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Aliases for C2orf74 Gene

Aliases for C2orf74 Gene

  • Chromosome 2 Open Reading Frame 74 2 3 5

External Ids for C2orf74 Gene

Previous GeneCards Identifiers for C2orf74 Gene

  • GC02P061225
  • GC02P061372
  • GC02P061113

Summaries for C2orf74 Gene

GeneCards Summary for C2orf74 Gene

C2orf74 (Chromosome 2 Open Reading Frame 74) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf74 Gene

Genomics for C2orf74 Gene

Regulatory Elements for C2orf74 Gene

Enhancers for C2orf74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F060837 1.1 FANTOM5 ENCODE 3.5 -305.2 -305228 4.3 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 KLF13 PAPOLG REL LINC01185 KIAA1841 AHSA2 PUS10 ENSG00000232713 C2orf74 PEX13 RN7SL632P
GH02F061144 0.2 ENCODE 0.8 +0.1 84 1.6 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MXD4 MIER2 REST PPARG AHSA2 C2orf74 PIR46388
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C2orf74 on UCSC Golden Path with GeneCards custom track

Promoters for C2orf74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000591161 -67 1600 WRNIP1 ARID4B DMAP1 ZNF2 YY1 MXD4 MIER2 REST PPARG KAT8

Genomic Location for C2orf74 Gene

Chromosome:
2
Start:
61,145,068 bp from pter
End:
61,164,830 bp from pter
Size:
19,763 bases
Orientation:
Plus strand

Genomic View for C2orf74 Gene

Genes around C2orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf74 Gene

Proteins for C2orf74 Gene

  • Protein details for C2orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MZ97-CB074_HUMAN
    Recommended name:
    Uncharacterized protein C2orf74
    Protein Accession:
    A8MZ97
    Secondary Accessions:
    • C9JP62

    Protein attributes for C2orf74 Gene

    Size:
    194 amino acids
    Molecular mass:
    21915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf74 Gene

Post-translational modifications for C2orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C2orf74 Gene

Domains & Families for C2orf74 Gene

Protein Domains for C2orf74 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf74: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf74 Gene

Function for C2orf74 Gene

Phenotypes for C2orf74 Gene

genes like me logo Genes that share phenotypes with C2orf74: view

Animal Model Products

miRNA for C2orf74 Gene

miRTarBase miRNAs that target C2orf74

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf74 Gene

Localization for C2orf74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2orf74 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2orf74 Gene COMPARTMENTS Subcellular localization image for C2orf74 gene
Compartment Confidence
extracellular 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C2orf74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C2orf74: view

Pathways & Interactions for C2orf74 Gene

SuperPathways for C2orf74 Gene

No Data Available

Interacting Proteins for C2orf74 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000402915%0d%0a9606.ENSP00000350249%0d%0a
Selected Interacting proteins: ENSP00000402915 A8MZ97-CB074_HUMAN for C2orf74 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C2orf74 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf74 Gene

Transcripts for C2orf74 Gene

Unigene Clusters for C2orf74 Gene

Chromosome 2 open reading frame 74:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf74 Gene

No ASD Table

Relevant External Links for C2orf74 Gene

GeneLoc Exon Structure for
C2orf74
ECgene alternative splicing isoforms for
C2orf74

Expression for C2orf74 Gene

Protein differential expression in normal tissues from HIPED for C2orf74 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf74 Gene



Protein tissue co-expression partners for C2orf74 Gene

NURSA nuclear receptor signaling pathways regulating expression of C2orf74 Gene:

C2orf74

SOURCE GeneReport for Unigene cluster for C2orf74 Gene:

Hs.140617

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C2orf74 Gene

Orthologs for C2orf74 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2orf74 35
  • 100 (a)
OneToOne
C2AH2orf74 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia C10H2orf74 34
  • 83.51 (n)
C2orf74 35
  • 40 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H2orf74 34
  • 81.62 (n)
C2orf74 35
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700093K21Rik 34 16 35
  • 74.34 (n)
rat
(Rattus norvegicus)
Mammalia LOC690352 34
  • 69.71 (n)
Species where no ortholog for C2orf74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf74 Gene

ENSEMBL:
Gene Tree for C2orf74 (if available)
TreeFam:
Gene Tree for C2orf74 (if available)

Paralogs for C2orf74 Gene

No data available for Paralogs for C2orf74 Gene

Variants for C2orf74 Gene

Sequence variations from dbSNP and Humsavar for C2orf74 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10171258 -- 61,149,574(+) CCttt(C/T)ttttt intron-variant
rs10174244 -- 61,150,064(+) TCGCC(A/G)AATGG intron-variant
rs10177445 -- 61,151,088(+) cgagg(C/T)gggag intron-variant, downstream-variant-500B
rs10190405 -- 61,165,266(+) aagct(C/G)agatt downstream-variant-500B
rs1055499 -- 61,143,566(-) GAATT(A/T)AAAAA intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C2orf74 Gene

Variant ID Type Subtype PubMed ID
dgv702e214 CNV loss 21293372
esv2760616 CNV loss 21179565
esv3583840 CNV loss 25503493
esv3591015 CNV gain 21293372
nsv518805 CNV loss 19592680

Variation tolerance for C2orf74 Gene

Gene Damage Index Score: 9.75; 89.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf74 Gene

Disorders for C2orf74 Gene

Relevant External Links for C2orf74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf74

No disorders were found for C2orf74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf74 Gene

Publications for C2orf74 Gene

  1. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3 64
  2. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3 64
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  4. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A. … Parkes M. (Nat. Genet. 2010) 3 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for C2orf74 Gene

Sources for C2orf74 Gene

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