Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C4BPB Gene

protein-coding   GIFtS: 60
GCID: GC01P207262

Complement Component 4 Binding Protein, Beta

(Previous names: complement component 4-binding protein, beta)
(Previous symbol: C4BP)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Complement Component 4 Binding Protein, Beta1 2     Complement Component 4 Binding Protein1
C4BP1 2     Complement Component 4-Binding Protein, Beta1
Beta Chain1     C4b-Binding Protein Beta Chain2
C4b Binding Protein1     

External Ids:    HGNC: 13281   Entrez Gene: 7252   Ensembl: ENSG000001238437   OMIM: 1208315   UniProtKB: P208513   

Export aliases for C4BPB gene to outside databases

Previous GC identifers: GC01P205922 GC01P202972 GC01P203905 GC01P204346 GC01P203650 GC01P205328 GC01P177959


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for C4BPB Gene:
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus
repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven
identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls
activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in
the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein
that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located
adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative
splicing gives rise to multiple transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for C4BPB Gene: 
C4BPB (complement component 4 binding protein, beta) is a protein-coding gene. Diseases associated with C4BPB include atypical hemolytic-uremic syndrome, and critical limb ischemia, and among its related super-pathways are Immune response Lectin induced complement pathway and Immune System.

UniProtKB/Swiss-Prot: C4BPB_HUMAN, P20851
Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator
(C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a
complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein
S and with serum amyloid P component. The beta chain binds protein S




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C4BPB gene promoter:
         C/EBPbeta   GATA-3   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): C4BPB promoter sequence
   Search SABiosciences Chromatin IP Primers for C4BPB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4BPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32

C4BPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C4BPB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207262:  view genomic region     (about GC identifiers)

Start:
207,262,187 bp from pter      End:
207,273,338 bp from pter
Size:
11,152 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: C4BPB_HUMAN, P20851 (See protein sequence)
Recommended Name: C4b-binding protein beta chain precursor  
Size: 252 amino acids; 28357 Da
Subunit: Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha
chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta
chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at
the end
Subcellular location: Secreted
Secondary accessions: A5JYP8 D3DT81 Q5VVR0 Q9BS25
Alternative splicing: 2 isoforms:  P20851-1   P20851-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C4BPB: NX_P20851

Explore proteomics data for C4BPB at MOPED 

C4BPB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

C4BPB Protein Expression

REFSEQ proteins (5 alternative transcripts): 
NP_000707.1  NP_001017364.1  NP_001017365.1  NP_001017366.1  NP_001017367.1  

ENSEMBL proteins: 
 ENSP00000356045   ENSP00000392237   ENSP00000243611   ENSP00000356043   ENSP00000375790  
 ENSP00000405649  
Reactome Protein details: P20851
Human Recombinant Protein Products for C4BPB: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for C4BPB
OriGene Custom MassSpec 
OriGene Custom Protein Services for C4BPB
GenScript Custom Purified and Recombinant Proteins Services for C4BPB
Novus Biologicals C4BPB Proteins
Novus Biologicals C4BPB Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for C4BPB
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS14718574
GO:0005886plasma membrane TAS--

C4BPB for ontologies           About GeneDecksing



C4BPB Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of C4BPB
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for C4BPB
GenScript Custom Superior Antibodies Services for C4BPB
Novus Biologicals C4BPB Antibodies
Abcam antibodies for C4BPB
Browse Antibodies at Cloud-Clone Corp. 
ThermoFisher Antibody for C4BPB
LSBio Antibodies in human, mouse, rat for C4BPB 

Assay Products for C4BPB: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for C4BPB
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for C4BPB
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR000436 Sushi_SCR_CCP

Graphical View of Domain Structure for InterPro Entry P20851

ProtoNet protein and cluster: P20851

1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

UniProtKB/Swiss-Prot: C4BPB_HUMAN, P20851
Similarity: Contains 3 Sushi (CCP/SCR) domains


C4BPB for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: C4BPB_HUMAN, P20851
Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator
(C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a
complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein
S and with serum amyloid P component. The beta chain binds protein S

     Genatlas biochemistry entry for C4BPB:
complement component 4,binding protein beta,45kDa,regulator of C3 convertase of classical pathway,see RCA@

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for C4BPB 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C4BPB

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C4BPB 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C4BPB 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C4BPB
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate C4BPB
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for C4BPB
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C4BPB

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for C4BPB
Sirion Biotech Customized adenovirus for overexpression of C4BPB

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for C4BPB (see all 23)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 5): C4BPB (NM_000716)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for C4BPB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4BPB
Sirion Biotech Customized lentivirus for stable overexpression of C4BPB 
                     Customized lentivirus expression plasmids for stable overexpression of C4BPB 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for C4BPB
Search LifeMap BioReagents cell lines for C4BPB
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4BPB


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for C4BPB About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1Immune response Lectin induced complement pathway
Immune response Lectin induced complement pathway0.56
Immune response Classical complement pathway0.52
Immune response Lectin Induced complement pathway0.56
Regulation of Complement cascade0.50
Immune response Classic complement pathway0.53
2Immune System
Immune System0.56
Innate Immune System0.50
3Classical antibody-mediated complement activation
Complement cascade0.76
4Complement and coagulation cascades
Complement and coagulation cascades0.71
5Pertussis
Pertussis

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 EMD Millipore Pathways for C4BPB
    Immune response Classic complement pathway
Immune response Lectin Induced complement pathway


2 GeneGo (Thomson Reuters) Pathways for C4BPB
    Immune response Classical complement pathway
Immune response Lectin induced complement pathway

1 BioSystems Pathway for C4BPB
    FOXA1 transcription factor network

4        Reactome Pathways for C4BPB
    Regulation of Complement cascade
Complement cascade
Immune System
Innate Immune System


2         Kegg Pathways  (Kegg details for C4BPB):
    Complement and coagulation cascades
Pertussis


C4BPB for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for C4BPB

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/10 Interacting proteins for C4BPB (P208513 ENSP000002436114) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
PROS1P072253, ENSP000003777834I2D: score=1 STRING: ENSP00000377783
C4BPAENSP000003560374STRING: ENSP00000356037
CFIENSP000003781304STRING: ENSP00000378130
NFIAENSP000003845234STRING: ENSP00000384523
NFICENSP000003968434STRING: ENSP00000396843
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006958complement activation, classical pathway IEA--
GO:0007596blood coagulation TAS8325877
GO:0030449regulation of complement activation TAS--
GO:0045087innate immune response TAS--

C4BPB for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

C4BPB for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C4BPB

6 Novoseek inferred chemical compound relationships for C4BPB gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylserine 39.4 5 15096498 (1), 12570163 (1), 17699521 (1)
phospholipid 21.2 3 2144523 (2), 19878975 (1)
heparin 16 6 9626699 (3), 10408373 (1), 15179322 (1)
calcium 0 3 9132028 (2), 2144524 (1)
alanine 0 1 12431388 (1)
serine 0 1 11090879 (1)

Search CenterWatch for drugs/clinical trials and news about C4BPB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C4BPB gene (5 alternative transcripts): 
NM_000716.3  NM_001017364.1  NM_001017365.1  NM_001017366.1  NM_001017367.1  

Unigene Cluster for C4BPB:

Complement component 4 binding protein, beta
Hs.99886  [show with all ESTs]
Unigene Representative Sequence: AK315137
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000367078(uc001hfj.3 uc001hfi.3) ENST00000492730 ENST00000452902
ENST00000243611(uc001hfl.3 uc001hfm.3) ENST00000367076(uc001hfk.3 uc009xcd.3)
ENST00000469326 ENST00000470767 ENST00000391923 ENST00000451804(uc010pse.1)


miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C4BPB
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate C4BPB
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for C4BPB
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C4BPB
Clone
Products:
     
OriGene clones in human, mouse for C4BPB (see all 23)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 5): C4BPB (NM_000716)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for C4BPB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4BPB
Sirion Biotech Customized lentivirus for stable overexpression of C4BPB 
                     Customized lentivirus expression plasmids for stable overexpression of C4BPB 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for C4BPB
OriGene qSTAR qPCR primer pairs in human, mouse for C4BPB
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C4BPB
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4BPB
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4BPB

Additional mRNA sequence: 

AK293379.1 AK315137.1 BC005378.1 L11245.1 M29964.1 

9 DOTS entries:

DT.456049  DT.91703213  DT.40131808  DT.91703225  DT.100741677  DT.91703220  DT.100741678  DT.101979475 
DT.95122434 

24/72 AceView cDNA sequences (see all 72):

CR598788 CD013941 CB163639 BC005378 CD013943 M29964 BM987840 CD013942 
CR625432 BE545748 T41035 AA969142 H78142 BQ650658 BG618718 AA677687 
BG568230 BG569016 T40992 L11245 BX401108 AK092427 AW081315 BU528611 

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for C4BPB (see all 9)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1:                                            -     -     -           -                                 
SP2:                                            -     -     -           -                                 
SP3:                                      -     -     -     -           -                                 
SP4:                                      -     -     -     -     -     -                                 
SP5:                                            -     -     -     -     -                                 


ECgene alternative splicing isoforms for C4BPB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C4BPB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACAATGGAGG
C4BPB Expression
About this image


See C4BPB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C4BPB

SOURCE GeneReport for Unigene cluster: Hs.99886
    SABiosciences Custom PCR Arrays for C4BPB
Primer
Products:
OriGene qPCR primer pairs and template standards for C4BPB
OriGene qSTAR qPCR primer pairs in human, mouse for C4BPB
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C4BPB
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4BPB
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4BPB
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4BPB

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C4BPB gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia C4bp-ps15 complement component 4 binding protein, pseudogene more   --   1 (56.89 cM) 130670202 


ENSEMBL Gene Tree for C4BPB (if available)
TreeFam Gene Tree for C4BPB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for C4BPB gene
18/36 SIMAP similar genes for C4BPB using alignment to 3 protein entries:     C4BPB_HUMAN (see all proteins) (see all similar genes):
ATL2    ZNF564    COQ5    SH2B3    SUMO1    UBXN4
FAM175A    FLJ00047    SNRPF    GBGT1    PFKFB3    RQCD1
GALK2    CASC4    HC6    MST132    RBP7    ZRSR2

C4BPB for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/324 SNPs in C4BPB are shown (see all 324)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1493146241,2
--177970018(+) TTTCAC/TGCTCT 5 -- int10--------
rs1882420831,2
--177970043(+) GCCACC/TTCTGA 5 -- int10--------
rs563303031,2
C,F--177970120(+) CTTTGC/TTTGCC 5 -- int11Minor allele frequency- T:0.03NA 120
rs796536511,2
C,F--177970130(+) CTGCCC/TGCTGC 5 -- int11Minor allele frequency- T:0.03WA 118
rs1926801161,2
--177970184(+) GGTACC/TGGTCT 5 -- int10--------
rs1147640711,2
C,F--177970194(+) TGTGGC/TCCTGG 5 -- int11Minor allele frequency- T:0.01NA 120
rs1847277651,2
--177970243(+) CAATGC/TGTGAG 5 -- int10--------
rs1435622821,2
--177970251(+) GAGAAC/TTGGAA 5 -- int10--------
rs1891058511,2
--177970377(+) TATTTA/GAGCCA 5 -- int10--------
rs2004032101,2
C--177970584(+) CCATGG/AAGAAC 10 /K /E mis11Minor allele frequency- A:0.00EU 1323

HapMap Linkage Disequilibrium report for C4BPB (207262187 - 207273338 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for C4BPB:    About this table     
Variant IDTypeSubtypePubMed ID
nsv832426CNV Gain17160897

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing C4BPB
DNA2.0 Custom Variant and Variant Library Synthesis for C4BPB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 120831    OMIM disorders: --

19 diseases for C4BPB:    About MalaCards
atypical hemolytic-uremic syndrome    critical limb ischemia    hemolytic-uremic syndrome    pertussis
age related macular degeneration    macular degeneration    thrombosis    influenza
protein s deficiency    non-hodgkin lymphoma    hodgkin's lymphoma    ischemia
meningioma    pneumonia    hepatitis b    alzheimer's disease
hepatitis    endotheliitis    leukemia

1 disease from the University of Copenhagen DISEASES database for C4BPB:
Protein S deficiency

C4BPB for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

4 Novoseek inferred disease relationships for C4BPB gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
response acute phase 29.5 6 7561114 (2), 8598458 (1)
inflammation 3.06 2 19563958 (1), 12907438 (1)
necrosis 0 2 19563958 (2)
thrombosis 0 1 9169428 (1)

Genetic Association Database (GAD): C4BPB
Human Genome Epidemiology (HuGE) Navigator: C4BPB (9 documents)

Export disorders for C4BPB gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C4BPB gene, integrated from 9 sources (see all 93):
(articles sorted by number of sources associating them with C4BPB)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human C4b-binding protein beta-chain gene. (PubMed id 8325877)1, 2, 3, 9 Hillarp A....Dahlback B. (1993)
  2. Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: sequence homology with the alpha chain. (PubMed id 2300577)1, 2, 3 Hillarp A. and Dahlback B. (1990)
  3. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
  4. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  6. C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S independent mechanism: results from genome-wi de association and gene expression analyses followed by case-control studies. (PubMed id 20212171)1, 4 Buil A....Morange P.E. (2010)
  7. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (2009)
  8. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. (PubMed id 18842294)1, 4 Ennis S....Lotery A. (2008)
  9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 725 HGNC: 1328 AceView: C4BPB Ensembl:ENSG00000123843 euGenes: HUgn725
ECgene: C4BPB Kegg: 725 H-InvDB: C4BPB

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C4BPB Pharmacogenomics, SNPs, Pathways
SeattleSNPshttp://pga.gs.washington.edu/data/c4bpb/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C4BPB gene:
Search GeneIP for patents involving C4BPB

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 Browse for Gene Knock-down Tools from EMD Millipore
 EMD Millipore Mono- and Polyclonal Antibodies for the study of C4BPB
 Browse Purified and Recombinant Proteins at EMD Millipore
 Browse Small Molecules at EMD Millipore
 Browse Kits and Assays available from EMD Millipore
 Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for C4BPB  
 OriGene qPCR primer pairs and template standards for C4BPB   OriGene Protein Over-expression Lysate for C4BPB  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for C4BPB  
 OriGene qSTAR qPCR primer pairs in human, mouse for C4BPB   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for C4BPB   OriGene Custom Protein Services for C4BPB  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C4BPB
 QIAGEN SeqTarget long-range PCR primers for resequencing C4BPB
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4BPB
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C4BPB
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4BPB
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4BPB
 GenScript Custom Purified and Recombinant Proteins Services for C4BPB GenScript cDNA clones with any tag delivered in your preferred vector for C4BPB
 GenScript Custom Assay Services for C4BPB GenScript Custom Superior Antibodies Services for C4BPB
 GenScript Custom overexpressing Cell Line Services for C4BPB CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in C4BPB promoter
 Search Chromatin IP Primers for C4BPB
 RT2 qPCR Primer Assay in human, mouse / rat C4BPB
 GNC Network for C4BPB
 SABiosciences Custom PCR Arrays for C4BPB
 Search Tocris compounds for C4BPB
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 C4BPB antibodies
 C4BPB proteins
 C4BPB lysates
 Antibodies for C4BPB
 See all of Abcam's Antibodies, Kits and Proteins for C4BPB
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for C4BPB




 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for C4BPB
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4BPB
 Browse SwitchGear 3'UTR luciferase reporter plasmids for C4BPB
 SwitchGear Promoter luciferase reporter plasmids for C4BPB
 ThermoFisher Antibody for C4BPB
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4BPB
 inGenious Targeting Laboratory - Custom generated mouse model solutions for C4BPB
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C4BPB
Customized:
 lentivirus for stable overexpression of C4BPB
 lentivirus expression plasmids for stable overexpression of C4BPB
 adenovirus for overexpression of C4BPB
 LSBio Antibodies in human, mouse, rat for C4BPB
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      C4BPB gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4