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Aliases for C3orf22 Gene

Aliases for C3orf22 Gene

  • Chromosome 3 Open Reading Frame 22 2 3 5

External Ids for C3orf22 Gene

Previous GeneCards Identifiers for C3orf22 Gene

  • GC03M127752
  • GC03M126267
  • GC03M123648

Summaries for C3orf22 Gene

GeneCards Summary for C3orf22 Gene

C3orf22 (Chromosome 3 Open Reading Frame 22) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf22 Gene

Genomics for C3orf22 Gene

Regulatory Elements for C3orf22 Gene

Enhancers for C3orf22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G126522 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.5 +31.8 31849 8.6 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 GLIS2 ZNF143 PAF1 CHST13 TXNRD3NB TXNRD3 NUP210P1 OR7E29P C3orf22 ZXDC UROC1
GH03G126516 0.9 dbSUPER 4.4 +40.6 40583 3.2 FOXA2 ARID4B DMAP1 BMI1 RAD21 ZNF48 RARA YY1 CREM CEBPB CHST13 C3orf22 UROC1
GH03G126539 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +17.6 17614 3.8 PKNOX1 SIN3A ARID4B DMAP1 ZNF48 YY1 ZNF766 FOS ZNF263 REST CHST13 ZXDC C3orf22
GH03G126547 0.7 FANTOM5 dbSUPER 0.4 +11.0 11020 0.2 ZNF341 ZKSCAN1 ZXDC C3orf22 CHST13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C3orf22 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the C3orf22 gene promoter:

Genomic Location for C3orf22 Gene

Chromosome:
3
Start:
126,521,997 bp from pter
End:
126,558,965 bp from pter
Size:
36,969 bases
Orientation:
Minus strand

Genomic View for C3orf22 Gene

Genes around C3orf22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf22 Gene

Proteins for C3orf22 Gene

  • Protein details for C3orf22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5N4-CC022_HUMAN
    Recommended name:
    Uncharacterized protein C3orf22
    Protein Accession:
    Q8N5N4
    Secondary Accessions:
    • B3KUS9

    Protein attributes for C3orf22 Gene

    Size:
    141 amino acids
    Molecular mass:
    15686 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C3orf22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf22 Gene

Post-translational modifications for C3orf22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C3orf22 Gene

No data available for DME Specific Peptides for C3orf22 Gene

Domains & Families for C3orf22 Gene

Protein Domains for C3orf22 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C3orf22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf22: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C3orf22 Gene

Function for C3orf22 Gene

genes like me logo Genes that share phenotypes with C3orf22: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C3orf22 Gene

Localization for C3orf22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf22 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C3orf22 Gene

Pathways & Interactions for C3orf22 Gene

SuperPathways for C3orf22 Gene

No Data Available

Interacting Proteins for C3orf22 Gene

Gene Ontology (GO) - Biological Process for C3orf22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C3orf22 Gene

Transcripts for C3orf22 Gene

mRNA/cDNA for C3orf22 Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C3orf22 Gene

Chromosome 3 open reading frame 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf22 Gene

No ASD Table

Relevant External Links for C3orf22 Gene

GeneLoc Exon Structure for
C3orf22
ECgene alternative splicing isoforms for
C3orf22

Expression for C3orf22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf22 Gene

mRNA differential expression in normal tissues according to GTEx for C3orf22 Gene

This gene is overexpressed in Testis (x50.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C3orf22 Gene



NURSA nuclear receptor signaling pathways regulating expression of C3orf22 Gene:

C3orf22

SOURCE GeneReport for Unigene cluster for C3orf22 Gene:

Hs.178210
genes like me logo Genes that share expression patterns with C3orf22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf22 Gene

Orthologs for C3orf22 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C3orf22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3orf22 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H3orf22 34
  • 77.06 (n)
C3orf22 35
  • 58 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3H3orf22 34 35
  • 72.78 (n)
mouse
(Mus musculus)
Mammalia BC048671 35
  • 46 (a)
OneToOne
Species where no ortholog for C3orf22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C3orf22 Gene

ENSEMBL:
Gene Tree for C3orf22 (if available)
TreeFam:
Gene Tree for C3orf22 (if available)

Paralogs for C3orf22 Gene

No data available for Paralogs for C3orf22 Gene

Variants for C3orf22 Gene

Sequence variations from dbSNP and Humsavar for C3orf22 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000045188 -- 126,545,734(+) CCACC(C/T)TTCCC intron-variant, downstream-variant-500B
rs1000072177 -- 126,532,101(+) CCCAT(G/T)TAAAA intron-variant
rs1000190774 -- 126,539,558(+) ACACT(-/GC)GCACA intron-variant
rs1000300113 -- 126,532,789(+) TGTCA(A/G)TTTTG intron-variant
rs1000316401 -- 126,550,122(+) CCCCT(A/G)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf22 Gene

Variant ID Type Subtype PubMed ID
esv2658491 CNV deletion 23128226
esv2725872 CNV deletion 23290073
nsv1111249 CNV tandem duplication 24896259
nsv829717 CNV loss 17160897

Variation tolerance for C3orf22 Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C3orf22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf22 Gene

Disorders for C3orf22 Gene

Relevant External Links for C3orf22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3orf22

No disorders were found for C3orf22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf22 Gene

Publications for C3orf22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64

Products for C3orf22 Gene

Sources for C3orf22 Gene

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