C4BPA Gene
protein-coding GIFtS: 59
GCID: GC01P207277
|
|
complement component 4 binding protein, alpha(Previous names: complement component 4-binding protein, alpha )
(Previous symbol: C4BP)
| |
Aliases
for C4BPA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Complement Component 4 Binding Protein, Alpha1 2 | | Complement Component 4-Binding Protein, Alpha1 | | C4BP1 2 3 | | C4b-Binding Protein Alpha Chain2 | | Proline-Rich Protein2 3 | | C4bp3 | | PRP2 3 | | |
Export aliases for C4BPA gene to outside databasesPrevious GC identifers: GC01P205937 GC01P202987 GC01P203921 GC01P204361 GC01P203666 GC01P205344 GC01P177975 |
Summaries
for C4BPA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for C4BPA:
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensusrepeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encodedby this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controlsactivation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains arelocated adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Twopseudogenes of this gene are also found in the cluster. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator(C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex(C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also withanticoagulant protein S and with serum amyloid P component
|
Genomic Views
for C4BPA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C4BPA gene promoter:
ISGF-3 C/EBPbeta AML1a POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 FOXO1a Sox9 Pax-4a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C4BPA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4BPA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32C4BPA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P207277: view genomic region
(about GC identifiers)
Start:
|
207,277,607 bp from pter |
End:
|
207,318,317 bp from pter |
Size:
|
40,711 bases |
Orientation:
|
plus strand |
|
Proteins
for C4BPA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003 (See
protein sequence)Recommended Name: C4b-binding protein alpha chain precursor Size: 597 amino acids; 67033 Da
Subunit: Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha chains and1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. Thecentral body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at the end
Subcellular location: Secreted
Caution: It is uncertain whether Met-1 or Met-17 is the initiator
2 PDB 3D structures from  and Proteopedia  for C4BPA:2A55 (3D)
4B0F (3D)
Explore the universe of human proteins at neXtProt for C4BPA: NX_P04003
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P04003
C4BPA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000706.1
ENSEMBL proteins: ENSP00000356037 ENSP00000403386 ENSP00000395968 Reactome Protein details: P04003
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
C4BPA for ontologies About GeneDecksing
C4BPA Antibody Products:
Assay Products for C4BPA: |
Protein
Domains /
Families
for C4BPA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C4BPA for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P04003ProtoNet protein and cluster: P04003 1 Blocks protein family: IPB000436 Sushi domain/SCR domain/CCP module
UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003Similarity: Contains 8 Sushi (CCP/SCR) domains |
Function
for C4BPA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator(C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex(C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also withanticoagulant protein S and with serum amyloid P component Genatlas biochemistry entry for C4BPA:complement component 4,binding protein alpha,70kDa,regulator of C3 convertase of classical pathway,see RCA@
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4BPA (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4BPA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C4BPA (NM_000715) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C4BPA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4BPA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4BPA |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
C4BPA for ontologies About GeneDecksing
|
Pathways & Interactions
for C4BPA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of C3 and C5 | | | 2 | Immune response_Classical complement pathway | | | 3 | Immune System | | | 4 | Immune response_Alternative complement pathway | | | 5 | CD40/CD40L signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for C4BPA
2  GeneGo (Thomson Reuters) Pathways for C4BPA
1  BioSystems Pathway for C4BPA
5/6 
Reactome Pathways for C4BPA (see all 6)
2 
Kegg Pathways (Kegg details for C4BPA):
C4BPA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for C4BPA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/20 Interacting proteins for C4BPA (P040031, 3 ENSP000003560374) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006958 | complement activation, classical pathway |
IEA | -- | | GO:0030449 | regulation of complement activation |
TAS | -- | | GO:0045087 | innate immune response |
TAS | -- |
C4BPA for ontologies About GeneDecksing
|
Drugs & Compounds
for C4BPA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
C4BPA for compounds About GeneDecksing
 Browse Tocris compounds for C4BPA
10/11 Novoseek chemical compound relationships for C4BPA gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phosphoethanolamine |
49.5 |
2 |
7592941 (1), 1375509 (1) |
| gamma-carboxyglutamic acid |
43.9 |
1 |
1533219 (1) |
| heparin |
41.5 |
17 |
2136880 (3), 8845035 (2), 8133054 (2), 18266273 (2) (see all 7) |
| phosphorylcholine |
36.8 |
2 |
16751408 (1), 17244159 (1) |
| cardiolipin |
20.8 |
2 |
9175020 (1), 10361122 (1) |
| fibrinogen |
15.7 |
6 |
15773976 (2), 18409149 (2), 9551922 (1), 20100644 (1) |
| cholesterol |
0 |
4 |
9222877 (2), 1527895 (1), 2049187 (1) |
| sucrose |
0 |
1 |
7654697 (1) |
| calcium |
0 |
5 |
2147688 (3), 1825786 (1), 8133054 (1) |
| lactate |
0 |
3 |
7654697 (2) |
Search CenterWatch for drugs/clinical trials and news about C4BPA
|
Transcripts
for C4BPA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C4BPA gene: NM_000715.3 Unigene Cluster for C4BPA: Complement component 4 binding protein, alpha Hs.1012 [show with all ESTs]Unigene Representative Sequence: BC0223123 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367070(uc001hfo.3) ENST00000421786 ENST00000424088
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4BPA (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4BPA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C4BPA (NM_000715) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C4BPA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4BPA |
Additional cDNA sequence: AK303793.1 AK303798.1 AK313164.1 BC022312.1 M31452.1 X02865.1 X07853.1 3 DOTS entries: DT.315516 DT.121343031 DT.92420453 24/84 AceView cDNA sequences (see all 84): AL602974 BM955614 CB156971 CB216627 CB111960 BU689016 CB157496 NM_000715 AA961146 BM982305 BQ019292 M31452 BX340564 CB216323 AI268588 CB154350 BC022312 CB164795 CB163868 AW268686 AI924529 CB154712 BG568629 CB161748
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for C4BPA About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C4BPA
|
Expression
for C4BPA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C4BPA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTGCTTT
About this image
See C4BPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C4BPA
SOURCE GeneReport for Unigene cluster: Hs.1012
UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003Tissue specificity: Chylomicrons in the plasma
SABiosciences Custom PCR Arrays for C4BPA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C4BPA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C4BPA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4BPA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4BPA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4BPA |
Orthologs
for C4BPA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C4BPA gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for C4BPA (if available)
TreeFam Gene Tree for C4BPA (if available) |
Paralogs
for C4BPA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C4BPA gene
- CSMD12 SEZ6L22 SELP2 CR22 SELL2 CR1L2 CSMD32 SEZ62
- SELE2 SEZ6L2 CSMD22 CR12 CD552 CD462 SVEP12
3 SIMAP similar genes for C4BPA using alignment to 4 protein entries: C4BPA_HUMAN (see all proteins):SVEP1 DAF CD55
C4BPA for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for C4BPA
PGOHUM00000259606 PGOHUM00000245185 PGOHUM00000245186
|
Genomic Variants
for C4BPA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C4BPA (207277607 - 207318317 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for C4BPA
1 CNV: 60926
5 Indels: 84811 65741 84812 84810 74869
1 Inversion: 59667
Human Gene Mutation Database (HGMD): C4BPA
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C4BPA |
|
Disorders
/ Diseases
for C4BPA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C4BPA for disorders About GeneDecksing
OMIM gene information: 120830
OMIM disorders: --
20/34  diseases for C4BPA (see all 34): About MalaCardshemolytic-uremic syndrome atypical hemolytic-uremic syndrome age related macular degeneration non-hodgkin lymphoma
membranoproliferative glomerulonephritis gonorrhea macular degeneration spontaneous abortion
lupus erythematosus systemic lupus erythematosus hodgkin's lymphoma protein s deficiency
lyme disease myocardial infarction mastitis glomerulopathy
glomerulonephritis alzheimer's disease hepatitis b purpura
1 disease from the University of Copenhagen DISEASES database for C4BPA:Mastitis 10/11 Novoseek disease relationships for C4BPA gene (see all 11) About this table
Human Genome Epidemiology (HuGE) Navigator: C4BPA (12 documents)
Export disorders for C4BPA gene to outside databases
|
Publications
for C4BPA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C4BPA gene, integrated from 9 sources (see all 183):
(articles sorted by number of sources associating them with C4BPA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic organization of the alpha chain of the human C4b-binding protein gene. (PubMed id 1989602)1, 2, 9 Aso T.... Niho Y. (1991)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein. (PubMed id 2590215)1, 2 Matsuguchi T.... Niho Y. (1989)
- Derivation of the sequence of the signal peptide in human C4b-binding protein and interspecies cross-hybridisation of the C4bp cDNA sequence. (PubMed id 3378624)1, 2 Lintin S.J.... Reid K.B.M. (1988)
- Studies on the structure of the human C4b-binding protein gene. (PubMed id 3017751)1, 2 Lintin S.J. and Reid K.B.M. (1986)
- Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment. (PubMed id 4033666)1, 2 Chung L.P.... Reid K.B.M. (1985)
- Molecular cloning and characterization of the cDNA coding for C4b- binding protein, a regulatory protein of the classical pathway of the human complement system. (PubMed id 3840370)1, 2 Chung L.P.... Reid K.B.M. (1985)
- Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b. (PubMed id 6222381)1, 2 Dahlback B.... Mueller-Eberhard H.J. (1983)
- Expression of the human gene coding for the alpha-chain of C4b-binding protein, C4BPA, is controlled by an HNF1-dependent hepatic-specific promoter. (PubMed id 7772049)1, 9 Arenzana N....Rey-Campos J. (1995)
|
External Searches for C4BPA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C4BPA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C4BPA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C4BPA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C4BPA | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C4BPA gene:
Search GeneIP for patents involving C4BPA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C4BPA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C4BPA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C4BPA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C4BPA | | | OriGene Protein Over-expression Lysate for C4BPA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C4BPA | | OriGene 3'-UTR Clone for C4BPA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4BPA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4BPA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C4BPA | | OriGene Custom Protein Services for C4BPA | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C4BPA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C4BPA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4BPA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C4BPA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4BPA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4BPA |
| |
 |  |  |  | |
| | | | Search Tocris compounds for C4BPA |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4BPA |
|  |  |  | | | | ThermoFisher Antibody for C4BPA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4BPA |
|
|
|
|
