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Aliases for C3orf14 Gene

Aliases for C3orf14 Gene

  • Chromosome 3 Open Reading Frame 14 2 3 5
  • Uncharacterized Protein C3orf14 3
  • HT021 3

External Ids for C3orf14 Gene

Previous GeneCards Identifiers for C3orf14 Gene

  • GC03P062279

Summaries for C3orf14 Gene

GeneCards Summary for C3orf14 Gene

C3orf14 (Chromosome 3 Open Reading Frame 14) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3orf14 Gene

Genomics for C3orf14 Gene

Regulatory Elements for C3orf14 Gene

Enhancers for C3orf14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F062318 0.2 ENCODE 24.3 +0.2 163 1.8 CBX3 ZNF133 SIN3A ZBTB40 ZNF143 KLF7 ZNF263 SP3 ZHX2 MIER2 C3orf14 PTPRG-AS1
GH03F062600 1.1 FANTOM5 Ensembl ENCODE 10.4 +284.2 284202 6.2 SIN3A YBX1 RAD21 ZNF366 SCRT2 FOS USF2 CEBPB ZNF217 SREBF1 PTPRG-AS1 C3orf14 GC03P062556 GC03M062779
GH03F062260 0.3 FANTOM5 1.8 -58.5 -58471 0.0 ZNF133 GABPA C3orf14 PIR41274
GH03F062437 0.3 FANTOM5 1.7 +118.2 118224 0.3 ZSCAN29 CADPS FEZF2 C3orf14 GC03P062465 LOC105377647
GH03F062326 0.3 FANTOM5 0.4 +7.2 7207 0.1 ZNF217 GATA3 ZNF384 FOSL2 C3orf14 PTPRG-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C3orf14 on UCSC Golden Path with GeneCards custom track

Promoters for C3orf14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001365854 128 1799 CBX3 ZNF133 SIN3A ZBTB40 ZNF143 KLF7 ZNF263 SP3 ZHX2 MIER2

Genomic Location for C3orf14 Gene

62,318,973 bp from pter
62,336,213 bp from pter
17,241 bases
Plus strand

Genomic View for C3orf14 Gene

Genes around C3orf14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C3orf14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C3orf14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3orf14 Gene

Proteins for C3orf14 Gene

  • Protein details for C3orf14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C3orf14
    Protein Accession:
    Secondary Accessions:
    • B2R9U0

    Protein attributes for C3orf14 Gene

    128 amino acids
    Molecular mass:
    15007 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C3orf14 Gene

Post-translational modifications for C3orf14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C3orf14 Gene

Domains & Families for C3orf14 Gene

Protein Domains for C3orf14 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C3orf14: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C3orf14 Gene

Function for C3orf14 Gene

Phenotypes for C3orf14 Gene

genes like me logo Genes that share phenotypes with C3orf14: view

Animal Model Products

miRNA for C3orf14 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C3orf14 Gene

Localization for C3orf14 Gene

Subcellular locations from

Jensen Localization Image for C3orf14 Gene COMPARTMENTS Subcellular localization image for C3orf14 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C3orf14 Gene

Pathways & Interactions for C3orf14 Gene

SuperPathways for C3orf14 Gene

No Data Available

Interacting Proteins for C3orf14 Gene

Selected Interacting proteins: Q9HBI5-CC014_HUMAN for C3orf14 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C3orf14 Gene


No data available for Pathways by source and SIGNOR curated interactions for C3orf14 Gene

Transcripts for C3orf14 Gene

Unigene Clusters for C3orf14 Gene

Chromosome 3 open reading frame 14:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C3orf14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: -
SP7: - -

Relevant External Links for C3orf14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C3orf14 Gene

mRNA expression in normal human tissues for C3orf14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C3orf14 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C3orf14 Gene

NURSA nuclear receptor signaling pathways regulating expression of C3orf14 Gene:


SOURCE GeneReport for Unigene cluster for C3orf14 Gene:

genes like me logo Genes that share expression patterns with C3orf14: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C3orf14 Gene

Orthologs for C3orf14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3orf14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C3H3orf14 34
  • 100 (n)
C3orf14 35
  • 99 (a)
(Canis familiaris)
Mammalia C20H3orf14 34
  • 90.29 (n)
C3orf14 35
  • 83 (a)
(Mus musculus)
Mammalia LOC102632117 34
  • 83.76 (n)
3830406C13Rik 35
  • 69 (a)
Gm30274 16
(Bos Taurus)
Mammalia C22H3orf14 34
  • 82.81 (n)
C3orf14 35
  • 74 (a)
(Rattus norvegicus)
Mammalia RGD1306063 34
  • 80.8 (n)
(Ornithorhynchus anatinus)
Mammalia C3orf14 35
  • 55 (a)
(Monodelphis domestica)
Mammalia C3orf14 35
  • 36 (a)
(Gallus gallus)
Aves C12H3ORF14 34
  • 68.14 (n)
C3orf14 35
  • 50 (a)
(Anolis carolinensis)
Reptilia C3orf14 35
  • 49 (a)
(Danio rerio)
Actinopterygii gb:bc152504 34
  • 52.91 (n)
C11H3orf14 35
  • 37 (a)
Species where no ortholog for C3orf14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3orf14 Gene

Gene Tree for C3orf14 (if available)
Gene Tree for C3orf14 (if available)

Paralogs for C3orf14 Gene

No data available for Paralogs for C3orf14 Gene

Variants for C3orf14 Gene

Sequence variations from dbSNP and Humsavar for C3orf14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111289094 -- 62,321,904(+) TAACT(A/C)TATAT intron-variant
rs111399350 -- 62,319,717(+) CTCCC(A/C/T)TAGGG intron-variant, upstream-variant-2KB
rs111548709 -- 62,323,307(+) CATCT(C/T)TGAGA intron-variant
rs111753952 -- 62,319,719(+) CCCTT(A/C/T)GGGCA intron-variant, upstream-variant-2KB, splice-acceptor-variant
rs112145483 -- 62,333,613(+) AAACA(C/T)GAATA utr-variant-3-prime

Variation tolerance for C3orf14 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C3orf14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C3orf14 Gene

Disorders for C3orf14 Gene

Relevant External Links for C3orf14

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C3orf14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C3orf14 Gene

Publications for C3orf14 Gene

  1. DNA methylation in glioblastoma: impact on gene expression and clinical outcome. (PMID: 21156036) Etcheverry A. … Mosser J. (BMC Genomics 2010) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64

Products for C3orf14 Gene

Sources for C3orf14 Gene

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