Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



C3orf58 Gene

protein-coding   GIFtS: 49
GCID: GC03P143690

Chromosome 3 Open Reading Frame 58

  See C3orf58-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 3 Open Reading Frame 581 2     HASF2 3
DIA12 3 5     Golgi Protein Of 49 KDa2 3
Deleted In Autism 11 2     Deleted In Autism Protein 12
Hypoxia And Akt Induced Stem Cell Factor1 2     Golgi Protein GoPro492
Hypoxia And AKT-Induced Stem Cell Factor2 3     UPF0672 Protein C3orf582
GoPro492 3     

External Ids:    HGNC: 284901   Entrez Gene: 2054282   Ensembl: ENSG000001817447   OMIM: 6122005   UniProtKB: Q8NDZ43   
ORGUL members:         

Export aliases for C3orf58 gene to outside databases

Previous GC identifers: GC03P145174 GC03P141062


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for C3orf58 Gene:
C3orf58 (chromosome 3 open reading frame 58) is a protein-coding gene. Diseases associated with C3orf58 include hypoxia. An important paralog of this gene is CXorf36.

UniProtKB/Swiss-Prot: DIA1_HUMAN, Q8NDZ4
Function: May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the
PPI3K-AKT-CDK7 signaling cascade




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the C3orf58 gene promoter:
         CREB   CHOP-10   LHX3b/Lhx3b   deltaCREB   LHX3a/Lhx3a   C/EBPalpha   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C3orf58

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C3orf58


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

C3orf58 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C3orf58 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P143690:  view genomic region     (about GC identifiers)

Start:
143,690,640 bp from pter      End:
143,767,561 bp from pter
Size:
76,922 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DIA1_HUMAN, Q8NDZ4 (See protein sequence)
Recommended Name: Deleted in autism protein 1 precursor  
Size: 430 amino acids; 49482 Da
Secondary accessions: B2RCF2 B7Z1W3
Alternative splicing: 2 isoforms:  Q8NDZ4-1   Q8NDZ4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C3orf58: NX_Q8NDZ4

Explore proteomics data for C3orf58 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C3orf58 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127942.1  NP_775823.1  

    ENSEMBL proteins: 
     ENSP00000320081   ENSP00000417382   ENSP00000419947   ENSP00000390796  

    C3orf58 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for C3orf58
    OriGene Custom MassSpec
    OriGene Custom Protein Services for C3orf58
    GenScript Custom Purified and Recombinant Proteins Services for C3orf58
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for C3orf58 

     
    antibodies-online proteins for C3orf58 (11 products) 

     
    antibodies-online peptides for C3orf58

    C3orf58 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for C3orf58
    Novus Biologicals C3orf58 Antibody
    Abcam antibodies for C3orf58
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for C3orf58
    antibodies-online antibodies for C3orf58 (64 products) 

    C3orf58 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for C3orf58
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for C3orf58
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for C3orf58 
    antibodies-online kits for C3orf58 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR020519 UPF0672
     IPR022049 FAM69_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8NDZ4

    ProtoNet protein and cluster: Q8NDZ4

    UniProtKB/Swiss-Prot: DIA1_HUMAN, Q8NDZ4
    Similarity: Belongs to the DIA1 family


    Find genes that share domains with C3orf58           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DIA1_HUMAN, Q8NDZ4
    Function: May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the
    PPI3K-AKT-CDK7 signaling cascade

    Phenotypes:
         1 GenomeRNAi human phenotype for C3orf58:

     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for C3orf58

    miRNA
    Products:
        
    miRTarBase miRNAs that target C3orf58:
    hsa-mir-148b-3p (MIRT019399), hsa-mir-155-5p (MIRT005247), hsa-mir-124-3p (MIRT022510)

    Block miRNA regulation of human, mouse, rat C3orf58 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate C3orf58 (see all 28):
    hsa-miR-142-5p hsa-miR-30c hsa-miR-137 hsa-miR-148b hsa-miR-575 hsa-miR-30d hsa-miR-340 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidC3orf58 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for C3orf58
    Predesigned siRNA for gene silencing in human, mouse, rat C3orf58

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for C3orf58

    Clone
    Products:
         
    OriGene clones in human, mouse for C3orf58 (see all 12)
    OriGene ORF clones in mouse, rat for C3orf58
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): C3orf58 (NM_001134470)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C3orf58
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf58

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for C3orf58
    Browse ESI BIO Cell Lines and PureStem Progenitors for C3orf58 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf58


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DIA1_HUMAN, Q8NDZ4: Cytoplasmic vesicle, COPI-coated vesicle. Golgi apparatus. Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular3
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA18651652
    GO:0005615extracellular space IDA--
    GO:0030126COPI vesicle coat IDA18651652
    GO:0030137COPI-coated vesicle ----

    Find genes that share ontologies with C3orf58           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for C3orf58
        Antioxidant Action of Vitamin-C


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C3orf58
    Interactions:

        Search GeneGlobe Interaction Network for C3orf58

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for C3orf58 (ENSP000003200814) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AFTPHENSP000002388554STRING: ENSP00000238855
    AP1G2ENSP000003124424STRING: ENSP00000312442
    AP1S1ENSP000003366664STRING: ENSP00000336666
    AP2A1ENSP000003519264STRING: ENSP00000351926
    AP2A2ENSP000004132344STRING: ENSP00000413234
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0014066regulation of phosphatidylinositol 3-kinase signaling IDA--
    GO:0060038cardiac muscle cell proliferation IDA--

    Find genes that share ontologies with C3orf58           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C3orf58 (DIA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for C3orf58 gene (2 alternative transcripts): 
    NM_001134470.1  NM_173552.3  

    Unigene Cluster for C3orf58:

    Chromosome 3 open reading frame 58
    Hs.288954  [show with all ESTs]
    Unigene Representative Sequence: NM_173552
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315691(uc003evo.3) ENST00000493396 ENST00000491798 ENST00000483808
    ENST00000495414 ENST00000492452 ENST00000441925(uc011bnl.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat C3orf58 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate C3orf58 (see all 28):
    hsa-miR-142-5p hsa-miR-30c hsa-miR-137 hsa-miR-148b hsa-miR-575 hsa-miR-30d hsa-miR-340 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidC3orf58 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C3orf58
    Predesigned siRNA for gene silencing in human, mouse, rat C3orf58
    Clone
    Products:
         
    OriGene clones in human, mouse for C3orf58 (see all 12)
    OriGene ORF clones in mouse, rat for C3orf58
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): C3orf58 (NM_001134470)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C3orf58
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf58
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for C3orf58
    OriGene qSTAR qPCR primer pairs in human, mouse for C3orf58
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C3orf58
      QuantiTect SYBR Green Assays in human, mouse, rat C3orf58
      QuantiFast Probe-based Assays in human, mouse, rat C3orf58

    Additional mRNA sequence: 

    AK025119.1 AK095063.1 AK095161.1 AK095400.1 AK294020.1 AK315082.1 AL832839.1 BC037293.2 

    6 DOTS entries:

    DT.429627  DT.100024689  DT.40316157  DT.101965587  DT.97796275  DT.95226366 

    Selected AceView cDNA sequences (see all 110):

    BM984922 AW771551 AI480031 AI620877 AI741243 AI634832 BC037293 NM_173552 
    AI636481 AI148754 BX643372 AI971766 BU685433 BI257780 AI128284 CB215430 
    AW072186 AI076723 AW511286 AA286877 BU633913 AK095161 AW510643 AL832839 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    C3orf58 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTATGTG
    C3orf58 Expression
    About this image


    C3orf58 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             Midbrain dopaminergic-like neurons
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
     
     Brain (Nervous System)
             Midbrain dopaminergic-like neurons
    C3orf58 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C3orf58 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288954
        Custom PCR Arrays for C3orf58
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for C3orf58
    OriGene qSTAR qPCR primer pairs in human, mouse for C3orf58
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C3orf58
    QuantiTect SYBR Green Assays in human, mouse, rat C3orf58
    QuantiFast Probe-based Assays in human, mouse, rat C3orf58
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf58

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for C3orf58 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1190002N15Rik1 , 5 RIKEN cDNA 1190002N15 gene1, 5 93.72(n)1
    97.67(a)1
      9 (49.03 cM)5
    688611  NM_001033145.21  NP_001028317.21 
     945178645 
    chicken
    (Gallus gallus)
    Aves C3ORF581 chromosome 9 open reading frame, human C3orf58 86.25(n)
    89.74(a)
      424771  XM_422591.3  XP_422591.2 
    lizard
    (Anolis carolinensis)
    Reptilia C3orf586
    chromosome 3 open reading frame 58
    95(a)
    1 ↔ 1
    3(20979547-20980816)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.161822 Xenopus laevis transcribed sequences 84.55(n)    BU912640.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dia1b1 deleted in autism 1b 70.71(n)
    82.05(a)
      100141362  NM_001114926.1  NP_001108398.1 


    ENSEMBL Gene Tree for C3orf58 (if available)
    TreeFam Gene Tree for C3orf58 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for C3orf58 gene
    CXorf362  
    1 SIMAP similar gene for C3orf58 using alignment to 3 protein entries:     DIA1_HUMAN (see all proteins):
    CXorf36

    Find genes that share paralogs with C3orf58           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for C3orf58 (see all 583)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856420981,2
    --143688755(+) TCAAAC/TGATGC 1 -- us2k10--------
    rs7234901,2
    C,F,O,A,H--143688761(+) GATGCT/CTATAC 1 -- us2k126Minor allele frequency- C:0.36NA EA NS WA CSA 2587
    rs7234911,2
    C,F,A--143688768(+) ATACAA/GTTCCA 1 -- us2k111Minor allele frequency- G:0.48NA WA CSA EA 373
    rs1505291801,2
    --143688780(+) GCATCC/TGGAGG 1 -- us2k10--------
    rs1396348651,2
    C--143688967(+) ATTGT-/CTACTATT 1 -- us2k10--------
    rs7234921,2
    C,F,A--143689037(+) TAAGTC/AATAAC 1 -- us2k1 tfbs39Minor allele frequency- A:0.39WA NA CSA EA 369
    rs1901089241,2
    --143689213(+) TCCCAA/CCAAAG 1 -- us2k10--------
    rs19920931,2
    C,F,O,A,H--143689222(+) AGGCGG/ACATAA 1 -- us2k1105Minor allele frequency- A:0.38NS EA PA EU CA WA NA CSA 6527
    rs1996892831,2
    C--143689369(+) TTTTT-/TCAAAA 1 -- us2k10--------
    rs1921385981,2
    --143689413(+) ACAAAC/TACCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C3orf58 (143690640 - 143767561 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for C3orf58:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726004CNV Deletion23290073
    esv2726005CNV Deletion23290073
    esv2726007CNV Deletion23290073
    esv2321998CNV Deletion18987734
    nsv238021CNV Loss16902084
    nsv877568CNV Gain21882294
    nsv518814CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C3orf58
    DNA2.0 Custom Variant and Variant Library Synthesis for C3orf58

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612200    OMIM disorders: --

    UniProtKB/Swiss-Prot: DIA1_HUMAN, Q8NDZ4
  • Note=Genetic variations in C3orf58 may be associated with susceptibility to autism

  • 1 disease for C3orf58:    
    About MalaCards
    hypoxia

    1 disease from the University of Copenhagen DISEASES database for C3orf58:
    Autistic disorder

    Find genes that share disorders with C3orf58           About GenesLikeMe

    Genetic Association Database (GAD): C3orf58

    Export disorders for C3orf58 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for C3orf58 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with C3orf58)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. (PubMed id 23784961)1, 2, 3 Beigi F....Dzau V.J. (Circ. Res. 2013)
    2. HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. (PubMed id 24269490)1, 3 Huang J....Dzau V.J. (J. Mol. Cell. Cardiol. 2014)
    3. Characterization of the deleted in autism 1 protein family: implications for studying cognitive disorders. (PubMed id 21283809)1, 3 Aziz A....Bishop N.E. (PLoS ONE 2011)
    4. Expression of the novel Golgi protein GoPro49 is developmentally regulated during mesenchymal differentiation. (PubMed id 18651652)1, 2 Takatalo M....RAPnnholm R. (Dev. Dyn. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. DIA1R is an X-linked gene related to Deleted In Autism-1. (PubMed id 21264219)1 Aziz A.... Bishop N.E. (PLoS ONE 2011)
    8. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PubMed id 19247474)4 Caporaso N....Bergen A.W. (PLoS ONE 2009)
    9. Identifying autism loci and genes by tracing recent shared ancestry. (PubMed id 18621663)2 Morrow E.M.... Walsh C.A. (Science 2008)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 205428 HGNC: 28490 AceView: MGC33365 Ensembl:ENSG00000181744 euGenes: HUgn205428
    ECgene: C3orf58 H-InvDB: C3orf58

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for C3orf58 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for C3orf58 gene:
    Search GeneIP for patents involving C3orf58

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for C3orf58  
     OriGene qPCR primer pairs and template standards for C3orf58   OriGene Protein Over-expression Lysate for C3orf58  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for C3orf58  
     OriGene qSTAR qPCR primer pairs in human, mouse for C3orf58   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for C3orf58   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for C3orf58   OriGene Custom Protein Services for C3orf58  

     
     
     Block miRNA regulation of human, mouse, rat C3orf58 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing C3orf58
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C3orf58 Predesigned siRNA for gene silencing in human, mouse, rat C3orf58
     QuantiFast Probe-based Assays in human, mouse, rat C3orf58 QuantiTect SYBR Green Assays in human, mouse, rat C3orf58
     Custom PCR Arrays for C3orf58 Search Chromatin IP Primers for C3orf58
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C3orf58  Search GeneGlobe Interaction Network for C3orf58
     Regulatory tfbs in C3orf58 promoter
     GenScript Custom Purified and Recombinant Proteins Services for C3orf58 GenScript cDNA clones with any tag delivered in your preferred vector for C3orf58
     GenScript Custom Assay Services for C3orf58 GenScript Custom overexpressing Cell Line Services for C3orf58
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for C3orf58 (DIA1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     C3orf58 antibodies
     Antibodies for C3orf58
     See all of Abcam's Antibodies, Kits and Proteins for C3orf58
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for C3orf58
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf58
     SwitchGear 3'UTR luciferase reporter plasmids for C3orf58
     Browse SwitchGear Promoter luciferase reporter plasmids for C3orf58
     ThermoFisher Antibodies for C3orf58
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf58
     Browse compounds at ApexBio
     Search Addgene for plasmids for C3orf58
      Search eBioscience for proteins for C3orf58
      Search eBioscience for elisas for C3orf58
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for C3orf58
     antibodies-online antibodies for C3orf58 (64 products)
     antibodies-online kits for C3orf58 (8 products)
     antibodies-online peptides for C3orf58
     antibodies-online proteins for C3orf58 (11 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      C3orf58 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4