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Aliases for C2orf73 Gene

Aliases for C2orf73 Gene

  • Chromosome 2 Open Reading Frame 73 2 3

External Ids for C2orf73 Gene

Previous GeneCards Identifiers for C2orf73 Gene

  • GC02P054411
  • GC02P054557
  • GC02P054292

Summaries for C2orf73 Gene

GeneCards Summary for C2orf73 Gene

C2orf73 (Chromosome 2 Open Reading Frame 73) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf73 Gene

Genomics for C2orf73 Gene

Regulatory Elements for C2orf73 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C2orf73 Gene

Chromosome:
2
Start:
54,330,013 bp from pter
End:
54,383,742 bp from pter
Size:
53,730 bases
Orientation:
Plus strand

Genomic View for C2orf73 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C2orf73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf73 Gene

Proteins for C2orf73 Gene

  • Protein details for C2orf73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5S3-CB073_HUMAN
    Recommended name:
    Uncharacterized protein C2orf73
    Protein Accession:
    Q8N5S3
    Secondary Accessions:
    • A0AV79
    • A0AV81
    • Q8N7V4

    Protein attributes for C2orf73 Gene

    Size:
    287 amino acids
    Molecular mass:
    32142 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31669.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C2orf73 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C2orf73 Gene

Proteomics data for C2orf73 Gene at MOPED

Post-translational modifications for C2orf73 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf73 Gene

No data available for DME Specific Peptides for C2orf73 Gene

Domains & Families for C2orf73 Gene

Protein Domains for C2orf73 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C2orf73 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf73: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C2orf73 Gene

Function for C2orf73 Gene

Phenotypes for C2orf73 Gene

GenomeRNAi human phenotypes for C2orf73:
genes like me logo Genes that share phenotypes with C2orf73: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf73 Gene

Localization for C2orf73 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C2orf73 Gene

Pathways & Interactions for C2orf73 Gene

SuperPathways for C2orf73 Gene

No Data Available

Interacting Proteins for C2orf73 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381631%0d%0a9606.ENSP00000340237%0d%0a9606.ENSP00000386722%0d%0a
Selected Interacting proteins: Q8N5S3-CB073_HUMAN ENSP00000381631 for C2orf73 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for C2orf73 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf73 Gene

Drugs & Compounds for C2orf73 Gene

No Compound Related Data Available

Transcripts for C2orf73 Gene

Unigene Clusters for C2orf73 Gene

Chromosome 2 open reading frame 73:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf73 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2: - -
SP3: -
SP4: - -

Relevant External Links for C2orf73 Gene

GeneLoc Exon Structure for
C2orf73
ECgene alternative splicing isoforms for
C2orf73

Expression for C2orf73 Gene

mRNA expression in normal human tissues for C2orf73 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf73 Gene

This gene is overexpressed in Testis (x28.9).

Protein differential expression in normal tissues from HIPED for C2orf73 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C2orf73 Gene



SOURCE GeneReport for Unigene cluster for C2orf73 Gene Hs.732626

genes like me logo Genes that share expression patterns with C2orf73: view

Protein tissue co-expression partners for C2orf73 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C2orf73 Gene

Orthologs for C2orf73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf73 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C11H2orf73 35
  • 85.56 (n)
  • 76.41 (a)
C2orf73 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C10H2orf73 35
  • 85.33 (n)
  • 76.41 (a)
C2orf73 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930505A04Rik 35
  • 79.42 (n)
  • 68.26 (a)
4930505A04Rik 16
4930505A04Rik 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf73 35
  • 99.07 (n)
  • 97.91 (a)
C2orf73 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562229 35
  • 81.01 (n)
  • 66.96 (a)
oppossum
(Monodelphis domestica)
Mammalia C2orf73 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf73 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c2orf73 35
  • 61.11 (n)
  • 44.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToOne
Species with no ortholog for C2orf73:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf73 Gene

ENSEMBL:
Gene Tree for C2orf73 (if available)
TreeFam:
Gene Tree for C2orf73 (if available)

Paralogs for C2orf73 Gene

No data available for Paralogs for C2orf73 Gene

Variants for C2orf73 Gene

Sequence variations from dbSNP and Humsavar for C2orf73 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13184 - 54,360,522(+) CACTA(C/G)GCACA missense, reference, utr-variant-3-prime
rs843667 -- 54,331,877(+) tcaca(C/T)ttgaa intron-variant
rs843668 -- 54,332,254(+) ctcct(A/G)catac intron-variant
rs843669 -- 54,332,656(+) AACCC(A/G)TAGGC intron-variant
rs843670 -- 54,335,967(+) ttaga(A/T)tgcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf73 Gene

Variant ID Type Subtype PubMed ID
esv2720078 CNV Deletion 23290073
nsv511174 CNV Loss 21212237
nsv436294 CNV Deletion 17901297
esv2604967 CNV Loss 19546169
esv2535207 CNV Deletion 19546169
nsv511786 CNV Loss 21212237
esv2276399 CNV Deletion 18987734
nsv820112 CNV Gain 19587683
esv5301 CNV Deletion 18987735
dgv631n67 CNV Loss 20364138
nsv821415 CNV Deletion 20802225
esv2720080 CNV Deletion 23290073
esv1008998 CNV Deletion 20482838
esv5705 CNV Loss 19470904
esv23352 CNV Gain 19812545

Variation tolerance for C2orf73 Gene

Residual Variation Intolerance Score: 80.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.15; 75.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf73 Gene

HapMap Linkage Disequilibrium report
C2orf73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf73 Gene

Disorders for C2orf73 Gene

Relevant External Links for C2orf73

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf73
genes like me logo Genes that share disorders with C2orf73: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf73 Gene

Publications for C2orf73 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 67
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 67
  3. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PMID: 18654987) Thalappilly S. … Dusetti N.J. (Proteomics 2008) 67
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for C2orf73 Gene

Sources for C2orf73 Gene

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