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Aliases for C3orf20 Gene

Aliases for C3orf20 Gene

  • Chromosome 3 Open Reading Frame 20 2 3 5

External Ids for C3orf20 Gene

Previous GeneCards Identifiers for C3orf20 Gene

  • GC03P014692

Summaries for C3orf20 Gene

GeneCards Summary for C3orf20 Gene

C3orf20 (Chromosome 3 Open Reading Frame 20) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf20 Gene

Genomics for C3orf20 Gene

Regulatory Elements for C3orf20 Gene

Enhancers for C3orf20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F014408 1.8 FANTOM5 Ensembl ENCODE 11.6 -261.4 -261415 8.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 FOS KLF13 SP3 ENSG00000230172 ENSG00000223398 HDAC11-AS1 SH3BP5-AS1 CAPN7 ENSG00000228242 C3orf20 SLC6A6 CCDC174 GC03P014418
GH03F015287 1.8 FANTOM5 Ensembl ENCODE 11.5 +618.4 618376 11.2 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 CBX5 ZNF207 FOS SH3BP5 EAF1 ENSG00000230172 RPS24P10 CAPN7 RNU6-454P C3orf20 COL6A4P1 RNU6-1024P EAF1-AS1
GH03F014724 0.9 Ensembl ENCODE 21.2 +51.7 51714 2.5 GATAD2A ZFHX2 ATF3 FOXA3 CEBPA ZNF16 ZNF24 NR2F2 EGR2 C3orf20 ENSG00000230172 CCDC174 ENSG00000235629 PIR53505 PIR51472
GH03F014438 1.6 FANTOM5 Ensembl ENCODE 11.6 -233.9 -233925 4.2 PKNOX1 ZNF493 FEZF1 ZNF2 ZNF121 GLIS2 KLF7 FOS ZNF263 REST SH3BP5-AS1 SLC6A6 ENSG00000228242 ENSG00000230172 ENSG00000223398 HDAC11-AS1 CAPN7 C3orf20 CCDC174 XPC
GH03F014450 1.6 FANTOM5 Ensembl ENCODE 11.6 -220.9 -220927 5.0 ARID4B SIN3A FEZF1 GLI4 ZNF48 ZNF121 GLIS2 KLF7 ZNF548 FOS SH3BP5-AS1 CAPN7 ENSG00000228242 SLC6A6 ENSG00000230172 HDAC11-AS1 ENSG00000223398 C3orf20 FGD5 TMEM43
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C3orf20 on UCSC Golden Path with GeneCards custom track

Genomic Location for C3orf20 Gene

Chromosome:
3
Start:
14,674,225 bp from pter
End:
14,773,036 bp from pter
Size:
98,812 bases
Orientation:
Plus strand

Genomic View for C3orf20 Gene

Genes around C3orf20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf20 Gene

Proteins for C3orf20 Gene

  • Protein details for C3orf20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND61-CC020_HUMAN
    Recommended name:
    Uncharacterized protein C3orf20
    Protein Accession:
    Q8ND61
    Secondary Accessions:
    • Q7L0U6
    • Q8NCP2
    • Q9H0I7

    Protein attributes for C3orf20 Gene

    Size:
    904 amino acids
    Molecular mass:
    101266 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C3orf20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf20 Gene

Post-translational modifications for C3orf20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C3orf20 Gene

Domains & Families for C3orf20 Gene

Protein Domains for C3orf20 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf20: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C3orf20 Gene

Function for C3orf20 Gene

Phenotypes for C3orf20 Gene

genes like me logo Genes that share phenotypes with C3orf20: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C3orf20 Gene

Localization for C3orf20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf20 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf20 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C3orf20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C3orf20: view

Pathways & Interactions for C3orf20 Gene

SuperPathways for C3orf20 Gene

No Data Available

Interacting Proteins for C3orf20 Gene

Selected Interacting proteins: Q8ND61-CC020_HUMAN for C3orf20 Gene via IID

Symbol External ID(s) Details
APP
BIRC6

Gene Ontology (GO) - Biological Process for C3orf20 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C3orf20 Gene

Transcripts for C3orf20 Gene

mRNA/cDNA for C3orf20 Gene

Unigene Clusters for C3orf20 Gene

Chromosome 3 open reading frame 20:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf20 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2: -
SP3:

Relevant External Links for C3orf20 Gene

GeneLoc Exon Structure for
C3orf20
ECgene alternative splicing isoforms for
C3orf20

Expression for C3orf20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C3orf20 Gene

mRNA differential expression in normal tissues according to GTEx for C3orf20 Gene

This gene is overexpressed in Testis (x35.2).

Protein differential expression in normal tissues from HIPED for C3orf20 Gene

This gene is overexpressed in Heart (23.2), Tlymphocyte (10.8), Fetal gut (10.0), Kidney (9.4), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C3orf20 Gene



NURSA nuclear receptor signaling pathways regulating expression of C3orf20 Gene:

C3orf20

SOURCE GeneReport for Unigene cluster for C3orf20 Gene:

Hs.661452
genes like me logo Genes that share expression patterns with C3orf20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C3orf20 Gene

Orthologs for C3orf20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf20 34
  • 99.26 (n)
C3orf20 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H3orf20 34
  • 79.57 (n)
C3orf20 35
  • 66 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C22H3orf20 34
  • 78.73 (n)
C3orf20 35
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560289 34
  • 74.43 (n)
mouse
(Mus musculus)
Mammalia 4930590J08Rik 34 16 35
  • 74.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia C3orf20 35
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3orf20 35
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
OneToOne
Species where no ortholog for C3orf20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C3orf20 Gene

ENSEMBL:
Gene Tree for C3orf20 (if available)
TreeFam:
Gene Tree for C3orf20 (if available)

Paralogs for C3orf20 Gene

No data available for Paralogs for C3orf20 Gene

Variants for C3orf20 Gene

Sequence variations from dbSNP and Humsavar for C3orf20 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10084704 -- 14,753,579(+) aaatt(C/T)ttttc intron-variant
rs10212315 -- 14,715,902(+) TGGCT(A/G)TTCAG intron-variant
rs10470604 -- 14,695,675(+) ctcca(G/T)tgttg intron-variant
rs10470639 -- 14,695,826(+) ttcca(C/T)tggca intron-variant
rs10579534 -- 14,715,995(+) AAAGC(-/AACT)AACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf20 Gene

Variant ID Type Subtype PubMed ID
esv2658697 CNV deletion 23128226
esv2667245 CNV deletion 23128226
esv2671265 CNV deletion 23128226
esv2724945 CNV deletion 23290073
esv2724959 CNV deletion 23290073
esv33420 CNV gain 17666407
esv3568627 CNV loss 25503493
esv3595373 CNV loss 21293372
esv3595374 CNV loss 21293372
esv3595375 CNV loss 21293372
nsv507082 OTHER sequence alteration 20534489
nsv508210 CNV deletion 20534489
nsv520162 CNV loss 19592680
nsv589777 CNV loss 21841781
nsv589778 CNV loss 21841781
nsv999144 CNV gain 25217958

Variation tolerance for C3orf20 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.88; 98.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C3orf20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf20 Gene

Disorders for C3orf20 Gene

Relevant External Links for C3orf20

Genetic Association Database (GAD)
C3orf20
Human Genome Epidemiology (HuGE) Navigator
C3orf20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3orf20

No disorders were found for C3orf20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf20 Gene

Publications for C3orf20 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64

Products for C3orf20 Gene

Sources for C3orf20 Gene

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