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Aliases for C2orf88 Gene

Aliases for C2orf88 Gene

  • Chromosome 2 Open Reading Frame 88 2 3 5
  • Small Membrane AKAP 2 3 4
  • SmAKAP 3 4
  • Small A-Kinase Anchoring Protein 3

External Ids for C2orf88 Gene

Previous GeneCards Identifiers for C2orf88 Gene

  • GC02P190710
  • GC02P182862
  • GC02P190745

Summaries for C2orf88 Gene

GeneCards Summary for C2orf88 Gene

C2orf88 (Chromosome 2 Open Reading Frame 88) is a Protein Coding gene. GO annotations related to this gene include protein kinase A regulatory subunit binding.

UniProtKB/Swiss-Prot for C2orf88 Gene

  • Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf88 Gene

Genomics for C2orf88 Gene

Regulatory Elements for C2orf88 Gene

Enhancers for C2orf88 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C2orf88 on UCSC Golden Path with GeneCards custom track

Genomic Location for C2orf88 Gene

189,879,553 bp from pter
190,203,484 bp from pter
323,932 bases
Plus strand

Genomic View for C2orf88 Gene

Genes around C2orf88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf88 Gene

Proteins for C2orf88 Gene

  • Protein details for C2orf88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small membrane A-kinase anchor protein
    Protein Accession:
    Secondary Accessions:
    • D3DPI3
    • P0C876
    • Q53TC7

    Protein attributes for C2orf88 Gene

    95 amino acids
    Molecular mass:
    10970 Da
    Quaternary structure:
    • Interacts with PRKAR1A and PRKAR1B.

neXtProt entry for C2orf88 Gene

Proteomics data for C2orf88 Gene at MOPED

Post-translational modifications for C2orf88 Gene

No data available for DME Specific Peptides for C2orf88 Gene

Domains & Families for C2orf88 Gene

Protein Domains for C2orf88 Gene


Suggested Antigen Peptide Sequences for C2orf88 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small membrane AKAP family.
  • Belongs to the small membrane AKAP family.
genes like me logo Genes that share domains with C2orf88: view

No data available for Gene Families for C2orf88 Gene

Function for C2orf88 Gene

Molecular function for C2orf88 Gene

UniProtKB/Swiss-Prot Function:
Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane.
genes like me logo Genes that share phenotypes with C2orf88: view

Animal Model Products

CRISPR Products

miRNA for C2orf88 Gene

miRTarBase miRNAs that target C2orf88

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf88 Gene

Localization for C2orf88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2orf88 Gene

Cell membrane. Note=The GFP-tagged protein has been detected at the plasma membrane, enriched in filopodia and cell-cell junctions. {ECO:0000269 PubMed:23115245}.

Subcellular locations from

Jensen Localization Image for C2orf88 Gene COMPARTMENTS Subcellular localization image for C2orf88 gene
Compartment Confidence
nucleus 5
plasma membrane 4
extracellular 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for C2orf88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with C2orf88: view

Pathways & Interactions for C2orf88 Gene

SuperPathways for C2orf88 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C2orf88 Gene


No data available for Pathways by source and SIGNOR curated interactions for C2orf88 Gene

Drugs & Compounds for C2orf88 Gene

No Compound Related Data Available

Transcripts for C2orf88 Gene

Unigene Clusters for C2orf88 Gene

Chromosome 2 open reading frame 88:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf88 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b
SP2: - -
SP3: -

Relevant External Links for C2orf88 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf88 Gene

mRNA expression in normal human tissues for C2orf88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C2orf88 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (40.2) and Platelet (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C2orf88 Gene

SOURCE GeneReport for Unigene cluster for C2orf88 Gene Hs.389311

mRNA Expression by UniProt/SwissProt for C2orf88 Gene

Tissue specificity: Expressed in heart (at protein level).
genes like me logo Genes that share expression patterns with C2orf88: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for C2orf88 Gene

Orthologs for C2orf88 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf88 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C2H2orf88 35
  • 85.26 (n)
  • 74.74 (a)
C2H2orf88 36
  • 75 (a)
(Canis familiaris)
Mammalia C37H2orf88 35
  • 83.16 (n)
  • 73.68 (a)
C2orf88 36
  • 74 (a)
(Mus musculus)
Mammalia 1700019D03Rik 35
  • 72.34 (n)
  • 59.57 (a)
1700019D03Rik 16
1700019D03Rik 36
  • 52 (a)
(Pan troglodytes)
Mammalia C2BH2orf88 35
  • 99.3 (n)
  • 98.95 (a)
C2orf88 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC102556334 35
  • 75.53 (n)
  • 61.7 (a)
(Monodelphis domestica)
Mammalia C2orf88 36
  • 37 (a)
Species with no ortholog for C2orf88:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf88 Gene

Gene Tree for C2orf88 (if available)
Gene Tree for C2orf88 (if available)

Paralogs for C2orf88 Gene

No data available for Paralogs for C2orf88 Gene

Variants for C2orf88 Gene

Sequence variations from dbSNP and Humsavar for C2orf88 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6753459 - 190,200,027(+) CAATA(C/T)TGTGA reference, missense, utr-variant-3-prime
rs698584 -- 190,184,621(+) AAGGG(C/G/T)GGGAG intron-variant
rs698585 -- 190,184,517(+) AAGAA(A/C)AAAAT intron-variant
rs698586 -- 190,183,580(+) AAACT(A/T)TTAGT intron-variant
rs698587 -- 190,183,501(+) AAATC(C/T)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf88 Gene

Variant ID Type Subtype PubMed ID
esv1004357 CNV Insertion 20482838
esv9098 CNV Gain 19470904
esv1262321 CNV Insertion 17803354
nsv526659 CNV Loss 19592680
esv2505341 CNV Deletion 19546169
nsv875619 CNV Gain 21882294
esv2053772 CNV Deletion 18987734
esv2558230 CNV Deletion 19546169

Variation tolerance for C2orf88 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C2orf88 Gene

Disorders for C2orf88 Gene

Relevant External Links for C2orf88

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C2orf88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf88 Gene

Publications for C2orf88 Gene

  1. Cypher/ZASP is a novel A-kinase anchoring protein. (PMID: 23996002) Lin C. … Cheng H. (J. Biol. Chem. 2013) 2 3 67
  2. Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. (PMID: 24962325) Kapoor M. … Goate A. (Drug Alcohol Depend 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3
  5. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. (PMID: 22344221) Okada Y. … Tanaka T. (Nat. Genet. 2012) 3

Products for C2orf88 Gene

Sources for C2orf88 Gene