Aliases for C2orf69 Gene
External Ids for C2orf69 Gene
- HGNC: 26799
- Entrez Gene: 205327
- Ensembl: ENSG00000178074
- UniProtKB: Q8N8R5
Previous GeneCards Identifiers for C2orf69 Gene
- GC02P200485
- GC02P200775
- GC02P192628
Summaries for C2orf69 Gene
GeneCards Summary for C2orf69 Gene
C2orf69 (Chromosome 2 Open Reading Frame 69) is a Protein Coding gene.
Additional gene information for C2orf69 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf69 Gene
Genomics for C2orf69 Gene
GeneHancer (GH) Regulatory Elements for C2orf69 Gene
Promoters and enhancers for C2orf69 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around C2orf69 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for C2orf69 Gene
Genomic Locations for C2orf69 Gene
- chr2:199,911,256-199,955,935
- (GRCh38/hg38)
- Size:
- 44,680 bases
- Orientation:
- Plus strand
- chr2:200,775,979-200,820,658
- (GRCh37/hg19)
Genomic View for C2orf69 Gene
Genes around C2orf69 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q33.1 by Ensembl
- 2q33.1 by Entrez Gene
- 2q33.1 by HGNC
C2orf69 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C2orf69 Gene
Proteins for C2orf69 Gene
-
Protein details for C2orf69 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N8R5-CB069_HUMAN
- Recommended name:
- UPF0565 protein C2orf69
- Protein Accession:
- Q8N8R5
- Q8NE30
Protein attributes for C2orf69 Gene
- Size:
- 385 amino acids
- Molecular mass:
- 43448 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=EAW70190.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for C2orf69 Gene
Post-translational modifications for C2orf69 Gene
- Glycosylation at posLast=128128 and Asn196
Other Protein References for C2orf69 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C2orf69
-
Abcam antibodies for C2orf69
- Invitrogen Antibodies for C2orf69
- Search GeneTex for Antibodies for C2orf69
Protein Products
-
OriGene Purified Proteins for C2orf69
- Search Origene for MassSpec and Protein Over-expression Lysates for C2orf69
- Origene Custom Protein Services for C2orf69
- Search GeneTex for Proteins for C2orf69
Assay Products
No data available for DME Specific Peptides for C2orf69 Gene
Domains & Families for C2orf69 Gene
Gene Families for C2orf69 Gene
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for C2orf69 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N8R5- Family:
-
- Belongs to the UPF0565 family.
Function for C2orf69 Gene
Phenotypes From GWAS Catalog for C2orf69 Gene
Phenotypes for C2orf69 Gene
- GenomeRNAi human phenotypes for C2orf69:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for C2orf69
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C2orf69 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C2orf69 gene
- Search ViGene Biosciences for C2orf69
CRISPR Products
-
OriGene CRISPR knockouts for C2orf69
- genomics-online: gRNA clones - Search results for 40 available C2ORF69 gene related products
- Overview of 40 available C2ORF69 gene related products
- Applied Biological Materials CRISPR for C2orf69
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C2orf69
miRNA for C2orf69 Gene
- miRTarBase miRNAs that target C2orf69
-
- hsa-mir-181b-5p (MIRT047301)
- hsa-mir-23a-3p (MIRT050433)
- hsa-mir-449c-3p (MIRT052656)
- hsa-mir-181a-5p (MIRT086584)
- hsa-mir-181c-5p (MIRT086585)
- hsa-mir-181d-5p (MIRT086587)
- hsa-mir-17-5p (MIRT156639)
- hsa-mir-20a-5p (MIRT156640)
- hsa-mir-93-5p (MIRT156643)
- hsa-mir-106b-5p (MIRT156647)
- hsa-mir-20b-5p (MIRT156655)
- hsa-mir-519d-3p (MIRT156665)
- hsa-mir-32-5p (MIRT156698)
- hsa-mir-92a-3p (MIRT156699)
- hsa-mir-23b-3p (MIRT156700)
- hsa-mir-130a-5p (MIRT156701)
- hsa-mir-92b-3p (MIRT156709)
- hsa-mir-23c (MIRT156720)
- hsa-mir-3117-3p (MIRT156732)
- hsa-mir-4759 (MIRT156733)
- hsa-mir-3674 (MIRT549093)
- hsa-mir-135b-3p (MIRT549094)
- hsa-mir-8065 (MIRT549095)
- hsa-mir-8083 (MIRT549096)
- hsa-mir-3169 (MIRT549097)
miRNA Products
- Search ViGene Biosciences for C2orf69
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for C2orf69
- Browse OriGene Inhibitory RNA Products For C2orf69
- genomics-online: shRNA clones - Search results for 40 available C2ORF69 gene related products
- Overview of 40 available C2ORF69 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for C2orf69 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C2orf69
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C2orf69
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for C2orf69
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for C2orf69
-
ViGene Biosciences adenoviral particle packaged cDNA for C2orf69 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C2orf69 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C2orf69 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf69 Gene
Localization for C2orf69 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C2orf69 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| mitochondrion | 2 |
| peroxisome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for C2orf69 Gene
Pathways & Interactions for C2orf69 Gene
No Data Available
Interacting Proteins for C2orf69 Gene
No data available for Pathways by source and SIGNOR curated interactions for C2orf69 Gene
Transcripts for C2orf69 Gene
mRNA/cDNA for C2orf69 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (90) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C2orf69 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C2orf69
- genomics-online: gRNA clones - Search results for 40 available C2ORF69 gene related products
- Overview of 40 available C2ORF69 gene related products
- Applied Biological Materials CRISPR for C2orf69
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C2orf69
miRNA Products
- Search ViGene Biosciences for C2orf69
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for C2orf69
- Browse OriGene Inhibitory RNA Products For C2orf69
- genomics-online: shRNA clones - Search results for 40 available C2ORF69 gene related products
- Overview of 40 available C2ORF69 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for C2orf69 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C2orf69
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C2orf69
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for C2orf69
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for C2orf69 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (40.9), Frontal cortex (10.8), and Testis (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C2orf69 Gene
NURSA nuclear receptor signaling pathways regulating expression of C2orf69 Gene:
C2orf69SOURCE GeneReport for Unigene cluster for C2orf69 Gene:
Hs.471040Evidence on tissue expression from TISSUES for C2orf69 Gene
- Nervous system(2.9)
Primer Products
-
OriGene qPCR primer pairs for C2orf69
-
OriGene qPCR primer pairs and template standards for C2orf69
- genomics-online: primer clones - Search results for 40 available C2ORF69 gene related products
- Overview of 40 available C2ORF69 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf69 Gene
Orthologs for C2orf69 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C2BH2orf69 33 |
|
||
| C2orf69 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C2H2orf69 33 |
|
||
| C2orf69 34 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C37H2orf69 33 |
|
||
| C2orf69 34 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | RGD1306941 33 |
|
||
| mouse (Mus musculus) |
Mammalia | 1700066M21Rik 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | C2orf69 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | C2orf69 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C7H2ORF69 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | C2orf69 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | c2orf69 33 |
|
||
| Str.9332 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:153521 33 |
|
||
| C9H2orf69 34 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG31122 33 34 |
|
- Species where no ortholog for C2orf69 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for C2orf69 Gene
Pseudogenes.org Pseudogenes for C2orf69 Gene
No data available for Paralogs for C2orf69 Gene
Variants for C2orf69 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000199366 | -- | 199,910,523(+) | CCC/C | upstream_transcript_variant | |
| rs1000543718 | -- | 199,927,914(+) | T/C | 3_prime_UTR_variant | |
| rs1001063519 | -- | 199,917,392(+) | G/T | intron_variant | |
| rs1001121677 | -- | 199,924,628(+) | G/A | intron_variant | |
| rs1001186372 | -- | 199,920,320(+) | T/A | intron_variant |
Residual Variation Intolerance Score:
69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.50;
71.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C2orf69 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C2orf69
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf69 Gene
Disorders for C2orf69 Gene
Additional Disease Information for C2orf69
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for C2orf69 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf69 Gene
Publications for C2orf69 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
- Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S … Sullivan PF (Nature genetics 2013) 3 58
- Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 58
Products for C2orf69 Gene
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- Invitrogen Antibodies for C2orf69
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for C2orf69
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C2orf69
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for C2orf69
- Search GeneTex for Proteins for C2orf69
- ViGene Biosciences adenoviral particle packaged cDNA for C2orf69 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C2orf69 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C2orf69 gene
- Search ViGene Biosciences for C2orf69
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- genomics-online: cdna clones - Search results for 40 available C2ORF69 gene related products
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- Overview of 40 available C2ORF69 gene related products
Sources for C2orf69 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
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- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew