C2orf69 Gene
protein-coding GIFtS: 41
GCID: GC02P200775
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Chromosome 2 Open Reading Frame 69
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Aliases
for C2orf69 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 2 Open Reading Frame 691 2 | | Hypothetical Protein FLJ389731 | | UPF0565 Protein C2orf692 |
Export aliases for C2orf69 gene to outside databasesPrevious GC identifers: GC02P200485 GC02P192628 |
Summaries
for C2orf69 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for C2orf69 Gene: 
C2orf69 (chromosome 2 open reading frame 69) is a protein-coding gene.
|
Genomic Views
for C2orf69 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.2 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C2orf69 gene promoter:
Elk-1 RP58 AML1a Bach2 POU6F1 (c2) Tal-1beta YY1 S8 Sox9 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for C2orf69
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf69 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33.1 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33.1C2orf69 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P200775: view genomic region
(about GC identifiers)
Start:
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200,775,979 bp from pter |
End:
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200,820,658 bp from pter |
Size:
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44,680 bases |
Orientation:
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plus strand |
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Proteins
for C2orf69 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: CB069_HUMAN, Q8N8R5 (See
protein sequence)Recommended Name: UPF0565 protein C2orf69 precursor Size: 385 amino acids; 43448 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=EAW70190.1; Type=Erroneous gene model prediction;
Secondary accessions: Q8NE30Explore the universe of human proteins at neXtProt for C2orf69: NX_Q8N8R5
Explore proteomics data for C2orf69 at MOPED
C2orf69 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_710156.3
ENSEMBL proteins: ENSP00000312770
Human Recombinant Protein Products for C2orf69:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
C2orf69 for ontologies About GeneDecksing
C2orf69 Antibody Products:
Assay Products for C2orf69: |
Protein
Domains /
Families
for C2orf69 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q8N8R5 ProtoNet protein and cluster: Q8N8R5 UniProtKB/Swiss-Prot: CB069_HUMAN, Q8N8R5Similarity: Belongs to the UPF0565 family
C2orf69 for domains About GeneDecksing
|
Function
for C2orf69 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
3 GenomeRNAi human phenotypes for C2orf69:
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf69 |
|
Pathways & Interactions
for C2orf69 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C2orf69
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
4 Interacting proteins for C2orf69 (Q8N8R53 ENSP000003127704) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for C2orf69 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
IUPHAR,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C2orf69 (CB069)
Search CenterWatch for drugs/clinical trials and news about C2orf69 / CB069
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Transcripts
for C2orf69 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C2orf69 gene: NM_153689.5 Unigene Cluster for C2orf69: Chromosome 2 open reading frame 69 Hs.471040 [show with all ESTs]Unigene Representative Sequence: NM_1536892 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000319974(uc010zhb.2) ENST00000491721
Primer
Products: |  | OriGene qPCR primer pairs and template standards for C2orf69
OriGene qSTAR qPCR primer pairs in human, mouse for C2orf69
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C2orf69 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf69 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf69 |
Additional mRNA sequence: AK096292.1 BC036456.1 4 DOTS entries: DT.312247 DT.451928 DT.121026018 DT.95155462 24/90 AceView cDNA sequences (see all 90): AA291133 AA845433 CK818874 AA946724 AI276538 BU076261 H85463 AA814824 CK818875 AK096292 BP375015 AI335602 AI080344 AI342816 AA883996 BU679909 BM126285 AA815049 AA417956 CD238278 AI810100 AI472937 CB130830 N47077
GeneLoc Exon Structure
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Expression
for C2orf69 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C2orf69 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATGTATAAT
About this image
See C2orf69 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C2orf69
SOURCE GeneReport for Unigene cluster: Hs.471040
SABiosciences Custom PCR Arrays for C2orf69
Primer
Products: | | OriGene qPCR primer pairs and template standards for C2orf69
OriGene qSTAR qPCR primer pairs in human, mouse for C2orf69
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C2orf69 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf69 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf69 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf69 |
Orthologs
for C2orf69 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C2orf69 gene from 6/13 species (see all 13) About this table
ENSEMBL Gene Tree for C2orf69 (if available)
TreeFam Gene Tree for C2orf69 (if available) |
Paralogs
for C2orf69 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C2orf69 gene
C2orf69 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for C2orf69
PGOHUM00000249104 PGOHUM00000249106 PGOHUM00000249108 PGOHUM00000249110 PGOHUM00000249112
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Genomic Variants
for C2orf69 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C2orf69 (200775979 - 200820658 bp)
Structural Variations
Database of Genomic Variants (DGV) 2 variations for C2orf69: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2orf69 |
|
Disorders
/ Diseases
for C2orf69 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C2orf69 for disorders About MalaCards
C2orf69 for disorders About GeneDecksing
Genetic Association Database (GAD): C2orf69
Export disorders for C2orf69 gene to outside databases
|
Publications
for C2orf69 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C2orf69 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C2orf69) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for C2orf69 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C2orf69 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C2orf69 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C2orf69 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C2orf69 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C2orf69 gene:
Search GeneIP for patents involving C2orf69
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C2orf69 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C2orf69 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2orf69 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf69 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C2orf69 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf69 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf69 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf69 |
|  |  |  |  | | | | ThermoFisher Antibodies for C2orf69 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf69 |
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