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Aliases for C3orf38 Gene

Aliases for C3orf38 Gene

  • Chromosome 3 Open Reading Frame 38 2 3 5

External Ids for C3orf38 Gene

Previous GeneCards Identifiers for C3orf38 Gene

  • GC03P088282
  • GC03P088198

Summaries for C3orf38 Gene

GeneCards Summary for C3orf38 Gene

C3orf38 (Chromosome 3 Open Reading Frame 38) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C3orf38 Gene

  • May be involved in apoptosis regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf38 Gene

Genomics for C3orf38 Gene

Regulatory Elements for C3orf38 Gene

Enhancers for C3orf38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G088113 0.6 ENCODE 11.9 -36.0 -35978 0.2 CTCF JUND ZNF654 TRIM22 SMC3 RAD21 CGGBP1 C3orf38 ZNF654 GC03P088128 CBX5P1
GH03G088030 1.4 FANTOM5 Ensembl ENCODE dbSUPER 2.1 -119.3 -119290 0.7 MAFG ZBTB40 ZNF507 YY1 ZNF316 MAFF IRF1 MAFK EMSY CGGBP1 ZNF654 C3orf38 GC03P088032 RNU6ATAC6P
GH03G088038 0.2 ENCODE 11 -111.0 -110958 0.2 CGGBP1 C3orf38 GC03P088045 GC03P088032
GH03G087996 1.1 FANTOM5 Ensembl ENCODE 1.9 -152.4 -152443 1.0 PBX2 FOS IRF1 CGGBP1 C3orf38 ZNF654 GC03P088032 RNU6ATAC6P
GH03G088159 0.3 FANTOM5 2 +10.2 10236 0.4 ZNF654 C3orf38 CGGBP1 GC03P088161
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C3orf38 on UCSC Golden Path with GeneCards custom track

Promoters for C3orf38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000155188 657 2801 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for C3orf38 Gene

Chromosome:
3
Start:
88,149,743 bp from pter
End:
88,168,729 bp from pter
Size:
18,987 bases
Orientation:
Plus strand

Genomic View for C3orf38 Gene

Genes around C3orf38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf38 Gene

Proteins for C3orf38 Gene

  • Protein details for C3orf38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JPI3-CC038_HUMAN
    Recommended name:
    Uncharacterized protein C3orf38
    Protein Accession:
    Q5JPI3
    Secondary Accessions:
    • B2R8X6
    • Q8TC85

    Protein attributes for C3orf38 Gene

    Size:
    329 amino acids
    Molecular mass:
    37541 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C3orf38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf38 Gene

Post-translational modifications for C3orf38 Gene

  • Ubiquitination at posLast=318318
  • Modification sites at PhosphoSitePlus

Other Protein References for C3orf38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C3orf38 Gene

Domains & Families for C3orf38 Gene

Protein Domains for C3orf38 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C3orf38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf38: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C3orf38 Gene

Function for C3orf38 Gene

Molecular function for C3orf38 Gene

UniProtKB/Swiss-Prot Function:
May be involved in apoptosis regulation.
genes like me logo Genes that share phenotypes with C3orf38: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf38 Gene

Localization for C3orf38 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf38 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C3orf38 Gene

Pathways & Interactions for C3orf38 Gene

SuperPathways for C3orf38 Gene

No Data Available

Interacting Proteins for C3orf38 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000322469%0d%0a9606.ENSP00000359799%0d%0a
Selected Interacting proteins: ENSP00000322469 Q5JPI3-CC038_HUMAN for C3orf38 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C3orf38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with C3orf38: view

No data available for Pathways by source and SIGNOR curated interactions for C3orf38 Gene

Drugs & Compounds for C3orf38 Gene

No Compound Related Data Available

Transcripts for C3orf38 Gene

Unigene Clusters for C3orf38 Gene

Chromosome 3 open reading frame 38:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf38 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: -
SP3:

Relevant External Links for C3orf38 Gene

GeneLoc Exon Structure for
C3orf38
ECgene alternative splicing isoforms for
C3orf38

Expression for C3orf38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf38 Gene

Protein differential expression in normal tissues from HIPED for C3orf38 Gene

This gene is overexpressed in Fetal ovary (41.7) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C3orf38 Gene



Protein tissue co-expression partners for C3orf38 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C3orf38 Gene:

C3orf38

SOURCE GeneReport for Unigene cluster for C3orf38 Gene:

Hs.518099

Evidence on tissue expression from TISSUES for C3orf38 Gene

  • Lymph node(4.2)
genes like me logo Genes that share expression patterns with C3orf38: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf38 Gene

Orthologs for C3orf38 Gene

This gene was present in the common ancestor of animals.

Orthologs for C3orf38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3orf38 35
  • 100 (a)
OneToOne
C3H3orf38 34
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia C33H3orf38 34
  • 89.57 (n)
C3orf38 35
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H3orf38 34
  • 88.96 (n)
C3orf38 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930453N24Rik 34 16 35
  • 85.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf38 35
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C3orf38 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H3ORF38 34
  • 66.78 (n)
C3orf38 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3orf38 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c3orf38 34
  • 56.89 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330300 34
  • 56.96 (n)
C9H3orf38 35
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13876 34 35
  • 43.11 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToOne
Species where no ortholog for C3orf38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3orf38 Gene

ENSEMBL:
Gene Tree for C3orf38 (if available)
TreeFam:
Gene Tree for C3orf38 (if available)

Paralogs for C3orf38 Gene

Pseudogenes.org Pseudogenes for C3orf38 Gene

genes like me logo Genes that share paralogs with C3orf38: view

No data available for Paralogs for C3orf38 Gene

Variants for C3orf38 Gene

Sequence variations from dbSNP and Humsavar for C3orf38 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000826514 -- 88,149,424(+) GAGAC(A/G/T)GTCCC intron-variant, upstream-variant-2KB
rs1001532077 -- 88,157,523(+) AAAAA(A/C)CCCAA utr-variant-3-prime
rs1001542184 -- 88,157,884(+) ATGCT(A/G)TGCCT utr-variant-3-prime
rs1002315140 -- 88,152,590(+) ACCCT(A/G)TCTGT intron-variant
rs1002652148 -- 88,154,207(+) AAAAA(A/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf38 Gene

Variant ID Type Subtype PubMed ID
esv3596913 CNV gain 21293372
esv3596915 CNV gain 21293372

Variation tolerance for C3orf38 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C3orf38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf38 Gene

Disorders for C3orf38 Gene

Relevant External Links for C3orf38

Genetic Association Database (GAD)
C3orf38
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3orf38

No disorders were found for C3orf38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf38 Gene

Publications for C3orf38 Gene

  1. Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. (PMID: 21177773) Moyer A.M. … Weinshilboum R.M. (Toxicol. Sci. 2011) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for C3orf38 Gene

Sources for C3orf38 Gene

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