillarp A. and Dahlback B. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    3. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies. (PubMed id 20212171)1, 4 Buil A....Morange P.E. (Blood 2010)
    7. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (Br. J. Haematol. 2009)
    8. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. (PubMed id 18842294)1, 4 Ennis S....Lotery A. (Lancet 2008)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 725 HGNC: 1328 AceView: C4BPB Ensembl:ENSG00000123843 euGenes: HUgn725
    ECgene: C4BPB Kegg: 725 H-InvDB: C4BPB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C4BPB Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/c4bpb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C4BPB gene:
    Search GeneIP for patents involving C4BPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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