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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C3orf27 Gene

protein-coding   GIFtS: 39
GCID: GC03M128290

Chromosome 3 Open Reading Frame 27

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 3 Open Reading Frame 271 2
GR62
Protein GR62
Putative GR6 Protein2

External Ids:    HGNC: 170991   Entrez Gene: 234342   Ensembl: ENSG000001986857   UniProtKB: O155443   

Export aliases for C3orf27 gene to outside databases

Previous GC identifers: GC03M129774 GC03M125675


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C3orf27 Gene: 
C3orf27 (chromosome 3 open reading frame 27) is a protein-coding gene. Diseases associated with C3orf27 include leukemia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C3orf27 gene promoter:
         AML1a   p53   CUTL1   LCR-F1   c-Ets-1   GATA-2   Pax-3   Sox9   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C3orf27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C3orf27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21

C3orf27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C3orf27 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M128290:  view genomic region     (about GC identifiers)

Start:
128,290,843 bp from pter      End:
128,294,929 bp from pter
Size:
4,087 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GR6_HUMAN, O15544 (See protein sequence)
Recommended Name: Protein GR6  
Size: 149 amino acids; 16056 Da

Explore the universe of human proteins at neXtProt for C3orf27: NX_O15544

Explore proteomics data for C3orf27 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15544

  • C3orf27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C3orf27 Protein Expression
    REFSEQ proteins: NP_031380.1  
    ENSEMBL proteins: 
     ENSP00000348302  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O15544


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C3orf27

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C3orf27 (GR6)

    Search CenterWatch for drugs/clinical trials and news about C3orf27 / GR6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for C3orf27 gene: 
    NM_007354.2  

    Unigene Cluster for C3orf27:

    Chromosome 3 open reading frame 27
    Hs.194283
    Unigene Representative Sequence: NM_007354
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000356020(uc003ekq.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: AF008192.1 

    1 DOTS entry:

    DT.304023 

    2 AceView cDNA sequences:

    NM_007354 AF008192 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C3orf27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGATGAT
    C3orf27 Expression
    About this image


    See C3orf27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C3orf27

    SOURCE GeneReport for Unigene cluster: Hs.194283
        SABiosciences Custom PCR Arrays for C3orf27
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for C3orf27 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia C3H3orf271 chromosome 3 open reading frame, human C3orf27 98.66(n)
    99.33(a)
      737366  XM_003309989.1  XP_003310037.1 


    ENSEMBL Gene Tree for C3orf27 (if available)
    TreeFam Gene Tree for C3orf27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/191 SNPs in C3orf27 are shown (see all 191)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs757586831,2
    C,F--128290433(+) AAATGG/ATTATG 1 -- int11Minor allele frequency- A:0.13WA 118
    rs1436713201,2
    C--128290452(+) TTTTA-/TTGTT 
            
    TTGTT
    1 -- int10--------
    rs1885876671,2
    --128290631(+) CACCCA/GGCTAT 1 -- int10--------
    rs3701207081,2
    C--128290712(+) GATCCA/GCCGCC 1 -- int10--------
    rs604405041,2
    C,F--128290715(+) CCGCCC/TGCCTC 1 -- int12Minor allele frequency- T:0.50NA CSA 4
    rs1404590771,2
    --128290722(+) CCTCGA/GCCTCC 1 -- int10--------
    rs27135871,2
    C,F--128290848(+) TGGGTA/GAAGTT 1 -- ut3116Minor allele frequency- N:0.00EA NA WA CSA 592
    rs27124231,2
    C,F,A,H--128290938(+) CCTCCG/TGGGAC 1 -- ut3120Minor allele frequency- T:0.40NS EA NA WA 2344
    rs1932616551,2
    --128291076(+) CCTGCA/GCATGG 1 -- ut310--------
    rs1843040641,2
    --128291090(+) CCACCA/GGGACG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for C3orf27 (128290843 - 128294929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C3orf27:    About this table     
    Variant IDTypeSubtypePubMed ID
    essv17207CNV CNV17122850
    dgv1494e1CNV Complex17122850
    dgv1493e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for C3orf27:    About MalaCards
    leukemia    


    C3orf27 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C3orf27

    Export disorders for C3orf27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C3orf27 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C3orf27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. (PubMed id 9307271)1, 2, 3 Pekarsky Y.... Gardiner K. (1997)
    2. [Structural features of GR6 gene and its expression in colorectal neoplasm] (PubMed id 15067727)1, 9 Lin J....Lai M.D. (2004)
    3. Multiple loci are associated with white blood cell phe notypes. (PubMed id 21738480)1 Nalls M.A....Ganesh S.K. (2011)
    4. Identification of nine novel loci associated with whi te blood cell subtypes in a Japanese population. (PubMed id 21738478)4 Okada Y....Kamatani N. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23434 HGNC: 17099 AceView: GR6 Ensembl:ENSG00000198685 euGenes: HUgn23434
    ECgene: C3orf27 H-InvDB: C3orf27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C3orf27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C3orf27 gene:
    Search GeneIP for patents involving C3orf27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C3orf27
    Customized:
     lentivirus for stable overexpression of C3orf27
     lentivirus expression plasmids for stable overexpression of C3orf27
     adenovirus for overexpression of C3orf27
     Search LSBio for Antibodies for C3orf27
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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