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Aliases for C3orf17 Gene

Aliases for C3orf17 Gene

  • Chromosome 3 Open Reading Frame 17 2 3 5
  • NEPRO 3 4
  • Uncharacterized Protein C3orf17 3
  • NET17 3

External Ids for C3orf17 Gene

Previous GeneCards Identifiers for C3orf17 Gene

  • GC03M114207
  • GC03M112721
  • GC03M110104

Summaries for C3orf17 Gene

GeneCards Summary for C3orf17 Gene

C3orf17 (Chromosome 3 Open Reading Frame 17) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C3orf17 Gene

  • May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf17 Gene

Genomics for C3orf17 Gene

Regulatory Elements for C3orf17 Gene

Enhancers for C3orf17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C3orf17 on UCSC Golden Path with GeneCards custom track

Promoters for C3orf17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C3orf17 on UCSC Golden Path with GeneCards custom track

Genomic Location for C3orf17 Gene

Chromosome:
3
Start:
113,002,440 bp from pter
End:
113,019,861 bp from pter
Size:
17,422 bases
Orientation:
Minus strand

Genomic View for C3orf17 Gene

Genes around C3orf17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf17 Gene

Proteins for C3orf17 Gene

  • Protein details for C3orf17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NW34-NEPRO_HUMAN
    Recommended name:
    Protein nepro homolog
    Protein Accession:
    Q6NW34
    Secondary Accessions:
    • D3DN69
    • Q68DM6
    • Q9H7U0
    • Q9UFM4

    Protein attributes for C3orf17 Gene

    Size:
    567 amino acids
    Molecular mass:
    64552 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB55998.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for C3orf17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C3orf17 Gene

Proteomics data for C3orf17 Gene at MOPED

Post-translational modifications for C3orf17 Gene

  • Ubiquitination at Lys 257
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C3orf17 Gene

Domains & Families for C3orf17 Gene

Protein Domains for C3orf17 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6NW34

UniProtKB/Swiss-Prot:

NEPRO_HUMAN :
  • Belongs to the nepro family.
Family:
  • Belongs to the nepro family.
genes like me logo Genes that share domains with C3orf17: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C3orf17 Gene

Function for C3orf17 Gene

Molecular function for C3orf17 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.
genes like me logo Genes that share phenotypes with C3orf17: view

Animal Models for C3orf17 Gene

MGI Knock Outs for C3orf17:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C3orf17 Gene

Localization for C3orf17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3orf17 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C3orf17 Gene COMPARTMENTS Subcellular localization image for C3orf17 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for C3orf17 Gene

Pathways & Interactions for C3orf17 Gene

SuperPathways for C3orf17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C3orf17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045665 negative regulation of neuron differentiation ISS --
genes like me logo Genes that share ontologies with C3orf17: view

No data available for Pathways by source and SIGNOR curated interactions for C3orf17 Gene

Drugs & Compounds for C3orf17 Gene

No Compound Related Data Available

Transcripts for C3orf17 Gene

Unigene Clusters for C3orf17 Gene

Chromosome 3 open reading frame 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a ·
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - - - - - -
SP9:
SP10: - - - - - - - - - - - - - - - - - -
SP11: - -
SP12:
SP13: - - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - - - - - - - - - - - - - - - - -
SP16: - - - - - - -
SP17:

ExUns: 9b · 9c ^ 10a · 10b · 10c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for C3orf17 Gene

GeneLoc Exon Structure for
C3orf17
ECgene alternative splicing isoforms for
C3orf17

Expression for C3orf17 Gene

mRNA expression in normal human tissues for C3orf17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C3orf17 Gene

This gene is overexpressed in Lung (52.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C3orf17 Gene



SOURCE GeneReport for Unigene cluster for C3orf17 Gene Hs.591288

genes like me logo Genes that share expression patterns with C3orf17: view

Protein tissue co-expression partners for C3orf17 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C3orf17 Gene

Orthologs for C3orf17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1H3orf17 35
  • 86.83 (n)
  • 80.78 (a)
C3orf17 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C33H3orf17 35
  • 86.73 (n)
  • 81.25 (a)
C3orf17 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC027231 35
  • 76.26 (n)
  • 66.25 (a)
Nepro 16
BC027231 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf17 35
  • 99.47 (n)
  • 98.94 (a)
C3H3orf17 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1311458 35
  • 75.93 (n)
  • 65.84 (a)
oppossum
(Monodelphis domestica)
Mammalia C3orf17 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf17 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H3orf17 35
  • 53.93 (n)
  • 44.51 (a)
C3orf17 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3orf17 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c3orf17 35
  • 50.8 (n)
  • 39.39 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-22a1.3 35
  • 47.03 (n)
  • 35.47 (a)
C9H3orf17 36
  • 30 (a)
OneToOne
Species with no ortholog for C3orf17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3orf17 Gene

ENSEMBL:
Gene Tree for C3orf17 (if available)
TreeFam:
Gene Tree for C3orf17 (if available)

Paralogs for C3orf17 Gene

No data available for Paralogs for C3orf17 Gene

Variants for C3orf17 Gene

Sequence variations from dbSNP and Humsavar for C3orf17 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1110819 -- 113,007,199(-) GATGG(C/G)TCCTC intron-variant
rs2276769 -- 113,012,998(-) AATAA(C/T)GGGAA intron-variant
rs2291465 -- 113,013,993(-) ATTTG(A/G)AGGGC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2293559 -- 113,019,455(+) AGTCC(A/C)GGTAC intron-variant
rs2293560 -- 113,019,471(+) CCGCC(C/T)ACATG intron-variant

Variation tolerance for C3orf17 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.17; 87.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf17 Gene

HapMap Linkage Disequilibrium report
C3orf17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C3orf17 Gene

Disorders for C3orf17 Gene

Relevant External Links for C3orf17

Genetic Association Database (GAD)
C3orf17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C3orf17

No disorders were found for C3orf17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf17 Gene

Publications for C3orf17 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for C3orf17 Gene

Sources for C3orf17 Gene

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