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Aliases for C3orf33 Gene

Aliases for C3orf33 Gene

  • Chromosome 3 Open Reading Frame 33 2 3 5
  • AP-1 Activity Suppressor 3
  • Protein C3orf33 3
  • Protein AC3-33 4
  • AC3-33 3

External Ids for C3orf33 Gene

Previous GeneCards Identifiers for C3orf33 Gene

  • GC03M156964
  • GC03M155480
  • GC03M152875

Summaries for C3orf33 Gene

GeneCards Summary for C3orf33 Gene

C3orf33 (Chromosome 3 Open Reading Frame 33) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot for C3orf33 Gene

  • Isoform 2: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.

Additional gene information for C3orf33 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf33 Gene

Genomics for C3orf33 Gene

Regulatory Elements for C3orf33 Gene

Enhancers for C3orf33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H155743 1.5 FANTOM5 Ensembl ENCODE 11.7 +60.9 60896 3.6 PKNOX1 ARID4B SIN3A ETS1 GLIS2 MXD4 REST SREBF1 NFIL3 MIER3 C3orf33 SLC33A1 PLCH1 RPL7AP24
GH03H155804 1.1 ENCODE 9.5 +0.7 655 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 REST GMPS C3orf33 PLCH1 SLC33A1 RPL7AP24
GH03H155869 1.1 ENCODE 9.4 -64.9 -64934 3.8 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF143 ZNF207 SP3 C3orf33 GMPS PLCH1 SETP14
GH03H155888 1.2 Ensembl ENCODE 6 -83.8 -83809 2.7 HDAC1 TBP PKNOX1 FOXA2 ATF1 TBL1XR1 ARNT ZBTB40 CHAMP1 TCF12 SLC33A1 PLCH1 ENSG00000214919 GMPS C3orf33 SETP14
GH03H155851 1.2 ENCODE 5 -47.3 -47318 3.9 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SLC33A1 GMPS C3orf33
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C3orf33 on UCSC Golden Path with GeneCards custom track

Promoters for C3orf33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for C3orf33 Gene

Genomic Locations for C3orf33 Gene
43,740 bases
Minus strand

Genomic View for C3orf33 Gene

Genes around C3orf33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf33 Gene

Proteins for C3orf33 Gene

  • Protein details for C3orf33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein C3orf33
    Protein Accession:
    Secondary Accessions:
    • A8K1H5
    • Q86YE6
    • Q8IXA7
    • Q96NB5

    Protein attributes for C3orf33 Gene

    294 amino acids
    Molecular mass:
    33765 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAO06952.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C3orf33 Gene


neXtProt entry for C3orf33 Gene

Post-translational modifications for C3orf33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C3orf33 Gene

Domains & Families for C3orf33 Gene

Gene Families for C3orf33 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for C3orf33 Gene

Suggested Antigen Peptide Sequences for C3orf33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf33: view

No data available for UniProtKB/Swiss-Prot for C3orf33 Gene

Function for C3orf33 Gene

Molecular function for C3orf33 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.
genes like me logo Genes that share phenotypes with C3orf33: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf33 Gene

Localization for C3orf33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf33 Gene

Isoform 1: Membrane; Single-pass membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf33 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C3orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20680465
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C3orf33: view

Pathways & Interactions for C3orf33 Gene

SuperPathways for C3orf33 Gene

No Data Available

Interacting Proteins for C3orf33 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000445446 Q6P1S2-CC033_HUMAN for C3orf33 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C3orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity IDA 20680465
GO:0070373 negative regulation of ERK1 and ERK2 cascade IDA 20680465
genes like me logo Genes that share ontologies with C3orf33: view

No data available for Pathways by source and SIGNOR curated interactions for C3orf33 Gene

Drugs & Compounds for C3orf33 Gene

No Compound Related Data Available

Transcripts for C3orf33 Gene

Unigene Clusters for C3orf33 Gene

Chromosome 3 open reading frame 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf33 Gene

No ASD Table

Relevant External Links for C3orf33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C3orf33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf33 Gene

Protein differential expression in normal tissues from HIPED for C3orf33 Gene

This gene is overexpressed in Adrenal (21.5), Liver (17.7), and Testis (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C3orf33 Gene

Protein tissue co-expression partners for C3orf33 Gene

NURSA nuclear receptor signaling pathways regulating expression of C3orf33 Gene:


SOURCE GeneReport for Unigene cluster for C3orf33 Gene:


mRNA Expression by UniProt/SwissProt for C3orf33 Gene:

Tissue specificity: Highly expressed in ileocecal tissue and endometrium.

Evidence on tissue expression from TISSUES for C3orf33 Gene

  • Heart(4.2)
  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with C3orf33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf33 Gene

Orthologs for C3orf33 Gene

This gene was present in the common ancestor of animals.

Orthologs for C3orf33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C3H3orf33 33
  • 99.34 (n)
C3ORF33 34
  • 85 (a)
(Bos Taurus)
Mammalia C1H3orf33 33
  • 89.07 (n)
C3orf33 34
  • 71 (a)
(Canis familiaris)
Mammalia C23H3orf33 33
  • 89.07 (n)
C3orf33 34
  • 85 (a)
(Rattus norvegicus)
Mammalia RGD1565059 33
  • 81.41 (n)
(Mus musculus)
Mammalia E130311K13Rik 33 16 34
  • 80.88 (n)
(Ornithorhynchus anatinus)
Mammalia C3orf33 34
  • 49 (a)
(Monodelphis domestica)
Mammalia C3orf33 34
  • 44 (a)
(Gallus gallus)
Aves C9H3orf33 33
  • 59.61 (n)
C3orf33 34
  • 44 (a)
(Anolis carolinensis)
Reptilia C3orf33 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496931 33
  • 63.05 (n)
(Danio rerio)
Actinopterygii c3orf33 33
  • 50.79 (n)
C18H3orf33 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea W09H1.3 34
  • 30 (a)
F32A11.1 34
  • 21 (a)
Species where no ortholog for C3orf33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C3orf33 Gene

Gene Tree for C3orf33 (if available)
Gene Tree for C3orf33 (if available)

Paralogs for C3orf33 Gene

genes like me logo Genes that share paralogs with C3orf33: view

No data available for Paralogs for C3orf33 Gene

Variants for C3orf33 Gene

Sequence variations from dbSNP and Humsavar for C3orf33 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000007567 -- 155,797,462(+) AGCAC(C/T)CAGAC intron-variant
rs1000237901 -- 155,792,486(+) ACTAA(A/T)TAAGG intron-variant
rs1000288973 -- 155,791,139(+) CTATA(C/G)TAGGA intron-variant
rs1000394122 -- 155,804,520(+) TGTAG(A/T)GCATT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000459641 -- 155,793,699(+) CAGCT(A/G)CTCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf33 Gene

Variant ID Type Subtype PubMed ID
nsv819264 CNV loss 19587683
nsv818180 CNV gain 17921354
nsv592081 CNV gain 21841781
nsv592080 CNV gain 21841781
nsv592079 CNV gain 21841781
nsv516712 CNV gain 19592680
nsv514997 CNV loss 21397061
nsv441844 CNV gain 18776908
nsv1136778 CNV deletion 24896259
nsv1117035 CNV deletion 24896259
nsv1009618 CNV gain 25217958
esv3893791 CNV loss 25118596
esv3598285 CNV gain 21293372
esv3598284 CNV loss 21293372
esv3598283 CNV loss 21293372
esv3575620 CNV gain 25503493
esv3575619 CNV gain 25503493
esv3562765 CNV deletion 23714750
esv33346 CNV gain 17666407
esv2763741 CNV gain 21179565
esv2759192 CNV gain 17122850
esv25006 CNV gain 19812545
dgv8657n54 CNV gain 21841781
dgv4928n100 CNV gain 25217958
dgv4927n100 CNV gain 25217958
dgv4926n100 CNV gain 25217958
dgv1421e212 CNV gain 25503493

Variation tolerance for C3orf33 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf33 Gene

Disorders for C3orf33 Gene

Relevant External Links for C3orf33

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C3orf33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf33 Gene

Publications for C3orf33 Gene

  1. AC3-33, a novel secretory protein, inhibits Elk1 transcriptional activity via ERK pathway. (PMID: 20680465) Hao D … Zhang X (Molecular biology reports 2011) 2 3 4 60
  2. in situ (PMID: 26137149) Hu F … Zhang X (Oncology letters 2015) 2 3 60
  3. Prokaryotic expression and characterization of human AC3-33 protein. (PMID: 20515784) Zhang X … Yang W (Frontiers in bioscience (Elite edition) 2010) 3 22 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for C3orf33 Gene

Sources for C3orf33 Gene

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