Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C3orf70 Gene

Aliases for C3orf70 Gene

  • Chromosome 3 Open Reading Frame 70 2 3 5

External Ids for C3orf70 Gene

Previous GeneCards Identifiers for C3orf70 Gene

  • GC03M186278
  • GC03M184795
  • GC03M182205

Summaries for C3orf70 Gene

GeneCards Summary for C3orf70 Gene

C3orf70 (Chromosome 3 Open Reading Frame 70) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf70 Gene

Genomics for C3orf70 Gene

Regulatory Elements for C3orf70 Gene

Enhancers for C3orf70 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C3orf70 on UCSC Golden Path with GeneCards custom track

Promoters for C3orf70 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C3orf70 on UCSC Golden Path with GeneCards custom track

Genomic Location for C3orf70 Gene

Chromosome:
3
Start:
185,078,050 bp from pter
End:
185,153,014 bp from pter
Size:
74,965 bases
Orientation:
Minus strand

Genomic View for C3orf70 Gene

Genes around C3orf70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf70 Gene

Proteins for C3orf70 Gene

  • Protein details for C3orf70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLC5-CC070_HUMAN
    Recommended name:
    UPF0524 protein C3orf70
    Protein Accession:
    A6NLC5
    Secondary Accessions:
    • B2RNY2
    • B9EH83

    Protein attributes for C3orf70 Gene

    Size:
    250 amino acids
    Molecular mass:
    27769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C3orf70 Gene

Proteomics data for C3orf70 Gene at MOPED

Post-translational modifications for C3orf70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C3orf70 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C3orf70 Gene

Domains & Families for C3orf70 Gene

Protein Domains for C3orf70 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C3orf70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NLC5

UniProtKB/Swiss-Prot:

CC070_HUMAN :
  • Belongs to the UPF0524 family.
Family:
  • Belongs to the UPF0524 family.
genes like me logo Genes that share domains with C3orf70: view

No data available for Gene Families for C3orf70 Gene

Function for C3orf70 Gene

Phenotypes for C3orf70 Gene

GenomeRNAi human phenotypes for C3orf70:
genes like me logo Genes that share phenotypes with C3orf70: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf70 Gene

Localization for C3orf70 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C3orf70 Gene COMPARTMENTS Subcellular localization image for C3orf70 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C3orf70 Gene

Pathways & Interactions for C3orf70 Gene

SuperPathways for C3orf70 Gene

No Data Available

Interacting Proteins for C3orf70 Gene

Gene Ontology (GO) - Biological Process for C3orf70 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C3orf70 Gene

Drugs & Compounds for C3orf70 Gene

No Compound Related Data Available

Transcripts for C3orf70 Gene

mRNA/cDNA for C3orf70 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C3orf70 Gene

Chromosome 3 open reading frame 70:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf70 Gene

No ASD Table

Relevant External Links for C3orf70 Gene

GeneLoc Exon Structure for
C3orf70
ECgene alternative splicing isoforms for
C3orf70

Expression for C3orf70 Gene

mRNA expression in normal human tissues for C3orf70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for C3orf70 Gene Hs.380048

genes like me logo Genes that share expression patterns with C3orf70: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C3orf70 Gene

Orthologs for C3orf70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf70 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1H3orf70 35
  • 92.93 (n)
  • 96.8 (a)
C3orf70 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C34H3orf70 35
  • 93.73 (n)
  • 96 (a)
C3orf70 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2510009E07Rik 35
  • 88.71 (n)
  • 94.76 (a)
2510009E07Rik 16
2510009E07Rik 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf70 35
  • 99.07 (n)
  • 100 (a)
C3orf70 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562339 35
  • 89.3 (n)
  • 95.12 (a)
oppossum
(Monodelphis domestica)
Mammalia C3orf70 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf70 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves C9H3orf70 35
  • 78.28 (n)
  • 83.15 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494388 35
  • 69.83 (n)
  • 73.55 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-22o12.2 35
  • 66.67 (n)
  • 66.95 (a)
C1H3orf70 (2 of 2) 36
  • 58 (a)
OneToMany
C9H3orf70 (1 of 2) 36
  • 61 (a)
OneToMany
Species with no ortholog for C3orf70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3orf70 Gene

ENSEMBL:
Gene Tree for C3orf70 (if available)
TreeFam:
Gene Tree for C3orf70 (if available)

Paralogs for C3orf70 Gene

No data available for Paralogs for C3orf70 Gene

Variants for C3orf70 Gene

Sequence variations from dbSNP and Humsavar for C3orf70 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1043435 -- 185,079,977(-) ATTAT(A/G)TGAAG utr-variant-3-prime
rs1080471 -- 185,111,435(-) catat(C/T)tattc intron-variant
rs1107655 -- 185,080,780(+) GGGGG(A/C)AGCTC utr-variant-3-prime
rs1876803 -- 185,080,279(-) TTAAT(A/G)ATAGT utr-variant-3-prime
rs2292297 -- 185,078,175(-) TGACT(C/G)TTCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C3orf70 Gene

Variant ID Type Subtype PubMed ID
nsv521893 CNV Loss 19592680

Variation tolerance for C3orf70 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf70 Gene

HapMap Linkage Disequilibrium report
C3orf70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf70 Gene

Disorders for C3orf70 Gene

Relevant External Links for C3orf70

Genetic Association Database (GAD)
C3orf70
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3orf70

No disorders were found for C3orf70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf70 Gene

Publications for C3orf70 Gene

  1. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. (PMID: 21042317) Wray N.R. … Sullivan P.F. (Mol. Psychiatry 2012) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C3orf70 Gene

Sources for C3orf70 Gene

Content