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Aliases for C3orf67 Gene

Aliases for C3orf67 Gene

  • Chromosome 3 Open Reading Frame 67 2 3 5

External Ids for C3orf67 Gene

Summaries for C3orf67 Gene

GeneCards Summary for C3orf67 Gene

C3orf67 (Chromosome 3 Open Reading Frame 67) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf67 Gene

Genomics for C3orf67 Gene

Regulatory Elements for C3orf67 Gene

Enhancers for C3orf67 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F058996 1.7 FANTOM5 Ensembl ENCODE 11.9 +51.2 51240 4.1 HDAC1 PKNOX1 ATF1 CHAMP1 FOS CREM USF2 ZEB2 CREB3 TFDP1 C3orf67 C3orf67-AS1 PIR52028
GH03F058994 0.5 Ensembl 11.8 +55.1 55110 0.5 CTCF ZNF654 TRIM22 REST RAD21 FOXK2 ZNF512 SCRT2 SMC3 C3orf67 C3orf67-AS1 PIR52028
GH03F059048 0.4 ENCODE 8.3 +0.3 330 1.9 HDGF TBP ATF1 BMI1 FEZF1 YY1 CREM SMAD5 REST NR2F2 C3orf67 PIR52028
GH03F059100 0.9 ENCODE 8 -51.4 -51405 1.4 JUND SIN3A EMSY MAFK C3orf67 LOC105377110 GC03M059329
GH03F059128 0.4 ENCODE 7.7 -79.0 -78966 1.4 JUND BCL11A TEAD4 MAX CTBP2 POU5F1 FAM3D-AS1 C3orf67 LOC105377110 GC03M059329
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C3orf67 on UCSC Golden Path with GeneCards custom track

Promoters for C3orf67 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C3orf67 Gene

58,717,365 bp from pter
59,050,084 bp from pter
332,720 bases
Minus strand

Genomic View for C3orf67 Gene

Genes around C3orf67 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf67 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf67 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf67 Gene

Proteins for C3orf67 Gene

  • Protein details for C3orf67 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C3orf67
    Protein Accession:
    Secondary Accessions:
    • B9EKV6
    • Q6ZV69

    Protein attributes for C3orf67 Gene

    689 amino acids
    Molecular mass:
    76271 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85994.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C3orf67 Gene


neXtProt entry for C3orf67 Gene

Post-translational modifications for C3orf67 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C3orf67 Gene

Domains & Families for C3orf67 Gene

Protein Domains for C3orf67 Gene

Suggested Antigen Peptide Sequences for C3orf67 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf67: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C3orf67 Gene

Function for C3orf67 Gene

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C3orf67 Gene

Localization for C3orf67 Gene

Subcellular locations from

Jensen Localization Image for C3orf67 Gene COMPARTMENTS Subcellular localization image for C3orf67 gene
Compartment Confidence
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C3orf67 Gene

Pathways & Interactions for C3orf67 Gene

SuperPathways for C3orf67 Gene

No Data Available

Interacting Proteins for C3orf67 Gene

Selected Interacting proteins: Q6ZVT6-CC067_HUMAN for C3orf67 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C3orf67 Gene


No data available for Pathways by source and SIGNOR curated interactions for C3orf67 Gene

Transcripts for C3orf67 Gene

Unigene Clusters for C3orf67 Gene

Chromosome 3 open reading frame 67:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf67 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - - - - - -
SP2: - - -
SP3: -

Relevant External Links for C3orf67 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C3orf67 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C3orf67 Gene

mRNA differential expression in normal tissues according to GTEx for C3orf67 Gene

This gene is overexpressed in Testis (x15.9) and Esophagus - Mucosa (x9.6).

Protein differential expression in normal tissues from HIPED for C3orf67 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C3orf67 Gene

Protein tissue co-expression partners for C3orf67 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C3orf67 Gene:


SOURCE GeneReport for Unigene cluster for C3orf67 Gene:

genes like me logo Genes that share expression patterns with C3orf67: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C3orf67 Gene

Orthologs for C3orf67 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf67 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C3H3orf67 34
  • 99.17 (n)
C3orf67 35
  • 99 (a)
(Canis familiaris)
Mammalia C20H3orf67 34
  • 86.33 (n)
C3orf67 35
  • 84 (a)
(Mus musculus)
Mammalia 4930452B06Rik 34 16 35
  • 78.81 (n)
(Rattus norvegicus)
Mammalia LOC361016 34
  • 77.39 (n)
(Bos Taurus)
Mammalia C3orf67 35
  • 64 (a)
(Monodelphis domestica)
Mammalia C3orf67 35
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia C3orf67 35
  • 51 (a)
(Gallus gallus)
Aves C3orf67 35
  • 44 (a)
(Anolis carolinensis)
Reptilia C3orf67 35
  • 39 (a)
(Danio rerio)
Actinopterygii C6H3orf67 35
  • 25 (a)
Dr.19459 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
Species where no ortholog for C3orf67 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3orf67 Gene

Gene Tree for C3orf67 (if available)
Gene Tree for C3orf67 (if available)

Paralogs for C3orf67 Gene

No data available for Paralogs for C3orf67 Gene

Variants for C3orf67 Gene

Sequence variations from dbSNP and Humsavar for C3orf67 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10049052 -- 58,762,736(+) tggtg(A/G)tgaca intron-variant
rs10049054 -- 58,762,896(+) ttctg(C/T)ggaga intron-variant
rs10049299 -- 58,762,728(+) ggcag(A/G)cctgg intron-variant
rs10049357 -- 58,858,605(+) ATGAT(A/C)ATATT intron-variant
rs10084666 -- 58,993,810(+) accat(A/T)ctttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf67 Gene

Variant ID Type Subtype PubMed ID
dgv4749n100 CNV gain 25217958
esv21695 CNV loss 19812545
esv2422022 CNV deletion 20811451
esv274884 CNV gain+loss 21479260
esv2763270 CNV loss 21179565
esv3305385 CNV mobile element insertion 20981092
esv3309525 CNV mobile element insertion 20981092
esv3345190 CNV insertion 20981092
esv3395124 CNV insertion 20981092
esv3596257 CNV loss 21293372
esv3596258 CNV loss 21293372
esv3596261 CNV loss 21293372
esv3596262 CNV loss 21293372
esv3893702 CNV loss 25118596
nsv1002940 CNV gain 25217958
nsv472555 CNV novel sequence insertion 20440878
nsv511230 CNV loss 21212237
nsv822104 CNV loss 20364138
nsv834704 CNV loss 17160897
nsv997365 CNV loss 25217958

Variation tolerance for C3orf67 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf67 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf67 Gene

Disorders for C3orf67 Gene

Relevant External Links for C3orf67

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C3orf67 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf67 Gene

Publications for C3orf67 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64
  4. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. (PMID: 17903304) Larson M.G. … Levy D. (BMC Med. Genet. 2007) 46 64
  5. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PMID: 17903306) Newton-Cheh C. … Larson M.G. (BMC Med. Genet. 2007) 46 64

Products for C3orf67 Gene

Sources for C3orf67 Gene

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