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Aliases for C2orf76 Gene

Aliases for C2orf76 Gene

  • Chromosome 2 Open Reading Frame 76 2 3 5
  • UPF0538 Protein C2orf76 3
  • AIM29 3

External Ids for C2orf76 Gene

Previous GeneCards Identifiers for C2orf76 Gene

  • GC02M119776
  • GC02M120059
  • GC02M112386

Summaries for C2orf76 Gene

GeneCards Summary for C2orf76 Gene

C2orf76 (Chromosome 2 Open Reading Frame 76) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf76 Gene

Genomics for C2orf76 Gene

Regulatory Elements for C2orf76 Gene

Enhancers for C2orf76 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F119387 1.3 Ensembl ENCODE 12.5 -20.9 -20931 1.5 ELF3 HDAC1 RAD21 RARA YY1 EGR1 SCRT2 FOS CEBPB JUNB DBI ENSG00000231013 C2orf76 TMEM37 SCTR STEAP3 PIR46529
GH02F119355 0.9 FANTOM5 Ensembl 8.8 +10.9 10927 1.0 ZNF146 MTA2 RNF2 CBX5 IKZF1 EP300 DBI C2orf76 LOC105373581
GH02F119306 0.2 Ensembl 6.7 +60.3 60328 1.0 ZNF362 RFX1 RNF2 MYNN STEAP3 C2orf76 LOC105373581
GH02F120242 1.2 Ensembl ENCODE 5.2 -878.3 -878266 4.2 PKNOX1 KLF17 SIN3A FEZF1 RARA ZNF366 SMARCC2 ZNF207 RCOR1 ZNF263 RALB ENSG00000224789 MTND4P26 C2orf76 LOC105373583
GH02F120011 0.5 ENCODE 4.4 -646.4 -646417 3.2 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 FOS SP3 EPB41L5 TMEM185B C2orf76 LOC105373582
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C2orf76 on UCSC Golden Path with GeneCards custom track

Promoters for C2orf76 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000597313 -72 3001 HDGF MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 SP3

Genomic Location for C2orf76 Gene

Chromosome:
2
Start:
119,300,442 bp from pter
End:
119,366,828 bp from pter
Size:
66,387 bases
Orientation:
Minus strand

Genomic View for C2orf76 Gene

Genes around C2orf76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf76 Gene

Proteins for C2orf76 Gene

  • Protein details for C2orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KRA6-CB076_HUMAN
    Recommended name:
    UPF0538 protein C2orf76
    Protein Accession:
    Q3KRA6
    Secondary Accessions:
    • B7ZLS8
    • Q4VC35

    Protein attributes for C2orf76 Gene

    Size:
    126 amino acids
    Molecular mass:
    14609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf76 Gene

Post-translational modifications for C2orf76 Gene

  • Ubiquitination at Lys 65
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C2orf76 Gene

Domains & Families for C2orf76 Gene

Protein Domains for C2orf76 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C2orf76 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KRA6

UniProtKB/Swiss-Prot:

CB076_HUMAN :
  • Belongs to the UPF0538 family.
Family:
  • Belongs to the UPF0538 family.
genes like me logo Genes that share domains with C2orf76: view

No data available for Gene Families for C2orf76 Gene

Function for C2orf76 Gene

Phenotypes for C2orf76 Gene

GenomeRNAi human phenotypes for C2orf76:
genes like me logo Genes that share phenotypes with C2orf76: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf76 Gene

Localization for C2orf76 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2orf76 Gene COMPARTMENTS Subcellular localization image for C2orf76 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf76 Gene

Pathways & Interactions for C2orf76 Gene

SuperPathways for C2orf76 Gene

No Data Available

Interacting Proteins for C2orf76 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335041%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000335041 for C2orf76 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for C2orf76 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf76 Gene

Transcripts for C2orf76 Gene

Unigene Clusters for C2orf76 Gene

Chromosome 2 open reading frame 76:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf76 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2: - - - -
SP3: - - -
SP4: - -

Relevant External Links for C2orf76 Gene

GeneLoc Exon Structure for
C2orf76
ECgene alternative splicing isoforms for
C2orf76

Expression for C2orf76 Gene

mRNA expression in normal human tissues for C2orf76 Gene

Protein differential expression in normal tissues from HIPED for C2orf76 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.9), Uterus (10.5), Adrenal (6.9), and Oral epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C2orf76 Gene



NURSA nuclear receptor signaling pathways regulating expression of C2orf76 Gene:

C2orf76

SOURCE GeneReport for Unigene cluster for C2orf76 Gene:

Hs.99488
genes like me logo Genes that share expression patterns with C2orf76: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C2orf76 Gene

Orthologs for C2orf76 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C2orf76 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2BH2orf76 34
  • 98.15 (n)
C2orf76 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C2H2orf76 34
  • 91.53 (n)
C2orf76 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C19H2orf76 34
  • 89.95 (n)
C2orf76 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 3110009E18Rik 34 16 35
  • 85.98 (n)
rat
(Rattus norvegicus)
Mammalia LOC288978 34
  • 82.8 (n)
oppossum
(Monodelphis domestica)
Mammalia C2orf76 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves C7H2ORF76 34 35
  • 74.34 (n)
lizard
(Anolis carolinensis)
Reptilia C2orf76 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:101851 34
  • 63.23 (n)
C9H2orf76 35
  • 63 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM29 35 37
  • 32 (a)
OneToOne
Species where no ortholog for C2orf76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf76 Gene

ENSEMBL:
Gene Tree for C2orf76 (if available)
TreeFam:
Gene Tree for C2orf76 (if available)

Paralogs for C2orf76 Gene

No data available for Paralogs for C2orf76 Gene

Variants for C2orf76 Gene

Sequence variations from dbSNP and Humsavar for C2orf76 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10167755 -- 119,328,619(+) tattt(A/C/T)tttta intron-variant
rs10170509 -- 119,357,370(+) caagt(A/G)gtttt intron-variant
rs10175289 -- 119,337,067(+) TATTT(A/T)TTTTT intron-variant
rs10181496 -- 119,368,773(+) TCCTG(A/G)TGATA intron-variant, upstream-variant-2KB
rs10193312 -- 119,281,184(+) ctcat(C/G)tcatg downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C2orf76 Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV gain 19166990
nsv508862 CNV insertion 20534489
nsv582784 CNV gain 21841781

Variation tolerance for C2orf76 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf76 Gene

Disorders for C2orf76 Gene

Relevant External Links for C2orf76

Genetic Association Database (GAD)
C2orf76
Human Genome Epidemiology (HuGE) Navigator
C2orf76
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf76

No disorders were found for C2orf76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf76 Gene

Publications for C2orf76 Gene

  1. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K. … . (J. Infect. Dis. 2010) 3 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for C2orf76 Gene

Sources for C2orf76 Gene

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