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Aliases for C2orf70 Gene

Aliases for C2orf70 Gene

  • Chromosome 2 Open Reading Frame 70 2 3 5
  • Hypothetical Protein LOC339778 2

External Ids for C2orf70 Gene

Previous GeneCards Identifiers for C2orf70 Gene

  • GC02P026638
  • GC02P026785

Summaries for C2orf70 Gene

GeneCards Summary for C2orf70 Gene

C2orf70 (Chromosome 2 Open Reading Frame 70) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf70 Gene

Genomics for C2orf70 Gene

Regulatory Elements for C2orf70 Gene

Enhancers for C2orf70 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F026493 1.2 FANTOM5 Ensembl 11.3 -68.8 -68839 0.4 STAT1 ZBTB40 POLR2A ZFP3 ZNF512 STAT2 ADNP NFYB IRF1 SPI1 OTOF C2orf70 RAB10 GAREM2 DRC1
GH02F026492 1.2 Ensembl ENCODE 11.3 -69.5 -69456 0.6 BCOR HDAC1 PKNOX1 ESRRA TAL1 ZMYM3 ZFHX2 GATA2 NCOR1 STAT2 C2orf70 OTOF MPV17 DRC1
GH02F026495 0.2 ENCODE 11.3 -66.6 -66557 0.6 SCRT1 PKNOX1 SCRT2 OTOF C2orf70 DRC1
GH02F026717 1.4 VISTA FANTOM5 Ensembl ENCODE 10.8 +159.7 159699 10.1 HDGF MLX SIN3A DMAP1 YY1 FOS ZNF263 SP5 REST SMARCB1 CENPA GPN1 CAD LOC105374363 ZNF512 NRBP1 GTF3C2-AS1 KCNK3 SLC35F6 ENSG00000235267
GH02F026612 1.2 Ensembl ENCODE 4.7 +52.2 52241 5.3 CTCF PKNOX1 ZMYM3 ZNF644 ZIC2 RAD21 GATA3 ZNF766 POLR2A SMC3 ENSG00000272148 AGBL5-IT1 C2orf70 GC02P026627
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C2orf70 on UCSC Golden Path with GeneCards custom track

Genomic Location for C2orf70 Gene

Chromosome:
2
Start:
26,562,556 bp from pter
End:
26,579,532 bp from pter
Size:
16,977 bases
Orientation:
Plus strand

Genomic View for C2orf70 Gene

Genes around C2orf70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf70 Gene

Proteins for C2orf70 Gene

  • Protein details for C2orf70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJV1-CB070_HUMAN
    Recommended name:
    UPF0573 protein C2orf70
    Protein Accession:
    A6NJV1

    Protein attributes for C2orf70 Gene

    Size:
    201 amino acids
    Molecular mass:
    23421 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf70 Gene

Post-translational modifications for C2orf70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C2orf70 Gene

Domains & Families for C2orf70 Gene

Protein Domains for C2orf70 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C2orf70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NJV1

UniProtKB/Swiss-Prot:

CB070_HUMAN :
  • Belongs to the UPF0573 family.
Family:
  • Belongs to the UPF0573 family.
genes like me logo Genes that share domains with C2orf70: view

No data available for Gene Families for C2orf70 Gene

Function for C2orf70 Gene

genes like me logo Genes that share phenotypes with C2orf70: view

Animal Models for C2orf70 Gene

MGI Knock Outs for C2orf70:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf70 Gene

Localization for C2orf70 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2orf70 Gene COMPARTMENTS Subcellular localization image for C2orf70 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C2orf70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with C2orf70: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C2orf70 Gene

Pathways & Interactions for C2orf70 Gene

SuperPathways for C2orf70 Gene

No Data Available

Interacting Proteins for C2orf70 Gene

Gene Ontology (GO) - Biological Process for C2orf70 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf70 Gene

Transcripts for C2orf70 Gene

Unigene Clusters for C2orf70 Gene

Chromosome 2 open reading frame 70:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf70 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2: -

Relevant External Links for C2orf70 Gene

GeneLoc Exon Structure for
C2orf70
ECgene alternative splicing isoforms for
C2orf70

Expression for C2orf70 Gene

mRNA expression in normal human tissues for C2orf70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C2orf70 Gene

This gene is overexpressed in Testis (x27.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf70 Gene



Protein tissue co-expression partners for C2orf70 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C2orf70 Gene:

C2orf70

SOURCE GeneReport for Unigene cluster for C2orf70 Gene:

Hs.407083
genes like me logo Genes that share expression patterns with C2orf70: view

Primer Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C2orf70 Gene

Orthologs for C2orf70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf70 34
  • 97.25 (n)
C2orf70 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17H2orf70 34
  • 84.58 (n)
C2orf70 35
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H2orf70 34 35
  • 83.91 (n)
mouse
(Mus musculus)
Mammalia 1700001C02Rik 34 16 35
  • 77 (n)
rat
(Rattus norvegicus)
Mammalia RGD1559683 34
  • 76.33 (n)
oppossum
(Monodelphis domestica)
Mammalia C2orf70 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C2orf70 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H2ORF70 34
  • 64.47 (n)
C2orf70 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf70 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c2orf70 34
  • 62.25 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-198b3.4 34
  • 53.79 (n)
C20H2orf70 35
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToOne
Species where no ortholog for C2orf70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf70 Gene

ENSEMBL:
Gene Tree for C2orf70 (if available)
TreeFam:
Gene Tree for C2orf70 (if available)

Paralogs for C2orf70 Gene

No data available for Paralogs for C2orf70 Gene

Variants for C2orf70 Gene

Sequence variations from dbSNP and Humsavar for C2orf70 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10170055 -- 26,566,436(+) gtggt(A/G)tactg intron-variant
rs10190837 -- 26,565,239(+) GCACG(C/T)GCCAC intron-variant
rs10194860 -- 26,566,954(+) atttg(A/C)ctgcc intron-variant
rs1053807 -- 26,577,554(+) AAGAC(A/G)GGCAC reference, synonymous-codon, missense
rs10595879 -- 26,569,017(+) GTCTC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf70 Gene

Variant ID Type Subtype PubMed ID
esv33316 CNV loss 17666407
esv3583675 CNV loss 25503493
nsv517800 CNV loss 19592680

Variation tolerance for C2orf70 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.63; 72.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf70 Gene

Disorders for C2orf70 Gene

Relevant External Links for C2orf70

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf70

No disorders were found for C2orf70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf70 Gene

Publications for C2orf70 Gene

  1. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for C2orf70 Gene

Sources for C2orf70 Gene

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