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Aliases for C2orf78 Gene

Aliases for C2orf78 Gene

  • Chromosome 2 Open Reading Frame 78 2 3 5
  • Uncharacterized Protein C2orf78 3
  • HCG1989538 3
  • COG5373 3

External Ids for C2orf78 Gene

Previous GeneCards Identifiers for C2orf78 Gene

  • GC02P073864
  • GC02P074011

Summaries for C2orf78 Gene

GeneCards Summary for C2orf78 Gene

C2orf78 (Chromosome 2 Open Reading Frame 78) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf78 Gene

Genomics for C2orf78 Gene

Regulatory Elements for C2orf78 Gene

Enhancers for C2orf78 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F073759 0.7 ENCODE 11.8 -24.5 -24508 0.8 SMARCA5 PKNOX1 MIER1 ZIC2 ZBTB40 NR2F2 POLR2A GLIS1 SCRT2 NBN C2orf78 DUSP11 TPRKB STAMBP TET3 BOLA3 BOLA3-AS1 ENSG00000280037 ENSG00000273245
GH02F073782 0.5 ENCODE 0.8 -0.6 -625 1.2 SIN3A GLIS2 RCOR1 EGR2 ZNF263 SP5 ZHX2 ZNF843 SREBF1 MTA1 TPRKB CCT7 DUSP11 C2orf78
GH02F073824 0.2 ENCODE 0.3 +39.9 39940 0.2 CTCF ZNF654 TBL1XR1 NRF1 TRIM22 REST ZSCAN9 RAD21 OSR2 JUND STAMBP C2orf78
GH02F073821 0.4 FANTOM5 0.3 +37.3 37280 0.1 PKNOX1 JUNB EBF1 TBX21 RELA SP1 POLR2A ZNF585B IKZF1 EED WBP1 SMYD5 C2orf81 MOB1A MTHFD2 STAMBP C2orf78
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C2orf78 on UCSC Golden Path with GeneCards custom track

Genomic Location for C2orf78 Gene

Chromosome:
2
Start:
73,784,189 bp from pter
End:
73,817,148 bp from pter
Size:
32,960 bases
Orientation:
Plus strand

Genomic View for C2orf78 Gene

Genes around C2orf78 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf78 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf78 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf78 Gene

Proteins for C2orf78 Gene

  • Protein details for C2orf78 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCI8-CB078_HUMAN
    Recommended name:
    Uncharacterized protein C2orf78
    Protein Accession:
    A6NCI8

    Protein attributes for C2orf78 Gene

    Size:
    922 amino acids
    Molecular mass:
    100170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf78 Gene

Post-translational modifications for C2orf78 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf78 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2orf78 Gene

Domains & Families for C2orf78 Gene

Protein Domains for C2orf78 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf78: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf78 Gene

Function for C2orf78 Gene

Phenotypes for C2orf78 Gene

genes like me logo Genes that share phenotypes with C2orf78: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf78 Gene

Localization for C2orf78 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2orf78 Gene COMPARTMENTS Subcellular localization image for C2orf78 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf78 Gene

Pathways & Interactions for C2orf78 Gene

SuperPathways for C2orf78 Gene

No Data Available

Interacting Proteins for C2orf78 Gene

Gene Ontology (GO) - Biological Process for C2orf78 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf78 Gene

Transcripts for C2orf78 Gene

mRNA/cDNA for C2orf78 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2orf78 Gene

Chromosome 2 open reading frame 78:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf78 Gene

No ASD Table

Relevant External Links for C2orf78 Gene

GeneLoc Exon Structure for
C2orf78
ECgene alternative splicing isoforms for
C2orf78

Expression for C2orf78 Gene

mRNA expression in normal human tissues for C2orf78 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf78 Gene

This gene is overexpressed in Testis (x51.5).

NURSA nuclear receptor signaling pathways regulating expression of C2orf78 Gene:

C2orf78

SOURCE GeneReport for Unigene cluster for C2orf78 Gene:

Hs.456833
genes like me logo Genes that share expression patterns with C2orf78: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C2orf78 Gene

Orthologs for C2orf78 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf78 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf78 34
  • 98.84 (n)
C2orf78 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17H2orf78 34
  • 82.73 (n)
C2orf78 35
  • 72 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H2orf78 34
  • 81.47 (n)
C2orf78 35
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC690284 34
  • 67.29 (n)
oppossum
(Monodelphis domestica)
Mammalia C2orf78 35
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5114 35
  • 48 (a)
OneToMany
Gm5591 35
  • 47 (a)
OneToMany
Gm5592 35
  • 46 (a)
OneToMany
4930433I11Rik 35
  • 45 (a)
OneToMany
Gm4884 35
  • 45 (a)
OneToMany
Gm2128 35
  • 44 (a)
OneToMany
Gm6605 35
  • 43 (a)
OneToMany
Gm21142 35
  • 39 (a)
OneToMany
Gm21276 35
  • 39 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 35 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
Species where no ortholog for C2orf78 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf78 Gene

ENSEMBL:
Gene Tree for C2orf78 (if available)
TreeFam:
Gene Tree for C2orf78 (if available)

Paralogs for C2orf78 Gene

No data available for Paralogs for C2orf78 Gene

Variants for C2orf78 Gene

Sequence variations from dbSNP and Humsavar for C2orf78 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111417087 -- 73,805,783(+) CCTGG(A/C)CAACG intron-variant
rs111604294 -- 73,786,740(+) ATAAA(A/C)AACCA intron-variant
rs111924333 -- 73,802,814(+) AATAT(C/T)CACGA intron-variant
rs112115287 -- 73,812,947(+) ATGCC(-/ATATT)AAAAG intron-variant
rs112200759 -- 73,783,311(+) GAAGA(C/G)AGATC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C2orf78 Gene

Variant ID Type Subtype PubMed ID
dgv15n31 CNV gain 19718026
dgv3870n100 CNV gain 25217958
esv2759060 CNV gain 17122850
esv28264 CNV gain+loss 19812545
esv3327234 CNV duplication 20981092
esv3391910 CNV duplication 20981092
esv3392660 CNV duplication 20981092
esv3402088 CNV duplication 20981092
esv3419356 CNV duplication 20981092
esv3591270 CNV loss 21293372
nsv10024 CNV gain+loss 18304495
nsv1115560 CNV duplication 24896259
nsv1115561 CNV duplication 24896259
nsv1146325 CNV duplication 26484159
nsv1153492 CNV duplication 26484159
nsv2780 CNV deletion 18451855
nsv2781 CNV insertion 18451855
nsv482051 CNV gain 20164927
nsv508842 CNV insertion 20534489
nsv511053 OTHER complex 20534489
nsv582211 CNV loss 21841781
nsv582212 CNV loss 21841781
nsv834260 CNV gain 17160897
nsv953150 CNV duplication 24416366
nsv961416 CNV duplication 23825009
nsv961417 CNV duplication 23825009
nsv961418 CNV duplication 23825009
nsv963622 CNV duplication 23825009
nsv979023 CNV duplication 23825009
nsv979024 CNV duplication 23825009
nsv979025 CNV duplication 23825009

Variation tolerance for C2orf78 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf78 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf78

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf78 Gene

Disorders for C2orf78 Gene

Relevant External Links for C2orf78

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf78

No disorders were found for C2orf78 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf78 Gene

Publications for C2orf78 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for C2orf78 Gene

Sources for C2orf78 Gene

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