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C3 Gene

protein-coding GIFtS: 68

GC19M006628

complement component 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARMD9 ^², ⁵
ASP ^²
CPAMD1 ^¹, ², ³

Descriptions
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 ^³
acylation-stimulating protein cleavage product ^²
complement component 3 ^²
complement component C3 ^²

External Ids
HGNC: 1318¹
Entrez Gene: 718²
UniProtKB: P01024³
Ensembl: ENSG00000125730⁷

Search outside databases for aliases for C3 gene

Previous GC identifers: GC19M006772 GC19M006617

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for C3:

Complement component C3 plays a central role in the activation of complement system. Its activation

is required for both classical and alternative complement activation pathways. People with C3

deficiency are susceptible to bacterial infection. [provided by RefSeq]

UniProtKB/Swiss-Prot: CO3_HUMAN, P01024

Function: Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of

local inflammatory process. It induces the contraction of smooth muscle, increases vascular

permeability and causes histamine release from mast cells and basophilic leukocytes

Gene Wiki entry for C3 (Complement_component_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C3 gene

Entrez Gene cytogenetic band: 19p13.3-p13.2 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3-p13.2

C3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M006628: (about GC identifiers)

Start:	6,628,846 bp from pter
End:	6,671,662 bp from pter
Size:	42,817 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CO3_HUMAN, P01024 (See protein sequence)

Recommended Name: Complement C3 precursor

Size: 1663 amino acids; 187148 Da

Subunit: C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta

and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain,

releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). During pregnancy, C3dg

exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts

with CR2 and VSIG4

Subcellular location: Secreted

PDB structures from and Proteopedia :

1C3D (3D)

1GHQ (3D)

1W2S (3D)

2A73 (3D)

2A74 (3D)

2GOX (3D)

2HR0 (3D)

2I07 (3D)

2ICE (3D)

2ICF (3D)

2NOJ (3D)

2QKI (3D)

3D5R (3D)

3D5S (3D)

3G6J (3D)

Post-translational modifications:

C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and

C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain

+ alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other

fragments such as C3d or C3g¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000055.2

ENSEMBL proteins:

ENSP00000245907

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for C3
	R&D Systems Recombinant & Natural Proteins for C3 (Complement Component C3a)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (C3, C3 / C3b, C3c, C3a / C3a des Arg, C3d, C3 / C3a)
	Human Recombinant Proteins from Abnova (C3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

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Antibodies for C3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of C3
	Sigma-Aldrich Antibodies for C3
	R&D Systems Antibodies for C3 (Complement Component C3a, Complement Component C3d)
	Antibodies from Abcam (C3, C3 / C3b, C3c, C3a / C3a des Arg, C3d, C3 / C3a), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (C3)
	Novus Biologicals Antibodies for C3

Assays for C3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01024

ProtoNet protein and cluster: P01024

5 Blocks protein families:

IPB001134 Netrin

IPB001599 Alpha-2-macroglobulin

IPB001840 Anaphylatoxin domain signature

IPB002890 Alpha-2-macroglobulin

IPB009048 Alpha-macroglobulin

UniProtKB/Swiss-Prot: CO3_HUMAN, P01024

Similarity: Contains 1 anaphylatoxin-like domain

Similarity: Contains 1 NTR domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (C3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000064

Applied Biosystems Silencer® siRNAs for C3

Sigma-Aldrich siRNA for C3

Sigma-Aldrich shRNA for C3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000064
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000064
untagged cDNA clones in CMV expression vector (see all 2): AK094728

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000064

UniProtKB/Swiss-Prot: CO3_HUMAN, P01024

Function: C3 plays a central role in the activation of the complement system. Its processing by C3

convertase is the central reaction in both classical and alternative complement pathways. After

activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or

immune aggregates

Function: Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of

local inflammatory process. It induces the contraction of smooth muscle, increases vascular

permeability and causes histamine release from mast cells and basophilic leukocytes

Genatlas biochemistry entry for C3:

complement component 3,glycoprotein,180kDa,activated by classical or alternative pathway with two

forms,C3a (anaphylatoxin),C3b (opsonin)

15/18 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for C3) (see all 18 ):

	adipose tissue	behavior/neurological	digestive/alimentary	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-prenatal/perinatal
life span-post-weaning/aging	liver/biliary system	muscle	normal	renal/urinary system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004866	endopeptidase inhibitor activity	IEA	--
GO:0005102	receptor binding	TAS	9164946

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for C3 (Your Favorite Gene powered by Ingenuity)

Complement System
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
Acute Phase Response Signaling

GeneDecks C3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for C3

5/51 Interacting proteins for C3 (ENSP00000245907³ P01024¹) via UniProtKB, MINT, and/or STRING (see all 51 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000204319	ENSP00000372814³	STRING (score=.916) STRING (score=.829)
VSIG4	Q9Y279-1¹	STRING (score=.99) EBI-905851, EBI-903144
CR2	ENSP00000356024³	STRING (score=.999)
CD46	ENSP00000313875³	STRING (score=.997)
CFH	ENSP00000356399³	STRING (score=.997)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001798	positive regulation of type IIa hypersensitivity	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0006957	complement activation, alternative pathway	IEA	--
GO:0006958	complement activation, classical pathway	IEA	--
GO:0007165	signal transduction	TAS	10085065

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for C3 available from Tocris Bioscience

Compound	Action	CAS number
Compstatin	C3-binding protein, inhibits complement activation	[206645-99-0]

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10/18 Novoseek chemical compound relationships for C3 gene (see all 18 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
triacylglycerol	63.05	36	8582446 (4), 9555951 (4), 8492712 (3), 8068623 (3) (see all 17)
fatty acid	41.80	30	11108729 (3), 14703506 (3), 8574269 (2), 9105570 (1) (see all 16)
glucose	41.21	96	9059512 (8), 8492712 (6), 9130021 (5), 15043507 (3) (see all 34)
oleic acid	35.41	10	18004729 (2), 8492712 (1), 9034195 (1), 14703506 (1)
lipid	35.07	48	11836332 (3), 16302015 (3), 17372315 (2), 19022911 (2) (see all 25)
cholesterol	31.36	39	11714853 (3), 18206145 (2), 18075846 (2), 16302015 (2) (see all 14)
neopterin	29.02	3	8925815 (1), 7702398 (1), 7874897 (1)
glycerol 3-phosphate	15.77	2	8582446 (1), 1943492 (1)
steroid	12.07	4	18615583 (2), 18671285 (1)
oxygen	0.00	3	1417490 (1), 16099291 (1)

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1 PharmGKB drug compound relationship for C3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
gemfibrozil	PD GN	96192469

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (C3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000064

Sigma-Aldrich siRNA for C3

Sigma-Aldrich shRNA for C3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000064

REFSEQ mRNAs for C3 gene:

NM_000064.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000064

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000064
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000064
                                 untagged cDNA clones in CMV expression vector (see all 2): AK094728

Additional cDNA sequence:

AK094728.1 AK304071.1 AY927485.1 BC022897.1 BC063852.1 BC150179.1 BC150200.1 BC150299.1

CR599189.1 CR619237.1 K02765.1

24/35 DOTS entries (see all 35 ):

DT.95200471 DT.100805138 DT.95212039 DT.100642455 DT.95288012 DT.92469022 DT.100865720 DT.92469028

DT.121504652 DT.100642643 DT.95365044 DT.100668443 DT.86844052 DT.92068615 DT.100668436 DT.92469035

DT.121504611 DT.100668437 DT.40256655 DT.95347307 DT.95356787 DT.95365047 DT.95365050 DT.121504605

24/731 AceView cDNA sequences (see all 731 ):

CD607286 CR619237 CK429838 AW368852 BM972120 AF064090 AA593902 CB131043

BI823457 AI133409 CD607310 AA345518 AA166723 BM543925 AW368868 BQ013364

BF032613 BQ652672 BQ939823 CA396736 AI093026 AV654754 AA344723 BG567618

highest scoring ESTs for C3:

AL531538 AL531541 AL532114 AL557768 AL589340 BQ717819 BX406393 K02765 AA009782 AA025993

Unigene Cluster for C3:

Complement component 3

Hs.529053 [show with all ESTs]

Unigene Representative Sequence: BC063852

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C3 (see all 7 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18a	·	18b	^	19	^	20	^	21	^	22	^	23	^
SP1:																									-														-
SP2:
SP3:
SP4:
SP5:

ExUns:	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33a	·	33b	^	34a	·	34b	^	35a	·	35b	^	36	^	37	^	38a	·	38b	^	39	^	40	^	41	^	42a	·	42b
SP1:											-														-		-										-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for C3

1 Ensembl transcript including schematic representation:

ENST00000245907

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

C3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C3

¹ / ² / ³

2 probe-sets matching C3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
217767_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000064	0.60	1.00	0.82	1
217767_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.529053

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for C3 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	C3¹	--	complement component 3	80.27(n) 74.37(a)	476728 XM_533932.2 XP_533932.2
chimpanzee (Pan troglodytes)	C3¹	--	complement component 3	96.19(n) 95.12(a)	455644 XM_512318.2 XP_512318.2
cow (Bos taurus)	C3¹	--	complement component 3	81.14(n) 77.17(a)	280677 NM_001040469.2 NP_001035559.2
rat (Rattus norvegicus)	C3¹	--	complement component 3	79.26(n) 78.31(a)	24232 NM_016994.1 NP_058690.1
mouse (Mus musculus)	C3^{1, 5}	17 (34.30 cM)⁵	complement component 3^{1, 5}	79.18(n)¹ 77.29(a)¹	12266¹ NM_009778.2¹ NP_033908.2¹ AI255234⁵ AI528519⁵ (see all 19)

About this table Species with no ortholog for C3

ENSEMBL Gene Tree for C3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for C3 gene

ENSG00000204319² C3P1² ENSG00000204342²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: CO3_HUMAN, P01024

Polymorphism: There are two alleles: C3S (C3 slow), the most common allele in all races and C3F (C3

fast), relatively frequent in Caucasoids, less common in Black Americans, extremely rare in

Orientals

10/517 NCBI SNPs in C3 are shown (see all 517 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 160)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs163913^1,2	A,C,F,H,O	6673635(+)	`atgcaT/Ctggta`	1	--	ng3¹		9	EA NA EU WA	635
	rs339392^1,2	A,C,F,H	6673022(+)	`GAACTT/GCCTCA`	1	--	ng3¹		8	EU EA WA	832
	rs11569541^1,2	C,F,H	6635591(-)	`CACCAT/CAAAAC`	1	T/I	mis¹		6	NS EU EA WA	496
	rs11569422^1,2	C,F,H	6662070(-)	`GGGGAG/CACCCT`	1	D/E	mis¹ ese³		9	NS EA WA EU	808
--	rs4513211^1,2	C,F,H	6628475(+)	`ACCACC/TATGGC`	1	--	ng5¹		6	NS EU EA WA	498
	rs11569534^1,2	C,F,H	6637274(-)	`CCCTGG/ATAAGC`	1	D/G	mis¹		10	NS EU EA WA	928
	rs2230199^1,2	C,F,H	6669387(-)	`AGGGGC/GGCAAC`	1	R/G	mis¹		13	MN NS EU EA WA	1196
--	rs11569472^1,2	F,H	6648563(-)	`GGTGAG/AGGTGG`	1	K/R	mis¹ ese³		6	NS EU EA WA	500
	rs2230210^1,2	C,F	6629030(-)	`GCCTCA/CGCTAC`	1	S/R	mis¹ ese³		5	MN EU EA WA	466
--	rs10402399^1,2	C,F	6672767(+)	`CCATGC/TCCGGA`	1	--	ng3¹		2	NS	90

About this table

HapMap Linkage Disequilibrium images for C3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 120700

UniProtKB/Swiss-Prot: CO3_HUMAN, P01024

Defects in C3 are the cause of C3 deficiency [MIM:120700]. It can result in susceptibility

to pyogenic infection

Genetic variation in C3 is associated with susceptibility to age-related macular

degeneration type 9 (ARMD9) [MIM:611378]. ARMD is a multifactorial eye disease and the most common

cause of irreversible vision loss in the developed world. In most patients, the disease is

manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie

beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch

membrane

10/36 Novoseek disease relationships for C3 gene (see all 36 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
complement deficiency	67.16	3	18667363 (1)
afibrinogenemia	61.28	1	1966986 (1)
hyperlipidemia familial combined	57.24	3	11979403 (2), 11348883 (1)
lipodystrophy	53.02	2	12942374 (1)
glomerulonephritis membranoproliferative	50.23	1	8395463 (1)
insulin resistance	47.21	19	17595349 (3), 16302015 (2), 18206145 (1), 12679444 (1) (see all 10)
obesity	46.82	30	15853826 (3), 8574269 (2), 1885258 (2), 14564690 (2) (see all 15)
meningococcal diseases	39.83	1	9844044 (1)
insulin sensitivity	35.60	10	11397716 (1), 12679444 (1), 15809665 (1), 18702682 (1) (see all 8)
dyslipidemia	31.33	5	18253759 (1), 11836332 (1), 18680692 (1), 14612209 (1)

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Genatlas disease: C3

glomerulonephritis,pyogenic recurrent infections,lupus systemic syndrome

Human Gene Mutation Database: C3
Genetic Association Database: C3
Human Genome Epidemiology Navigator: C3 (82 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/414 PubMed articles for C3 gene (see all 414 ):

Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (Asp549 to Asn) impairs C3 secretion. (PubMed id 7961791)^{1, 3, 4} Singer L....Wetsel R.A. (1994)
The structure of complement C3b provides insights into complement activation and regulation. (PubMed id 17051152)^{1, 3, 4} Abdul Ajees A.... Murthy H.M.K. (2006)
Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. (PubMed id 15278436)^{1, 3, 6} Hasegawa K....Suzuki Y. (2004)
[Analysis of heterozygosity levels at P1,TF, PGM1, ACP1, HP, GC, GLO, C3, and ESD loci in pulmonary tuberculosis patients with different treatment outcomes] (PubMed id 11785295)^{1, 3, 6} Sergeev A.S....Perel'man M.I. (2001)
Complement C3 variant and the risk of age-related macular degeneration. (PubMed id 17634448)^{3, 4} Yates J.R.W....Moore A.T. (2007)
Structure of C3b in complex with CRIg gives insights into regulation of complement activation. (PubMed id 17051150)^{3, 4} Wiesmann C....van Lookeren Campagne M. (2006)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{3, 4} Lewandrowski U.... Sickmann A. (2006)
Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. (PubMed id 16355111)^{3, 6} Barnes K.C....Wills-Karp M. (2006)
Structure of C3b reveals conformational changes that underlie complement activity. (PubMed id 17051160)^{3, 4} Janssen B.J.C....Gros P. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 718	HGNC: 1318	AceView: C3andTNFSF14	Ensembl:ENSG00000125730	euGenes: HUgn718
ECgene: C3	H-InvDB: C3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for C3	Genetics and Cytogenetics in Oncology and Haematology
C3base	http://bioinf.uta.fi/C3base/
GeneReviews	http://www.genetests.org/query?gene=C3
Wikipedia	http://en.wikipedia.org/wiki/Complement_c3
SeattleSNPs	http://pga.gs.washington.edu/data/c3/

Licensable Technologies for C3
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for C3 gene:

Weizmann Institute:

Synthetic Peptides for Treatment of Allergies

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for C3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for C3		Antibodies for C3
	Explore super-pooled esiRNAs		Proteins for C3
	Lentivirus-delivered shRNAs for C3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (C3)
	Antibodies (C3)
	Chimera RNAi (C3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (C3, C3 / C3b, C3c, C3a / C3a des Arg, C3d, C3 / C3a)
	Antibodies (C3, C3 / C3b, C3c, C3a / C3a des Arg, C3d, C3 / C3a)

Search OriGene for C3

Tocris compounds for C3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for C3

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
C3 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

C3 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for C3

Summaries
for C3

Genomic Location
for C3

Proteins
for C3

Protein Domains/
Families
for C3

Gene Function
for C3

Pathways & Interactions
for C3

Drugs & Compounds
for C3

Transcripts
for C3

Expression
for C3

Orthologs
for C3

Paralogs
for C3

SNPs/Variants
for C3

Disorders & Mutations
for C3

Medical News
for C3

Publications
for C3

Search for C3

Genome Databases showing C3

Other Databases showing C3

Specialized Databases showing C3

Licensable Technologies
for C3

Services
for C3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C3 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor C3

Summariesfor C3

Genomic Locationfor C3

Proteinsfor C3

Protein Domains/Familiesfor C3

Gene Functionfor C3

Pathways & Interactionsfor C3

Drugs & Compoundsfor C3

Transcriptsfor C3

Expression for C3

Orthologsfor C3

Paralogsfor C3

SNPs/Variantsfor C3

Disorders & Mutationsfor C3

Medical Newsfor C3

Publicationsfor C3

Search for C3

Genome Databases showing C3

Other Databases showing C3

Specialized Databases showing C3

Licensable Technologiesfor C3

Servicesfor C3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C3

Summaries
for C3

Genomic Location
for C3

Proteins
for C3

Protein Domains/
Families
for C3

Gene Function
for C3

Pathways & Interactions
for C3

Drugs & Compounds
for C3

Transcripts
for C3

Expression
for C3

Orthologs
for C3

Paralogs
for C3

SNPs/Variants
for C3

Disorders & Mutations
for C3

Medical News
for C3

Publications
for C3

Licensable Technologies
for C3

Services
for C3