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Aliases for C2orf76 Gene

Aliases for C2orf76 Gene

  • Chromosome 2 Open Reading Frame 76 2 3
  • UPF0538 Protein C2orf76 3
  • AIM29 3

External Ids for C2orf76 Gene

Previous GeneCards Identifiers for C2orf76 Gene

  • GC02M119776
  • GC02M120059
  • GC02M112386

Summaries for C2orf76 Gene

GeneCards Summary for C2orf76 Gene

C2orf76 (Chromosome 2 Open Reading Frame 76) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf76 Gene

Genomics for C2orf76 Gene

Regulatory Elements for C2orf76 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C2orf76 Gene

Start:
119,301,204 bp from pter
End:
119,366,875 bp from pter
Size:
65,672 bases
Orientation:
Minus strand

Genomic View for C2orf76 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C2orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf76 Gene

Proteins for C2orf76 Gene

  • Protein details for C2orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KRA6-CB076_HUMAN
    Recommended name:
    UPF0538 protein C2orf76
    Protein Accession:
    Q3KRA6
    Secondary Accessions:
    • B7ZLS8
    • Q4VC35

    Protein attributes for C2orf76 Gene

    Size:
    126 amino acids
    Molecular mass:
    14609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf76 Gene

Proteomics data for C2orf76 Gene at MOPED

Post-translational modifications for C2orf76 Gene

  • Ubiquitination at Lys65
  • Modification sites at PhosphoSitePlus

Other Protein References for C2orf76 Gene

No data available for DME Specific Peptides for C2orf76 Gene

Domains for C2orf76 Gene

Protein Domains for C2orf76 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C2orf76 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KRA6

UniProtKB/Swiss-Prot:

CB076_HUMAN :
  • Q3KRA6
Family:
  • Belongs to the UPF0538 family.
genes like me logo Genes that share domains with C2orf76: view

No data available for Gene Families for C2orf76 Gene

Function for C2orf76 Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2orf76

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C2orf76 Gene

Localization for C2orf76 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2orf76 Gene COMPARTMENTS Subcellular localization image for C2orf76 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf76 Gene

Pathways for C2orf76 Gene

SuperPathways for C2orf76 Gene

No Data Available

Interacting Proteins for C2orf76 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335041%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000335041 for C2orf76 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for C2orf76 Gene

None

No data available for Pathways by source for C2orf76 Gene

Transcripts for C2orf76 Gene

Unigene Clusters for C2orf76 Gene

Chromosome 2 open reading frame 76:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2orf76

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for C2orf76

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf76 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2: - - - -
SP3: - - -
SP4: - -

Relevant External Links for C2orf76 Gene

GeneLoc Exon Structure for
C2orf76
ECgene alternative splicing isoforms for
C2orf76

Expression for C2orf76 Gene

mRNA expression in normal human tissues for C2orf76 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C2orf76 Gene

SOURCE GeneReport for Unigene cluster for C2orf76 Gene Hs.99488

genes like me logo Genes that share expressions with C2orf76: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C2orf76 Gene

Orthologs for C2orf76 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C2orf76 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2BH2orf76 35
  • 98.15 (n)
  • 97.62 (a)
C2orf76 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C2H2orf76 35
  • 91.53 (n)
  • 91.27 (a)
C2orf76 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C19H2orf76 35
  • 89.95 (n)
  • 88.89 (a)
C2orf76 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 3110009E18Rik 35
  • 85.98 (n)
  • 83.33 (a)
3110009E18Rik 16
3110009E18Rik 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C2orf76 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC288978 35
  • 82.8 (n)
  • 80.16 (a)
chicken
(Gallus gallus)
Aves C7H2ORF76 35
  • 74.34 (n)
  • 74.6 (a)
C7H2ORF76 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf76 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C9H2orf76 36
  • 63 (a)
OneToOne
zgc:101851 35
  • 63.23 (n)
  • 63.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM29 36
  • 32 (a)
OneToOne
AIM29 38
Species with no ortholog for C2orf76:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf76 Gene

ENSEMBL:
Gene Tree for C2orf76 (if available)
TreeFam:
Gene Tree for C2orf76 (if available)

Paralogs for C2orf76 Gene

No data available for Paralogs for C2orf76 Gene

Variants for C2orf76 Gene

Sequence variations from dbSNP and Humsavar for C2orf76 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1890 -- 119,302,412(+) AAAAA(C/T)TCAGC downstream-variant-500B, utr-variant-3-prime
rs8600 -- 119,302,345(-) ATCTG(G/T)TTATT downstream-variant-500B, utr-variant-3-prime
rs16744 -- 119,302,319(+) AGAAG(-/GAAA)GAAAG downstream-variant-500B, utr-variant-3-prime
rs752185 -- 119,312,179(+) TCACC(C/T)GGTCA intron-variant
rs935394 -- 119,350,654(+) AGGGA(A/C)GCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf76 Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV Gain 19166990
nsv874960 CNV Gain 21882294
nsv508862 CNV Insertion 20534489

Relevant External Links for C2orf76 Gene

HapMap Linkage Disequilibrium report
C2orf76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf76 Gene

Disorders for C2orf76 Gene

Relevant External Links for C2orf76

Genetic Association Database (GAD)
C2orf76
Human Genome Epidemiology (HuGE) Navigator
C2orf76
genes like me logo Genes that share disorders with C2orf76: view

No data available for UniProtKB/Swiss-Prot for C2orf76 Gene

Publications for C2orf76 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K. … . (J. Infect. Dis. 2010) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for C2orf76 Gene

Sources for C2orf76 Gene

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