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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C3AR1 Gene

protein-coding   GIFtS: 64
GCID: GC12M008210

Complement Component 3a Receptor 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Complement Component 3a Receptor 11 2     HNFAG092 3
AZ3B2 3     C3a Anaphylatoxin Chemotactic Receptor2
C3AR2 3     Complement Component 3 Receptor 12
C3a-R2 3     C3R13

External Ids:    HGNC: 13191   Entrez Gene: 7192   Ensembl: ENSG000001718607   OMIM: 6052465   UniProtKB: Q165813   

Export aliases for C3AR1 gene to outside databases

Previous GC identifers: GC12M007906 GC12M008358 GC12M008111 GC12M008102 GC12M008022


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C3AR1 Gene: 
C3AR1 (complement component 3a receptor 1) is a protein-coding gene. Diseases associated with C3AR1 include lupus nephritis, and bacterial meningitis, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Immune response Lectin induced complement pathway. GO annotations related to this gene include complement component C3a receptor activity and G-protein coupled receptor activity. An important paralog of this gene is LTB4R.

UniProtKB/Swiss-Prot: C3AR_HUMAN, Q16581
Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates
chemotaxis, granule enzyme release and superoxide anion production

Gene Wiki entry for C3AR1 (C3a receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C3AR1 gene promoter:
         Bach1   Elk-1   AML1a   Pbx1a   Pax-2   Pax-2a   AP-2gamma   FOXO4   Cart-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC3AR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for C3AR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C3AR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

C3AR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C3AR1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M008210:  view genomic region     (about GC identifiers)

Start:
8,210,898 bp from pter      End:
8,219,067 bp from pter
Size:
8,170 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: C3AR_HUMAN, Q16581 (See protein sequence)
Recommended Name: C3a anaphylatoxin chemotactic receptor  
Size: 482 amino acids; 53864 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: O43771 Q92868

Explore the universe of human proteins at neXtProt for C3AR1: NX_Q16581

Explore proteomics data for C3AR1 at MOPED 

Post-translational modifications:

  • UniProtKB: Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin
  • UniProtKB: O-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16581

  • C3AR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C3AR1 Protein Expression
    REFSEQ proteins: NP_004045.1  
    ENSEMBL proteins: 
     ENSP00000302079   ENSP00000444500  
    Reactome Protein details: Q16581
    Human Recombinant Protein Products for C3AR1: 
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    Novus Biologicals C3AR1 Proteins
    Novus Biologicals C3AR1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8702752
    GO:0016021integral to membrane ----

    C3AR1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CNAR: GPCR / Class A : Complement component receptors
    complement: Complement system

    IUPHAR Guide to PHARMACOLOGY protein family classification: C3a receptor 
    Complement peptide receptors

    5 InterPro protein domains:
     IPR002234 Anphylx_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000826 Formyl_pep_rcpt
     IPR001644 C3A_anaphtx_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q16581

    ProtoNet protein and cluster: Q16581

    2 Blocks protein domains:
    IPB001644 C3A-anaphylatoxin receptor signature
    IPB002234 Anaphylatoxin chemotactic receptor signature


    UniProtKB/Swiss-Prot: C3AR_HUMAN, Q16581
    Similarity: Belongs to the G-protein coupled receptor 1 family


    C3AR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C3AR_HUMAN, Q16581
    Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates
    chemotaxis, granule enzyme release and superoxide anion production

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity TAS8765043
    GO:0004876complement component C3a receptor activity TAS8765043
    GO:0004930G-protein coupled receptor activity IGI10571060
    GO:0004943C3a anaphylatoxin receptor activity IEA--
    GO:0004982N-formyl peptide receptor activity IEA--
         
    C3AR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for C3AR1:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for C3ar1):
     adipose tissue  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  nervous system  respiratory system 
     skeleton 

    C3AR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for C3AR1: C3ar1tm1Cge C3ar1tm1Raw

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for C3AR1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.37
    2Immune response Lectin induced complement pathway
    Immune response Lectin induced complement pathway0.56
    Immune response Classic complement pathway0.53
    Immune response Alternative complement pathway0.56
    Immune response Classical complement pathway0.52
    Immune response Lectin Induced complement pathway0.56
    3Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for C3AR1
        Immune response Alternative complement pathway
    Immune response Classic complement pathway
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Immune response Lectin Induced complement pathway

    1 R&D Systems Pathway for C3AR1
        A-beta Uptake & Degradation


    3 GeneGo (Thomson Reuters) Pathways for C3AR1
        Immune response Alternative complement pathway
    Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    3 BioSystems Pathways for C3AR1
        GPCRs, Class A Rhodopsin-like
    Complement and Coagulation Cascades
    Peptide GPCRs


    5/7        Reactome Pathways for C3AR1 (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events


    3         Kegg Pathways  (Kegg details for C3AR1):
        Neuroactive ligand-receptor interaction
    Complement and coagulation cascades
    Staphylococcus aureus infection


    C3AR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for C3AR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/153 Interacting proteins for C3AR1 (Q165813 ENSP000003020794) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C4AP0C0L43, ENSP000003966884I2D: score=1 STRING: ENSP00000396688
    ENSG00000206340P0C0L43I2D: score=1 
    ENSG00000227746P0C0L43I2D: score=1 
    C3P010243, ENSP000002459074I2D: score=1 STRING: ENSP00000245907
    SNTA1Q134243I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response TAS8765043
    GO:0007186G-protein coupled receptor signaling pathway TAS8898085
    GO:0007204elevation of cytosolic calcium ion concentration IGI10571060
    GO:0008015blood circulation TAS8765043

    C3AR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    C3AR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C3AR1 (C3AR)

    8 IUPHAR Ligands for C3AR1 (C3a receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    E7
    AgonistFull agonist8.79476119
    [125I]C3a (human)
    AgonistFull agonist8.410092660
    SB290157
    AntagonistAntagonist7.611342658
    C3a
    AgonistFull agonist7.320527893
    YSFKPMPLaR
    AgonistFull agonist6.720527893
    FLTChaAR
    AntagonistAntagonist6.620527893
    FLPLAR
    AgonistFull agonist6.420527893
    WWGKKYRASKLGLAR
    AgonistFull agonist5.920527893

    7 Novoseek inferred chemical compound relationships for C3AR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anaphylatoxin 97.1 29 8765043 (3), 8702752 (1), 9164946 (1), 10358194 (1) (see all 26)
    calcium 26.8 6 8702752 (1), 9164946 (1), 8955209 (1), 12670702 (1) (see all 5)
    fmlp 23.7 2 10358194 (2)
    threonine 0 5 10508278 (1), 12672058 (1)
    tyrosine 0 2 10508278 (1), 15153516 (1)
    histamine 0 1 9694514 (1)
    serine 0 5 10508278 (1), 12672058 (1)

    Search CenterWatch for drugs/clinical trials and news about C3AR1 / C3AR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C3AR1 gene: 
    NM_004054.2  

    Unigene Cluster for C3AR1:

    Complement component 3a receptor 1
    Hs.591148  [show with all ESTs]
    Unigene Representative Sequence: U62027
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307637(uc001qtv.1) ENST00000546241
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK223388.1 AK290242.1 AK312458.1 BC020742.1 U28488.1 U62027.1 Z73157.1 

    3 DOTS entries:

    DT.114099  DT.100783745  DT.95265305 

    24/103 AceView cDNA sequences (see all 103):

    AA683528 BP345808 AL513912 BX396411 NM_004054 CR591233 BX337391 AA464711 
    BX395616 AA039537 CA419088 BI821479 BM804784 BX355871 CR590169 Z73157 
    CA307734 AI032041 CR623914 AU138812 CR609272 CR601349 BX381444 BP343952 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for C3AR1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c
    SP1:                    -                     
    SP2:                    -                     
    SP3:                                          


    ECgene alternative splicing isoforms for C3AR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C3AR1 expression in normal human tissues (normalized intensities)      C3AR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGCATTGC
    C3AR1 Expression
    About this image


    C3AR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
             monocytes   
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Adipose (Muscoskeletal System)
             epididymal fat pads   
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros

    See C3AR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C3AR1

    SOURCE GeneReport for Unigene cluster: Hs.591148

    UniProtKB/Swiss-Prot: C3AR_HUMAN, Q16581
    Tissue specificity: Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen,
    ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in
    lymphoid tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including C3AR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3AR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C3AR1 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C3ar11 , 5 complement component 3a receptor 11, 5 76.05(n)1
    66.31(a)1
      6 (57.93 cM)5
    122671  NM_009779.21  NP_033909.11 
     1228471385 
    chicken
    (Gallus gallus)
    Aves C3AR11 complement component 3a receptor 1 56.03(n)
    48.36(a)
      418198  NM_001030769.1  NP_001025940.1 
    lizard
    (Anolis carolinensis)
    Reptilia C3AR16
    Uncharacterized protein
    38(a)
    1 ↔ 1
    GL343236.1(1218277-1219686)
    zebrafish
    (Danio rerio)
    Actinopterygii c3ar11 C3a anaphylatoxin chemotactic receptor 51.8(n)
    42.23(a)
      794255  XM_001334155.3  XP_001334191.3 


    ENSEMBL Gene Tree for C3AR1 (if available)
    TreeFam Gene Tree for C3AR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C3AR1 gene
    LTB4R2  LTB4R22  GPR332  FPR32  FPR12  C5AR12  GPR322  GPR1522  
    FPR22  C5AR22  PTGDR22  GPR12  CMKLR12  
    12 SIMAP similar genes for C3AR1 using alignment to 3 protein entries:     C3AR_HUMAN (see all proteins):
    FPR1    GPR1    FPR2    CMKLR1    CXCR2    GPR18
    SSTR5    F2RL1    CCR5    LTB4R    CCR7    LTB4R2

    C3AR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/242 SNPs in C3AR1 are shown (see all 242)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474758271,2
    --8210589(+) AACAGA/TACTCC 1 -- int10--------
    rs20724491,2
    C,F,O,A,H--8210637(-) TATTGC/TGTGAA 1 -- int137Minor allele frequency- N:0.00EA NS NA WA CSA 4481
    rs1399949721,2
    --8210692(+) AAATTG/TCTATA 1 -- int10--------
    rs20724481,2
    C,F,A,H--8210697(-) CAGGAT/CATAGA 1 -- int133Minor allele frequency- C:0.38EA NS NA WA CSA 3411
    rs1875762561,2
    --8210813(+) TTCGTA/TTAAAA 1 -- int10--------
    rs1916857771,2
    C--8210834(+) CACACA/GACAAC 1 -- int10--------
    rs752036351,2
    C,F--8210953(+) AATATC/TGACAA 1 -- ut311Minor allele frequency- T:0.01EA 120
    rs33011,2
    C,F,H--8210954(+) ATATCG/AACAAA 1 -- ut31 ese35Minor allele frequency- A:0.00MN EA NS NA 484
    rs1825920741,2
    --8210969(+) CAACAC/TCATTT 1 -- ut310--------
    rs1883966121,2
    --8211088(+) TAAGTC/GCCCTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for C3AR1 (8210898 - 8219067 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for C3AR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428270CNV Gain18775914
    dgv455e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): C3AR1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing C3AR1
    DNA2.0 Custom Variant and Variant Library Synthesis for C3AR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605246    OMIM disorders: --

    20/22 diseases for C3AR1 (see all 22):    About MalaCards
    lupus nephritis    bacterial meningitis    nephritis    skin disease
    meningitis    chronic obstructive pulmonary disease    encephalitis    allergic rhinitis
    rhinitis    choroiditis    multiple sclerosis    encephalomyelitis
    non-hodgkin lymphoma    hodgkin's lymphoma    asthma    hypoxia
    astrocytoma    ischemia    endotheliitis    cervicitis


    C3AR1 for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for C3AR1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia basophilic 56.9 3 10508278 (1), 11564766 (1), 11342658 (1)
    inflammation 38.7 6 16253992 (1), 9221749 (1), 11412308 (1), 17498719 (1) (see all 6)
    lupus nephritis 26.5 3 16034139 (2), 17472841 (1)
    multiple sclerosis 21.6 2 9531317 (2)
    skin diseases 16.1 4 11086104 (1)
    encephalitis 11.5 1 10340761 (1)
    asthma 0 3 15940127 (1), 15758041 (1), 11160252 (1)
    necrosis 0 3 10349852 (1), 17472841 (1), 15056381 (1)
    pneumonia 0 1 11160252 (1)
    renal disease 0 4 17472841 (3), 16034139 (1)

    Genetic Association Database (GAD): C3AR1
    Human Genome Epidemiology (HuGE) Navigator: C3AR1 (4 documents)

    Export disorders for C3AR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C3AR1 gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with C3AR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure. (PubMed id 8605247)1, 2, 3 Roglic A.... Ye R.D. (1996)
    2. Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. (PubMed id 8765043)1, 2, 9 Crass T....Bautsch W. (1996)
    3. Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. (PubMed id 12871936)1, 2, 9 Gao J.... Gerard N.P. (2003)
    4. Molecular cloning and characterization of the human anaphylatoxin C3a receptor. (PubMed id 8702752)1, 2, 9 Ames R.S.... Kumar C. (1996)
    5. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. (PubMed id 15278436)1, 4, 9 Hasegawa K....Suzuki Y. (2004)
    6. Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells. (PubMed id 20484595)1, 4 Skeie J.M....Mullins R.F. (2010)
    7. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (2009)
    8. Analyses of associations with asthma in four asthma population samples from Canada and Australia. (PubMed id 19247692)1, 4 Daley D....Hudson T.J. (2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. High levels of complement C3a receptor in the glomeruli in lupus nephritis. (PubMed id 17472841)1, 9 Mizuno M....Matsuo S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 719 HGNC: 1319 AceView: C3AR1 Ensembl:ENSG00000171860 euGenes: HUgn719
    ECgene: C3AR1 Kegg: 719 H-InvDB: C3AR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C3AR1 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/c3ar1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C3AR1 gene:
    Search GeneIP for patents involving C3AR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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