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Aliases for C3orf35 Gene

Aliases for C3orf35 Gene

  • Chromosome 3 Open Reading Frame 35 2 3 5
  • APRG1 Tumor Suppressor Candidate 2 3
  • APRG1 3 4
  • AP20 Region Protein 1 3
  • AP20 Region Protein1 3
  • AP20 Region Protein 2

External Ids for C3orf35 Gene

Previous GeneCards Identifiers for C3orf35 Gene

  • GC03P037403

Summaries for C3orf35 Gene

GeneCards Summary for C3orf35 Gene

C3orf35 (Chromosome 3 Open Reading Frame 35) is a Protein Coding gene. Diseases associated with C3orf35 include Muir-Torre Syndrome.

Additional gene information for C3orf35 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf35 Gene

Genomics for C3orf35 Gene

Regulatory Elements for C3orf35 Gene

Enhancers for C3orf35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H037984 1.6 Ensembl ENCODE dbSUPER 21.7 +605.9 605863 15 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YY1 ZNF766 C3orf35 CTDSPL VILL ITGA9-AS1 OXSR1 GC03P038014
GH03H038163 2 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +780.9 780930 7 HDGF PKNOX1 MLX ARNT ZFP64 SIN3A FEZF1 DMAP1 ZNF2 YY1 OXSR1 ACAA1 MYD88 C3orf35 GORASP1 SLC22A13 ACVR2B-AS1 VILL PLCD1 DLEC1
GH03H036911 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13 -473.8 -473830 2 PKNOX1 ATF1 FOXA2 ARNT YBX1 TCF12 FOS ATF7 RUNX3 JUNB LRRFIP2 C3orf35 ENSG00000272334 EPM2AIP1 TRANK1 GOLGA4 MLH1 GC03M036882 GC03P036930
GH03H036957 1.7 FANTOM5 Ensembl ENCODE 13 -428.1 -428058 2 HDGF PKNOX1 ARNT ARID4B YY1 ZNF766 CBX5 ZNF143 FOS REST LRRFIP2 C3orf35 EPM2AIP1 ENSG00000272334 RPL29P11 MLH1 RNU6ATAC4P GC03M036968 GC03P036930
GH03H037485 0.7 FANTOM5 dbSUPER 12.5 +99.2 99185 0 ZFHX2 EGR2 ITGA9 C3orf35 RNU7-73P GC03M037573
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C3orf35 on UCSC Golden Path with GeneCards custom track

Genomic Location for C3orf35 Gene

Chromosome:
3
Start:
37,386,269 bp from pter
End:
37,435,497 bp from pter
Size:
49,229 bases
Orientation:
Plus strand

Genomic View for C3orf35 Gene

Genes around C3orf35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf35 Gene

Proteins for C3orf35 Gene

  • Protein details for C3orf35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVJ8-APRG1_HUMAN
    Recommended name:
    AP20 region protein 1
    Protein Accession:
    Q8IVJ8
    Secondary Accessions:
    • B7ZMA0
    • Q8IVJ5
    • Q8IVJ9

    Protein attributes for C3orf35 Gene

    Size:
    170 amino acids
    Molecular mass:
    18525 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C3orf35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf35 Gene

Post-translational modifications for C3orf35 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C3orf35 Gene

Domains & Families for C3orf35 Gene

Protein Domains for C3orf35 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C3orf35 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf35: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C3orf35 Gene

Function for C3orf35 Gene

Phenotypes for C3orf35 Gene

GenomeRNAi human phenotypes for C3orf35:
genes like me logo Genes that share phenotypes with C3orf35: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C3orf35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C3orf35 Gene

Localization for C3orf35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf35 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf35 gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C3orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C3orf35: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C3orf35 Gene

Pathways & Interactions for C3orf35 Gene

SuperPathways for C3orf35 Gene

No Data Available

Interacting Proteins for C3orf35 Gene

Selected Interacting proteins: Q8IVJ8-APRG1_HUMAN for C3orf35 Gene via IID

Symbol External ID(s) Details
GOLGA4

Gene Ontology (GO) - Biological Process for C3orf35 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C3orf35 Gene

Drugs & Compounds for C3orf35 Gene

No Compound Related Data Available

Transcripts for C3orf35 Gene

Unigene Clusters for C3orf35 Gene

Chromosome 3 open reading frame 35:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C3orf35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf35 Gene

No ASD Table

Relevant External Links for C3orf35 Gene

GeneLoc Exon Structure for
C3orf35
ECgene alternative splicing isoforms for
C3orf35

Expression for C3orf35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf35 Gene

NURSA nuclear receptor signaling pathways regulating expression of C3orf35 Gene:

C3orf35

SOURCE GeneReport for Unigene cluster for C3orf35 Gene:

Hs.475945

mRNA Expression by UniProt/SwissProt for C3orf35 Gene:

Q8IVJ8-APRG1_HUMAN
Tissue specificity: Isoform 1 is expressed at high levels in the pancreas and placenta. Isoform 2 is expressed at high levels in the kidney.

Evidence on tissue expression from TISSUES for C3orf35 Gene

  • Heart(4.1)
  • Kidney(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with C3orf35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf35 Gene

Orthologs for C3orf35 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C3orf35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf35 33
  • 98.43 (n)
C3orf35 34
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C23H3orf35 33
  • 92 (n)
Species where no ortholog for C3orf35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C3orf35 Gene

ENSEMBL:
Gene Tree for C3orf35 (if available)
TreeFam:
Gene Tree for C3orf35 (if available)

Paralogs for C3orf35 Gene

No data available for Paralogs for C3orf35 Gene

Variants for C3orf35 Gene

Sequence variations from dbSNP and Humsavar for C3orf35 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000044538 -- 37,396,310(+) CTCAC(G/T)TGCCC intron-variant
rs1000056613 -- 37,428,941(+) CTAAT(A/C)TTTAC intron-variant
rs1000122638 -- 37,385,042(+) GCCAT(A/C)AGGTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000218644 -- 37,413,403(+) TTCAG(A/T)CCCCG intron-variant
rs1000313239 -- 37,409,053(+) CCCAG(G/T)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf35 Gene

Variant ID Type Subtype PubMed ID
esv2213427 CNV deletion 18987734
esv23838 CNV loss 19812545
esv26009 CNV loss 19812545
esv2619121 CNV deletion 19546169
esv2664814 CNV deletion 23128226
esv2670691 CNV deletion 23128226
esv3595885 CNV gain 21293372
esv3595886 CNV gain 21293372
esv3595887 CNV gain 21293372
esv3595890 CNV loss 21293372
esv3595891 CNV loss 21293372
esv3595892 CNV loss 21293372
nsv519352 CNV loss 19592680

Variation tolerance for C3orf35 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf35 Gene

Human Gene Mutation Database (HGMD)
C3orf35
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C3orf35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf35 Gene

Disorders for C3orf35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C3orf35 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
muir-torre syndrome
  • keratoacanthoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C3orf35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3orf35
genes like me logo Genes that share disorders with C3orf35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C3orf35 Gene

Publications for C3orf35 Gene

  1. An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. (PMID: 12543795) Protopopov A … Zabarovsky ER (Cancer research 2003) 2 3 4 22 60
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 60
  4. Evidence for a tumour suppressive function of APRG1 in breast cancer. (PMID: 16187228) Leris AC … Mokbel K (Breast cancer research and treatment 2005) 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for C3orf35 Gene

Sources for C3orf35 Gene

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