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C3orf14 Gene

protein-coding   GIFtS: 38
GCID: GC03P062304          (predicted)

Chromosome 3 Open Reading Frame 14

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 3 Open Reading Frame 141 2
Uncharacterized Protein C3orf142

External Ids:    HGNC: 250241   Entrez Gene: 574152   Ensembl: ENSG000001144057   UniProtKB: Q9HBI53   

Export aliases for C3orf14 gene to outside databases

Previous GC identifer: GC03P062279


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C3orf14 Gene:
C3orf14 (chromosome 3 open reading frame 14) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C3orf14 gene promoter:
         C/EBPbeta   NRSF form 1   POU6F1 (c2)   STAT5A   POU3F2   NRSF form 2   HNF-1A   POU2F1a   FOXO4   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC3orf14 promoter sequence
   Search Chromatin IP Primers for C3orf14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C3orf14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.2   Ensembl cytogenetic band:  3p14.2   HGNC cytogenetic band: 3p14.2

C3orf14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C3orf14 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P062304:  view genomic region     (about GC identifiers)

Start:
62,304,648 bp from pter      End:
62,321,888 bp from pter
Size:
17,241 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CC014_HUMAN, Q9HBI5 (See protein sequence)
Recommended Name: Uncharacterized protein C3orf14  
Size: 128 amino acids; 15007 Da
Secondary accessions: B2R9U0

Explore the universe of human proteins at neXtProt for C3orf14: NX_Q9HBI5

Explore proteomics data for C3orf14 at MOPED


See C3orf14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_065736.1  
ENSEMBL proteins: 
 ENSP00000419977   ENSP00000232519   ENSP00000419937   ENSP00000418086   ENSP00000438275  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR028006 DUF4570

Graphical View of Domain Structure for InterPro Entry Q9HBI5

ProtoNet protein and cluster: Q9HBI5


Find genes that share domains with C3orf14           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for C3orf14

miRNA
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1 qRT-PCR Assays for microRNA that regulate C3orf14:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
extracellular1
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C3orf14
Interactions:

    Search GeneGlobe Interaction Network for C3orf14

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C3orf14 (CC014)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C3orf14 gene: 
NM_020685.3  

Unigene Cluster for C3orf14:

Chromosome 3 open reading frame 14
Hs.47166  [show with all ESTs]
Unigene Representative Sequence: BF246075
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000462069 ENST00000486169 ENST00000232519 ENST00000465142 ENST00000494481(uc003dlf.3 uc010hnq.3 uc003dlg.3)
ENST00000491323 ENST00000542214
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1 qRT-PCR Assays for microRNA that regulate C3orf14:
hsa-miR-3185
SwitchGear 3'UTR luciferase reporter plasmidC3orf14 3' UTR sequence
Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat C3orf14

Additional mRNA sequence: 

AF236158.1 AK310431.1 AK313915.1 BC017772.2 

7 DOTS entries:

DT.99983616  DT.120926414  DT.408428  DT.91711782  DT.95273479  DT.101968687  DT.91711787 

Selected AceView cDNA sequences (see all 92):

AI948907 BM699709 BQ632765 N44200 BU737529 N63604 CA941426 BM313142 
BM311522 NM_020685 CB069401 BQ632477 AF236158 AI093850 BU074692 BM264513 
AI348657 BC017772 BM068735 BM699794 CB528592 BM054764 BU074407 CK904650 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for C3orf14 (see all 7)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1:                    -     -                             -     -     -                           
SP2:                          -                             -     -     -                           
SP3:                    -     -                             -                                       
SP4:                    -     -     -                       -     -     -                           
SP5:                          -                                                                     


ECgene alternative splicing isoforms for C3orf14

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C3orf14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATTTGCTTT
C3orf14 Expression
About this image

C3orf14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C3orf14 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.47166
    Custom PCR Arrays for C3orf14
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3orf14

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for C3orf14 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 3830406C13Rik5
LOC1026321171
RIKEN cDNA 3830406C13 gene5
uncharacterized LOC1026321171
83.76(n)1
71.79(a)1
  14 (6.34 cM)5
1026321171  XM_006519748.11  XP_006519811.11 
 122842095 
chicken
(Gallus gallus)
Aves C12H3ORF141 chromosome 12 open reading frame, human C3orf14 68.14(n)
58.41(a)
  416073  XM_414410.4  XP_414410.1 
lizard
(Anolis carolinensis)
Reptilia C3orf146
chromosome 3 open reading frame 14
49(a)
1 ↔ 1
GL343210.1(3227354-3256326)
zebrafish
(Danio rerio)
Actinopterygii gb:bc1525041 expressed sequence BC152504 52.91(n)
46.79(a)
  100148013  XM_005155851.1  XP_005155908.1 


ENSEMBL Gene Tree for C3orf14 (if available)
TreeFam Gene Tree for C3orf14 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C3orf14 (see all 213)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1853388211,2
--62306635(+) TATTCA/GCTCTT 1 -- int10--------
rs1439661181,2
--62306696(+) CCAGAC/TGTTCT 1 -- int10--------
rs1486630671,2
--62306697(+) CAGACA/GTTCTT 1 -- int10--------
rs728781851,2
C--62306768(+) TAATTC/TCACCT 1 -- int11Minor allele frequency- T:0.50WA 2
rs1412842901,2
--62306914(+) TAAAAC/TAAGCA 1 -- int10--------
rs98603751,2
C,F,H--62306915(+) AAAATA/TAGCAT 1 -- int115Minor allele frequency- T:0.20NS EA WA CSA NA 1203
rs1161072221,2
F--62306926(+) TTGACC/AAGCAA 1 -- int11Minor allele frequency- A:0.02WA 118
rs1415219741,2
--62307288(+) TTCACC/TAAAAA 1 -- int10--------
rs1876262611,2
C--62307570(+) TTACTC/TTTTTA 1 -- int10--------
rs1393599171,2
C--62307592(+) TCTTCA/G/TTTTTT 1 -- int10--------

HapMap Linkage Disequilibrium report for C3orf14 (62304648 - 62321888 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for C3orf14: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing C3orf14
DNA2.0 Custom Variant and Variant Library Synthesis for C3orf14

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with C3orf14           About GenesLikeMe

Human Genome Epidemiology (HuGE) Navigator: C3orf14 (1 document)

Export disorders for C3orf14 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C3orf14 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C3orf14)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57415 HGNC: 25024 AceView: C3orf14 Ensembl:ENSG00000114405 euGenes: HUgn57415
ECgene: C3orf14 H-InvDB: C3orf14

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C3orf14 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C3orf14 gene:
Search GeneIP for patents involving C3orf14

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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