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Aliases for C3orf33 Gene

Aliases for C3orf33 Gene

  • Chromosome 3 Open Reading Frame 33 2 3
  • AP-1 Activity Suppressor 3
  • Protein C3orf33 3
  • Protein AC3-33 4
  • AC3-33 3

External Ids for C3orf33 Gene

Previous GeneCards Identifiers for C3orf33 Gene

  • GC03M156964
  • GC03M155480
  • GC03M152875

Summaries for C3orf33 Gene

GeneCards Summary for C3orf33 Gene

C3orf33 (Chromosome 3 Open Reading Frame 33) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot for C3orf33 Gene

  • Isoform 2: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf33 Gene

Genomics for C3orf33 Gene

Regulatory Elements for C3orf33 Gene

Genomic Location for C3orf33 Gene

Start:
155,762,612 bp from pter
End:
155,806,351 bp from pter
Size:
43,740 bases
Orientation:
Minus strand

Genomic View for C3orf33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C3orf33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf33 Gene

Proteins for C3orf33 Gene

  • Protein details for C3orf33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1S2-CC033_HUMAN
    Recommended name:
    Protein C3orf33
    Protein Accession:
    Q6P1S2
    Secondary Accessions:
    • A8K1H5
    • Q86YE6
    • Q8IXA7
    • Q96NB5

    Protein attributes for C3orf33 Gene

    Size:
    294 amino acids
    Molecular mass:
    33765 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO06952.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C3orf33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf33 Gene

Proteomics data for C3orf33 Gene at MOPED

Post-translational modifications for C3orf33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C3orf33 Gene

No data available for DME Specific Peptides for C3orf33 Gene

Domains for C3orf33 Gene

Protein Domains for C3orf33 Gene

Suggested Antigen Peptide Sequences for C3orf33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf33: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C3orf33 Gene

Function for C3orf33 Gene

Molecular function for C3orf33 Gene

UniProtKB/Swiss-Prot Function: Isoform 2: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane

Gene Ontology (GO) - Molecular Function for C3orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0016788 hydrolase activity, acting on ester bonds --
genes like me logo Genes that share ontologies with C3orf33: view

Phenotypes for C3orf33 Gene

GenomeRNAi human phenotypes for C3orf33:
genes like me logo Genes that share phenotypes with C3orf33: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C3orf33 Gene

Localization for C3orf33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf33 Gene

Isoform 1: Membrane; Single-pass membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C3orf33 Gene COMPARTMENTS Subcellular localization image for C3orf33 gene
Compartment Confidence
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for C3orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20680465
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C3orf33: view

Pathways for C3orf33 Gene

SuperPathways for C3orf33 Gene

No Data Available

Interacting Proteins for C3orf33 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000445446%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000445446 for C3orf33 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for C3orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity IDA 20680465
GO:0070373 negative regulation of ERK1 and ERK2 cascade IDA 20680465
genes like me logo Genes that share ontologies with C3orf33: view

No data available for Pathways by source for C3orf33 Gene

Transcripts for C3orf33 Gene

Unigene Clusters for C3orf33 Gene

Chromosome 3 open reading frame 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf33 Gene

No ASD Table

Relevant External Links for C3orf33 Gene

GeneLoc Exon Structure for
C3orf33
ECgene alternative splicing isoforms for
C3orf33

Expression for C3orf33 Gene

mRNA expression in normal human tissues for C3orf33 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for C3orf33 Gene

SOURCE GeneReport for Unigene cluster for C3orf33 Gene Hs.350846

mRNA Expression by UniProt/SwissProt for C3orf33 Gene

Q6P1S2-CC033_HUMAN
Tissue specificity: Highly expressed in ileocecal tissue and endometrium.
genes like me logo Genes that share expressions with C3orf33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for C3orf33 Gene

Orthologs for C3orf33 Gene

This gene was present in the common ancestor of animals.

Orthologs for C3orf33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf33 35
  • 99.34 (n)
  • 99.2 (a)
C3ORF33 36
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H3orf33 35
  • 89.07 (n)
  • 83.6 (a)
C3orf33 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C23H3orf33 35
  • 89.07 (n)
  • 84.8 (a)
C3orf33 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia E130311K13Rik 35
  • 80.88 (n)
  • 74.9 (a)
E130311K13Rik 16
E130311K13Rik 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C3orf33 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf33 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565059 35
  • 81.41 (n)
  • 76.1 (a)
chicken
(Gallus gallus)
Aves C3orf33 36
  • 44 (a)
OneToOne
C9H3orf33 35
  • 59.61 (n)
  • 54.5 (a)
lizard
(Anolis carolinensis)
Reptilia C3orf33 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496931 35
  • 63.05 (n)
  • 55.43 (a)
zebrafish
(Danio rerio)
Actinopterygii C18H3orf33 36
  • 35 (a)
OneToOne
c3orf33 35
  • 50.79 (n)
  • 43.92 (a)
worm
(Caenorhabditis elegans)
Secernentea F32A11.1 36
  • 21 (a)
OneToMany
W09H1.3 36
  • 30 (a)
OneToMany
Species with no ortholog for C3orf33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C3orf33 Gene

ENSEMBL:
Gene Tree for C3orf33 (if available)
TreeFam:
Gene Tree for C3orf33 (if available)

Paralogs for C3orf33 Gene

genes like me logo Genes that share paralogs with C3orf33: view

No data available for Paralogs for C3orf33 Gene

Variants for C3orf33 Gene

Sequence variations from dbSNP and Humsavar for C3orf33 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs183089 -- 155,768,130(-) ggccg(A/T)ggtgg intron-variant
rs191683 -- 155,771,674(-) catgc(C/G)tgtat intron-variant
rs358699 -- 155,798,287(-) gctcc(A/G)tagaa intron-variant
rs358700 -- 155,797,984(-) aagca(A/C)ttctc intron-variant
rs358701 -- 155,796,625(-) gaatc(A/G)tttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf33 Gene

Variant ID Type Subtype PubMed ID
nsv877680 CNV Gain 21882294
esv25006 CNV Gain 19812545
nsv514997 CNV Complex 21397061
nsv441844 CNV CNV 18776908
esv33346 CNV Gain 17666407
nsv516712 CNV Gain 19592680
nsv818180 CNV Gain 17921354
nsv819264 CNV Loss 19587683
dgv1524e1 CNV Complex 17122850

Relevant External Links for C3orf33 Gene

HapMap Linkage Disequilibrium report
C3orf33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf33 Gene

Disorders for C3orf33 Gene

Relevant External Links for C3orf33

Genetic Association Database (GAD)
C3orf33
genes like me logo Genes that share disorders with C3orf33: view

No data available for UniProtKB/Swiss-Prot for C3orf33 Gene

Publications for C3orf33 Gene

  1. AC3-33, a novel secretory protein, inhibits Elk1 transcriptional activity via ERK pathway. (PMID: 20680465) Hao D. … Zhang X. (Mol. Biol. Rep. 2011) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Prokaryotic expression and characterization of human AC3-33 protein. (PMID: 20515784) Zhang X. … Yang W. (Front Biosci (Elite Ed) 2010) 3 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C3orf33 Gene

  • antibodies-online peptides for C3orf33
  • antibodies-online antibodies for C3orf33
  • antibodies-online kits for C3orf33

Sources for C3orf33 Gene

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