C2orf83 Gene
protein-coding GIFtS: 39
GCID: GC02M228474
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chromosome 2 open reading frame 83
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Aliases
for C2orf83 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 2 Open Reading Frame 831 2 | | DKFZp547H0251 | | Folate Transporter-Like Protein C2orf832 |
Export aliases for C2orf83 gene to outside databasesPrevious GC identifers: GC02M228184 GC02M220318 |
Summaries
for C2orf83 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C2orf83 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C2orf83 gene promoter:
HOXA9 NF-AT4 NF-AT2 AML1a Brachyury NF-AT3 POU6F1 (c2) NF-AT1 NF-AT FOXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C2orf83
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf83 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q36.3 Ensembl cytogenetic band: 2q36.3 HGNC cytogenetic band: 2q36.3C2orf83 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M228474: view genomic region
(about GC identifiers)
Start:
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228,474,806 bp from pter |
End:
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228,498,036 bp from pter |
Size:
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23,231 bases |
Orientation:
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minus strand |
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Proteins
for C2orf83 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CB083_HUMAN, Q53S99 (See
protein sequence)Recommended Name: Folate transporter-like protein C2orf83 Size: 150 amino acids; 16373 Da
Caution: Although related to reduced folate carrier family, it lacks transmembrane domains, suggesting that it hasprobably no transporter function
Sequence caution: Sequence=CAB95774.1; Type=Erroneous termination; Positions=141; Note=Translated as Trp;Sequence=CAH18470.1; Type=Erroneous termination; Positions=141; Note=Translated as Trp;
Secondary accessions: A2RRG6 B8ZZI8 Q9NPW4Alternative splicing: 2 isoforms: Q53S99-1 Q53S99-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C2orf83: NX_Q53S99
C2orf83 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001155955.1 NP_064546.3
ENSEMBL proteins: ENSP00000264387 ENSP00000387149
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- |
C2orf83 for ontologies About GeneDecksing
C2orf83 Antibody Products:
Assay Products for C2orf83: |
Protein
Domains /
Families
for C2orf83 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C2orf83 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q53S99ProtoNet protein and cluster: Q53S99 UniProtKB/Swiss-Prot: CB083_HUMAN, Q53S99Similarity: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family |
Function
for C2orf83 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf83 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf83 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for C2orf83 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf83 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf83 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005542 | folic acid binding |
IEA | -- | | GO:0008518 | reduced folate carrier activity |
IEA | -- |
C2orf83 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for C2orf83:
|
Pathways & Interactions
for C2orf83 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C2orf83
|
Drugs & Compounds
for C2orf83 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C2orf83
1 HMDB Compound for C2orf83 About this table
Search CenterWatch for drugs/clinical trials and news about C2orf83 / CB083
|
Transcripts
for C2orf83 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C2orf83 gene (2 alternative transcripts): NM_001162483.1 NM_020161.3 Unigene Cluster for C2orf83: Chromosome 2 open reading frame 83 Hs.283092 [show with all ESTs]Unigene Representative Sequence: NM_0011624832 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264387 ENST00000409066(uc010zlu.2 uc002vph.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf83 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf83 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C2orf83 (NM_020161) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C2orf83 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf83 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2orf83
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C2orf83 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf83 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf83 |
Additional cDNA sequence: AK055355.1 AL359944.1 BC131618.1 CR749679.1 2 DOTS entries: DT.91973066 DT.95362907 6 AceView cDNA sequences: BX360578 AL359944 NM_020161 BX371898 CR749679 AK055355
GeneLoc Exon Structure
|
Expression
for C2orf83 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C2orf83 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGGCCAAT
About this image
See C2orf83 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C2orf83
SOURCE GeneReport for Unigene cluster: Hs.283092
SABiosciences Custom PCR Arrays for C2orf83
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2orf83
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C2orf83 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf83 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf83 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf83 |
Orthologs
for C2orf83 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
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ENSEMBL Gene Tree for C2orf83 (if available)
TreeFam Gene Tree for C2orf83 (if available) |
Paralogs
for C2orf83 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C2orf83 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C2orf83 (228474806 - 228498036 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for C2orf83
2 CNVs: 6035 68239 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2orf83 |
|
Disorders
/ Diseases
for C2orf83 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C2orf83 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C2orf83 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C2orf83) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
- DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
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External Searches for C2orf83 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C2orf83 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C2orf83 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C2orf83 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C2orf83 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C2orf83 gene:
Search GeneIP for patents involving C2orf83
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C2orf83 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C2orf83 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C2orf83 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2orf83 | | | OriGene Protein Over-expression Lysate for C2orf83 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C2orf83 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf83 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf83 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for C2orf83 |
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 | | | C2orf83 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf83 |
|  |  |  | | | | Search ThermoFisher Antibodies for C2orf83 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf83 |
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