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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C3orf36 Gene

protein-coding   GIFtS: 32
GCID: GC03M133646

chromosome 3 open reading frame 36
  Search for C3orf36
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C3orf36    

Aliases
for C3orf36 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 3 Open Reading Frame 361 2
FLJ221731
Uncharacterized Protein C3orf362

External Ids:    HGNC: 261701   Entrez Gene: 801112   Ensembl: ENSG000002219727   UniProtKB: Q3SXR23   

Export aliases for C3orf36 gene to outside databases

Previous GC identifers: GC03M135130 GC03M131025


Summaries
for C3orf36 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C3orf36 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C3orf36 gene promoter:
         Pbx1a   p300   Ik-3   Meis-1b   C/EBPalpha   HFH-1   c-Myb   Sox9   Meis-1a   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C3orf36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C3orf36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

C3orf36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C3orf36 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M133646:  view genomic region     (about GC identifiers)

Start:
 133,646,989 bp from pter      End:
 133,648,656 bp from pter
Size:
 1,668 bases      Orientation:
 minus strand

Proteins
for C3orf36 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CC036_HUMAN, Q3SXR2 (See protein sequence)
Recommended Name: Uncharacterized protein C3orf36  
Size: 165 amino acids; 16908 Da
Secondary accessions: Q3SXR3 Q9H6K8

Explore the universe of human proteins at neXtProt for C3orf36: NX_Q3SXR2

C3orf36 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_079317.2  
ENSEMBL proteins: 
 ENSP00000386219  

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Protein Domains /
Families
for C3orf36 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q3SXR2


Function
for C3orf36 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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In Situ Assay
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Pathways & Interactions
for C3orf36 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C3orf36

Drugs & Compounds
for C3orf36 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C3orf36
Search CenterWatch for drugs/clinical trials and news about C3orf36 / CC036 

Transcripts
for C3orf36 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for C3orf36 gene: 
NM_025041.2  

Unigene Cluster for C3orf36:

Chromosome 3 open reading frame 36
Hs.287691  [show with all ESTs]
Unigene Representative Sequence: BC051274
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000408895(uc003epz.1)

miRNA
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Inhib. RNA
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Clone
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Primer
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Additional cDNA sequence: 

AK025826.1 AK225383.1 BC051274.1 BC064502.1 BC082257.1 BC104161.1 BC104162.1 

1 DOTS entry:

DT.100017952 

9 AceView cDNA sequences:

BC082257 BC051274 NM_025041 BQ707756 AK025826 BC064502 BQ712001 BQ710797 
BQ711031 

GeneLoc Exon Structure


Expression
for C3orf36 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C3orf36 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCCTACCC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

C3orf36 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
OvaryAntral FollicleCumulus CellsOvary
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See C3orf36 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C3orf36

SOURCE GeneReport for Unigene cluster: Hs.287691
    SABiosciences Custom PCR Arrays for C3orf36
Primer
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In Situ
Assay Products: 
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Orthologs
for C3orf36 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for C3orf36 (if available)
TreeFam Gene Tree for C3orf36 (if available) 

Paralogs
for C3orf36 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for C3orf36 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/70 NCBI SNPs in C3orf36 are shown (see all 70)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 3 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs68085471,2
C,F,H,--133646650(+) TCCGCG/ACCTTT 1 -- int116Minor allele frequency- A:0.11NS EA NA WA 1922
rs1462803611,2
--133646711(+) TTCCTC/TGTCTG 1 -- int10--------
rs1393640181,2
--133646789(+) CGCTTC/TGGATG 1 -- int10--------
rs744506831,2
F,--133646865(+) TCAAAG/CAGGAA 1 -- int11Minor allele frequency- C:0.06WA 118
rs1924576551,2
--133646936(+) CAGAAA/CCCCCA 1 -- int10--------
rs1439940091,2
--133646974(+) GAGATA/GTAATG 1 -- int10--------
rs1814850281,2
--133647075(+) TGCCTA/TCTGTG 1 -- ut310--------
rs1859696581,2
--133647080(+) ACTGTG/TGCCCA 1 -- ut310--------
rs1389836571,2
C--133647163(+) GTTGCC/TCCGCT 2 E G mis11Minor allele frequency- T:0.00NA 4468
rs771411751,2
C,F,--133647207(+) TTCACC/GCTTGG 2 S R mis13Minor allele frequency- G:0.02WA NA EU 5719

HapMap Linkage Disequilibrium report for C3orf36 (133646989 - 133648656 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for C3orf36: --

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Disorders / Diseases
for C3orf36 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Publications
for C3orf36 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C3orf36 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C3orf36)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

External Searches for C3orf36 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing C3orf36 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 80111 HGNC: 26170 AceView: FLJ22173 Ensembl:ENSG00000221972 euGenes: HUgn80111
ECgene: C3orf36 H-InvDB: C3orf36

Other Databases showing C3orf36 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing C3orf36 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C3orf36 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for C3orf36 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C3orf36 gene:
Search GeneIP for patents involving C3orf36

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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