C3orf37 Gene
protein-coding GIFtS: 43
GCID: GC03P128997
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|
chromosome 3 open reading frame 37
| |
Aliases
for C3orf37 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 3 Open Reading Frame 371 2 | | DC121 | | UPF0361 Protein C3orf372 |
Export aliases for C3orf37 gene to outside databasesPrevious GC identifers: GC03P130481 GC03P126382 |
Summaries
for C3orf37 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C3orf37 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C3orf37 gene promoter:
AML1a Pax-2 Pax-2a Tal-1beta E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for C3orf37
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C3orf37 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.3 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3q21.3C3orf37 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P128997: view genomic region
(about GC identifiers)
Start:
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128,997,671 bp from pter |
End:
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129,024,146 bp from pter |
Size:
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26,476 bases |
Orientation:
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plus strand |
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Proteins
for C3orf37 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC037_HUMAN, Q96FZ2 (See
protein sequence)Recommended Name: UPF0361 protein C3orf37 Size: 354 amino acids; 40575 Da
Sequence caution: Sequence=AAF86870.1; Type=Frameshift; Positions=285, 326, 344;
Secondary accessions: A6NJR9 Q96G34 Q9NRP3Explore the universe of human proteins at neXtProt for C3orf37: NX_Q96FZ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96FZ2
C3orf37 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001006109.1 NP_064572.2
ENSEMBL proteins: ENSP00000423132 ENSP00000372955 ENSP00000392966 ENSP00000426276 ENSP00000426215 ENSP00000374385 ENSP00000424594 ENSP00000421895
Human Recombinant Protein Products:
C3orf37 Antibody Products:
Assay Products for C3orf37: |
Protein
Domains /
Families
for C3orf37 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C3orf37 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96FZ2ProtoNet protein and cluster: Q96FZ2 UniProtKB/Swiss-Prot: CC037_HUMAN, Q96FZ2Similarity: Belongs to the UPF0361 family |
Function
for C3orf37 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf37 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf37 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for C3orf37 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf37 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf37 |
1 GenomeRNAi human phenotype for C3orf37:
|
Pathways & Interactions
for C3orf37 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C3orf37
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for C3orf37 (ENSP000003729554) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C3orf37 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C3orf37
Search CenterWatch for drugs/clinical trials and news about C3orf37 / CC037
|
Transcripts
for C3orf37 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C3orf37 gene (2 alternative transcripts): NM_001006109.1 NM_020187.2 Unigene Cluster for C3orf37: Chromosome 3 open reading frame 37 Hs.458320 [show with all ESTs]Unigene Representative Sequence: NM_0010061098 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000509042 ENST00000383463(uc003elt.3 uc003elu.3) ENST00000417226
ENST00000510314 ENST00000502878(uc003elv.3 uc003elw.3) ENST00000389735
ENST00000509551 ENST00000511665
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf37 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf37 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C3orf37 (NM_001006109) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C3orf37 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf37 |
Additional cDNA sequence: AF035296.1 AF201934.1 AK025883.1 AK225264.1 AK297501.1 AK309891.1 AY007144.1 BC009993.2 BC010125.2 BC050686.1 BC088363.1 18 DOTS entries: DT.99930548 DT.92443933 DT.217677 DT.100716123 DT.100659158 DT.100862734 DT.100659155 DT.100659152 DT.92443937 DT.100659149 DT.95247239 DT.120857784 DT.92443935 DT.92443940 DT.95247234 DT.95247238 DT.100000603 DT.92471821 24/424 AceView cDNA sequences (see all 424): BE513921 BU193095 BU187972 AA485133 BQ014982 AW662466 CB851095 BI964072 AI391614 AI734859 AW081903 BM826192 AA364661 AW471383 BE792652 CD368001 CD367895 BQ219198 BU679711 BU629638 BX354064 AA970686 AI468078 F11994
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for C3orf37 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b |
|---|
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| SP1: | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C3orf37
|
Expression
for C3orf37 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C3orf37 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTACCCAG
About this image
See C3orf37 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C3orf37
SOURCE GeneReport for Unigene cluster: Hs.458320
SABiosciences Custom PCR Arrays for C3orf37
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C3orf37
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C3orf37 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C3orf37 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C3orf37 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf37 |
Orthologs
for C3orf37 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for C3orf37 gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for C3orf37 (if available)
TreeFam Gene Tree for C3orf37 (if available) |
Paralogs
for C3orf37 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C3orf37 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C3orf37 (128997671 - 129024146 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C3orf37
1 CNV: 50924 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C3orf37 |
|
Disorders
/ Diseases
for C3orf37 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C3orf37 for disorders About GeneDecksing
4  diseases for C3orf37: About MalaCardschildhood leukemia tuberculosis leukemia mycobacterium tuberculosis
Export disorders for C3orf37 gene to outside databases
|
Publications
for C3orf37 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C3orf37 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with C3orf37) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
|
External Searches for C3orf37 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C3orf37 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C3orf37 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C3orf37 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C3orf37 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C3orf37 gene:
Search GeneIP for patents involving C3orf37
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C3orf37 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for C3orf37 | | OriGene Custom Protein Services for C3orf37 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C3orf37 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C3orf37 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C3orf37 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C3orf37 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C3orf37 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C3orf37 |
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 |  |  |  | |
| | | | Search Tocris compounds for C3orf37 |
| |  |  |  |  | | | | |
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 | | | C3orf37 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf37 |
|  |  |  | | | | ThermoFisher Antibodies for C3orf37 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf37 |
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