Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C3 Gene

protein-coding   GIFtS: 72
GCID: GC19M006677

Complement Component 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Complement Component 31 2     ARMD92 5
C3a Anaphylatoxin1 2     ASP2
Complement Component C3a1 2     C3a2
Complement Component C3b1 2     C3b2
prepro-C31 2     Acylation-Stimulating Protein Cleavage Product2
CPAMD12 3     Complement C32
C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 12 3     Complement Component C32
AHUS52 5     

External Ids:    HGNC: 13181   Entrez Gene: 7182   Ensembl: ENSG000001257307   OMIM: 1207005   UniProtKB: P010243   

Export aliases for C3 gene to outside databases

Previous GC identifers: GC19M006772 GC19M006617 GC19M006628 GC19M006440


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for C3 Gene:
Complement component C3 plays a central role in the activation of complement system. Its activation is required
for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to
bacterial infection. (provided by RefSeq, Feb 2009)

GeneCards Summary for C3 Gene: 
C3 (complement component 3) is a protein-coding gene. Diseases associated with C3 include c3 deficiency, and autoimmune disease of central nervous system, and among its related super-pathways are Immune response Lectin induced complement pathway and Complement Pathway. GO annotations related to this gene include C5L2 anaphylatoxin chemotactic receptor binding and receptor binding. An important paralog of this gene is A2M.

UniProtKB/Swiss-Prot: CO3_HUMAN, P01024
Function: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is
the central reaction in both classical and alternative complement pathways. After activation C3b can bind
covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates
Function: Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local
inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes
histamine release from mast cells and basophilic leukocytes
Function: Acylation stimulating protein (ASP): adipogenic hormone that stimulates triglyceride (TG) synthesis and
glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears
to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes
the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2

summary for C3 Gene:
The complement system is a biochemical pathway involved in both innate and adaptive immune responses. There
are four main functions of the complement system; lysis of microorganisms, promotion of phagocytosis,
triggering inflammation and immune clearance. There are three pathways that can activate the complement
system; the classical complement pathway (in response to IgG- or IgM-antigen complexes), the alternative
complement pathway (spontaneous activation) and the mannose-binding lectin pathway (in response to lectin
residues on pathogen cell surface membranes). All three pathway generate variants of C3 convertase, which
cleaves C3 into C3a and C3b. C3a and C3b activate a series of further cleavage events that activates the
complement cascade. This leads to immune defence responses such as degranulation of mast cells, increasing
vascular permeability and initiation of the membrane attack pathway. Deregulation of the complement system
would be extremely damaging to the host, so it is tightly regulated by complement control proteins. These
regulatory proteins are found in much higher concentrations that complement proteins themselves and prevent
complement system activation in 'self' tissues. The complement system has been implicated in many autoimmune
disorders, including systemic lupus erythematosus, multiple sclerosis and arthritis, and more recently has
been suggested to have a pathophysiological role in Alzheimer's and other neurodegenerative disorders.

Gene Wiki entry for C3 (Complement component 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C3 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   STAT3   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): C3 promoter sequence
   Search SABiosciences Chromatin IP Primers for C3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3-p13.2

C3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006677:  view genomic region     (about GC identifiers)

Start:
6,677,715 bp from pter      End:
6,730,573 bp from pter
Size:
52,859 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CO3_HUMAN, P01024 (See protein sequence)
Recommended Name: Complement C3 precursor  
Size: 1663 amino acids; 187148 Da
Subunit: C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha,
linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin
and generating C3b (beta chain + alpha' chain). C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and
2). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2.
Interacts with VSIG4. C3b interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 2 (HHV-2)
envelope glycoprotein C; this interaction inhibits the activation of the complement system. Interacts with
S.aureus immunoglobulin-binding protein sbi, this prevents interaction between C3dg and CR2. Interacts with
S.aureus fib. Interacts (both C3a and ASP) with C5AR2; the interaction occurs with higher affinity for ASP,
enhancing the phosphorylation and activation of C5AR2, recruitment of ARRB2 to the cell surface and endocytosis
of GRP77
Subcellular location: Secreted
Caution: According to PubMed:21527715, the interaction surface between C3 and CR2 reported in PubMed:11387479 is
artifactual and can be ascribed to the presence of zinc acetate in the buffer
6/33 PDB 3D structures from and Proteopedia for C3 (see all 33):
1C3D (3D)        1GHQ (3D)        1W2S (3D)        2A73 (3D)        2A74 (3D)        2GOX (3D)    
Secondary accessions: A7E236

Explore the universe of human proteins at neXtProt for C3: NX_P01024

Explore proteomics data for C3 at MOPED 

Post-translational modifications:

  • UniProtKB: C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is
    released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 +
    alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is
    further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation
    stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by insulin
    and dietary chylomicrons
  • UniProtKB: Phosphorylation sites are present in the extracellular medium
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01024

  • C3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C3 Protein Expression
    REFSEQ proteins: NP_000055.2  
    ENSEMBL proteins: 
     ENSP00000245907   ENSP00000469482   ENSP00000471384   ENSP00000469744   ENSP00000472044  
    Reactome Protein details: P01024
    Human Recombinant Protein Products for C3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for C3 (Complement Component C3a)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for C3
    OriGene Protein Over-expression Lysate for C3
    OriGene MassSpec for C3 
    OriGene Custom Protein Services for C3
    GenScript Custom Purified and Recombinant Proteins Services for C3
    Novus Biologicals C3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for C3
    Cloud-Clone Corp. Proteins for C3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS--
    GO:0070062extracellular vesicular exosome IDA--

    C3 for ontologies           About GeneDecksing



    C3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of C3
    R&D Systems Antibodies for C3 (Complement Component C3a, Complement Component C3d)
    OriGene Antibodies for C3
    OriGene Custom Antibody Services for C3
    GenScript Superior Antibodies for C3
    Novus Biologicals C3 Antibodies
    Abcam antibodies for C3
    Cloud-Clone Corp. Antibodies for C3 
    ThermoFisher Antibody for C3
    LSBio Antibodies in human, mouse, rat for C3 

    Assay Products for C3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for C3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for C3
    Enzo Life Sciences assays for C3
    Cloud-Clone Corp. ELISAs for C3 
    Cloud-Clone Corp. CLIAs for C3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    complement: Complement system

    5/14 InterPro protein domains (see all 14):
     IPR008993 TIMP-like_OB-fold
     IPR019742 MacrogloblnA2_CS
     IPR001599 Macroglobln_a2
     IPR000020 Anaphylatoxin/fibulin
     IPR011626 A2M_comp

    Graphical View of Domain Structure for InterPro Entry P01024

    ProtoNet protein and cluster: P01024

    5 Blocks protein domains:
    IPB001134 Netrin
    IPB001599 Alpha-2-macroglobulin
    IPB001840 Anaphylatoxin domain signature
    IPB002890 Alpha-2-macroglobulin
    IPB009048 Alpha-macroglobulin


    UniProtKB/Swiss-Prot: CO3_HUMAN, P01024
    Similarity: Contains 1 anaphylatoxin-like domain
    Similarity: Contains 1 NTR domain


    C3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CO3_HUMAN, P01024
    Function: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is
    the central reaction in both classical and alternative complement pathways. After activation C3b can bind
    covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates
    Function: Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local
    inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes
    histamine release from mast cells and basophilic leukocytes
    Function: Acylation stimulating protein (ASP): adipogenic hormone that stimulates triglyceride (TG) synthesis and
    glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears
    to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes
    the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2

         Genatlas biochemistry entry for C3:
    complement component 3,glycoprotein,180kDa,activated by classical or alternative pathway with two forms,C3a
    (anaphylatoxin),C3b (opsonin)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity IEA--
    GO:0005102receptor binding TAS9164946
    GO:0005515protein binding IPI12540846
    GO:0031715C5L2 anaphylatoxin chemotactic receptor binding IDA15833747
         
    C3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for C3:
     Increased gamma-H2AX phosphory 

         15/21 MGI mutant phenotypes (inferred from 4 alleles(MGI details for C3) (see all 21):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  muscle  nervous system 

    C3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for C3: C3tm1Pkna C3tm1Crr C3tm1Hrc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for C3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate C3:
    hsa-miR-127-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for C3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for C3
    Sirion Biotech Customized adenovirus for overexpression of C3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for C3 (see all 4)
    OriGene ORF clones in mouse, rat for C3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): C3 (NM_182962)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for C3
    Search LifeMap BioReagents cell lines for C3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for C3 About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Lectin induced complement pathway0.56
    Immune response Classic complement pathway0.53
    Immune response Alternative complement pathway0.56
    Immune response Classical complement pathway0.52
    Immune response Lectin Induced complement pathway0.56
    Regulation of Complement cascade0.50
    2Classical Complement Pathway
    Classical Complement Pathway0.75
    Complement Activation, Classical Pathway0.68
    Complement Pathway0.75
    Lectin Induced Complement Pathway0.65
    3Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    4Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for C3
        Immune response Alternative complement pathway
    Immune response Classic complement pathway
    Immune response Lectin Induced complement pathway

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for C3
        Alternative Complement Pathway
    Classical Complement Pathway
    Lectin Induced Complement Pathway
    Complement Pathway
    Phagocytosis of Microbes

    3 GeneGo (Thomson Reuters) Pathways for C3
        Immune response Alternative complement pathway
    Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    2 BioSystems Pathways for C3
        Complement Activation, Classical Pathway
    Complement and Coagulation Cascades

    5/16        Reactome Pathways for C3 (see all 16)
        Signal Transduction
    Regulation of Complement cascade
    Activation of C3 and C5
    Immune System
    GPCR downstream signaling


    5/11         Kegg Pathways  (Kegg details for C3) (see all 11):
        Phagosome
    Complement and coagulation cascades
    Pertussis
    Legionellosis
    Leishmaniasis


    C3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for C3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/211 Interacting proteins for C3 (P010241, 2, 3 ENSP000002459074) via UniProtKB, MINT, STRING, and/or I2D (see all 211)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000231543P066813, ENSP000004079614I2D: score=1 STRING: ENSP00000407961
    C2P066813, ENSP000002993674I2D: score=1 STRING: ENSP00000299367
    ENSG00000204364P066813I2D: score=1 
    ENSG00000206372P066813I2D: score=1 
    ENSG00000226560P066813I2D: score=1 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001798positive regulation of type IIa hypersensitivity IEA--
    GO:0001934positive regulation of protein phosphorylation IDA15833747
    GO:0001970positive regulation of activation of membrane attack complex IEA--
    GO:0006631fatty acid metabolic process IEA--
    GO:0006954inflammatory response IEA--

    C3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    C3 for compounds           About GeneDecksing

    EMD Millipore small molecules for C3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for C3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Compstatin C3-binding protein, inhibits complement activation [206645-99-0]
    Compstatin control peptideControl peptide for Compstatin (Cat. No. 2585)[301544-78-5]
    NDT 9513727 Potent, selective human C5a receptor antagonist [439571-48-9]

    2 DrugBank Compounds for C3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Intravenous ImmunoglobulinIg alpha-2 chain C region (see all 3)9007-83-4targetbinder17351760 20441428 17911465
    S-Hydroxycysteine-- --target--17139284 17016423 10592235

    10/30 Novoseek inferred chemical compound relationships for C3 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anaphylatoxin 72.2 7 1431125 (1), 11037838 (1), 11487475 (1), 19687018 (1) (see all 6)
    triacylglycerol 61.6 36 8582446 (4), 9555951 (4), 8492712 (3), 8068623 (3) (see all 17)
    fatty acid 46.6 34 11108729 (3), 14703506 (3), 8574269 (2), 20416070 (1) (see all 19)
    glucose 42.8 100 9059512 (8), 8492712 (6), 9130021 (5), 15043507 (3) (see all 36)
    lipid 37 49 11836332 (3), 16302015 (3), 17372315 (2), 19022911 (2) (see all 26)
    oleic acid 33.4 10 18004729 (2), 8492712 (1), 9034195 (1), 14703506 (1)
    cholesterol 32.8 42 11714853 (3), 18206145 (2), 18075846 (2), 16302015 (2) (see all 16)
    neopterin 27.5 3 8925815 (1), 7702398 (1), 7874897 (1)
    glycerol 3-phosphate 13.9 2 8582446 (1), 1943492 (1)
    steroid 9.97 4 18615583 (2), 18671285 (1)

    Search CenterWatch for drugs/clinical trials and news about C3 / CO3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C3 gene: 
    NM_000064.2  

    Unigene Cluster for C3:

    Complement component 3
    Hs.529053  [show with all ESTs]
    Unigene Representative Sequence: BC063852
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000245907(uc002mfm.3) ENST00000601475 ENST00000599899 ENST00000602229
    ENST00000599668 ENST00000601008 ENST00000596548 ENST00000596179 ENST00000596238
    ENST00000598805 ENST00000594005 ENST00000602053 ENST00000600763 ENST00000594270
    ENST00000597442 ENST00000595577 ENST00000594936 ENST00000600744
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate C3:
    hsa-miR-127-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for C3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C3
    Clone
    Products:
         
    OriGene clones in human, mouse for C3 (see all 4)
    OriGene ORF clones in mouse, rat for C3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): C3 (NM_182962)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for C3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C3

    Additional mRNA sequence: 

    AK094728.1 AK304071.1 AY927485.1 BC022897.1 BC063852.1 BC150179.1 BC150200.1 BC150299.1 
    K02765.1 

    24/36 DOTS entries (see all 36):

    DT.95200471  DT.100805138  DT.95212039  DT.100642455  DT.95288012  DT.92469022  DT.100865720  DT.92469028 
    DT.121504652  DT.100642643  DT.95365044  DT.100668443  DT.86844052  DT.92068615  DT.100668436  DT.92469035 
    DT.121504611  DT.100668437  DT.40256655  DT.95347307  DT.95356787  DT.95365047  DT.95365050  DT.121504605 

    24/731 AceView cDNA sequences (see all 731):

    CA405709 AA344197 R29008 AL531541 BQ687459 BQ694606 AI133462 AA477152 
    BF340032 CK429838 AI133649 BI823457 K02765 T53801 AL046048 AA344720 
    BF379269 BQ939823 AI287351 BQ641572 CD607286 R91326 T61804 AA343624 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C3 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                                          -                                         -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35a · 35b ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41 ^ 42a · 42b
    SP1:                                -                                         -     -                             -                                 
    SP2:                                                                                                                                                
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for C3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C3 expression in normal human tissues (normalized intensities)      C3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    C3 Expression
    About this image


    C3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Mature Mesothelial Cells Hepatic Mesenchyme
             Human Hepatocyte (HH)   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
             Human corneal endothelial cells
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Mature Cardiac Fibroblasts Myocardium
             Human Cardiac Fibroblasts-adult ventrical (HCF-av)   
     
     Colon (Gastrointestinal Tract)
             Appendix   
     
     Fibroblast (Uncategorized)
             Human Cardiac Fibroblasts-adult ventrical (HCF-av)   

    See C3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C3

    SOURCE GeneReport for Unigene cluster: Hs.529053

    UniProtKB/Swiss-Prot: CO3_HUMAN, P01024
    Tissue specificity: Plasma. The acylation stimulating protein (ASP) is expressed in adiopocytes and released into
    the plasma during both the fasting and postprandial periods

        SABiosciences Expression via Pathway-Focused PCR Arrays including C3 (see all 9): 
              Innate & Adaptive Immune Responses in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Obesity in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for C3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for C3 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C31 , 5 complement component 31, 5 79.18(n)1
    77.29(a)1
      17 (29.72 cM)5
    122661  NM_009778.21  NP_033908.21 
     572039705 
    chicken
    (Gallus gallus)
    Aves C31 complement component 3 62.54(n)
    54.17(a)
      396370  NM_205405.1  NP_990736.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    53(a)
    53(a)
    (see all 5)
    1 ↔ many
    1 ↔ many
    (see all 5)
    2(75798369-75880702)
    2(77547966-77615105)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX851366.12   -- 72.79(n)    BX851366.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055564.12   -- 75.23(n)   321046  BC055564.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TepI6
    TepII6
    (see all 6)
    Thiolester containing protein II
    (see all 6)
    20(a)
    20(a)
    (see all 6)
    possible ortholog
    possible ortholog
    (see all 6)
    2L(15888639-15893811)
    2L(7693800-7701585)


    ENSEMBL Gene Tree for C3 (if available)
    TreeFam Gene Tree for C3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C3 gene
    A2M2  C52  C4B2  A2ML12  C4A2  PZP2  CPAMD82  CD1092  
    6 SIMAP similar genes for C3 using alignment to 5 protein entries:     CO3_HUMAN (see all proteins):
    C4B    ZA    C4B_2    C5    OVOS2    C4A

    C3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for C3
    PGOHUM00000250593


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CO3_HUMAN, P01024
    Polymorphism: There are two alleles: C3S (C3 slow), the most common allele in all races and C3F (C3 fast),
    relatively frequent in Caucasians, less common in Black Americans, extremely rare in Orientals


    10/1597 SNPs in C3 are shown (see all 1597)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0632194
    Hemolytic uremic syndrome atypical 5 (AHUS5)4--see VAR_0632192 Q K mis40--------
    VAR_0632134
    Hemolytic uremic syndrome atypical 5 (AHUS5)4--see VAR_0632132 R Q mis40--------
    VAR_0632184
    Hemolytic uremic syndrome atypical 5 (AHUS5)4--see VAR_0632182 C W mis40--------
    VAR_0632204
    Hemolytic uremic syndrome atypical 5 (AHUS5)4--see VAR_0632202 H D mis40--------
    VAR_0636554
    Hemolytic uremic syndrome atypical 5 (AHUS5)4--see VAR_0636552 R L mis40--------
    VAR_0019854
    Complement component 3 deficiency (C3D)4--see VAR_0019852 D N mis40--------
    VAR_0632174
    Hemolytic uremic syndrome atypical 5 (AHUS5)4--see VAR_0632172 D N mis40--------
    VAR_0636544
    Hemolytic uremic syndrome atypical 5 (AHUS5)4--see VAR_0636542 F V mis40--------
    VAR_0632164
    Hemolytic uremic syndrome atypical 5 (AHUS5)4--see VAR_0632162 A V mis40--------
    VAR_0019864
    Complement component 3 deficiency (C3D)4--see VAR_0019862 R Q mis40--------

    HapMap Linkage Disequilibrium report for C3 (6677715 - 6730573 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for C3 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677585CNV Deletion23128226
    esv2718067CNV Deletion23290073
    esv2265092CNV Deletion18987734
    esv5110CNV Deletion18987735
    esv2718068CNV Deletion23290073
    esv2718070CNV Deletion23290073
    esv2718069CNV Deletion23290073
    dgv14e196CNV Duplication17116639
    nsv470120CNV Loss18288195
    dgv3703n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): C3

    Locus Specific Mutation Databases (LSDB): C3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing C3
    DNA2.0 Custom Variant and Variant Library Synthesis for C3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 120700   
    OMIM disorders: 611378  612925  
    UniProtKB/Swiss-Prot: CO3_HUMAN, P01024
  • Complement component 3 deficiency (C3D) [MIM:613779]: A rare defect of the complement classical pathway.
    Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some
    patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and
    membranoproliferative glomerulonephritis. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Age-related macular degeneration 9 (ARMD9) [MIM:611378]: A form of age-related macular degeneration, a
    multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most
    patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid
    that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch
    membrane. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry
  • Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]: An atypical form of hemolytic uremic syndrome.
    It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal
    failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome,
    atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal
    disease. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Other genes may play a role in modifying the phenotype
  • Note=Increased levels of C3 and its cleavage product ASP, are associated with obesity, diabetes and
    coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage

  • 20/120 diseases for C3 (see all 120):    About MalaCards
    c3 deficiency    autoimmune disease of central nervous system    c3 deficiency, autosomal recessive    c3-related atypical hemolytic-uremic syndrome
    age-related macular degeneration 9    complement deficiency    pediatric systemic lupus erythematosus    pneumococcal meningitis
    retinal drusen    multiple sclerosis    capillary leak syndrome    atypical hemolytic-uremic syndrome
    age related macular degeneration    hemolytic-uremic syndrome    lupus erythematosus    membranoproliferative glomerulonephritis
    afibrinogenemia    lipoprotein lipase deficiency    macular degeneration    glomerulonephritis

    7 diseases from the University of Copenhagen DISEASES database for C3:
    C3 deficiency     Nephritis     Lupus erythematosus     Connective tissue disease
    Age related macular degeneration     Proteinuria     Vascular disease

    C3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/37 Novoseek inferred disease relationships for C3 gene (see all 37)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    afibrinogenemia 65.7 1 1966986 (1)
    complement deficiency 65.6 3 18667363 (1)
    hyperlipidemia familial combined 55.9 3 11979403 (2), 11348883 (1)
    lipodystrophy 51.2 2 12942374 (1)
    glomerulonephritis membranoproliferative 48.8 1 8395463 (1)
    insulin resistance 48.1 19 17595349 (3), 16302015 (2), 18206145 (1), 12679444 (1) (see all 10)
    obesity 47.2 31 15853826 (3), 8574269 (2), 1885258 (2), 14564690 (2) (see all 16)
    dyslipidemia 38.8 7 18253759 (1), 11836332 (1), 20173020 (1), 20069551 (1) (see all 6)
    meningococcal diseases 38.2 1 9844044 (1)
    insulin sensitivity 33.1 10 11397716 (1), 12679444 (1), 15809665 (1), 18702682 (1) (see all 8)

    Genatlas disease: C3
    glomerulonephritis,pyogenic recurrent infections,lupus systemic syndrome

    Genetic Association Database (GAD): C3
    Human Genome Epidemiology (HuGE) Navigator: C3 (142 documents)

    Export disorders for C3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C3 gene, integrated from 9 sources (see all 624):
    (articles sorted by number of sources associating them with C3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. (PubMed id 20513133)1, 2, 4 Maga T.K....Smith R.J. (2010)
    2. Complement C3 variant and the risk of age-related macular degeneration. (PubMed id 17634448)1, 2, 4 Yates J.R.W....Moore A.T. (2007)
    3. Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line. (PubMed id 9059512)1, 2, 9 Tao Y....Germinario R.J. (1997)
    4. Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (Asp549 to Asn) impairs C3 secretion. (PubMed id 7961791)1, 2, 9 Singer L....Wetsel R.A. (1994)
    5. Acylation stimulating protein but not complement C3 associates with metabolic syndrome components in Chinese children and adolescents. (PubMed id 18805911)1, 2, 9 Wamba P.C....Cianflone K. (2008)
    6. C5L2 is a functional receptor for acylation-stimulating protein. (PubMed id 15833747)1, 2, 9 Kalant D....Cianflone K. (2005)
    7. Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity. (PubMed id 10432298)1, 2, 9 Murray I....Cianflone K. (1999)
    8. Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period. (PubMed id 9555951)1, 2, 9 Saleh J....Frayn K.N. (1998)
    9. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. (PubMed id 15278436)1, 4, 9 Hasegawa K....Suzuki Y. (2004)
    10. Systemic complement activation in age-related macular degeneration. (PubMed id 18596911)1, 4, 9 Scholl H.P....Oppermann M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 718 HGNC: 1318 AceView: C3andTNFSF14 Ensembl:ENSG00000125730 euGenes: HUgn718
    ECgene: C3 Kegg: 718 H-InvDB: C3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for C3 Genetics and Cytogenetics in Oncology and Haematology
    C3basehttp://bioinf.uta.fi/C3base/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/C3
    Wikipedia http://en.wikipedia.org/wiki/Complement_c3
    SeattleSNPshttp://pga.gs.washington.edu/data/c3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C3 gene:
    Search GeneIP for patents involving C3

    Licensable Technologies for C3 gene:
    Weizmann Institute:Synthetic Peptides for Treatment of Allergies
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for C3
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of C3
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for C3 (Complement Component C3a)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for C3 (Complement Component C3a)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for C3   OriGene RNAi products in human, mouse, rat for C3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for C3  
     OriGene MassSpec something-or-other for C3   OriGene clones in human, mouse for C3  
     OriGene qSTAR qPCR primer pairs in human, mouse for C3   OriGene Purified Protein for C3  
     OriGene ORF clones in mouse, rat for C3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for C3   OriGene Custom Protein Services for C3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C3
     QIAGEN SeqTarget long-range PCR primers for resequencing C3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C3
     GenScript Custom Purified and Recombinant Proteins Services for C3 GenScript cDNA clones with any tag delivered in your preferred vector for C3
     GenScript Custom Assay Services for C3 GenScript Superior Antibodies for C3
     GenScript Custom overexpressing Cell Line Services for C3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in C3 promoter
     Search Chromatin IP Primers for C3
     RT2 qPCR Primer Assay in human, mouse, rat C3
     GNC Network for C3
     SABiosciences PCR Arrays including human, mouse, rat C3
     Tocris compounds for C3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays for C3
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     C3 antibodies
     C3 proteins
     Antibodies for C3
     See all of Abcam's Antibodies, Kits and Proteins for C3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for C3




     Proteins for C3
     Antibodies for C3
     ELISAs for C3
     CLIAs for C3
     Search LifeMap BioReagents cell lines for C3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for C3
     SwitchGear Promoter luciferase reporter plasmids for C3
     ThermoFisher Antibody for C3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for C3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C3
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of C3
     LSBio Antibodies in human, mouse, rat for C3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      C3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4