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Aliases for C2orf81 Gene

Aliases for C2orf81 Gene

  • Chromosome 2 Open Reading Frame 81 2 3 5
  • Uncharacterized Protein C2orf81 3
  • HCG40743 3

External Ids for C2orf81 Gene

Previous GeneCards Identifiers for C2orf81 Gene

  • GC02M074473
  • GC02M074641
  • GC02M074377
  • GC02M074415
  • GC02M074417
  • GC02M074393
  • GC02M074428

Summaries for C2orf81 Gene

GeneCards Summary for C2orf81 Gene

C2orf81 (Chromosome 2 Open Reading Frame 81) is a Protein Coding gene. An important paralog of this gene is ENSG00000159239.

Additional gene information for C2orf81 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf81 Gene

Genomics for C2orf81 Gene

Regulatory Elements for C2orf81 Gene

Enhancers for C2orf81 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H074575 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -155.5 -155498 3 PKNOX1 MAX CEBPG ZBTB40 BATF RAD21 GATA3 POLR2A EED ETV6 DOK1 LOXL3 HTRA2 AUP1 DQX1 TLX2 PCGF1 LBX2 TTC31 CCDC142
GH02H074372 1.2 Ensembl ENCODE dbSUPER 10.7 +47.6 47602 2 MXI1 KLF1 ATF1 ZFHX2 POLR2A ZNF600 ATF7 CREM EGR2 MAZ SLC4A5 WDR54 C2orf81 ENSG00000159239 RTKN BOLA3 BOLA3-AS1 ENSG00000272183 MOGS GC02M074371
GH02H074266 0.9 ENCODE 10 +154.3 154287 1 HDAC1 ELF3 PKNOX1 FOXA2 ATF1 RB1 ZBTB40 RAD21 RARA ZNF143 ENSG00000273245 SLC4A5 C2orf81 ENSG00000159239 WDR54 RTKN KRT18P26 GC02P074217
GH02H074334 0.7 ENCODE 10.4 +86.6 86553 0 ELF3 GTF2F1 CTCF ZSCAN9 RAD21 RFX5 SMC3 ZNF143 IKZF2 STAT1 ENSG00000272183 WDR54 C2orf81 ENSG00000159239 RTKN SLC4A5 RNU6-542P
GH02H074452 0.6 ENCODE 11.8 -31.3 -31311 1 ZNF664 IKZF1 ZNF384 ZBTB40 SPI1 TEAD3 WDR54 ENSG00000159239 C2orf81 GC02M074444 RTKN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C2orf81 on UCSC Golden Path with GeneCards custom track

Promoters for C2orf81 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119156 -109 1001 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ETS1 GLIS2 ELK1 ZNF143

Genomic Location for C2orf81 Gene

Chromosome:
2
Start:
74,414,176 bp from pter
End:
74,421,591 bp from pter
Size:
7,416 bases
Orientation:
Minus strand

Genomic View for C2orf81 Gene

Genes around C2orf81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf81 Gene

Proteins for C2orf81 Gene

  • Protein details for C2orf81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NN90-CB081_HUMAN
    Recommended name:
    Uncharacterized protein C2orf81
    Protein Accession:
    A6NN90

    Protein attributes for C2orf81 Gene

    Size:
    581 amino acids
    Molecular mass:
    63053 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf81 Gene

Post-translational modifications for C2orf81 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C2orf81 Gene

Domains & Families for C2orf81 Gene

Gene Families for C2orf81 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C2orf81 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf81: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf81 Gene

Function for C2orf81 Gene

Phenotypes From GWAS Catalog for C2orf81 Gene

genes like me logo Genes that share phenotypes with C2orf81: view

Animal Model Products

CRISPR Products

miRNA for C2orf81 Gene

miRTarBase miRNAs that target C2orf81

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C2orf81
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf81 Gene

Localization for C2orf81 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf81 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C2orf81 Gene

Pathways & Interactions for C2orf81 Gene

SuperPathways for C2orf81 Gene

No Data Available

Interacting Proteins for C2orf81 Gene

Gene Ontology (GO) - Biological Process for C2orf81 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf81 Gene

Drugs & Compounds for C2orf81 Gene

No Compound Related Data Available

Transcripts for C2orf81 Gene

mRNA/cDNA for C2orf81 Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2orf81 Gene

Chromosome 2 open reading frame 81:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C2orf81
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf81 Gene

No ASD Table

Relevant External Links for C2orf81 Gene

GeneLoc Exon Structure for
C2orf81
ECgene alternative splicing isoforms for
C2orf81

Expression for C2orf81 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf81 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf81 Gene

This gene is overexpressed in Testis (x6.3) and Pituitary (x4.9).

Protein differential expression in normal tissues from HIPED for C2orf81 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C2orf81 Gene



Protein tissue co-expression partners for C2orf81 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C2orf81 Gene:

C2orf81

SOURCE GeneReport for Unigene cluster for C2orf81 Gene:

Hs.445377
genes like me logo Genes that share expression patterns with C2orf81: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf81 Gene

Orthologs for C2orf81 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf81 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C11H2orf81 33
  • 78.13 (n)
dog
(Canis familiaris)
Mammalia C17H2orf81 33
  • 75.78 (n)
mouse
(Mus musculus)
Mammalia 1700003E16Rik 33 16
  • 68.23 (n)
rat
(Rattus norvegicus)
Mammalia LOC500227 33
  • 67.8 (n)
Species where no ortholog for C2orf81 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf81 Gene

ENSEMBL:
Gene Tree for C2orf81 (if available)
TreeFam:
Gene Tree for C2orf81 (if available)

Paralogs for C2orf81 Gene

Paralogs for C2orf81 Gene

genes like me logo Genes that share paralogs with C2orf81: view

Variants for C2orf81 Gene

Sequence variations from dbSNP and Humsavar for C2orf81 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000002846 -- 74,415,088(+) TGGTG(G/T)TGGGC reference, missense
rs1000603634 -- 74,416,706(+) CCTTA(C/T)ACCAG intron-variant
rs1000909908 -- 74,419,041(+) CCAGG(A/C)ATGGT intron-variant, upstream-variant-2KB
rs1002221556 -- 74,419,107(+) ACCCG(C/G)GAGGC intron-variant, upstream-variant-2KB
rs1002510898 -- 74,420,131(+) GGATA(A/C)AAACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C2orf81 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv1072414 CNV deletion 25765185
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for C2orf81 Gene

Gene Damage Index Score: 2.63; 45.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf81 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf81

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf81 Gene

Disorders for C2orf81 Gene

Relevant External Links for C2orf81

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf81

No disorders were found for C2orf81 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf81 Gene

Publications for C2orf81 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 2 3 4 60

Products for C2orf81 Gene

Sources for C2orf81 Gene

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