C2orf76 Gene
protein-coding GIFtS: 38
GCID: GC02M120059 (predicted)
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chromosome 2 open reading frame 76
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Aliases
for C2orf76 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 2 Open Reading Frame 761 2 | | AIM291 2 | | LOC1303551 | | MGC1044371 | | UPF0538 Protein C2orf762 |
Export aliases for C2orf76 gene to outside databasesPrevious GC identifers: GC02M119776 GC02M112386 |
Summaries
for C2orf76 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C2orf76 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C2orf76 gene promoter:
Nkx3-1 Nkx3-1 v4 Nkx3-1 v1 Nkx3-1 v2 PPAR-gamma1 Nkx3-1 v3 PPAR-gamma2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for C2orf76
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf76 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q14.2 Ensembl cytogenetic band: 2q14.2 HGNC cytogenetic band: 2q14.2C2orf76 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M120059: view genomic region
(about GC identifiers)
Start:
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120,059,801 bp from pter |
End:
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120,124,404 bp from pter |
Size:
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64,604 bases |
Orientation:
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minus strand |
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Proteins
for C2orf76 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CB076_HUMAN, Q3KRA6 (See
protein sequence)Recommended Name: UPF0538 protein C2orf76 Size: 126 amino acids; 14609 Da
Secondary accessions: B7ZLS8 Q4VC35Explore the universe of human proteins at neXtProt for C2orf76: NX_Q3KRA6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q3KRA6
C2orf76 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001017927.2
ENSEMBL proteins: ENSP00000386302 ENSP00000335041 ENSP00000387234 ENSP00000386714 ENSP00000388482
Human Recombinant Protein Products for C2orf76:
C2orf76 Antibody Products:
Assay Products for C2orf76: |
Protein
Domains /
Families
for C2orf76 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C2orf76 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q3KRA6ProtoNet protein and cluster: Q3KRA6 UniProtKB/Swiss-Prot: CB076_HUMAN, Q3KRA6Similarity: Belongs to the UPF0538 family |
Function
for C2orf76 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf76 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf76
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C2orf76 (NM_001017927) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C2orf76 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf76 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf76 |
|
Pathways & Interactions
for C2orf76 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C2orf76
|
Drugs & Compounds
for C2orf76 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C2orf76
Search CenterWatch for drugs/clinical trials and news about C2orf76 / CB076
|
Transcripts
for C2orf76 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C2orf76 gene: NM_001017927.2 Unigene Cluster for C2orf76: Chromosome 2 open reading frame 76 Hs.99488 [show with all ESTs]Unigene Representative Sequence: BC0473656 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409466(uc010yyg.1 uc002tlt.2) ENST00000334816(uc002tlu.2)
ENST00000409877(uc002tls.2) ENST00000409523(uc010flf.1) ENST00000414534
ENST00000498049
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf76 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf76
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C2orf76 (NM_001017927) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C2orf76 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf76 |
Additional cDNA sequence: BC047365.1 BC062434.1 BC105805.1 BC126395.1 BC126397.1 BC144012.1 BC144014.1 BC171737.1 5 DOTS entries: DT.100777052 DT.211804 DT.100659229 DT.97834817 DT.101973022 24/68 AceView cDNA sequences (see all 68): AA738440 AI091896 CR624749 AI383295 BC047365 BI763973 AW051480 BU599759 AI246250 AI191561 BX103499 AA243441 BC062434 AI817119 BU853537 BX444653 CD653775 BU729633 CK819433 BX506482 BU602593 BM701966 AI306531 AA252613
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for C2orf76 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for C2orf76
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Expression
for C2orf76 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C2orf76 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTCCTGGAG
About this image
See C2orf76 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C2orf76
SOURCE GeneReport for Unigene cluster: Hs.99488
SABiosciences Custom PCR Arrays for C2orf76
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2orf76
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C2orf76 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf76 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf76 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf76 |
Orthologs
for C2orf76 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C2orf76 gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for C2orf76 (if available)
TreeFam Gene Tree for C2orf76 (if available) |
Paralogs
for C2orf76 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C2orf76 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C2orf76 (120059801 - 120124404 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C2orf76: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2orf76 |
|
Disorders
/ Diseases
for C2orf76 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C2orf76 for disorders About MalaCards
C2orf76 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: C2orf76 (2 documents)
Export disorders for C2orf76 gene to outside databases
|
Publications
for C2orf76 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C2orf76 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C2orf76) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Host determinants of HIV-1 control in African America ns. (PubMed id 20205591)1 Pelak K....Weintrob A.C. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for C2orf76 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C2orf76 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C2orf76 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C2orf76 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C2orf76 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C2orf76 gene:
Search GeneIP for patents involving C2orf76
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C2orf76 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C2orf76 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C2orf76 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2orf76 | | | OriGene Protein Over-expression Lysate for C2orf76 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C2orf76 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf76 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf76 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C2orf76 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for C2orf76 |
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 | | | C2orf76 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf76 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for C2orf76 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf76 |
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