C3orf35 Gene
protein-coding GIFtS: 40
GCID: GC03P037428
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chromosome 3 open reading frame 35
| |
Aliases
for C3orf35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 3 Open Reading Frame 351 2 | | APRG11 2 | | AP20 Region Protein 12 | | AP20 Region Protein12 |
Export aliases for C3orf35 gene to outside databasesPrevious GC identifer: GC03P037403 |
Summaries
for C3orf35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C3orf35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C3orf35 gene promoter:
Max1 SRF TBP Pax-5 SRF (504 AA) IRF-1 CUTL1 TFIID FOXO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for C3orf35
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C3orf35 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p22.2 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p22.3C3orf35 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P037428: view genomic region
(about GC identifiers)
Start:
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37,427,760 bp from pter |
End:
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37,476,988 bp from pter |
Size:
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49,229 bases |
Orientation:
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plus strand |
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Proteins
for C3orf35 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: APRG1_HUMAN, Q8IVJ8 (See
protein sequence)Recommended Name: AP20 region protein 1 Size: 170 amino acids; 18525 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B7ZMA0 Q8IVJ5 Q8IVJ9Alternative splicing: 3 isoforms: Q8IVJ8-1 Q8IVJ8-2 Q8IVJ8-3 Explore the universe of human proteins at neXtProt for C3orf35: NX_Q8IVJ8
C3orf35 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_848029.2 NP_848032.1
ENSEMBL proteins: ENSP00000395513 ENSP00000331625 ENSP00000330443 ENSP00000392399 ENSP00000414104 ENSP00000413537
Human Recombinant Protein Products for C3orf35:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
C3orf35 for ontologies About GeneDecksing
C3orf35 Antibody Products:
Assay Products for C3orf35: |
Protein
Domains /
Families
for C3orf35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8IVJ8 |
Function
for C3orf35 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for C3orf35:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf35 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf35 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for C3orf35 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf35 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf35 |
|
Pathways & Interactions
for C3orf35 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C3orf35
|
Drugs & Compounds
for C3orf35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C3orf35
Search CenterWatch for drugs/clinical trials and news about C3orf35 / APRG1
|
Transcripts
for C3orf35 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C3orf35 gene (6 alternative transcripts): NM_178338.2 NM_178340.1 NM_178341.1 NM_178344.1 NM_178339.2 NM_178342.2 Unigene Cluster for C3orf35: Chromosome 3 open reading frame 35 Hs.475945 [show with all ESTs]Unigene Representative Sequence: BX5377148 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000425932 ENST00000328376(uc003cha.4) ENST00000332506 ENST00000481400
ENST00000466204 ENST00000426078(uc003chb.3) ENST00000425564 ENST00000452017(uc003cgy.1 uc003cgz.1 uc021wvf.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf35 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf35 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C3orf35 (NM_178342) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C3orf35 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf35 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C3orf35
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C3orf35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C3orf35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C3orf35 |
Additional cDNA sequence: AJ493600.1 AJ493601.1 AJ493602.1 AJ493603.1 AJ493604.1 BC100859.2 BC100860.2 BC100861.1 BC100862.2 BC113895.1 BC132691.1 BC133024.1 BC144376.1 BC144377.1 BX537714.1 5 DOTS entries: DT.99929208 DT.100016646 DT.120885609 DT.412638 DT.75176298 24 AceView cDNA sequences: T16587 BX478493 NM_178340 NM_178338 NM_178342 BX504048 AJ493603 AJ493605 BM701622 BX537714 AJ493602 AJ493599 NM_178341 NM_178339 AJ493600 AJ493604 AJ493601 NM_178343 BU738687 AA593744 NM_178344 AW152277 AA948736 H86663
GeneLoc Exon Structure
|
Expression
for C3orf35 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C3orf35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C3orf35 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C3orf35
SOURCE GeneReport for Unigene cluster: Hs.475945
UniProtKB/Swiss-Prot: APRG1_HUMAN, Q8IVJ8Tissue specificity: Isoform 1 is expressed at high levels in the pancreas and placenta. Isoform 2 is expressed at highlevels in the kidney
SABiosciences Custom PCR Arrays for C3orf35
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C3orf35
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C3orf35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C3orf35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C3orf35 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf35 |
Orthologs
for C3orf35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for C3orf35 (if available)
TreeFam Gene Tree for C3orf35 (if available) |
Paralogs
for C3orf35 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C3orf35 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C3orf35 (37427760 - 37476988 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for C3orf35
7 CNVs: 63442 44108 79738 98286 91271 63441 91272
6 Indels: 91275 79737 91273 79739 91274 51093 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C3orf35 |
|
Disorders
/ Diseases
for C3orf35 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C3orf35 for disorders About GeneDecksing
OMIM gene information: 611429
OMIM disorders: --
7  diseases for C3orf35: About MalaCardsmuir-torre syndrome lynch syndrome cervical carcinoma cervicitis
breast carcinoma breast cancer carcinoma
1 disease from the University of Copenhagen DISEASES database for C3orf35:Muir-Torre syndrome Export disorders for C3orf35 gene to outside databases
|
Publications
for C3orf35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C3orf35 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C3orf35) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. (PubMed id 12543795)1, 2, 3, 9 Protopopov A.... Zabarovsky E.R. (2003)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Evidence for a tumour suppressive function of APRG1 in breast cancer. (PubMed id 16187228)1 Leris A.C....Mokbel K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas. (PubMed id 15208675)1 Senchenko V.N....Zabarovsky E.R. (2004)
- Deletion mapping using quantitative real-time PCR identifies two distinct 3p21.3 regions affected in most cervical carcinomas. (PubMed id 12771950)1 Senchenko V....Zabarovsky E.R. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for C3orf35 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C3orf35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C3orf35 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C3orf35 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C3orf35 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C3orf35 gene:
Search GeneIP for patents involving C3orf35
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C3orf35 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C3orf35 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C3orf35 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C3orf35 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C3orf35 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf35 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf35 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | C3orf35 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf35 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf35 |
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