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Aliases for C4BPA Gene

Aliases for C4BPA Gene

  • Complement Component 4 Binding Protein, Alpha 2 3
  • Proline-Rich Protein 3 4
  • C4BP 3 4
  • PRP 3 4
  • Complement Component 4-Binding Protein, Alpha 2
  • C4b-Binding Protein Alpha Chain 3

External Ids for C4BPA Gene

Previous HGNC Symbols for C4BPA Gene

  • C4BP

Previous GeneCards Identifiers for C4BPA Gene

  • GC01P205937
  • GC01P202987
  • GC01P203921
  • GC01P204361
  • GC01P203666
  • GC01P205344
  • GC01P207277
  • GC01P177975

Summaries for C4BPA Gene

Entrez Gene Summary for C4BPA Gene

  • This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for C4BPA Gene

C4BPA (Complement Component 4 Binding Protein, Alpha) is a Protein Coding gene. Diseases associated with C4BPA include gonorrhea and protein s deficiency. Among its related pathways are Complement and coagulation cascades and CD40/CD40L signaling. An important paralog of this gene is CSMD3.

UniProtKB/Swiss-Prot for C4BPA Gene

  • Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4BPA Gene

Genomics for C4BPA Gene

Genomic Location for C4BPA Gene

Start:
207,104,241 bp from pter
End:
207,144,972 bp from pter
Size:
40,732 bases
Orientation:
Plus strand

Genomic View for C4BPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C4BPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4BPA Gene

Proteins for C4BPA Gene

  • Protein details for C4BPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04003-C4BPA_HUMAN
    Recommended name:
    C4b-binding protein alpha chain
    Protein Accession:
    P04003
    Secondary Accessions:
    • Q5VVQ8

    Protein attributes for C4BPA Gene

    Size:
    597 amino acids
    Molecular mass:
    67033 Da
    Quaternary structure:
    • Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at the end.

    Three dimensional structures from OCA and Proteopedia for C4BPA Gene

neXtProt entry for C4BPA Gene

Proteomics data for C4BPA Gene at MOPED

Post-translational modifications for C4BPA Gene

  • Glycosylation at Asn221, Asn506, and Asn528
  • Modification sites at PhosphoSitePlus

Other Protein References for C4BPA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for C4BPA Gene

Domains for C4BPA Gene

Protein Domains for C4BPA Gene

Suggested Antigen Peptide Sequences for C4BPA Gene

Graphical View of Domain Structure for InterPro Entry

P04003

UniProtKB/Swiss-Prot:

C4BPA_HUMAN :
  • P04003
Domain:
  • Contains 8 Sushi (CCP/SCR) domains.
genes like me logo Genes that share domains with C4BPA: view

No data available for Gene Families for C4BPA Gene

Function for C4BPA Gene

Molecular function for C4BPA Gene

GENATLAS Biochemistry:
complement component 4,binding protein alpha,70kDa,regulator of C3 convertase of classical pathway,see RCA@
UniProtKB/Swiss-Prot Function:
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component

Gene Ontology (GO) - Molecular Function for C4BPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14607961
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with C4BPA: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C4BPA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C4BPA Gene

Localization for C4BPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for C4BPA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C4BPA Gene COMPARTMENTS Subcellular localization image for C4BPA gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for C4BPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IDA 14607961
GO:0005886 plasma membrane TAS --
GO:0044216 other organism cell IDA 22333221
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with C4BPA: view

Pathways for C4BPA Gene

genes like me logo Genes that share pathways with C4BPA: view

Pathways by source for C4BPA Gene

1 BioSystems pathway for C4BPA Gene
2 Reactome pathways for C4BPA Gene

Gene Ontology (GO) - Biological Process for C4BPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006958 complement activation, classical pathway IEA --
GO:0030449 regulation of complement activation TAS --
GO:0045087 innate immune response TAS --
GO:0045732 positive regulation of protein catabolic process IDA 22333221
GO:0045959 negative regulation of complement activation, classical pathway IDA 22333221
genes like me logo Genes that share ontologies with C4BPA: view

Compounds for C4BPA Gene

(11) Novoseek inferred chemical compound relationships for C4BPA Gene

Compound -log(P) Hits PubMed IDs
phosphoethanolamine 49.5 2
gamma-carboxyglutamic acid 43.9 1
heparin 41.5 12
phosphorylcholine 36.8 2
cardiolipin 20.8 2
genes like me logo Genes that share compounds with C4BPA: view

Transcripts for C4BPA Gene

mRNA/cDNA for C4BPA Gene

Unigene Clusters for C4BPA Gene

Complement component 4 binding protein, alpha:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C4BPA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C4BPA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for C4BPA Gene

GeneLoc Exon Structure for
C4BPA
ECgene alternative splicing isoforms for
C4BPA

Expression for C4BPA Gene

mRNA expression in normal human tissues for C4BPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C4BPA Gene

This gene is overexpressed in Liver (48.7).

Protein differential expression in normal tissues for C4BPA Gene

This gene is overexpressed in Plasma (24.1), Serum (19.7), and Synovial fluid (11.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C4BPA Gene

SOURCE GeneReport for Unigene cluster for C4BPA Gene Hs.1012

mRNA Expression by UniProt/SwissProt for C4BPA Gene

P04003-C4BPA_HUMAN
Tissue specificity: Chylomicrons in the plasma
genes like me logo Genes that share expressions with C4BPA: view

Expression partners for C4BPA Gene

In Situ Assay Products

Orthologs for C4BPA Gene

This gene was present in the common ancestor of chordates.

Orthologs for C4BPA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C4BPA 35
  • 73.86 (n)
  • 61.64 (a)
C4BPA 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4BPA 35
  • 75.07 (n)
  • 59.8 (a)
C4BPA 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C4BPA 35
  • 98.49 (n)
  • 96.65 (a)
C4BPA 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C4bpa 35
  • 71.57 (n)
  • 59.63 (a)
mouse
(Mus musculus)
Mammalia C4bp 16
C4bp 36
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C4BPA 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C4BPA 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC419851 35
  • 45.79 (n)
  • 33.54 (a)
-- 36
  • 26 (a)
ManyToMany
C4BPA 36
  • 32 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii rca2.1 36
  • 27 (a)
ManyToMany
rca2.2 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
OneToMany
Species with no ortholog for C4BPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C4BPA Gene

ENSEMBL:
Gene Tree for C4BPA (if available)
TreeFam:
Gene Tree for C4BPA (if available)

Paralogs for C4BPA Gene

Paralogs for C4BPA Gene

Selected SIMAP similar genes for C4BPA Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for C4BPA Gene

genes like me logo Genes that share paralogs with C4BPA: view

Variants for C4BPA Gene

Sequence variations from dbSNP and Humsavar for C4BPA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1126618 -- 207,124,335(+) ATAGG(C/T)GTTTG synonymous-codon, reference
rs1801341 - 207,141,250(+) ACACT(G/T)GTCAG reference, missense
rs1804225 -- 207,134,570(+) AGTCC(A/C)CGAAC synonymous-codon, reference
rs2491393 -- 207,126,914(+) GTGAC(A/G)GAATT intron-variant
rs2491394 -- 207,127,036(+) ATTTT(A/T)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C4BPA Gene

Variant ID Type Subtype PubMed ID
nsv832426 CNV Gain 17160897
nsv511134 CNV Gain 21212237
esv1000470 CNV Deletion 20482838
esv2722040 CNV Deletion 23290073
esv9705 CNV Loss 19470904
esv7318 OTHER Inversion 19470904
esv28463 CNV Gain 19812545
nsv821224 CNV Deletion 20802225

Relevant External Links for C4BPA Gene

HapMap Linkage Disequilibrium report
C4BPA
Human Gene Mutation Database (HGMD)
C4BPA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C4BPA Gene

Disorders for C4BPA Gene

(11) Novoseek inferred disease relationships for C4BPA Gene

Disease -log(P) Hits PubMed IDs
protein s deficiency 64.2 1
response acute phase 54.6 9
gonorrhea 35 2
shock septic 12.5 2
tumors 1.45 1

Relevant External Links for C4BPA

Genetic Association Database (GAD)
C4BPA
Human Genome Epidemiology (HuGE) Navigator
C4BPA
genes like me logo Genes that share disorders with C4BPA: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for C4BPA Gene

Publications for C4BPA Gene

  1. Genomic organization of the alpha chain of the human C4b-binding protein gene. (PMID: 1989602) Aso T. … Niho Y. (Biochem. Biophys. Res. Commun. 1991) 3 4 23
  2. Reevaluation of total, free, and bound protein S and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin. (PMID: 1534488) Griffin J.H. … FernA!ndez J.A. (Blood 1992) 3 23
  3. C4BPAL1, a member of the human regulator of complement activation (RCA) gene cluster that resulted from the duplication of the gene coding for the alpha-chain of C4b-binding protein. (PMID: 8406448) SA!nchez-Corral P. … RodrA-guez de CA^rdoba S. (Genomics 1993) 3 23
  4. Expression of the human gene coding for the alpha-chain of C4b-binding protein, C4BPA, is controlled by an HNF1-dependent hepatic-specific promoter. (PMID: 7772049) Arenzana N. … Rey-Campos J. (Biochem. J. 1995) 3 23
  5. Serum amyloid P component binding to C4b-binding protein. (PMID: 7592941) GarcA-a de Frutos P. … DahlbAock B. (J. Biol. Chem. 1995) 3 23

Products for C4BPA Gene

Sources for C4BPA Gene

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