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Aliases for C2orf74 Gene

Aliases for C2orf74 Gene

  • Chromosome 2 Open Reading Frame 74 2 3

External Ids for C2orf74 Gene

Previous GeneCards Identifiers for C2orf74 Gene

  • GC02P061225
  • GC02P061372
  • GC02P061113

Summaries for C2orf74 Gene

GeneCards Summary for C2orf74 Gene

C2orf74 (Chromosome 2 Open Reading Frame 74) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf74 Gene

Genomics for C2orf74 Gene

Regulatory Elements for C2orf74 Gene

Genomic Location for C2orf74 Gene

61,145,068 bp from pter
61,164,829 bp from pter
19,762 bases
Plus strand

Genomic View for C2orf74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C2orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf74 Gene

Proteins for C2orf74 Gene

  • Protein details for C2orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C2orf74
    Protein Accession:
    Secondary Accessions:
    • C9JP62

    Protein attributes for C2orf74 Gene

    194 amino acids
    Molecular mass:
    21915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf74 Gene

Proteomics data for C2orf74 Gene at MOPED

Post-translational modifications for C2orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf74 Gene

No data available for DME Specific Peptides for C2orf74 Gene

Domains for C2orf74 Gene

Protein Domains for C2orf74 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf74: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf74 Gene

Function for C2orf74 Gene

miRNA for C2orf74 Gene

miRTarBase miRNAs that target C2orf74

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2orf74

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C2orf74 Gene

Localization for C2orf74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2orf74 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for C2orf74 Gene COMPARTMENTS Subcellular localization image for C2orf74 gene
Compartment Confidence
extracellular 3
cytoskeleton 1
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C2orf74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C2orf74: view

Pathways for C2orf74 Gene

SuperPathways for C2orf74 Gene

No Data Available

Interacting Proteins for C2orf74 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000402915 for C2orf74 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C2orf74 Gene


No data available for Pathways by source for C2orf74 Gene

Transcripts for C2orf74 Gene

Unigene Clusters for C2orf74 Gene

Chromosome 2 open reading frame 74:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2orf74

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf74 Gene

No ASD Table

Relevant External Links for C2orf74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf74 Gene

Protein differential expression in normal tissues for C2orf74 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C2orf74 Gene

SOURCE GeneReport for Unigene cluster for C2orf74 Gene Hs.140617

Expression partners for C2orf74 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C2orf74 Gene

Orthologs for C2orf74 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf74 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C11H2orf74 35
  • 81.62 (n)
  • 64.86 (a)
C2orf74 36
  • 64 (a)
(Canis familiaris)
Mammalia C10H2orf74 35
  • 83.51 (n)
  • 69.02 (a)
C2orf74 36
  • 40 (a)
(Mus musculus)
Mammalia 1700093K21Rik 35
  • 74.34 (n)
  • 59.55 (a)
1700093K21Rik 16
1700093K21Rik 36
  • 54 (a)
(Pan troglodytes)
Mammalia C2AH2orf74 35
  • 99.66 (n)
  • 100 (a)
C2orf74 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC690352 35
  • 69.71 (n)
  • 53.23 (a)
Species with no ortholog for C2orf74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf74 Gene

Gene Tree for C2orf74 (if available)
Gene Tree for C2orf74 (if available)

Paralogs for C2orf74 Gene

No data available for Paralogs for C2orf74 Gene

Variants for C2orf74 Gene

Sequence variations from dbSNP and Humsavar for C2orf74 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs720201 -- 61,149,328(-) ACTAC(A/G)AAGTT intron-variant
rs1177302 -- 61,161,255(-) caaca(A/G)caaac upstream-variant-2KB, intron-variant
rs1177303 -- 61,161,220(-) ttcaa(G/T)acatt upstream-variant-2KB, intron-variant
rs1177304 -- 61,161,029(-) gcact(C/G)ttggt upstream-variant-2KB, intron-variant
rs1177305 -- 61,160,736(-) gaggc(A/G)ggtgg upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf74 Gene

Variant ID Type Subtype PubMed ID
nsv874210 CNV Gain 21882294
nsv874211 CNV Loss 21882294
nsv518805 CNV Loss 19592680
nsv874212 CNV Gain 21882294

Relevant External Links for C2orf74 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf74 Gene

Disorders for C2orf74 Gene

No disorders were found for C2orf74 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for C2orf74 Gene

Publications for C2orf74 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A. … Parkes M. (Nat. Genet. 2010) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3
  5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3

Products for C2orf74 Gene

Sources for C2orf74 Gene

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