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Aliases for C4BPB Gene

Aliases for C4BPB Gene

  • Complement Component 4 Binding Protein, Beta 2 3
  • Complement Component 4-Binding Protein, Beta 2
  • Complement Component 4 Binding Protein 2
  • C4b-Binding Protein Beta Chain 3
  • C4b Binding Protein 2
  • Beta Chain 2
  • C4BP 3

External Ids for C4BPB Gene

Previous Symbols for C4BPB Gene

  • C4BP

Summaries for C4BPB Gene

Entrez Gene Summary for C4BPB Gene

  • This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for C4BPB Gene

C4BPB (Complement Component 4 Binding Protein, Beta) is a Protein Coding gene. Diseases associated with C4BPB include protein s deficiency. Among its related pathways are Complement and coagulation cascades and FOXA1 transcription factor network.

UniProtKB/Swiss-Prot for C4BPB Gene

  • Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4BPB Gene

Genomics for C4BPB Gene

Genomic Location for C4BPB Gene

Start:
207,006,845 bp from pter
End:
207,099,993 bp from pter
Size:
93,149 bases
Orientation:
Plus strand

Genomic View for C4BPB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C4BPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4BPB Gene

Regulatory Elements for C4BPB Gene

Proteins for C4BPB Gene

  • Protein details for C4BPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20851-C4BPB_HUMAN
    Recommended name:
    C4b-binding protein beta chain
    Protein Accession:
    P20851
    Secondary Accessions:
    • A5JYP8
    • D3DT81
    • Q5VVR0
    • Q9BS25

    Protein attributes for C4BPB Gene

    Size:
    252 amino acids
    Molecular mass:
    28357 Da
    Quaternary structure:
    • Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at the end

    Alternative splice isoforms for C4BPB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C4BPB Gene

Proteomics data for C4BPB Gene at MOPED

Post-translational modifications for C4BPB Gene

  • Glycosylation at Asn64, Asn71, Asn98, Asn117, and Asn154

Other Protein References for C4BPB Gene

No data available for DME Specific Peptides for C4BPB Gene

Domains for C4BPB Gene

Protein Domains for C4BPB Gene

UniProtKB/Swiss-Prot:

C4BPB_HUMAN
Domain:
  • Contains 3 Sushi (CCP/SCR) domains.:
    • P20851
genes like me logo Genes that share domains with C4BPB: view

No data available for Gene Families for C4BPB Gene

Function for C4BPB Gene

Molecular function for C4BPB Gene

GENATLAS Biochemistry: complement component 4,binding protein beta,45kDa,regulator of C3 convertase of classical pathway,see RCA@
UniProtKB/Swiss-Prot Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S

Gene Ontology (GO) - Molecular Function for C4BPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14607961
genes like me logo Genes that share ontologies with C4BPB: view

miRNA for C4BPB Gene

miRTarBase miRNAs that target C4BPB

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C4BPB Gene

Localization for C4BPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for C4BPB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C4BPB Gene COMPARTMENTS Subcellular localization image for C4BPB gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C4BPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IDA 14607961
GO:0005886 plasma membrane TAS --
GO:0044216 other organism cell IDA 22333221
genes like me logo Genes that share ontologies with C4BPB: view

Pathways for C4BPB Gene

genes like me logo Genes that share pathways with C4BPB: view

Pathways by source for C4BPB Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for C4BPB Gene
1 BioSystems pathway for C4BPB Gene
2 Reactome pathways for C4BPB Gene
2 KEGG pathways for C4BPB Gene

Gene Ontology (GO) - Biological Process for C4BPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006958 complement activation, classical pathway IEA --
GO:0007596 blood coagulation TAS 8325877
GO:0030449 regulation of complement activation TAS --
GO:0045087 innate immune response TAS --
GO:0045732 positive regulation of protein catabolic process IDA 22333221
genes like me logo Genes that share ontologies with C4BPB: view

Compounds for C4BPB Gene

(6) Novoseek inferred chemical compound relationships for C4BPB Gene

Compound -log(P) Hits PubMed IDs
phosphatidylserine 39.4 3
phospholipid 21.2 3
heparin 16 5
calcium 0 3
alanine 0 1
genes like me logo Genes that share compounds with C4BPB: view

Transcripts for C4BPB Gene

Unigene Clusters for C4BPB Gene

Complement component 4 binding protein, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C4BPB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7:
SP8: -
SP9:

Relevant External Links for C4BPB Gene

GeneLoc Exon Structure for
C4BPB
ECgene alternative splicing isoforms for
C4BPB

Expression for C4BPB Gene

mRNA expression in normal human tissues for C4BPB Gene

mRNA differential expression in normal tissues according to GTEx for C4BPB Gene

This gene is overexpressed in Liver (46.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C4BPB Gene

SOURCE GeneReport for Unigene cluster for C4BPB Gene Hs.99886

genes like me logo Genes that share expressions with C4BPB: view

Orthologs for C4BPB Gene

This gene was present in the common ancestor of mammals.

Orthologs for C4BPB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C4BPB 36
  • 99.2 (n)
  • 99.2 (a)
C4BPB 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C4BPB 37
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4BPB 36
  • 80.13 (n)
  • 69.6 (a)
C4BPB 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C4bp-ps1 16
oppossum
(Monodelphis domestica)
Mammalia C4BPB 37
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C4BPB 37
  • 35 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C4bpb 36
  • 76.71 (n)
  • 66.67 (a)
Species with no ortholog for C4BPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C4BPB Gene

ENSEMBL:
Gene Tree for C4BPB (if available)
TreeFam:
Gene Tree for C4BPB (if available)

Paralogs for C4BPB Gene

genes like me logo Genes that share paralogs with C4BPB: view

No data available for Paralogs for C4BPB Gene

Variants for C4BPB Gene

Sequence variations from dbSNP and Humsavar for C4BPB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7542292 -- 207,095,434(+) caagc(A/G)gttct intron-variant, reference, missense
rs7536934 -- 207,088,542(+) GATGG(A/G)GAAGA upstream-variant-2KB
rs7529011 -- 207,095,515(+) gtaga(A/G)actgg intron-variant, missense, reference
rs7525965 -- 207,088,650(+) ACAGA(C/G)AACCA upstream-variant-2KB
rs6690037 -- 207,090,484(+) GCTGT(A/G)AGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C4BPB Gene

Variant ID Type Subtype PubMed ID
nsv832426 CNV Gain 17160897

Relevant External Links for C4BPB Gene

HapMap Linkage Disequilibrium report
C4BPB

Disorders for C4BPB Gene

(1) MalaCards Diseases for C4BPB Gene

Search for C4BPB Gene in MalaCards »

(1) University of Copenhagen DISEASES for C4BPB Gene

(4) Novoseek inferred disease relationships for C4BPB Gene

Disease -log(P) Hits PubMed IDs
response acute phase 29.5 3
inflammation 3.06 2
necrosis 0 2
thrombosis 0 1

Relevant External Links for C4BPB

Genetic Association Database (GAD)
C4BPB
Human Genome Epidemiology (HuGE) Navigator
C4BPB
genes like me logo Genes that share disorders with C4BPB: view

No data available for UniProtKB/Swiss-Prot for C4BPB Gene

Publications for C4BPB Gene

  1. The human C4b-binding protein beta-chain gene. (PMID: 8325877) Hillarp A. … Dahlback B. (J. Biol. Chem. 1993) 2 3 4 23
  2. Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: sequence homology with the alpha chain. (PMID: 2300577) Hillarp A. … Dahlback B. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4
  3. Role of CCP2 of the C4b-binding protein beta-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies. (PMID: 12492479) Webb J.H. … Blom A.M. (Eur. J. Biochem. 2003) 3 23
  4. C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation. (PMID: 15967823) Trouw L.A. … Blom A.M. (J. Exp. Med. 2005) 3 23
  5. Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor. (PMID: 16330538) Jenkins H.T. … Barlow P.N. (J. Biol. Chem. 2006) 3 23

Products for C4BPB Gene

Sources for C4BPB Gene

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