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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C2orf70 Gene

protein-coding   GIFtS: 36
GCID: GC02P026785          (predicted)

chromosome 2 open reading frame 70
  Search for C2orf70
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C2orf70    

Aliases
for C2orf70 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 2 Open Reading Frame 701 2
LOC3397781
UPF0573 Protein C2orf702

External Ids:    HGNC: 279381   Entrez Gene: 3397782   Ensembl: ENSG000001735577   UniProtKB: A6NJV13   
ORGUL members:         
NONCODE:n338712    

Export aliases for C2orf70 gene to outside databases

Previous GC identifers: GC02P026638 GC02P026524


Summaries
for C2orf70 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C2orf70 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C2orf70 gene promoter:
         RFX1   p53   POU3F2   HNF-1A   Meis-1b   HSF2   Meis-1a   ZIC2/Zic2   Meis-1   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C2orf70

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

C2orf70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C2orf70 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P026785:  view genomic region     (about GC identifiers)

Start:
 26,785,450 bp from pter      End:
 26,802,400 bp from pter
Size:
 16,951 bases      Orientation:
 plus strand

Proteins
for C2orf70 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CB070_HUMAN, A6NJV1 (See protein sequence)
Recommended Name: UPF0573 protein C2orf70  
Size: 201 amino acids; 23421 Da

Explore the universe of human proteins at neXtProt for C2orf70: NX_A6NJV1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NJV1

    • C2orf70 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001098989.1  
    ENSEMBL proteins: 
     ENSP00000332875   ENSP00000386615   ENSP00000395924  

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    Protein Domains /
    Families
    for C2orf70 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    C2orf70 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR018902 UPF0573/UPF0605

    Graphical View of Domain Structure for InterPro Entry A6NJV1

    ProtoNet protein and cluster: A6NJV1

    UniProtKB/Swiss-Prot: CB070_HUMAN, A6NJV1
    Similarity: Belongs to the UPF0573 family


    Function
    for C2orf70 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    2 GenomeRNAi human phenotypes for C2orf70:
     Decreased viability of wild-ty  Increased S DNA content 


    Pathways & Interactions
    for C2orf70 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C2orf70

    Drugs & Compounds
    for C2orf70 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for C2orf70
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    Transcripts
    for C2orf70 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for C2orf70 gene: 
    NM_001105519.1  

    Unigene Cluster for C2orf70:

    Chromosome 2 open reading frame 70
    Hs.407083  [show with all ESTs]
    Unigene Representative Sequence: AK091483
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329615(uc010eyn.3) ENST00000409392 ENST00000479453 ENST00000453368


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    Additional cDNA sequence: AK091483.1 

    2 DOTS entries:

    DT.210401  DT.91953578 

    23 AceView cDNA sequences:

    AI125455 AA994248 AX747015 AI023484 AA609698 AA432361 AA725022 AA431363 
    AK091483 BX114846 AW448928 AA759197 AA577292 AI911006 AF281038 BF591162 
    AW082275 AA758869 AW362072 AI829675 AA778539 AA905348 AI215954 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for C2orf70    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:        -                       -         
    SP2:              -                           


    ECgene alternative splicing isoforms for C2orf70

    Expression
    for C2orf70 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C2orf70 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGACTTTTAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See C2orf70 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C2orf70

    SOURCE GeneReport for Unigene cluster: Hs.407083
        SABiosciences Custom PCR Arrays for C2orf70
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    In Situ
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    Orthologs
    for C2orf70 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for C2orf70 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 1700001C02Rik1 , 5 RIKEN cDNA 1700001C02 gene1, 5 77(n)1
    68.5(a)1    		   5 (16.57 cM)5
    754341  NM_029285.11  NP_083561.11 
     304660475 
    chicken
    (Gallus gallus)    		 Aves C3H2orf701 chromosome 3 open reading frame, human C2orf70 64.47(n)
    58.49(a)    		   422006  XM_420014.1  XP_420014.1 
    lizard
    (Anolis carolinensis)    		 Reptilia C2orf706
    		 --
    		 61(a)
    		 1 ↔ 1
    		 GL343824.1(42556-68153)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1001493291 UPF0573 protein C2orf70 homolog A-like 53.79(n)
    43.18(a)    		   100149329  XM_001923808.1  XP_001923843.2 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 21(a)
    		 1 ↔ 1
    		 Group8.33(5817-7982)


    ENSEMBL Gene Tree for C2orf70 (if available)
    TreeFam Gene Tree for C2orf70 (if available) 

    Paralogs
    for C2orf70 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C2orf70 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/378 NCBI SNPs in C2orf70 are shown (see all 378)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1447521431,2
    		C,other26800443(+) GTCCCC/TTACTT 2 P syn10--------
    rs1508026481,2
    		--26783599(+) ATGTGC/TTACCA 1 -- us2k10--------
    rs1829264131,2
    		--26783691(+) TGATCC/TGCCTG 1 -- us2k10--------
    rs1886715281,2
    		--26783712(+) CCAAAA/GTGCTG 1 -- us2k10--------
    rs75643331,2
    		C,--26783778(+) CTTCTA/GTTACC 1 -- us2k112Minor allele frequency- G:0.00NA WA CSA EA 374
    rs1932342011,2
    		--26783824(+) ACATTA/TACTGA 1 -- us2k10--------
    rs789026811,2
    		F,--26783833(+) GAATTC/TTTTCC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1158243471,2
    		--26783850(+) AGGTGC/GTGAGA 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1391334341,2
    		--26783873(+) TATGAC/TATGGA 1 -- us2k10--------
    rs75644541,2
    		C,F,A,H,--26783886(+) GCACAA/GGATCC 1 -- us2k129Minor allele frequency- G:0.08NS EA NA WA CSA 2362

    HapMap Linkage Disequilibrium report for C2orf70 (26785450 - 26802400 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for C2orf70
         1 CNV: 7261

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    Disorders / Diseases
    for C2orf70 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C2orf70 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C2orf70 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C2orf70)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    External Searches for C2orf70 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C2orf70 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339778 HGNC: 27938 AceView: LOC339778 Ensembl:ENSG00000173557 euGenes: HUgn339778
    ECgene: C2orf70 H-InvDB: C2orf70

    Other Databases showing C2orf70 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C2orf70 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C2orf70 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C2orf70 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C2orf70 gene:
    Search GeneIP for patents involving C2orf70

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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