C3orf18 Gene
protein-coding GIFtS: 39
GCID: GC03M050571
|
|
chromosome 3 open reading frame 18
| |
Aliases
for C3orf18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 3 Open Reading Frame 181 2 | | G201 2 | | Uncharacterized Protein C3orf182 | | Protein G203 |
Export aliases for C3orf18 gene to outside databases |
Summaries
for C3orf18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C3orf18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C3orf18 gene promoter:
NF-1 AML1a FOXD1 AP-4 LCR-F1 PPAR-alpha POU2F1 COMP1 POU2F1a Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for C3orf18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C3orf18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.2 HGNC cytogenetic band: 3p21.3C3orf18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M050571: view genomic region
(about GC identifiers)
Start:
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50,595,456 bp from pter |
End:
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50,608,458 bp from pter |
Size:
|
13,003 bases |
Orientation:
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minus strand |
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Proteins
for C3orf18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC018_HUMAN, Q9UK00 (See
protein sequence)Recommended Name: Uncharacterized protein C3orf18 Size: 162 amino acids; 17468 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: C9JNP0Alternative splicing: 2 isoforms: Q9UK00-1 Q9UK00-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C3orf18: NX_Q9UK00
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UK00
C3orf18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001165211.1 NP_001165212.1 NP_001165214.2 NP_057294.2
ENSEMBL proteins: ENSP00000387606 ENSP00000349732 ENSP00000404913 ENSP00000414124 ENSP00000400599 ENSP00000399129
Human Recombinant Protein Products for C3orf18:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
C3orf18 for ontologies About GeneDecksing
C3orf18 Antibody Products:
Assay Products for C3orf18: |
Protein
Domains /
Families
for C3orf18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9UK00 |
Function
for C3orf18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf18 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf18 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): C3orf18 (NM_016210) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C3orf18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf18 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf18 |
|
Pathways & Interactions
for C3orf18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C3orf18
|
Drugs & Compounds
for C3orf18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C3orf18
Search CenterWatch for drugs/clinical trials and news about C3orf18 / CC018
|
Transcripts
for C3orf18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C3orf18 gene (4 alternative transcripts): NM_001171740.2 NM_001171741.2 NM_001171743.2 NM_016210.4 Unigene Cluster for C3orf18: Chromosome 3 open reading frame 18 Hs.517860 [show with all ESTs]Unigene Representative Sequence: NM_01621011 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000426034 ENST00000357203(uc010hlo.3 uc003dar.3 uc003das.3 uc011bdr.2 uc010hlp.3)
ENST00000449241(uc003dat.3) ENST00000441239 ENST00000430746 ENST00000485902
ENST00000486175 ENST00000464080 ENST00000422619 ENST00000484982 ENST00000491269
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf18 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf18 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): C3orf18 (NM_016210) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C3orf18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf18 |
Additional cDNA sequence: AF188706.1 AK124438.1 AK308074.1 AK309486.1 AK311093.1 AK313128.1 AL833938.1 BC034766.1 4 DOTS entries: DT.95264848 DT.314292 DT.100748424 DT.120896460 24/97 AceView cDNA sequences (see all 97): AI468295 AI632398 BU621021 BM508252 AF188706 AI573215 AI800060 BQ182296 BM702664 BU634375 BE550686 AI572834 AK124438 T31218 NM_016210 BI819497 BC034766 BX111687 AL833938 BQ959810 AI571325 BM974542 BM821057 BU783139
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C3orf18 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C3orf18
|
Expression
for C3orf18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C3orf18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAAGGTTC
About this image
See C3orf18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C3orf18
SOURCE GeneReport for Unigene cluster: Hs.517860
SABiosciences Custom PCR Arrays for C3orf18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C3orf18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C3orf18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C3orf18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C3orf18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf18 |
Orthologs
for C3orf18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C3orf18 gene from 5/11 species (see all 11) About this table
ENSEMBL Gene Tree for C3orf18 (if available)
TreeFam Gene Tree for C3orf18 (if available) |
Paralogs
for C3orf18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C3orf18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C3orf18 (50595456 - 50608458 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C3orf18: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C3orf18 |
|
Disorders
/ Diseases
for C3orf18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C3orf18 for disorders About GeneDecksing
1  disease for C3orf18: About MalaCardssaethre-chotzen syndrome
Human Genome Epidemiology (HuGE) Navigator: C3orf18 (1 document)
Export disorders for C3orf18 gene to outside databases
|
Publications
for C3orf18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C3orf18 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C3orf18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Host determinants of HIV-1 control in African America ns. (PubMed id 20205591)1 Pelak K....Weintrob A.C. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for C3orf18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C3orf18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C3orf18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C3orf18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C3orf18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C3orf18 gene:
Search GeneIP for patents involving C3orf18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C3orf18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C3orf18 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C3orf18 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C3orf18 | | | OriGene Protein Over-expression Lysate for C3orf18 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C3orf18 | | OriGene 3'-UTR Clone for C3orf18 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf18 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C3orf18 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C3orf18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C3orf18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C3orf18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C3orf18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C3orf18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C3orf18 |
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 |  |  |  | |
| | | | Search Tocris compounds for C3orf18 |
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 | | | C3orf18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf18 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for C3orf18 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3orf18 |
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