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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C4BPA Gene

protein-coding   GIFtS: 61
GCID: GC01P207277

Complement Component 4 Binding Protein, Alpha

(Previous names: complement component 4-binding protein, alpha)
(Previous symbol: C4BP)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Complement Component 4 Binding Protein, Alpha1 2     Complement Component 4-Binding Protein, Alpha1
C4BP1 2 3     C4b-Binding Protein Alpha Chain2
Proline-Rich Protein2 3     C4bp3
PRP2 3     

External Ids:    HGNC: 13251   Entrez Gene: 7222   Ensembl: ENSG000001238387   OMIM: 1208305   UniProtKB: P040033   

Export aliases for C4BPA gene to outside databases

Previous GC identifers: GC01P205937 GC01P202987 GC01P203921 GC01P204361 GC01P203666 GC01P205344 GC01P177975


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for C4BPA Gene:
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus
repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains
encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that
controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and
beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation
gene cluster. Two pseudogenes of this gene are also found in the cluster. (provided by RefSeq, Jul 2008)

GeneCards Summary for C4BPA Gene: 
C4BPA (complement component 4 binding protein, alpha) is a protein-coding gene. Diseases associated with C4BPA include gonorrhea, and membranoproliferative glomerulonephritis, and among its related super-pathways are Immune response Lectin induced complement pathway and Immune System. GO annotations related to this gene include protein binding. An important paralog of this gene is CSMD1.

UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003
Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator
(C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a
complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also
with anticoagulant protein S and with serum amyloid P component




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C4BPA gene promoter:
         ISGF-3   C/EBPbeta   AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   FOXO1a   Sox9   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC4BPA promoter sequence
   Search SABiosciences Chromatin IP Primers for C4BPA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4BPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32

C4BPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C4BPA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207277:  view genomic region     (about GC identifiers)

Start:
207,277,607 bp from pter      End:
207,318,317 bp from pter
Size:
40,711 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003 (See protein sequence)
Recommended Name: C4b-binding protein alpha chain precursor  
Size: 597 amino acids; 67033 Da
Subunit: Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha
chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta
chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at
the end
Subcellular location: Secreted
Caution: It is uncertain whether Met-1 or Met-17 is the initiator
2 PDB 3D structures from and Proteopedia for C4BPA:
2A55 (3D)        4B0F (3D)    

Explore the universe of human proteins at neXtProt for C4BPA: NX_P04003

Explore proteomics data for C4BPA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04003

  • C4BPA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C4BPA Protein Expression
    REFSEQ proteins: NP_000706.1  
    ENSEMBL proteins: 
     ENSP00000356037   ENSP00000403386   ENSP00000395968  
    Reactome Protein details: P04003
    Human Recombinant Protein Products for C4BPA: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--

    C4BPA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry P04003

    ProtoNet protein and cluster: P04003

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003
    Similarity: Contains 8 Sushi (CCP/SCR) domains


    C4BPA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C4BPA_HUMAN, P04003
    Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator
    (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a
    complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also
    with anticoagulant protein S and with serum amyloid P component

         Genatlas biochemistry entry for C4BPA:
    complement component 4,binding protein alpha,70kDa,regulator of C3 convertase of classical pathway,see RCA@

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16330538
         
    C4BPA for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for C4BPA About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Lectin induced complement pathway0.56
    Immune response Classical complement pathway0.52
    Immune response Lectin Induced complement pathway0.56
    Regulation of Complement cascade0.50
    Immune response Classic complement pathway0.53
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3Classical antibody-mediated complement activation
    Complement cascade0.76
    4Complement and coagulation cascades
    Complement and coagulation cascades0.71
    5Pertussis
    Pertussis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for C4BPA
        Immune response Classic complement pathway
    Immune response Lectin Induced complement pathway


    2 GeneGo (Thomson Reuters) Pathways for C4BPA
        Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    1 BioSystems Pathway for C4BPA
        CD40/CD40L signaling

    4        Reactome Pathways for C4BPA
        Regulation of Complement cascade
    Complement cascade
    Immune System
    Innate Immune System


    2         Kegg Pathways  (Kegg details for C4BPA):
        Complement and coagulation cascades
    Pertussis


    C4BPA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for C4BPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/21 Interacting proteins for C4BPA (P040031, 3 ENSP000003560374) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C4BP0C0L53, ENSP000004159414I2D: score=1 STRING: ENSP00000415941
    C4B_2P0C0L53I2D: score=1 
    LRP1Q079543, ENSP000002430774I2D: score=1 STRING: ENSP00000243077
    APCSP027433, ENSP000002550404I2D: score=2 STRING: ENSP00000255040
    PROS1P072253, ENSP000003777834I2D: score=1 STRING: ENSP00000377783
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006958complement activation, classical pathway IEA--
    GO:0030449regulation of complement activation TAS--
    GO:0045087innate immune response TAS--

    C4BPA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    C4BPA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for C4BPA

    10/11 Novoseek inferred chemical compound relationships for C4BPA gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoethanolamine 49.5 2 7592941 (1), 1375509 (1)
    gamma-carboxyglutamic acid 43.9 1 1533219 (1)
    heparin 41.5 17 2136880 (3), 8845035 (2), 8133054 (2), 18266273 (2) (see all 7)
    phosphorylcholine 36.8 2 16751408 (1), 17244159 (1)
    cardiolipin 20.8 2 9175020 (1), 10361122 (1)
    fibrinogen 15.7 6 15773976 (2), 18409149 (2), 9551922 (1), 20100644 (1)
    cholesterol 0 4 9222877 (2), 1527895 (1), 2049187 (1)
    sucrose 0 1 7654697 (1)
    calcium 0 5 2147688 (3), 1825786 (1), 8133054 (1)
    lactate 0 3 7654697 (2)

    Search CenterWatch for drugs/clinical trials and news about C4BPA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C4BPA gene: 
    NM_000715.3  

    Unigene Cluster for C4BPA:

    Complement component 4 binding protein, alpha
    Hs.1012  [show with all ESTs]
    Unigene Representative Sequence: BC022312
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367070(uc001hfo.3) ENST00000421786 ENST00000424088

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    Additional mRNA sequence: 

    AK303793.1 AK303798.1 AK313164.1 BC022312.1 M31452.1 X02865.1 X07853.1 

    3 DOTS entries:

    DT.315516  DT.121343031  DT.92420453 

    24/84 AceView cDNA sequences (see all 84):

    AI268588 AL602974 CB163868 AI924529 CB154712 AA961146 BQ019292 BM955614 
    BM982305 M31452 BG568629 CB111960 BC022312 CB216627 NM_000715 CB154350 
    BX340564 CB164795 CB157496 CB156971 CB216323 BU689016 AW268686 CB162236 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for C4BPA    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                          -                 -                                                                           
    SP2:                          -                 -                                                                           
    SP3:                          -                                                                                             
    SP4:                                            -                                                                           


    ECgene alternative splicing isoforms for C4BPA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C4BPA expression in normal human tissues (normalized intensities)      C4BPA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTGCTTT
    C4BPA Expression
    About this image


    C4BPA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, pre-menopause ; cells in endometrial stroma   
             endometrium   
     
     Colon (Gastrointestinal Tract)
             colon ; endothelial cells   
     
     Pancreas (Endocrine System)
             Pancreatic Islet   
     
     Endothelium (Cardiovascular System)
             colon ; endothelial cells   
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow

    See C4BPA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C4BPA

    SOURCE GeneReport for Unigene cluster: Hs.1012

    UniProtKB/Swiss-Prot: C4BPA_HUMAN, P04003
    Tissue specificity: Chylomicrons in the plasma

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for C4BPA gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C4bp5 complement component 4 binding protein   --   1 (56.89 cM) 130634773 
    chicken
    (Gallus gallus)
    Aves C4BPA6
    complement component 4 binding protein, alpha chai...
    30(a)
    1 → many
    26(2627129-2639856)
    zebrafish
    (Danio rerio)
    Actinopterygii rca2.26
    rca2.16
    (see all 3)
    regulator of complement activation group 2 gene 1
    (see all 3)
    29(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    23(26413284-26415932)
    23(26381820-26407620)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90956
    --
    7(a)
    1 → many
    X(15033962-15057255)


    ENSEMBL Gene Tree for C4BPA (if available)
    TreeFam Gene Tree for C4BPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C4BPA gene
    CSMD12  CFHR52  CFHR42  F13B2  CFHR22  CD462  CD552  SELP2  
    CR22  CFH2  CSMD32  CR1L2  APOH2  SELE2  CSMD22  CFHR32  
    CR12  CFHR12  
    2 SIMAP similar genes for C4BPA using alignment to 4 protein entries:     C4BPA_HUMAN (see all proteins):
    SVEP1    CD55

    C4BPA for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for C4BPA
    PGOHUM00000259606 PGOHUM00000245185 PGOHUM00000245186


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/878 SNPs in C4BPA are shown (see all 878)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0019784
    ----see VAR_0019782 Y H mis40--------
    rs38413771,2
    C,F--207277350(-) TTATGG/-CAAGA 1 -- us2k14Minor allele frequency- -:0.38NA CSA 8
    rs2009975391,2
    --207279795(+) TTTTT-/GTTTTT 1 -- int10--------
    rs341018551,2
    C--207281706(+) TAAAAG/-TTACT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs681156511,2
    C--207281707(+) AAAAT-/GTACTG 1 -- int10--------
    rs112967191,2
    C--207284274(+) TTCTAT/-TTTGC 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1461318681,2
    C--207285535(+) TTTTC-/ATATATA 1 -- int10--------
    rs114064571,2
    C--207289711(+) TTTTTT/-CCTTA 1 -- int1 trp32Minor allele frequency- -:0.00NA CSA 4
    rs57803731,2
    C--207291455(+) TAGTT-/TATC  
            
    TATCA
    1 -- int11Minor allele frequency- TATC:0.00NA 2
    rs50238361,2
    C--207291514(+) TGTCTA/GTCTAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for C4BPA (207277607 - 207318317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for C4BPA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821224CNV Deletion20802225
    esv2722040CNV Deletion23290073
    esv1000470CNV Deletion20482838
    esv9705CNV Loss19470904
    nsv832426CNV Gain17160897
    esv28463CNV Gain19812545
    nsv511134CNV Gain21212237
    esv7318OTHER Inversion19470904


    Human Gene Mutation Database (HGMD): C4BPA
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing C4BPA
    DNA2.0 Custom Variant and Variant Library Synthesis for C4BPA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 120830    OMIM disorders: --

    20/30 diseases for C4BPA (see all 30):    About MalaCards
    gonorrhea    membranoproliferative glomerulonephritis    takayasu's arteritis    hemolytic-uremic syndrome
    atypical hemolytic-uremic syndrome    protein s deficiency    lyme disease    mastitis
    pertussis    age related macular degeneration    macular degeneration    glomerulonephritis
    purpura    thrombosis    lupus erythematosus    non-hodgkin lymphoma
    alzheimer's disease    hodgkin's lymphoma    meningioma    pneumonia


    C4BPA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for C4BPA gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    protein s deficiency 64.2 1 9108398 (1)
    response acute phase 54.6 14 1699702 (2), 19284503 (2), 7519078 (1), 9097083 (1) (see all 7)
    gonorrhea 35 2 16275906 (1), 19388167 (1)
    shock septic 12.5 3 7740486 (1), 1828915 (1)
    tumors 1.45 1 11441101 (1)
    skin lesion 0 1 9784543 (1)
    lupus erythematosus systemic 0 2 10337010 (1), 1699702 (1)
    hemolysis 0 3 10469045 (2), 10408369 (1)
    inflammation 0 2 16751408 (1)
    alzheimers disease 0 1 1632784 (1)

    Genetic Association Database (GAD): C4BPA
    Human Genome Epidemiology (HuGE) Navigator: C4BPA (12 documents)

    Export disorders for C4BPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C4BPA gene, integrated from 9 sources (see all 188):
    (articles sorted by number of sources associating them with C4BPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the alpha chain of the human C4b-binding protein gene. (PubMed id 1989602)1, 2, 9 Aso T.... Niho Y. (1991)
    2. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    3. Epidemiological approach to identifying genetic predi spositions for atypical hemolytic uremic syndrome. (PubMed id 20059470)1, 4 Sullivan M....Neumann H.P. (2010)
    4. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    5. Lack of association between polymorphisms in C4b-binding protein and atypical haemolytic uraemic syndrome in the Spanish population. (PubMed id 19076829)1, 4 MartA-nez-Barricarte R....RodrA-guez de CA^rdoba S. (2009)
    6. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (2009)
    7. A novel non-synonymous polymorphism (p.Arg240His) in C4b-binding protein is associated with atypical hemolytic uremic syndrome and leads to impaired alternative pathway cofactor activity. (PubMed id 18424762)1, 4 Blom A.M....Goodship T.H. (2008)
    8. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. (PubMed id 18842294)1, 4 Ennis S....Lotery A. (2008)
    9. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 722 HGNC: 1325 AceView: C4BPA Ensembl:ENSG00000123838 euGenes: HUgn722
    ECgene: C4BPA Kegg: 722 H-InvDB: C4BPA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C4BPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C4BPA gene:
    Search GeneIP for patents involving C4BPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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