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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C3AR1 Gene

protein-coding GIFtS: 62
GCID: GC12M008210

complement component 3a receptor 1

Explore 24 diseases affiliated with
C3AR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Complement Component 3a Receptor 1¹ ²		HNFAG09² ³
AZ3B¹ ² ³		C3a Anaphylatoxin Chemotactic Receptor²
C3AR¹ ² ³		Complement Component 3 Receptor 1²
C3a-R² ³		C3R1³

External Ids:	HGNC: 1319¹	Entrez Gene: 719²	Ensembl: ENSG00000171860⁷	OMIM: 605246⁵	UniProtKB: Q16581³

Export aliases for C3AR1 gene to outside databases

Previous GC identifers: GC12M007906 GC12M008358 GC12M008111 GC12M008102 GC12M008022

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: C3AR_HUMAN, Q16581

Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis,

granule enzyme release and superoxide anion production

Gene Wiki entry for C3AR1 (C3a receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C3AR1 gene promoter:
Bach1 Elk-1 AML1a Pbx1a Pax-2 Pax-2a AP-2gamma FOXO4 Cart-1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C3AR1 promoter sequence

Search SABiosciences Chromatin IP Primers for C3AR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C3AR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31

C3AR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C3AR1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M008210: view genomic region (about GC identifiers)

Start:	8,210,898 bp from pter	End:	8,219,067 bp from pter
Size:	8,170 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: C3AR_HUMAN, Q16581 (See protein sequence)

Recommended Name: C3a anaphylatoxin chemotactic receptor

Size: 482 amino acids; 53864 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: O43771 Q92868

Explore the universe of human proteins at neXtProt for C3AR1: NX_Q16581

Post-translational modifications:

Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin¹

O-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16581

C3AR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004045.1

ENSEMBL proteins:

ENSP00000302079 ENSP00000444500

Reactome Protein details: Q16581
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant C3AR1 Protein
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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8702752
GO:0016021	integral to membrane	--	--

C3AR1 for ontologies About GeneDecksing

C3AR1 Antibody Products:

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	Search for Antibodies for C3AR1 at Abcam
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	Search ThermoFisher Antibodies for C3AR1

Assay Products for C3AR1:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for C3AR1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C3AR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR002234 Anphylx_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR001644 C3A_anaphtx_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q16581

ProtoNet protein and cluster: Q16581

2 Blocks protein families:

IPB001644 C3A-anaphylatoxin receptor signature

IPB002234 Anaphylatoxin chemotactic receptor signature

UniProtKB/Swiss-Prot: C3AR_HUMAN, Q16581

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: C3AR_HUMAN, Q16581

Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis,

granule enzyme release and superoxide anion production

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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for C3AR1

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for C3AR1
		Search LifeMap BioReagents cell lines for C3AR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3AR1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001850	complement component C3a binding	--	--
GO:0004435	phosphatidylinositol phospholipase C activity	TAS	8765043
GO:0004876	complement component C3a receptor activity	TAS	8765043
GO:0004930	G-protein coupled receptor activity	IGI	10571060
GO:0004943	C3a anaphylatoxin receptor activity	IEA	--

C3AR1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for C3AR1:

Decreased viability of wild-ty

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for C3AR1: C3ar1^tm1Cge C3ar1^tm1Raw
11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for C3ar1):

adipose tissue	cellular	growth/size	hematopoietic system	homeostasis/metabolism
immune system	liver/biliary system	mortality/aging	nervous system	respiratory system
skeleton

C3AR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61	Neuroactive ligand-receptor interaction	0.38

Immune response_Alternative complement pathway

	Immune response_Alternative complement pathway	1.00			Immune response_Lectin induced complement pathway	0.56
	Immune response Alternative complement pathway	1.00			Immune response Lectin Induced complement pathway	0.56

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Immune response_Classical complement pathway

Immune response_Classical complement pathway

1.00

Immune response Classic complement pathway

0.98

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for C3AR1

	Immune response Alternative complement pathway
	Immune response Classic complement pathway
	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
	Immune response Lectin Induced complement pathway

1 R&D Systems Pathway for C3AR1

A-beta Uptake & Degradation

3 GeneGo (Thomson Reuters) Pathways for C3AR1

	Immune response Alternative complement pathway
	Immune response Classical complement pathway
	Immune response Lectin induced complement pathway

3 BioSystems Pathways for C3AR1

	Complement and Coagulation Cascades
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs

5/7 Reactome Pathways for C3AR1 (see all 7)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events

3 Kegg Pathways (Kegg details for C3AR1):

	Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Staphylococcus aureus infection

C3AR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for C3AR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/151 Interacting proteins for C3AR1 (Q16581³ ENSP00000302079⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 151)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C3	P01024³, ENSP00000245907⁴	I2D: score=1 STRING: ENSP00000245907
C4A	P0C0L4³, ENSP00000396688⁴	I2D: score=1 STRING: ENSP00000396688
SNTA1	Q13424³	I2D: score=1
ADORA3	ENSP00000358730⁴	STRING: ENSP00000358730
AGTR2	ENSP00000360973⁴	STRING: ENSP00000360973

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002430	complement receptor mediated signaling pathway	--	--
GO:0002462	tolerance induction to nonself antigen	--	--
GO:0006935	chemotaxis	IEA	--
GO:0006954	inflammatory response	TAS	8765043
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8898085

C3AR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

C3AR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C3AR1
7 Novoseek chemical compound relationships for C3AR1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
anaphylatoxin	97.1	29	8765043 (3), 8702752 (1), 9164946 (1), 10358194 (1) (see all 26)
calcium	26.8	6	8702752 (1), 9164946 (1), 8955209 (1), 12670702 (1) (see all 5)
fmlp	23.7	2	10358194 (2)
threonine	0	5	10508278 (1), 12672058 (1)
tyrosine	0	2	10508278 (1), 15153516 (1)
histamine	0	1	9694514 (1)
serine	0	5	10508278 (1), 12672058 (1)

Search CenterWatch for drugs/clinical trials and news about C3AR1 / C3AR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C3AR1 gene:

NM_004054.2

Unigene Cluster for C3AR1:

Complement component 3a receptor 1

Hs.591148 [show with all ESTs]

Unigene Representative Sequence: U62027

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000307637(uc001qtv.1) ENST00000546241

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Additional cDNA sequence:

AK223388.1 AK290242.1 AK312458.1 BC020742.1 U28488.1 U62027.1 Z73157.1

3 DOTS entries:

DT.114099 DT.100783745 DT.95265305

24/103 AceView cDNA sequences (see all 103):

BX381444 AA039537 NM_004054 CA307734 AI032041 CR590169 AL513912 BX396411

Z73157 CA419088 CR601349 CR623914 CR591233 AU138812 AA683528 BP344756

AA464711 BP343952 BX395616 BM804784 BC020742 BI821479 BP345808 CR609272

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for C3AR1 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c
SP1:							-
SP2:							-
SP3:

ECgene alternative splicing isoforms for C3AR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C3AR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGCATTGC

About this image

C3AR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C3AR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C3AR1

SOURCE GeneReport for Unigene cluster: Hs.591148

UniProtKB/Swiss-Prot: C3AR_HUMAN, Q16581

Tissue specificity: Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary,

placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including C3AR1:

G Protein Coupled Receptors 384HT in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C3AR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3AR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C3AR1 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	C3AR1¹	complement component 3a receptor 1	56.03(n) 48.36(a)		418198 NM_001030769.1 NP_001025940.1
lizard (Anolis carolinensis)	Reptilia	C3AR1⁶ -- (see all 3)	--	38(a) 29(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	GL343236.1(1218277-1219680) GL343604.1(277-1212)
zebrafish (Danio rerio)	Actinopterygii	c3ar1¹	C3a anaphylatoxin chemotactic receptor	51.8(n) 42.23(a)		794255 XM_001334155.3 XP_001334191.3

ENSEMBL Gene Tree for C3AR1 (if available)
TreeFam Gene Tree for C3AR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for C3AR1 gene

LTB4R² LTB4R2² FPR3² FPR1² C5AR1² GPR32² GPR152² FPR2²

C5AR2² PTGDR2² GPR1² CMKLR1²

10 SIMAP similar genes for C3AR1 using alignment to 3 protein entries: C3AR_HUMAN (see all proteins):

GPR1 CMKLR1 CXCR2 GPR18 SSTR5 F2RL1

CCR5 LTB4R CCR7 LTB4R2

C3AR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147475827^1,2		--	8210589(+)	`AACAGA/TACTCC`	1	--	int¹		0	--	--	--	--
rs2072449^1,2	C,F,O,A,H,	--	8210637(-)	`TATTGC/TGTGAA`	1	--	int¹		37		EA NS NA WA CSA	4481
rs139994972^1,2		--	8210692(+)	`AAATTG/TCTATA`	1	--	int¹		0	--	--	--	--
rs2072448^1,2	C,F,A,H,	--	8210697(-)	`CAGGAT/CATAGA`	1	--	int¹		33		EA NS NA WA CSA	3411
rs187576256^1,2		--	8210813(+)	`TTCGTA/TTAAAA`	1	--	int¹		0	--	--	--	--
rs191685777^1,2		--	8210834(+)	`CACACA/GACAAC`	1	--	int¹		0	--	--	--	--
rs75203635^1,2		--	8210953(+)	`AATATC/TGACAA`	1	--	ut3¹		1		EA	120
rs3301^1,2	C,H,	--	8210954(+)	`ATATCG/AACAAA`	1	--	ut3¹ ese³		5		MN EA NS NA	484
rs182592074^1,2		--	8210969(+)	`CAACAC/TCATTT`	1	--	ut3¹		0	--	--	--	--
rs188396612^1,2		--	8211088(+)	`TAAGTC/GCCCTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C3AR1 (8210898 - 8219067 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for C3AR1
2 CNVs: 3873 34469
Human Gene Mutation Database (HGMD): C3AR1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C3AR1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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C3AR1 for disorders           About GeneDecksing

OMIM gene information: 605246    OMIM disorders: --

20/24 diseases for C3AR1 (see all 24):    About MalaCards

non-hodgkin lymphoma lupus nephritis chronic obstructive pulmonary disease bacterial meningitis

allergic rhinitis hodgkin's lymphoma bronchial asthma nephritis

multiple sclerosis skin disease rhinitis encephalitis

meningitis pulmonary disease asthma encephalomyelitis

pneumonia choroiditis astrocytoma ischemia

10/11 Novoseek disease relationships for C3AR1 gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia basophilic	56.9	3	10508278 (1), 11564766 (1), 11342658 (1)
inflammation	38.7	6	16253992 (1), 9221749 (1), 11412308 (1), 17498719 (1) (see all 6)
lupus nephritis	26.5	3	16034139 (2), 17472841 (1)
multiple sclerosis	21.6	2	9531317 (2)
skin diseases	16.1	4	11086104 (1)
encephalitis	11.5	1	10340761 (1)
asthma	0	3	15940127 (1), 15758041 (1), 11160252 (1)
necrosis	0	3	10349852 (1), 17472841 (1), 15056381 (1)
pneumonia	0	1	11160252 (1)
renal disease	0	4	17472841 (3), 16034139 (1)

Genetic Association Database (GAD): C3AR1
Human Genome Epidemiology (HuGE) Navigator: C3AR1 (4 documents)

Export disorders for C3AR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for C3AR1 gene, integrated from 9 sources (see all 108):
(articles sorted by number of sources associating them with C3AR1)

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cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure. (PubMed id 8605247)^{1, 2, 3} Roglic A.... Ye R.D. (1996)
Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. (PubMed id 8765043)^{1, 2, 9} Crass T....Bautsch W. (1996)
Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. (PubMed id 12871936)^{1, 2, 9} Gao J.... Gerard N.P. (2003)
Molecular cloning and characterization of the human anaphylatoxin C3a receptor. (PubMed id 8702752)^{1, 2, 9} Ames R.S.... Kumar C. (1996)
Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. (PubMed id 15278436)^{1, 4, 9} Hasegawa K....Suzuki Y. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
High levels of complement C3a receptor in the glomeruli in lupus nephritis. (PubMed id 17472841)^{1, 9} Mizuno M....Matsuo S. (2007)
Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a. (PubMed id 10358194)^{1, 9} Settmacher B....Klos A. (1999)
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. (PubMed id 11342658)^{1, 9} Ames R.S....Sarau H.M. (2001)
Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells. (PubMed id 10340761)^{1, 9} Davoust N....Barnum S.R. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 719	HGNC: 1319	AceView: C3AR1	Ensembl:ENSG00000171860	euGenes: HUgn719
ECgene: C3AR1	Kegg: 719	H-InvDB: C3AR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C3AR1	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/c3ar1/

Intellectual Property for C3AR1 gene
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Patent Information for C3AR1 gene:
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complement component 3a receptor 1

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complement component 3a receptor 1

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