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Aliases for C2orf81 Gene

Aliases for C2orf81 Gene

  • Chromosome 2 Open Reading Frame 81 2 3 5
  • Uncharacterized Protein C2orf81 3
  • HCG40743 3

External Ids for C2orf81 Gene

Previous GeneCards Identifiers for C2orf81 Gene

  • GC02M074473
  • GC02M074641
  • GC02M074377
  • GC02M074415
  • GC02M074417

Summaries for C2orf81 Gene

GeneCards Summary for C2orf81 Gene

C2orf81 (Chromosome 2 Open Reading Frame 81) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf81 Gene

Genomics for C2orf81 Gene

Regulatory Elements for C2orf81 Gene

Enhancers for C2orf81 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C2orf81 on UCSC Golden Path with GeneCards custom track

Promoters for C2orf81 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C2orf81 Gene

74,393,836 bp from pter
74,421,662 bp from pter
27,827 bases
Minus strand

Genomic View for C2orf81 Gene

Genes around C2orf81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf81 Gene

Proteins for C2orf81 Gene

  • Protein details for C2orf81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C2orf81
    Protein Accession:

    Protein attributes for C2orf81 Gene

    581 amino acids
    Molecular mass:
    63053 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf81 Gene

Post-translational modifications for C2orf81 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf81 Gene

No data available for DME Specific Peptides for C2orf81 Gene

Domains & Families for C2orf81 Gene

Protein Domains for C2orf81 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf81: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf81 Gene

Function for C2orf81 Gene

genes like me logo Genes that share phenotypes with C2orf81: view

Animal Model Products

CRISPR Products

miRNA for C2orf81 Gene

miRTarBase miRNAs that target C2orf81

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf81 Gene

Localization for C2orf81 Gene

Subcellular locations from

Jensen Localization Image for C2orf81 Gene COMPARTMENTS Subcellular localization image for C2orf81 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf81 Gene

Pathways & Interactions for C2orf81 Gene

SuperPathways for C2orf81 Gene

No Data Available

Interacting Proteins for C2orf81 Gene

Gene Ontology (GO) - Biological Process for C2orf81 Gene


No data available for Pathways by source and SIGNOR curated interactions for C2orf81 Gene

Drugs & Compounds for C2orf81 Gene

No Compound Related Data Available

Transcripts for C2orf81 Gene

mRNA/cDNA for C2orf81 Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2orf81 Gene

Chromosome 2 open reading frame 81:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf81 Gene

No ASD Table

Relevant External Links for C2orf81 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf81 Gene

mRNA expression in normal human tissues for C2orf81 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf81 Gene

This gene is overexpressed in Testis (x6.3) and Pituitary (x4.9).

Protein differential expression in normal tissues from HIPED for C2orf81 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C2orf81 Gene

Protein tissue co-expression partners for C2orf81 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C2orf81 Gene:


SOURCE GeneReport for Unigene cluster for C2orf81 Gene:

genes like me logo Genes that share expression patterns with C2orf81: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C2orf81 Gene

Orthologs for C2orf81 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf81 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C11H2orf81 34
  • 78.13 (n)
  • 71.25 (a)
C11H2orf81 35
  • 67 (a)
(Canis familiaris)
Mammalia C17H2orf81 34
  • 75.78 (n)
  • 66.78 (a)
C2orf81 35
  • 62 (a)
(Mus musculus)
Mammalia 1700003E16Rik 34
  • 68.23 (n)
  • 57.94 (a)
1700003E16Rik 16
1700003E16Rik 35
  • 52 (a)
(Rattus norvegicus)
Mammalia LOC500227 34
  • 67.8 (n)
  • 58.35 (a)
(Monodelphis domestica)
Mammalia C2orf81 35
  • 41 (a)
(Anolis carolinensis)
Reptilia C2orf81 35
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1013 35
  • 25 (a)
Species where no ortholog for C2orf81 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf81 Gene

Gene Tree for C2orf81 (if available)
Gene Tree for C2orf81 (if available)

Paralogs for C2orf81 Gene

No data available for Paralogs for C2orf81 Gene

Variants for C2orf81 Gene

Sequence variations from dbSNP and Humsavar for C2orf81 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11267010 -- 74,418,508(-) CACCG(C/T)AGGCC upstream-variant-2KB
rs13036163 -- 74,416,702(+) TGGCC(C/T)TTATA intron-variant
rs59349435 -- 74,416,589(+) AAAAA(-/A)GAAAA intron-variant
rs7571984 -- 74,416,561(+) ACTGC(A/G)TCTCA intron-variant
rs60165458 -- 74,418,627(+) CGCCA(A/G)AAATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C2orf81 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv1072414 CNV deletion 25765185
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for C2orf81 Gene

Gene Damage Index Score: 2.63; 45.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf81 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf81 Gene

Disorders for C2orf81 Gene

Relevant External Links for C2orf81

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C2orf81 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf81 Gene

Publications for C2orf81 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 2 3 4 65

Products for C2orf81 Gene

Sources for C2orf81 Gene

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