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Aliases for C3AR1 Gene

Aliases for C3AR1 Gene

  • Complement Component 3a Receptor 1 2 3
  • HNFAG09 3 4
  • C3a-R 3 4
  • AZ3B 3 4
  • C3AR 3 4
  • C3a Anaphylatoxin Chemotactic Receptor 3
  • Complement Component 3 Receptor 1 3
  • C3R1 4

External Ids for C3AR1 Gene

Previous GeneCards Identifiers for C3AR1 Gene

  • GC12M007906
  • GC12M008358
  • GC12M008111
  • GC12M008102
  • GC12M008210

Summaries for C3AR1 Gene

GeneCards Summary for C3AR1 Gene

C3AR1 (Complement Component 3a Receptor 1) is a Protein Coding gene. Diseases associated with C3AR1 include lupus nephritis and bacterial meningitis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for C3AR1 Gene

  • Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production

Gene Wiki entry for C3AR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C3AR1 Gene

Genomics for C3AR1 Gene

Regulatory Elements for C3AR1 Gene

Genomic Location for C3AR1 Gene

Start:
8,058,302 bp from pter
End:
8,066,471 bp from pter
Size:
8,170 bases
Orientation:
Minus strand

Genomic View for C3AR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C3AR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C3AR1 Gene

Proteins for C3AR1 Gene

  • Protein details for C3AR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16581-C3AR_HUMAN
    Recommended name:
    C3a anaphylatoxin chemotactic receptor
    Protein Accession:
    Q16581
    Secondary Accessions:
    • O43771
    • Q92868

    Protein attributes for C3AR1 Gene

    Size:
    482 amino acids
    Molecular mass:
    53864 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C3AR1 Gene

Proteomics data for C3AR1 Gene at MOPED

Post-translational modifications for C3AR1 Gene

Other Protein References for C3AR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for C3AR1 Gene

Domains for C3AR1 Gene

Gene Families for C3AR1 Gene

HGNC:
  • CNAR :GPCR / Class A : Complement component receptors
  • complement :Complement system
IUPHAR :

Suggested Antigen Peptide Sequences for C3AR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16581

UniProtKB/Swiss-Prot:

C3AR_HUMAN :
  • Q16581
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with C3AR1: view

Function for C3AR1 Gene

Molecular function for C3AR1 Gene

UniProtKB/Swiss-Prot Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production

Gene Ontology (GO) - Molecular Function for C3AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 8765043
GO:0004876 complement component C3a receptor activity TAS 8765043
GO:0004930 G-protein coupled receptor activity IGI 10571060
GO:0004943 C3a anaphylatoxin receptor activity IEA --
genes like me logo Genes that share ontologies with C3AR1: view
genes like me logo Genes that share phenotypes with C3AR1: view

Animal Models for C3AR1 Gene

MGI Knock Outs for C3AR1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for C3AR1 Gene

Localization for C3AR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C3AR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C3AR1 Gene COMPARTMENTS Subcellular localization image for C3AR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for C3AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8702752
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with C3AR1: view

Pathways for C3AR1 Gene

genes like me logo Genes that share pathways with C3AR1: view

Gene Ontology (GO) - Biological Process for C3AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002430 complement receptor mediated signaling pathway TAS 8765043
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response TAS 8765043
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IGI 10571060
genes like me logo Genes that share ontologies with C3AR1: view

Compounds for C3AR1 Gene

(8) IUPHAR Ligand for C3AR1 Gene

Ligand Type Action Affinity Pubmed IDs
E7 Agonist Full agonist 8.7
[125I]C3a (human) Agonist Full agonist 8.4
SB290157 Antagonist Antagonist 7.6
C3a Agonist Full agonist 7.3
YSFKPMPLaR Agonist Full agonist 6.7
FLTChaAR Antagonist Antagonist 6.6
FLPLAR Agonist Full agonist 6.4
WWGKKYRASKLGLAR Agonist Full agonist 5.9

(7) Novoseek inferred chemical compound relationships for C3AR1 Gene

Compound -log(P) Hits PubMed IDs
anaphylatoxin 97.1 28
calcium 26.8 5
fmlp 23.7 2
threonine 0 2
tyrosine 0 2
genes like me logo Genes that share compounds with C3AR1: view

Transcripts for C3AR1 Gene

mRNA/cDNA for C3AR1 Gene

(103) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C3AR1 Gene

Complement component 3a receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C3AR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c
SP1: -
SP2: -
SP3:

Relevant External Links for C3AR1 Gene

GeneLoc Exon Structure for
C3AR1
ECgene alternative splicing isoforms for
C3AR1

Expression for C3AR1 Gene

mRNA expression in normal human tissues for C3AR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C3AR1 Gene

This gene is overexpressed in Whole Blood (21.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C3AR1 Gene

SOURCE GeneReport for Unigene cluster for C3AR1 Gene Hs.591148

mRNA Expression by UniProt/SwissProt for C3AR1 Gene

Q16581-C3AR_HUMAN
Tissue specificity: Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues
genes like me logo Genes that share expressions with C3AR1: view

Orthologs for C3AR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C3AR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3AR1 35
  • 99.31 (n)
  • 98.55 (a)
C3AR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3AR1 35
  • 81.59 (n)
  • 71.76 (a)
C3AR1 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C3AR1 35
  • 82.22 (n)
  • 71.25 (a)
C3AR1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C3ar1 35
  • 75.94 (n)
  • 66.03 (a)
C3ar1 16
C3ar1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C3ar1 35
  • 73.87 (n)
  • 61.99 (a)
chicken
(Gallus gallus)
Aves C3AR1 35
  • 56.65 (n)
  • 49.06 (a)
C3AR1 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3AR1 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498174 35
  • 56.01 (n)
  • 45.64 (a)
zebrafish
(Danio rerio)
Actinopterygii c3ar1 35
  • 51.95 (n)
  • 41.81 (a)
C3AR1 36
  • 38 (a)
OneToOne
Species with no ortholog for C3AR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C3AR1 Gene

ENSEMBL:
Gene Tree for C3AR1 (if available)
TreeFam:
Gene Tree for C3AR1 (if available)

Paralogs for C3AR1 Gene

Selected SIMAP similar genes for C3AR1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with C3AR1: view

Variants for C3AR1 Gene

Sequence variations from dbSNP and Humsavar for C3AR1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3301 -- 8,058,358(+) ATATC(A/G)ACAAA utr-variant-3-prime
rs7842 -- 8,058,591(-) TATTG(A/G)CATCA utr-variant-3-prime
rs1966409 -- 8,063,980(-) ATTCT(C/G)GTGCC intron-variant
rs2072448 -- 8,058,101(-) CAGGA(C/T)ATAGA downstream-variant-500B
rs2072449 -- 8,058,041(-) TATTG(C/T)GTGAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C3AR1 Gene

Variant ID Type Subtype PubMed ID
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914

Relevant External Links for C3AR1 Gene

HapMap Linkage Disequilibrium report
C3AR1
Human Gene Mutation Database (HGMD)
C3AR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C3AR1 Gene

Disorders for C3AR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for C3AR1 Gene including...

Search for C3AR1 Gene in MalaCards »

(11) Novoseek inferred disease relationships for C3AR1 Gene

Disease -log(P) Hits PubMed IDs
leukemia basophilic 56.9 3
inflammation 38.7 6
lupus nephritis 26.5 3
multiple sclerosis 21.6 2
skin diseases 16.1 1

Relevant External Links for C3AR1

Genetic Association Database (GAD)
C3AR1
Human Genome Epidemiology (HuGE) Navigator
C3AR1
genes like me logo Genes that share disorders with C3AR1: view

No data available for UniProtKB/Swiss-Prot for C3AR1 Gene

Publications for C3AR1 Gene

  1. Molecular cloning and characterization of the human anaphylatoxin C3a receptor. (PMID: 8702752) Ames R.S. … Kumar C. (J. Biol. Chem. 1996) 3 4 23
  2. Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. (PMID: 8765043) Crass T. … Bautsch W. (Eur. J. Immunol. 1996) 3 4 23
  3. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. (PMID: 15278436) Hasegawa K. … Suzuki Y. (Hum. Genet. 2004) 3 23 48
  4. Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. (PMID: 12871936) Gao J. … Gerard N.P. (J. Biol. Chem. 2003) 3 4 23
  5. cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure. (PMID: 8605247) Roglic A. … Ye R.D. (Biochim. Biophys. Acta 1996) 2 3 4

Products for C3AR1 Gene

Sources for C3AR1 Gene

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