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Aliases for C3orf20 Gene

Aliases for C3orf20 Gene

  • Chromosome 3 Open Reading Frame 20 2 3 5

External Ids for C3orf20 Gene

Previous GeneCards Identifiers for C3orf20 Gene

  • GC03P014692

Summaries for C3orf20 Gene

GeneCards Summary for C3orf20 Gene

C3orf20 (Chromosome 3 Open Reading Frame 20) is a Protein Coding gene.

Additional gene information for C3orf20 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf20 Gene

Genomics for C3orf20 Gene

Regulatory Elements for C3orf20 Gene

Enhancers for C3orf20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H014438 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -233.8 -233777 3 PKNOX1 ATF1 ARNT ZNF493 FEZF1 ZNF2 TCF12 ZNF121 GLIS2 FOS XPC CCDC174 CAPN7 SLC6A6 NR2C2 ENSG00000230172 ENSG00000223398 HDAC11-AS1 SH3BP5-AS1 TMEM43
GH03H014450 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -220.9 -220927 4 FOXA2 ARNT ARID4B SIN3A FEZF1 GLI4 ZNF121 GLIS2 FOS KLF7 SH3BP5-AS1 CCDC174 SLC6A6 CAPN7 NR2C2 ENSG00000228242 XPC ENSG00000230172 HDAC11-AS1 ENSG00000223398
GH03H014401 1.8 FANTOM5 ENCODE dbSUPER 10.9 -270.0 -269980 5 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 SLC6A6 CCDC174 NR2C2 ENSG00000230172 HDAC11-AS1 ENSG00000223398 MRPS25 XPC SH3BP5-AS1 ENSG00000228242
GH03H014724 0.9 Ensembl ENCODE 21.3 +51.7 51714 2 GATAD2A FOXA2 FOXA3 NR2F2 FOXA1 ZFHX2 JUND ATF3 CEBPA HNF4A C3orf20 ENSG00000230172 CCDC174 ENSG00000235629 PIR53505 PIR51472
GH03H015323 1.6 Ensembl ENCODE dbSUPER 10.9 +654.5 654531 11 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZBTB7B YY1 ZNF143 FOS SP3 RBSN SH3BP5 ENSG00000230172 NR2C2 CCDC174 C3orf20 METTL6 RPS3AP53 GC03P015339 PIR49400
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C3orf20 on UCSC Golden Path with GeneCards custom track

Genomic Location for C3orf20 Gene

Chromosome:
3
Start:
14,674,225 bp from pter
End:
14,773,036 bp from pter
Size:
98,812 bases
Orientation:
Plus strand

Genomic View for C3orf20 Gene

Genes around C3orf20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf20 Gene

Proteins for C3orf20 Gene

  • Protein details for C3orf20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND61-CC020_HUMAN
    Recommended name:
    Uncharacterized protein C3orf20
    Protein Accession:
    Q8ND61
    Secondary Accessions:
    • Q7L0U6
    • Q8NCP2
    • Q9H0I7

    Protein attributes for C3orf20 Gene

    Size:
    904 amino acids
    Molecular mass:
    101266 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C3orf20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf20 Gene

Post-translational modifications for C3orf20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C3orf20 Gene

Domains & Families for C3orf20 Gene

Gene Families for C3orf20 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C3orf20 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf20: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C3orf20 Gene

Function for C3orf20 Gene

Phenotypes From GWAS Catalog for C3orf20 Gene

Phenotypes for C3orf20 Gene

genes like me logo Genes that share phenotypes with C3orf20: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C3orf20 Gene

Localization for C3orf20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf20 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C3orf20 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C3orf20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C3orf20: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C3orf20 Gene

Pathways & Interactions for C3orf20 Gene

SuperPathways for C3orf20 Gene

No Data Available

Interacting Proteins for C3orf20 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000253697%0d%0a9606.ENSP00000393596%0d%0a
Selected Interacting proteins: ENSP00000253697 Q8ND61-CC020_HUMAN for C3orf20 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C3orf20 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C3orf20 Gene

Drugs & Compounds for C3orf20 Gene

No Compound Related Data Available

Transcripts for C3orf20 Gene

mRNA/cDNA for C3orf20 Gene

Unigene Clusters for C3orf20 Gene

Chromosome 3 open reading frame 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf20 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2: -
SP3:

Relevant External Links for C3orf20 Gene

GeneLoc Exon Structure for
C3orf20
ECgene alternative splicing isoforms for
C3orf20

Expression for C3orf20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C3orf20 Gene

mRNA differential expression in normal tissues according to GTEx for C3orf20 Gene

This gene is overexpressed in Testis (x35.2).

Protein differential expression in normal tissues from HIPED for C3orf20 Gene

This gene is overexpressed in Heart (23.2), Tlymphocyte (10.8), Fetal gut (10.0), Kidney (9.4), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C3orf20 Gene



NURSA nuclear receptor signaling pathways regulating expression of C3orf20 Gene:

C3orf20

SOURCE GeneReport for Unigene cluster for C3orf20 Gene:

Hs.661452

Evidence on tissue expression from TISSUES for C3orf20 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with C3orf20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C3orf20 Gene

Orthologs for C3orf20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf20 33
  • 99.26 (n)
C3orf20 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H3orf20 33
  • 79.57 (n)
C3orf20 34
  • 66 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C22H3orf20 33
  • 78.73 (n)
C3orf20 34
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560289 33
  • 74.43 (n)
mouse
(Mus musculus)
Mammalia 4930590J08Rik 33 16 34
  • 74.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
OneToMany
-- 34
  • 38 (a)
OneToMany
-- 34
  • 36 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia C3orf20 34
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3orf20 34
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
OneToOne
Species where no ortholog for C3orf20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C3orf20 Gene

ENSEMBL:
Gene Tree for C3orf20 (if available)
TreeFam:
Gene Tree for C3orf20 (if available)

Paralogs for C3orf20 Gene

No data available for Paralogs for C3orf20 Gene

Variants for C3orf20 Gene

Sequence variations from dbSNP and Humsavar for C3orf20 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000017181 -- 14,692,785(+) GGGGT(A/G)TTACT intron-variant
rs1000040492 -- 14,729,757(+) GCCAG(C/G)CTGGT intron-variant
rs1000140173 -- 14,771,160(+) CCTCG(C/T)CCCTT intron-variant
rs1000170897 -- 14,719,131(+) TTTTT(-/G)TTTTT intron-variant
rs1000222197 -- 14,744,240(+) TTCAA(A/T)GTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C3orf20 Gene

Variant ID Type Subtype PubMed ID
esv2658697 CNV deletion 23128226
esv2667245 CNV deletion 23128226
esv2671265 CNV deletion 23128226
esv2724945 CNV deletion 23290073
esv2724959 CNV deletion 23290073
esv33420 CNV gain 17666407
esv3568627 CNV loss 25503493
esv3595373 CNV loss 21293372
esv3595374 CNV loss 21293372
esv3595375 CNV loss 21293372
nsv507082 OTHER sequence alteration 20534489
nsv508210 CNV deletion 20534489
nsv520162 CNV loss 19592680
nsv589777 CNV loss 21841781
nsv589778 CNV loss 21841781
nsv999144 CNV gain 25217958

Variation tolerance for C3orf20 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.88; 98.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf20 Gene

Human Gene Mutation Database (HGMD)
C3orf20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C3orf20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf20 Gene

Disorders for C3orf20 Gene

Relevant External Links for C3orf20

Genetic Association Database (GAD)
C3orf20
Human Genome Epidemiology (HuGE) Navigator
C3orf20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3orf20

No disorders were found for C3orf20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf20 Gene

Publications for C3orf20 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 60

Products for C3orf20 Gene

Sources for C3orf20 Gene

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