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Aliases for C2orf73 Gene

Aliases for C2orf73 Gene

  • Chromosome 2 Open Reading Frame 73 2 3 5

External Ids for C2orf73 Gene

Previous GeneCards Identifiers for C2orf73 Gene

  • GC02P054411
  • GC02P054557
  • GC02P054292

Summaries for C2orf73 Gene

GeneCards Summary for C2orf73 Gene

C2orf73 (Chromosome 2 Open Reading Frame 73) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf73 Gene

Genomics for C2orf73 Gene

Regulatory Elements for C2orf73 Gene

Enhancers for C2orf73 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G054359 1.3 Ensembl ENCODE dbSUPER 29 +30.3 30338 1.3 PKNOX1 JUN ZNF175 FEZF1 ZNF48 RAD21 FOSL1 ZNF316 GATA2 ZNF366 C2orf73 SPTBN1 GC02M054359 GC02P054340
GH02G054370 1.3 Ensembl ENCODE dbSUPER 20 +41.4 41434 2.3 HDAC1 YY1 RARA ZNF350 MIER1 CEBPB REST NR2F2 NFIC SMARCA4 C2orf73 RTN4 GC02M054359 GC02M054422
GH02G054401 1.4 Ensembl ENCODE dbSUPER 11.2 +72.4 72358 2.4 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 FOS PAF1 JUNB SPTBN1 C2orf73 RNU7-172P GC02M054422 GC02M054359
GH02G054496 1.4 Ensembl ENCODE dbSUPER 11.2 +169.2 169198 4.5 ARID4B SIN3A DMAP1 BMI1 ZNF2 RAD21 ZNF335 TCF12 ZNF121 SLC30A9 EML6 SPTBN1 C2orf73 ACYP2 RNU7-81P LOC105374667 PRORSD1P GC02M054483 GC02P054516
GH02G054274 0.8 ENCODE 15.5 -55.0 -55048 1.3 TBP ZNF2 ZNF766 GATA2 ZNF362 CEBPB ZNF518A POLR2H PRDM6 ATF4 C2orf73 ACYP2 LOC105374610 TSPYL6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C2orf73 on UCSC Golden Path with GeneCards custom track

Promoters for C2orf73 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000117170 687 1001 FOXA2 PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2

Genomic Location for C2orf73 Gene

Chromosome:
2
Start:
54,330,013 bp from pter
End:
54,383,742 bp from pter
Size:
53,730 bases
Orientation:
Plus strand

Genomic View for C2orf73 Gene

Genes around C2orf73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf73 Gene

Proteins for C2orf73 Gene

  • Protein details for C2orf73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5S3-CB073_HUMAN
    Recommended name:
    Uncharacterized protein C2orf73
    Protein Accession:
    Q8N5S3
    Secondary Accessions:
    • A0AV79
    • A0AV81
    • Q8N7V4

    Protein attributes for C2orf73 Gene

    Size:
    287 amino acids
    Molecular mass:
    32142 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31669.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C2orf73 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C2orf73 Gene

Post-translational modifications for C2orf73 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C2orf73 Gene

Domains & Families for C2orf73 Gene

Protein Domains for C2orf73 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C2orf73 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf73: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C2orf73 Gene

Function for C2orf73 Gene

Phenotypes for C2orf73 Gene

genes like me logo Genes that share phenotypes with C2orf73: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf73 Gene

Localization for C2orf73 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf73 gene
Compartment Confidence
nucleus 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf73 Gene

Pathways & Interactions for C2orf73 Gene

SuperPathways for C2orf73 Gene

No Data Available

Interacting Proteins for C2orf73 Gene

Selected Interacting proteins: Q8N5S3-CB073_HUMAN for C2orf73 Gene via IID

Gene Ontology (GO) - Biological Process for C2orf73 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf73 Gene

Drugs & Compounds for C2orf73 Gene

No Compound Related Data Available

Transcripts for C2orf73 Gene

Unigene Clusters for C2orf73 Gene

Chromosome 2 open reading frame 73:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf73 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2: - -
SP3: -
SP4: - -

Relevant External Links for C2orf73 Gene

GeneLoc Exon Structure for
C2orf73
ECgene alternative splicing isoforms for
C2orf73

Expression for C2orf73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf73 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf73 Gene

This gene is overexpressed in Testis (x28.9).

Protein differential expression in normal tissues from HIPED for C2orf73 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf73 Gene



Protein tissue co-expression partners for C2orf73 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C2orf73 Gene:

C2orf73

SOURCE GeneReport for Unigene cluster for C2orf73 Gene:

Hs.732626

Evidence on tissue expression from TISSUES for C2orf73 Gene

  • Nervous system(3.3)
  • Lung(2)
genes like me logo Genes that share expression patterns with C2orf73: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf73 Gene

Orthologs for C2orf73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf73 34
  • 99.07 (n)
C2orf73 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H2orf73 34
  • 85.56 (n)
C2orf73 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C10H2orf73 34
  • 85.33 (n)
C2orf73 35
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562229 34
  • 81.01 (n)
mouse
(Mus musculus)
Mammalia 4930505A04Rik 34 16 35
  • 79.42 (n)
oppossum
(Monodelphis domestica)
Mammalia C2orf73 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf73 35
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c2orf73 34
  • 61.11 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToOne
Species where no ortholog for C2orf73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf73 Gene

ENSEMBL:
Gene Tree for C2orf73 (if available)
TreeFam:
Gene Tree for C2orf73 (if available)

Paralogs for C2orf73 Gene

No data available for Paralogs for C2orf73 Gene

Variants for C2orf73 Gene

Sequence variations from dbSNP and Humsavar for C2orf73 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000072481 -- 54,332,999(+) TATGT(G/T)TACTG intron-variant
rs1000162787 -- 54,366,115(+) GCTGA(C/G)CAGAA intron-variant
rs1000165354 -- 54,359,208(+) TGTTA(A/G)CCACA intron-variant
rs1000339090 -- 54,363,441(+) GACTG(A/G)TTTGC intron-variant
rs1000385974 -- 54,340,839(+) TCATG(C/T)CTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf73 Gene

Variant ID Type Subtype PubMed ID
dgv1914n106 CNV deletion 24896259
dgv3845n100 CNV gain 25217958
dgv631n67 CNV loss 20364138
dgv6891n54 CNV gain 21841781
dgv6892n54 CNV gain 21841781
dgv91n73 CNV deletion 24416366
esv1008998 CNV deletion 20482838
esv2276399 CNV deletion 18987734
esv23352 CNV gain 19812545
esv2535207 CNV deletion 19546169
esv2604967 CNV loss 19546169
esv2720078 CNV deletion 23290073
esv2720080 CNV deletion 23290073
esv2762639 CNV gain 21179565
esv2844236 CNV deletion 24192839
esv3556933 CNV deletion 23714750
esv3590837 CNV loss 21293372
esv5301 CNV loss 18987735
esv5705 CNV loss 19470904
nsv1004632 CNV loss 25217958
nsv1070291 CNV deletion 25765185
nsv1130224 CNV deletion 24896259
nsv436294 CNV deletion 17901297
nsv511174 CNV loss 21212237
nsv511786 CNV loss 21212237
nsv582018 CNV gain+loss 21841781
nsv582019 CNV gain 21841781
nsv582020 CNV loss 21841781
nsv582021 CNV loss 21841781
nsv582023 CNV loss 21841781
nsv820112 CNV gain 19587683
nsv821415 CNV deletion 20802225

Variation tolerance for C2orf73 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.15; 75.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf73 Gene

Disorders for C2orf73 Gene

Relevant External Links for C2orf73

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf73

No disorders were found for C2orf73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf73 Gene

Publications for C2orf73 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 64
  3. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PMID: 18654987) Thalappilly S. … Dusetti N.J. (Proteomics 2008) 3 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for C2orf73 Gene

Sources for C2orf73 Gene

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