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Aliases for C3orf70 Gene

Aliases for C3orf70 Gene

  • Chromosome 3 Open Reading Frame 70 2 3 5

External Ids for C3orf70 Gene

Previous GeneCards Identifiers for C3orf70 Gene

  • GC03M186278
  • GC03M184795
  • GC03M182205

Summaries for C3orf70 Gene

GeneCards Summary for C3orf70 Gene

C3orf70 (Chromosome 3 Open Reading Frame 70) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf70 Gene

Genomics for C3orf70 Gene

Regulatory Elements for C3orf70 Gene

Enhancers for C3orf70 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G185316 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 -164.4 -164436 2.3 HDAC1 TBP FOXA2 ZBTB40 RARA YY1 RELB CEBPB NR2F2 MAFF MAP3K13 EHHADH C3orf70 RPL4P4
GH03G185174 1.3 Ensembl ENCODE 11.8 -22.9 -22855 1.8 HDGF PKNOX1 ATF1 FOXA2 ARNT ARID4B DMAP1 ZNF2 ZNF48 ZNF766 C3orf70 VPS8 EHHADH-AS1 GC03M185246
GH03G184940 0.8 dbSUPER 16.6 +208.7 208708 8.0 ELF3 SOX13 PKNOX1 SAP130 TAL1 ARID4B RAD21 ZIC2 TEAD3 TCF12 VPS8 C3orf70 FAM131A CAMK2N2 GC03P184954
GH03G185502 1.2 Ensembl ENCODE dbSUPER 10.1 -350.4 -350385 1.9 ZFP64 ZNF697 NR2F6 NFIA NR2F1 ZNF426 ZNF394 ZNF518A ZNF781 ZNF83 MAGEF1 C3orf70 LOC105374254 LIPH
GH03G185297 1.1 Ensembl ENCODE 9.6 -146.4 -146374 2.8 HDGF PKNOX1 TCF12 GATA2 RELB ETV6 IKZF2 CREM JUNB TBX21 MAP3K13 C3orf70 RPL4P4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C3orf70 on UCSC Golden Path with GeneCards custom track

Promoters for C3orf70 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000163025 113 1800 YBX1 PLRG1 BMI1 ZNF207 EGR2 ZNF362 CBX8 ZNF341 ZBTB26 MGA

Genomic Location for C3orf70 Gene

Chromosome:
3
Start:
185,078,050 bp from pter
End:
185,153,014 bp from pter
Size:
74,965 bases
Orientation:
Minus strand

Genomic View for C3orf70 Gene

Genes around C3orf70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf70 Gene

Proteins for C3orf70 Gene

  • Protein details for C3orf70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLC5-CC070_HUMAN
    Recommended name:
    UPF0524 protein C3orf70
    Protein Accession:
    A6NLC5
    Secondary Accessions:
    • B2RNY2
    • B9EH83

    Protein attributes for C3orf70 Gene

    Size:
    250 amino acids
    Molecular mass:
    27769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C3orf70 Gene

Post-translational modifications for C3orf70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C3orf70 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C3orf70 Gene

Domains & Families for C3orf70 Gene

Protein Domains for C3orf70 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C3orf70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NLC5

UniProtKB/Swiss-Prot:

CC070_HUMAN :
  • Belongs to the UPF0524 family.
Family:
  • Belongs to the UPF0524 family.
genes like me logo Genes that share domains with C3orf70: view

No data available for Gene Families for C3orf70 Gene

Function for C3orf70 Gene

Phenotypes for C3orf70 Gene

GenomeRNAi human phenotypes for C3orf70:
genes like me logo Genes that share phenotypes with C3orf70: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf70 Gene

Localization for C3orf70 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf70 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C3orf70 Gene

Pathways & Interactions for C3orf70 Gene

SuperPathways for C3orf70 Gene

No Data Available

Interacting Proteins for C3orf70 Gene

Gene Ontology (GO) - Biological Process for C3orf70 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C3orf70 Gene

Drugs & Compounds for C3orf70 Gene

No Compound Related Data Available

Transcripts for C3orf70 Gene

mRNA/cDNA for C3orf70 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C3orf70 Gene

Chromosome 3 open reading frame 70:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf70 Gene

No ASD Table

Relevant External Links for C3orf70 Gene

GeneLoc Exon Structure for
C3orf70
ECgene alternative splicing isoforms for
C3orf70

Expression for C3orf70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of C3orf70 Gene:

C3orf70

SOURCE GeneReport for Unigene cluster for C3orf70 Gene:

Hs.380048
genes like me logo Genes that share expression patterns with C3orf70: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf70 Gene

Orthologs for C3orf70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3orf70 35
  • 100 (a)
OneToOne
C3H3orf70 34
  • 99.07 (n)
cow
(Bos Taurus)
Mammalia C3orf70 35
  • 97 (a)
OneToOne
C1H3orf70 34
  • 92.93 (n)
dog
(Canis familiaris)
Mammalia C3orf70 35
  • 96 (a)
OneToOne
C34H3orf70 34
  • 93.73 (n)
oppossum
(Monodelphis domestica)
Mammalia C3orf70 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562339 34
  • 89.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf70 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2510009E07Rik 34 16 35
  • 88.71 (n)
chicken
(Gallus gallus)
Aves C9H3orf70 34
  • 78.28 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494388 34
  • 69.83 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-22o12.2 34
  • 66.67 (n)
C9H3orf70 (1 of 2) 35
  • 61 (a)
OneToMany
C1H3orf70 (2 of 2) 35
  • 58 (a)
OneToMany
Species where no ortholog for C3orf70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3orf70 Gene

ENSEMBL:
Gene Tree for C3orf70 (if available)
TreeFam:
Gene Tree for C3orf70 (if available)

Paralogs for C3orf70 Gene

No data available for Paralogs for C3orf70 Gene

Variants for C3orf70 Gene

Sequence variations from dbSNP and Humsavar for C3orf70 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000028759 -- 185,105,964(+) TACAG(A/G)GCATA intron-variant
rs1000047123 -- 185,132,162(+) CATTC(C/G)ACGGG intron-variant
rs1000055843 -- 185,105,760(+) CGCTG(C/G)AGCGA intron-variant
rs1000069573 -- 185,078,782(+) AATAT(C/T)AAGAG utr-variant-3-prime
rs1000080539 -- 185,078,500(+) GAAGT(A/G)CCCTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C3orf70 Gene

Variant ID Type Subtype PubMed ID
dgv5002n100 CNV gain 25217958
esv3598958 CNV gain 21293372
esv3598961 CNV loss 21293372
esv3598962 CNV loss 21293372
nsv521893 CNV loss 19592680
nsv950020 CNV deletion 24416366

Variation tolerance for C3orf70 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C3orf70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf70 Gene

Disorders for C3orf70 Gene

Relevant External Links for C3orf70

Genetic Association Database (GAD)
C3orf70
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3orf70

No disorders were found for C3orf70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf70 Gene

Publications for C3orf70 Gene

  1. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. (PMID: 21042317) Wray N.R. … Sullivan P.F. (Mol. Psychiatry 2012) 3 46 64
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C3orf70 Gene

Sources for C3orf70 Gene

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