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Aliases for C3orf33 Gene

Aliases for C3orf33 Gene

  • Chromosome 3 Open Reading Frame 33 2 3 5
  • AP-1 Activity Suppressor 3
  • Protein AC3-33 4
  • AC3-33 3

External Ids for C3orf33 Gene

Previous GeneCards Identifiers for C3orf33 Gene

  • GC03M156964
  • GC03M155480
  • GC03M152875

Summaries for C3orf33 Gene

GeneCards Summary for C3orf33 Gene

C3orf33 (Chromosome 3 Open Reading Frame 33) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot for C3orf33 Gene

  • Isoform 2: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf33 Gene

Genomics for C3orf33 Gene

Regulatory Elements for C3orf33 Gene

Promoters for C3orf33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C3orf33 on UCSC Golden Path with GeneCards custom track

Genomic Location for C3orf33 Gene

Chromosome:
3
Start:
155,762,612 bp from pter
End:
155,806,351 bp from pter
Size:
43,740 bases
Orientation:
Minus strand

Genomic View for C3orf33 Gene

Genes around C3orf33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf33 Gene

Proteins for C3orf33 Gene

  • Protein details for C3orf33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1S2-CC033_HUMAN
    Recommended name:
    Protein C3orf33
    Protein Accession:
    Q6P1S2
    Secondary Accessions:
    • A8K1H5
    • Q86YE6
    • Q8IXA7
    • Q96NB5

    Protein attributes for C3orf33 Gene

    Size:
    294 amino acids
    Molecular mass:
    33765 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO06952.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C3orf33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf33 Gene

Proteomics data for C3orf33 Gene at MOPED

Post-translational modifications for C3orf33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C3orf33 Gene

No data available for DME Specific Peptides for C3orf33 Gene

Domains & Families for C3orf33 Gene

Protein Domains for C3orf33 Gene

Suggested Antigen Peptide Sequences for C3orf33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf33: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C3orf33 Gene

Function for C3orf33 Gene

Molecular function for C3orf33 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.
genes like me logo Genes that share phenotypes with C3orf33: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf33 Gene

Localization for C3orf33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf33 Gene

Isoform 1: Membrane; Single-pass membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C3orf33 Gene COMPARTMENTS Subcellular localization image for C3orf33 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for C3orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C3orf33: view

Pathways & Interactions for C3orf33 Gene

SuperPathways for C3orf33 Gene

No Data Available

Interacting Proteins for C3orf33 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000445446%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000445446 for C3orf33 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for C3orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity IDA 20680465
genes like me logo Genes that share ontologies with C3orf33: view

No data available for Pathways by source and SIGNOR curated interactions for C3orf33 Gene

Drugs & Compounds for C3orf33 Gene

No Compound Related Data Available

Transcripts for C3orf33 Gene

Unigene Clusters for C3orf33 Gene

Chromosome 3 open reading frame 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf33 Gene

No ASD Table

Relevant External Links for C3orf33 Gene

GeneLoc Exon Structure for
C3orf33
ECgene alternative splicing isoforms for
C3orf33

Expression for C3orf33 Gene

mRNA expression in normal human tissues for C3orf33 Gene

Protein differential expression in normal tissues from HIPED for C3orf33 Gene

This gene is overexpressed in Adrenal (21.5), Liver (17.7), and Testis (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C3orf33 Gene



SOURCE GeneReport for Unigene cluster for C3orf33 Gene Hs.350846

mRNA Expression by UniProt/SwissProt for C3orf33 Gene

Q6P1S2-CC033_HUMAN
Tissue specificity: Highly expressed in ileocecal tissue and endometrium.
genes like me logo Genes that share expression patterns with C3orf33: view

Protein tissue co-expression partners for C3orf33 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for C3orf33 Gene

Orthologs for C3orf33 Gene

This gene was present in the common ancestor of animals.

Orthologs for C3orf33 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1H3orf33 35
  • 89.07 (n)
  • 83.6 (a)
C3orf33 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C23H3orf33 35
  • 89.07 (n)
  • 84.8 (a)
C3orf33 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia E130311K13Rik 35
  • 80.88 (n)
  • 74.9 (a)
E130311K13Rik 16
E130311K13Rik 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf33 35
  • 99.34 (n)
  • 99.2 (a)
C3ORF33 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565059 35
  • 81.41 (n)
  • 76.1 (a)
oppossum
(Monodelphis domestica)
Mammalia C3orf33 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf33 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves C9H3orf33 35
  • 59.61 (n)
  • 54.5 (a)
C3orf33 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3orf33 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496931 35
  • 63.05 (n)
  • 55.43 (a)
zebrafish
(Danio rerio)
Actinopterygii c3orf33 35
  • 50.79 (n)
  • 43.92 (a)
C18H3orf33 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F32A11.1 36
  • 21 (a)
OneToMany
W09H1.3 36
  • 30 (a)
OneToMany
Species with no ortholog for C3orf33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C3orf33 Gene

ENSEMBL:
Gene Tree for C3orf33 (if available)
TreeFam:
Gene Tree for C3orf33 (if available)

Paralogs for C3orf33 Gene

genes like me logo Genes that share paralogs with C3orf33: view

No data available for Paralogs for C3orf33 Gene

Variants for C3orf33 Gene

Sequence variations from dbSNP and Humsavar for C3orf33 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9853408 - 155,802,567(+) TCCAG(C/T)TATGG intron-variant, reference, missense
rs358733 - 155,767,513(-) GGTGA(A/G)TAAGG reference, missense
rs427139 -- 155,801,551(-) atttt(C/T)gtcct intron-variant
rs183089 -- 155,768,130(-) ggccg(A/T)ggtgg intron-variant
rs368057 -- 155,790,079(-) tcaag(G/T)gattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf33 Gene

Variant ID Type Subtype PubMed ID
nsv877680 CNV Gain 21882294
esv25006 CNV Gain 19812545
nsv514997 CNV Complex 21397061
nsv441844 CNV CNV 18776908
esv33346 CNV Gain 17666407
nsv516712 CNV Gain 19592680
nsv818180 CNV Gain 17921354
nsv819264 CNV Loss 19587683
dgv1524e1 CNV Complex 17122850

Variation tolerance for C3orf33 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf33 Gene

HapMap Linkage Disequilibrium report
C3orf33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf33 Gene

Disorders for C3orf33 Gene

Relevant External Links for C3orf33

Genetic Association Database (GAD)
C3orf33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3orf33

No disorders were found for C3orf33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf33 Gene

Publications for C3orf33 Gene

  1. AC3-33, a novel secretory protein, inhibits Elk1 transcriptional activity via ERK pathway. (PMID: 20680465) Hao D. … Zhang X. (Mol. Biol. Rep. 2011) 2 3 4 67
  2. Prokaryotic expression and characterization of human AC3-33 protein. (PMID: 20515784) Zhang X. … Yang W. (Front Biosci (Elite Ed) 2010) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for C3orf33 Gene

Sources for C3orf33 Gene

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