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Aliases for C3orf35 Gene

Aliases for C3orf35 Gene

  • Chromosome 3 Open Reading Frame 35 2 3 5
  • APRG1 Tumor Suppressor Candidate 2 3
  • APRG1 3 4
  • AP20 Region Protein1 3
  • AP20 Region Protein 2

External Ids for C3orf35 Gene

Previous GeneCards Identifiers for C3orf35 Gene

  • GC03P037403

Summaries for C3orf35 Gene

GeneCards Summary for C3orf35 Gene

C3orf35 (Chromosome 3 Open Reading Frame 35) is a Protein Coding gene. Diseases associated with C3orf35 include muir-torre syndrome.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf35 Gene

Genomics for C3orf35 Gene

Regulatory Elements for C3orf35 Gene

Genomic Location for C3orf35 Gene

Chromosome:
3
Start:
37,386,269 bp from pter
End:
37,435,497 bp from pter
Size:
49,229 bases
Orientation:
Plus strand

Genomic View for C3orf35 Gene

Genes around C3orf35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf35 Gene

Proteins for C3orf35 Gene

  • Protein details for C3orf35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVJ8-APRG1_HUMAN
    Recommended name:
    AP20 region protein 1
    Protein Accession:
    Q8IVJ8
    Secondary Accessions:
    • B7ZMA0
    • Q8IVJ5
    • Q8IVJ9

    Protein attributes for C3orf35 Gene

    Size:
    170 amino acids
    Molecular mass:
    18525 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C3orf35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf35 Gene

Proteomics data for C3orf35 Gene at MOPED

Post-translational modifications for C3orf35 Gene

No Post-translational modifications

Other Protein References for C3orf35 Gene

No data available for DME Specific Peptides for C3orf35 Gene

Domains & Families for C3orf35 Gene

Protein Domains for C3orf35 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C3orf35 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf35: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C3orf35 Gene

Function for C3orf35 Gene

Phenotypes for C3orf35 Gene

GenomeRNAi human phenotypes for C3orf35:
genes like me logo Genes that share phenotypes with C3orf35: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C3orf35 Gene

Localization for C3orf35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf35 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C3orf35 Gene COMPARTMENTS Subcellular localization image for C3orf35 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for C3orf35 Gene

Pathways & Interactions for C3orf35 Gene

SuperPathways for C3orf35 Gene

No Data Available

Interacting Proteins for C3orf35 Gene

Gene Ontology (GO) - Biological Process for C3orf35 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C3orf35 Gene

Drugs & Compounds for C3orf35 Gene

No Compound Related Data Available

Transcripts for C3orf35 Gene

Unigene Clusters for C3orf35 Gene

Chromosome 3 open reading frame 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf35 Gene

No ASD Table

Relevant External Links for C3orf35 Gene

GeneLoc Exon Structure for
C3orf35
ECgene alternative splicing isoforms for
C3orf35

Expression for C3orf35 Gene

mRNA expression in normal human tissues for C3orf35 Gene

SOURCE GeneReport for Unigene cluster for C3orf35 Gene Hs.475945

mRNA Expression by UniProt/SwissProt for C3orf35 Gene

Q8IVJ8-APRG1_HUMAN
Tissue specificity: Isoform 1 is expressed at high levels in the pancreas and placenta. Isoform 2 is expressed at high levels in the kidney.
genes like me logo Genes that share expression patterns with C3orf35: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for C3orf35 Gene

Orthologs for C3orf35 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C3orf35 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C23H3orf35 35
  • 92 (n)
  • 88 (a)
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf35 35
  • 98.43 (n)
  • 96.47 (a)
C3orf35 36
  • 67 (a)
OneToOne
Species with no ortholog for C3orf35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C3orf35 Gene

ENSEMBL:
Gene Tree for C3orf35 (if available)
TreeFam:
Gene Tree for C3orf35 (if available)

Paralogs for C3orf35 Gene

No data available for Paralogs for C3orf35 Gene

Variants for C3orf35 Gene

Sequence variations from dbSNP and Humsavar for C3orf35 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs155527 -- 37,432,879(-) GCCAC(A/G)AGAAC intron-variant
rs199284 -- 37,405,784(+) ggatt(C/T)tttat intron-variant
rs149798 -- 37,426,814(-) tccta(A/G)gcaaa intron-variant
rs149817 -- 37,419,487(-) ccaaa(A/G)tgctg intron-variant
rs197716 -- 37,411,325(+) cctgg(C/G)taccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf35 Gene

Variant ID Type Subtype PubMed ID
nsv876704 CNV Gain 21882294
esv2664814 CNV Deletion 23128226
esv23838 CNV Loss 19812545
esv2619121 CNV Deletion 19546169
esv2213427 CNV Deletion 18987734
esv2670691 CNV Deletion 23128226
esv26009 CNV Loss 19812545
nsv519352 CNV Loss 19592680

Variation tolerance for C3orf35 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf35 Gene

HapMap Linkage Disequilibrium report
C3orf35
Human Gene Mutation Database (HGMD)
C3orf35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf35 Gene

Disorders for C3orf35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C3orf35 Gene - From: DISEASES

Disorder Aliases PubMed IDs
muir-torre syndrome
  • cutaneous sebaceous neoplasms and keratoacanthomas multiple with gastrointestinal and other carcinomas
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C3orf35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3orf35
genes like me logo Genes that share disorders with C3orf35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C3orf35 Gene

Publications for C3orf35 Gene

  1. An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. (PMID: 12543795) Protopopov A. … Zabarovsky E.R. (Cancer Res. 2003) 2 3 4 23 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Evidence for a tumour suppressive function of APRG1 in breast cancer. (PMID: 16187228) Leris A.C. … Mokbel K. (Breast Cancer Res. Treat. 2005) 3
  4. Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas. (PMID: 15208675) Senchenko V.N. … Zabarovsky E.R. (Oncogene 2004) 3
  5. Deletion mapping using quantitative real-time PCR identifies two distinct 3p21.3 regions affected in most cervical carcinomas. (PMID: 12771950) Senchenko V. … Zabarovsky E.R. (Oncogene 2003) 3

Products for C3orf35 Gene

Sources for C3orf35 Gene

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