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C4BPA Gene

protein-coding   GIFtS: 61
GCID: GC01P207277

Complement Component 4 Binding Protein, Alpha

(Previous names: complement component 4-binding protein, alpha)
(Previous symbol: C4BP)
  See C4BPA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Complement Component 4 Binding Protein, Alpha1 2     Complement Component 4-Binding Protein, Alpha1
C4BP1 2 3     C4b-Binding Protein Alpha Chain2
Proline-Rich Protein2 3     C4bp3
PRP2 3     

External Ids:    HGNC: 13251   Entrez Gene: 7222   Ensembl: ENSG000001238387   OMIM: 1208305   UniProtKB: P040033   

Export aliases for C4BPA gene to outside databases

Previous GC identifers: GC01P205937 GC01P202987 GC01P203921 GC01P204361 GC01P203666 GC01P205344 GC01P177975


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for C4BPA Gene:
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus
repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains
encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that
controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and
beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation
gene cluster. Two pseudogenes of this gene are also found in the cluster. (provided by RefSeq, Jul 2008)

GeneCards Summary for C4BPA Gene:
C4BPA (complement component 4 binding protein, alpha) is a protein-coding gene. Diseases associated with C4BPA include gonorrhea, and acute poststreptococcal glomerulonephritis. An important paralog of this gene is CSMD1.

UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003
Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator
(C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a
complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also
with anticoagulant protein S and with serum amyloid P component




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C4BPA gene promoter:
         ISGF-3   C/EBPbeta   AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   FOXO1a   Sox9   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC4BPA promoter sequence
   Search Chromatin IP Primers for C4BPA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C4BPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32

C4BPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C4BPA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207277:  view genomic region     (about GC identifiers)

Start:
207,277,607 bp from pter      End:
207,318,317 bp from pter
Size:
40,711 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003 (See protein sequence)
Recommended Name: C4b-binding protein alpha chain precursor  
Size: 597 amino acids; 67033 Da
Subunit: Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha
chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta
chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at
the end
Caution: It is uncertain whether Met-1 or Met-17 is the initiator
2 PDB 3D structures from and Proteopedia for C4BPA:
2A55 (3D)        4B0F (3D)    
Secondary accessions: Q5VVQ8

Explore the universe of human proteins at neXtProt for C4BPA: NX_P04003

Explore proteomics data for C4BPA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn221, Asn506, Asn528
  • Modification sites at PhosphoSitePlus

  • See C4BPA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000706.1  
    ENSEMBL proteins: 
     ENSP00000356037   ENSP00000403386   ENSP00000395968  
    Reactome Protein details: P04003

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry P04003

    ProtoNet protein and cluster: P04003

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003
    Similarity: Contains 8 Sushi (CCP/SCR) domains


    Find genes that share domains with C4BPA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C4BPA_HUMAN, P04003
    Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator
    (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a
    complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also
    with anticoagulant protein S and with serum amyloid P component

         Genatlas biochemistry entry for C4BPA:
    complement component 4,binding protein alpha,70kDa,regulator of C3 convertase of classical pathway,see RCA@

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16330538
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with C4BPA           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    C4BPA_HUMAN, P04003: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with C4BPA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for C4BPA About    
    See pathways by source

    SuperPathContained pathways About
    1Complement Pathway
    Immune response Lectin Induced complement pathway0.56
    Regulation of Complement cascade0.48
    Immune response Classic complement pathway0.56
    2Complement and coagulation cascades
    Complement and coagulation cascades0.71
    3Creation of C4 and C2 activators
    Complement cascade0.68
    4Pertussis
    Pertussis
    5CD40/CD40L signaling
    CD40/CD40L signaling


    Find genes that share SuperPaths with C4BPA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for C4BPA
        Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    1 BioSystems Pathway for C4BPA
        CD40/CD40L signaling

    1 Reactome Pathway for C4BPA
        Regulation of Complement cascade


    2 Kegg Pathways  (Kegg details for C4BPA):
        Complement and coagulation cascades
    Pertussis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C4BPA
    Interactions:

        GeneGlobe Interaction Network for C4BPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for C4BPA (P040031, 3 ENSP000003560374) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C4BP0C0L53, ENSP000004159414I2D: score=1 STRING: ENSP00000415941
    C4B_2P0C0L53I2D: score=1 
    ENSG00000228267P0C0L53I2D: score=1 
    ENSG00000228454P0C0L53I2D: score=1 
    ENSG00000236625P0C0L53I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006958complement activation, classical pathway IEA--
    GO:0030449regulation of complement activation TAS--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with C4BPA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C4BPA

    Selected Novoseek inferred chemical compound relationships for C4BPA gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoethanolamine 49.5 2 7592941 (1), 1375509 (1)
    gamma-carboxyglutamic acid 43.9 1 1533219 (1)
    heparin 41.5 17 2136880 (3), 8845035 (2), 8133054 (2), 18266273 (2) (see all 7)
    phosphorylcholine 36.8 2 16751408 (1), 17244159 (1)
    cardiolipin 20.8 2 9175020 (1), 10361122 (1)
    fibrinogen 15.7 6 15773976 (2), 18409149 (2), 9551922 (1), 20100644 (1)
    cholesterol 0 4 9222877 (2), 1527895 (1), 2049187 (1)
    sucrose 0 1 7654697 (1)
    calcium 0 5 2147688 (3), 1825786 (1), 8133054 (1)
    lactate 0 3 7654697 (2)



    Find genes that share compounds with C4BPA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C4BPA gene: 
    NM_000715.3  

    Unigene Cluster for C4BPA:

    Complement component 4 binding protein, alpha
    Hs.1012  [show with all ESTs]
    Unigene Representative Sequence: BC022312
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367070(uc001hfo.3) ENST00000421786 ENST00000424088
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat C4BPA
      QuantiFast Probe-based Assays in human, mouse, rat C4BPA

    Additional mRNA sequence: 

    AK303793.1 AK303798.1 AK313164.1 BC022312.1 M31452.1 X02865.1 X07853.1 

    3 DOTS entries:

    DT.315516  DT.121343031  DT.92420453 

    Selected AceView cDNA sequences (see all 84):

    CB156971 BG568629 CB111960 BC022312 BX340564 AA961146 CB163868 CB216627 
    M31452 CB154712 BM982305 NM_000715 CB164795 CB154350 AW268686 CB216323 
    CB157496 AL602974 BQ019292 AI268588 BM955614 BU689016 AI924529 BX098031 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for C4BPA    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                          -                 -                                                                           
    SP2:                          -                 -                                                                           
    SP3:                          -                                                                                             
    SP4:                                            -                                                                           


    ECgene alternative splicing isoforms for C4BPA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C4BPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTGCTTT
    C4BPA Expression
    About this image


    C4BPA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    C4BPA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C4BPA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1012

    UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003
    Tissue specificity: Chylomicrons in the plasma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4BPA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C4BPA gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C4bp5 complement component 4 binding protein   --   1 (56.89 cM) 130634773 
    chicken
    (Gallus gallus)
    Aves LOC4198511 complement component 4 binding protein, alpha chain 45.79(n)
    33.54(a)
      419851  NM_001033642.1  NP_001028814.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    32(a)
    many ↔ many
    GL344121.1(5670-32340)
    zebrafish
    (Danio rerio)
    Actinopterygii rca2.26
    rca2.16
    regulator of complement activation group 2 gene 1
    31(a)
    27(a)
    many ↔ many
    many ↔ many
    23(26413284-26415932) ENSDARG00000095512
    23(26381820-26407620) ENSDARG00000056075


    ENSEMBL Gene Tree for C4BPA (if available)
    TreeFam Gene Tree for C4BPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C4BPA gene
    CSMD12  SELP2  CR22  SELL2  CSMD32  CR1L2  APOH2  SELE2  
    CSMD22  CD462  CD552  CR12  SVEP12  
    3 SIMAP similar genes for C4BPA using alignment to 3 protein entries:     C4BPA_HUMAN (see all proteins):
    SVEP1    CD55    CR1

    Find genes that share paralogs with C4BPA           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for C4BPA
    PGOHUM00000259606 PGOHUM00000245185 PGOHUM00000245186


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C4BPA (see all 878)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38413771,2
    C,F--207277350(-) TTATGG/-CAAGA 1 -- us2k14Minor allele frequency- -:0.38NA CSA 8
    rs2009975391,2
    --207279795(+) TTTTT-/GTTTTT 1 -- int10--------
    rs341018551,2
    C--207281706(+) TAAAAG/-TTACT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs681156511,2
    C--207281707(+) AAAAT-/GTACTG 1 -- int10--------
    rs112967191,2
    C--207284274(+) TTCTAT/-TTTGC 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1461318681,2
    C--207285535(+) TTTTC-/ATATATA 1 -- int10--------
    rs114064571,2
    C--207289711(+) TTTTTT/-CCTTA 1 -- int1 trp32Minor allele frequency- -:0.00NA CSA 4
    rs57803731,2
    C--207291455(+) TAGTT-/TATC  
            
    TATCA
    1 -- int11Minor allele frequency- TATC:0.00NA 2
    rs50238361,2
    C--207291514(+) TGTCTA/GTCTAT 1 -- int10--------
    rs120718711,2
    A--207291520(+) tctatA/Ctatat 1 -- int10--------

    HapMap Linkage Disequilibrium report for C4BPA (207277607 - 207318317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for C4BPA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821224CNV Deletion20802225
    esv2722040CNV Deletion23290073
    esv1000470CNV Deletion20482838
    esv9705CNV Loss19470904
    nsv832426CNV Gain17160897
    esv28463CNV Gain19812545
    nsv511134CNV Gain21212237
    esv7318OTHER Inversion19470904

    Human Gene Mutation Database (HGMD): C4BPA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C4BPA
    DNA2.0 Custom Variant and Variant Library Synthesis for C4BPA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 120830    OMIM disorders: --

    5 diseases for C4BPA:    
    About MalaCards
    gonorrhea    acute poststreptococcal glomerulonephritis    protein s deficiency    membranoproliferative glomerulonephritis
    takayasu's arteritis


    Find genes that share disorders with C4BPA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for C4BPA gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    protein s deficiency 64.2 1 9108398 (1)
    response acute phase 54.6 14 1699702 (2), 19284503 (2), 7519078 (1), 9097083 (1) (see all 7)
    gonorrhea 35 2 16275906 (1), 19388167 (1)
    shock septic 12.5 3 7740486 (1), 1828915 (1)
    tumors 1.45 1 11441101 (1)
    skin lesion 0 1 9784543 (1)
    lupus erythematosus systemic 0 2 10337010 (1), 1699702 (1)
    hemolysis 0 3 10469045 (2), 10408369 (1)
    inflammation 0 2 16751408 (1)
    alzheimers disease 0 1 1632784 (1)

    Genetic Association Database (GAD): C4BPA
    Human Genome Epidemiology (HuGE) Navigator: C4BPA (12 documents)

    Export disorders for C4BPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for C4BPA gene, integrated from 10 sources (see all 189):
    (articles sorted by number of sources associating them with C4BPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the alpha chain of the human C4b-binding protein gene. (PubMed id 1989602)1, 2, 9 Aso T.... Niho Y. (Biochem. Biophys. Res. Commun. 1991)
    2. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    3. Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome. (PubMed id 20059470)1, 4 Sullivan M....Neumann H.P. (Ann. Hum. Genet. 2010)
    4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    5. Lack of association between polymorphisms in C4b-binding protein and atypical haemolytic uraemic syndrome in the Spanish population. (PubMed id 19076829)1, 4 MartA-nez-Barricarte R....RodrA-guez de CA^rdoba S. (Clin. Exp. Immunol. 2009)
    6. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (Br. J. Haematol. 2009)
    7. A novel non-synonymous polymorphism (p.Arg240His) in C4b-binding protein is associated with atypical hemolytic uremic syndrome and leads to impaired alternative pathway cofactor activity. (PubMed id 18424762)1, 4 Blom A.M....Goodship T.H. (J. Immunol. 2008)
    8. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. (PubMed id 18842294)1, 4 Ennis S....Lotery A. (Lancet 2008)
    9. Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor. (PubMed id 16330538)1, 2 Jenkins H.T....Barlow P.N. (J. Biol. Chem. 2006)
    10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 722 HGNC: 1325 AceView: C4BPA Ensembl:ENSG00000123838 euGenes: HUgn722
    ECgene: C4BPA Kegg: 722 H-InvDB: C4BPA

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for C4BPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for C4BPA gene:
    Search GeneIP for patents involving C4BPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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