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Aliases for C3orf18 Gene

Aliases for C3orf18 Gene

  • Chromosome 3 Open Reading Frame 18 2 3 5
  • Uncharacterized Protein C3orf18 3
  • Protein G20 4
  • G20 3

External Ids for C3orf18 Gene

Summaries for C3orf18 Gene

GeneCards Summary for C3orf18 Gene

C3orf18 (Chromosome 3 Open Reading Frame 18) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf18 Gene

Genomics for C3orf18 Gene

Regulatory Elements for C3orf18 Gene

Enhancers for C3orf18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F050453 0.3 FANTOM5 29.6 +119.9 119927 0.2 ZNF263 ZMYND10 C3orf18 GNAI2 HYAL3 NAT6 LOC105377082 RNA5SP131
GH03F050598 1.6 VISTA FANTOM5 ENCODE 14.1 -32.5 -32485 15.0 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 TMEM115 HEMK1 C3orf18 SEMA3F-AS1 RAD54L2 DOCK3 MANF GMPPB AMIGO3 CISH
GH03F050614 0.5 ENCODE 12.3 -40.2 -40243 0.2 CTCF DNMT3B RAD21 POLR2A ZBTB48 ZNF143 SMC3 PRDM10 RCOR1 ZNF600 DOCK3 C3orf18 HEMK1 MANF CISH ENSG00000273356
GH03F050616 1.8 FANTOM5 Ensembl ENCODE 12.3 -51.2 -51198 18.4 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 FOS DOCK3 HEMK1 MAPKAPK3 C3orf18 RAD54L2 MANF GNAI2 LSMEM2 HYAL1 RASSF1
GH03F050652 1.1 Ensembl ENCODE 11.3 -78.9 -78899 0.6 CTCF FOXA3 HLF REST RAD21 ZKSCAN1 ZBTB48 ZKSCAN8 SMC3 ZNF24 MAPKAPK3 CISH C3orf18 HEMK1 LSMEM2 ENSG00000273356
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C3orf18 on UCSC Golden Path with GeneCards custom track

Genomic Location for C3orf18 Gene

Chromosome:
3
Start:
50,558,025 bp from pter
End:
50,574,002 bp from pter
Size:
15,978 bases
Orientation:
Minus strand

Genomic View for C3orf18 Gene

Genes around C3orf18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf18 Gene

Proteins for C3orf18 Gene

  • Protein details for C3orf18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK00-CC018_HUMAN
    Recommended name:
    Uncharacterized protein C3orf18
    Protein Accession:
    Q9UK00
    Secondary Accessions:
    • C9JNP0

    Protein attributes for C3orf18 Gene

    Size:
    162 amino acids
    Molecular mass:
    17468 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C3orf18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf18 Gene

Post-translational modifications for C3orf18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C3orf18 Gene

Domains & Families for C3orf18 Gene

Protein Domains for C3orf18 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C3orf18 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf18: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C3orf18 Gene

Function for C3orf18 Gene

genes like me logo Genes that share phenotypes with C3orf18: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf18 Gene

Localization for C3orf18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf18 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C3orf18 Gene COMPARTMENTS Subcellular localization image for C3orf18 gene
Compartment Confidence
cytosol 3
plasma membrane 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C3orf18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C3orf18: view

Pathways & Interactions for C3orf18 Gene

SuperPathways for C3orf18 Gene

No Data Available

Interacting Proteins for C3orf18 Gene

Selected Interacting proteins: Q9UK00-CC018_HUMAN for C3orf18 Gene via IID

Symbol External ID(s) Details
SLC46A1

Gene Ontology (GO) - Biological Process for C3orf18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C3orf18 Gene

Transcripts for C3orf18 Gene

Unigene Clusters for C3orf18 Gene

Chromosome 3 open reading frame 18:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf18 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - - -
SP2: - -
SP3: - - - -
SP4:
SP5:
SP6: - -
SP7: - - - - - - -

Relevant External Links for C3orf18 Gene

GeneLoc Exon Structure for
C3orf18
ECgene alternative splicing isoforms for
C3orf18

Expression for C3orf18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C3orf18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C3orf18 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C3orf18 Gene



Protein tissue co-expression partners for C3orf18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C3orf18 Gene:

C3orf18

SOURCE GeneReport for Unigene cluster for C3orf18 Gene:

Hs.517860
genes like me logo Genes that share expression patterns with C3orf18: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C3orf18 Gene

Orthologs for C3orf18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf18 34
  • 99.38 (n)
C3ORF18 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C22H3ORF18 35
  • 92 (a)
OneToOne
C22H3orf18 34
  • 89.92 (n)
dog
(Canis familiaris)
Mammalia C3orf18 35
  • 91 (a)
OneToOne
C20H3orf18 34
  • 89.3 (n)
mouse
(Mus musculus)
Mammalia 6430571L13Rik 34 16 35
  • 85.19 (n)
rat
(Rattus norvegicus)
Mammalia RGD1307461 34
  • 83.74 (n)
oppossum
(Monodelphis domestica)
Mammalia C3orf18 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf18 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves C12H3ORF18 34
  • 70.09 (n)
C3orf18 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3orf18 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732317 34
  • 68.09 (n)
zebrafish
(Danio rerio)
Actinopterygii C3orf18 (1 of 2) 35
  • 64 (a)
OneToMany
LOC101883833 34
  • 62.8 (n)
C6H3orf18 (2 of 2) 35
  • 47 (a)
OneToMany
Species where no ortholog for C3orf18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3orf18 Gene

ENSEMBL:
Gene Tree for C3orf18 (if available)
TreeFam:
Gene Tree for C3orf18 (if available)

Paralogs for C3orf18 Gene

(1) SIMAP similar genes for C3orf18 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with C3orf18: view

No data available for Paralogs for C3orf18 Gene

Variants for C3orf18 Gene

Sequence variations from dbSNP and Humsavar for C3orf18 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1034405 -- 50,559,661(-) CCATG(C/T)GTGAG reference, missense, utr-variant-5-prime
rs1034406 -- 50,570,372(-) CCTAT(A/T)ATCCA intron-variant
rs111230001 -- 50,560,110(+) AGGTT(C/T)TCAGT intron-variant
rs111256172 -- 50,561,026(+) CGAAG(C/T)TGTAC intron-variant, reference, missense, utr-variant-5-prime
rs111467011 -- 50,571,942(+) GGGGC(C/T)GGGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C3orf18 Gene

Variant ID Type Subtype PubMed ID
esv3584502 CNV gain 24956385
nsv460532 CNV loss 19166990
nsv460533 CNV loss 19166990
nsv590272 CNV loss 21841781
nsv590273 CNV loss 21841781

Variation tolerance for C3orf18 Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C3orf18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3orf18 Gene

Disorders for C3orf18 Gene

Relevant External Links for C3orf18

Human Genome Epidemiology (HuGE) Navigator
C3orf18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3orf18

No disorders were found for C3orf18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf18 Gene

Publications for C3orf18 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K. … . (J. Infect. Dis. 2010) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for C3orf18 Gene

Sources for C3orf18 Gene

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