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Aliases for C2orf91 Gene

Aliases for C2orf91 Gene

  • Chromosome 2 Open Reading Frame 91 2 3 5

External Ids for C2orf91 Gene

Previous GeneCards Identifiers for C2orf91 Gene

  • GC02M042163

Summaries for C2orf91 Gene

GeneCards Summary for C2orf91 Gene

C2orf91 (Chromosome 2 Open Reading Frame 91) is a Protein Coding gene.

Additional gene information for C2orf91 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf91 Gene

Genomics for C2orf91 Gene

GeneHancer (GH) Regulatory Elements for C2orf91 Gene

Promoters and enhancers for C2orf91 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I041954 Enhancer 1.2 VISTA FANTOM5 dbSUPER 550.8 -2.0 -1981 4.2 PKNOX1 CBFB ZMYM3 EBF1 ATF2 IRF4 SP1 BCL11A POLR2A SCRT2 C2orf91 PKDCC LINC01914 GC02P041958
GH02I041953 Promoter/Enhancer 1.2 EPDnew dbSUPER 550.8 +0.5 490 0.1 HDGF SMAD1 JUN BACH1 BMI1 BATF RELA NFATC1 ATF7 ETV6 C2orf91 LINC01914
GH02I041930 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 27.5 +21.4 21449 4.6 PKNOX1 SIN3A IRF4 BRCA1 TCF12 FOS RUNX3 DEK RXRA JUNB LINC01914 C2orf91 PKDCC GC02P041891
GH02I042045 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.2 -101.0 -101043 20.3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF143 PKDCC C2orf91 LOC105374531
GH02I041936 Enhancer 1 Ensembl ENCODE dbSUPER 17.2 +14.7 14746 5.3 PKNOX1 ZSCAN4 GABPA EGR1 POLR2A IKZF1 VEZF1 GABPB1 ZNF24 EGR2 C2orf91 LINC01914 PKDCC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C2orf91 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C2orf91 Gene

Genomic Locations for C2orf91 Gene
chr2:41,935,368-41,954,266
(GRCh38/hg38)
Size:
18,899 bases
Orientation:
Minus strand
chr2:42,162,508-42,181,406
(GRCh37/hg19)

Genomic View for C2orf91 Gene

Genes around C2orf91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf91 Gene

Proteins for C2orf91 Gene

  • Protein details for C2orf91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZV80-CB091_HUMAN
    Recommended name:
    Uncharacterized protein C2orf91
    Protein Accession:
    Q6ZV80

    Protein attributes for C2orf91 Gene

    Size:
    131 amino acids
    Molecular mass:
    14825 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf91 Gene

Post-translational modifications for C2orf91 Gene

No Post-translational modifications

Other Protein References for C2orf91 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2orf91 Gene

Domains & Families for C2orf91 Gene

Gene Families for C2orf91 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C2orf91 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf91: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf91 Gene

Function for C2orf91 Gene

Phenotypes From GWAS Catalog for C2orf91 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf91 Gene

Localization for C2orf91 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf91 gene
Compartment Confidence
extracellular 2
nucleus 2
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C2orf91 Gene

Pathways & Interactions for C2orf91 Gene

SuperPathways for C2orf91 Gene

No Data Available

Interacting Proteins for C2orf91 Gene

Gene Ontology (GO) - Biological Process for C2orf91 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf91 Gene

Drugs & Compounds for C2orf91 Gene

No Compound Related Data Available

Transcripts for C2orf91 Gene

mRNA/cDNA for C2orf91 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2orf91 Gene

Chromosome 2 open reading frame 91:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf91 Gene

No ASD Table

Relevant External Links for C2orf91 Gene

GeneLoc Exon Structure for
C2orf91
ECgene alternative splicing isoforms for
C2orf91

Expression for C2orf91 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf91 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf91 Gene

This gene is overexpressed in Lung (x12.1) and Testis (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of C2orf91 Gene:

C2orf91

SOURCE GeneReport for Unigene cluster for C2orf91 Gene:

Hs.738713
genes like me logo Genes that share expression patterns with C2orf91: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf91 Gene

Orthologs for C2orf91 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C2orf91 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf91 33
  • 99.49 (n)
C2orf91 34
  • 99 (a)
OneToOne
Species where no ortholog for C2orf91 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf91 Gene

ENSEMBL:
Gene Tree for C2orf91 (if available)
TreeFam:
Gene Tree for C2orf91 (if available)

Paralogs for C2orf91 Gene

No data available for Paralogs for C2orf91 Gene

Variants for C2orf91 Gene

Sequence variations from dbSNP and Humsavar for C2orf91 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000022987 -- 41,962,268(-) A/G upstream_transcript_variant
rs1000043506 -- 41,938,149(-) C/T 3_prime_UTR_variant
rs1000227764 -- 41,947,265(-) G/A intron_variant
rs1000326115 -- 41,936,209(-) A/G 3_prime_UTR_variant
rs1000446078 -- 41,963,198(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf91 Gene

Variant ID Type Subtype PubMed ID
nsv457141 CNV loss 19166990
nsv581607 CNV loss 21841781
nsv833903 CNV gain 17160897

Variation tolerance for C2orf91 Gene

Gene Damage Index Score: 7.32; 81.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C2orf91 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf91 Gene

Disorders for C2orf91 Gene

Additional Disease Information for C2orf91

No disorders were found for C2orf91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf91 Gene

Publications for C2orf91 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for C2orf91 Gene

Sources for C2orf91 Gene

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