Aliases for C2orf69 Gene
External Ids for C2orf69 Gene
- HGNC: 26799
- Entrez Gene: 205327
- Ensembl: ENSG00000178074
- UniProtKB: Q8N8R5
Previous GeneCards Identifiers for C2orf69 Gene
- GC02P200485
- GC02P200775
- GC02P192628
Summaries for C2orf69 Gene
GeneCards Summary for C2orf69 Gene
C2orf69 (Chromosome 2 Open Reading Frame 69) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf69 Gene
Genomics for C2orf69 Gene
Regulatory Elements for C2orf69 Gene
Enhancers for C2orf69 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G200372 | 1.5 | Ensembl ENCODE dbSUPER | 4.9 | +467.3 | 467331 | 12.0 | PKNOX1 ZFP64 FEZF1 YBX1 ELK1 GATA2 ZNF143 FOS KLF13 JUNB | SPATS2L CFLAR C2orf69 LOC101927687 RNY4P34 LOC101927741 |
| GH02G200351 | 1.4 | Ensembl ENCODE dbSUPER | 4.7 | +444.0 | 444009 | 7.0 | ATF1 PKNOX1 FEZF1 TCF12 GATA2 FOS NCOA1 SMARCA4 NBN KDM1A | SPATS2L AOX1 C2orf69 GC02P200374 |
| GH02G200367 | 1.3 | Ensembl ENCODE | 5 | +456.4 | 456382 | 1.1 | HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 | SPATS2L C2orf69 GC02P200374 |
| GH02G200363 | 0.7 | dbSUPER | 5 | +453.7 | 453728 | 2.7 | BCOR CTCF FOXA2 PKNOX1 ZNF511 NRF1 ZMYM3 TEAD3 FOSL1 ZNF664 | SPATS2L C2orf69 GC02P200374 |
| GH02G200662 | 0.7 | ENCODE | 4.5 | +751.7 | 751702 | 1.8 | PKNOX1 RFX1 MAX CEBPB NR3C1 PPARG EP300 RARA TEAD3 CTBP1 | C2orf69 AOX3P GC02M200587 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C2orf69 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C2orf69 gene promoter:
Regulatory Element Products
Genomic Location for C2orf69 Gene
- Chromosome:
- 2
- Start:
- 199,911,256 bp from pter
- End:
- 199,955,935 bp from pter
- Size:
- 44,680 bases
- Orientation:
- Plus strand
Genomic View for C2orf69 Gene
Genes around C2orf69 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q33.1 by Ensembl
- 2q33.1 by Entrez Gene
- 2q33.1 by HGNC
C2orf69 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C2orf69 Gene
Proteins for C2orf69 Gene
-
Protein details for C2orf69 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N8R5-CB069_HUMAN
- Recommended name:
- UPF0565 protein C2orf69
- Protein Accession:
- Q8N8R5
- Q8NE30
Protein attributes for C2orf69 Gene
- Size:
- 385 amino acids
- Molecular mass:
- 43448 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=EAW70190.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for C2orf69 Gene
Post-translational modifications for C2orf69 Gene
Other Protein References for C2orf69 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C2orf69
-
Abcam antibodies for C2orf69
- Invitrogen Antibodies for C2orf69
- Search GeneTex for Antibodies for C2orf69
Protein Products
-
OriGene Purified Proteins for C2orf69
- Search Origene for MassSpec and Protein Over-expression Lysates for C2orf69
- Origene Custom Protein Services for C2orf69
- Search GeneTex for Proteins for C2orf69
No data available for DME Specific Peptides for C2orf69 Gene
Domains & Families for C2orf69 Gene
Suggested Antigen Peptide Sequences for C2orf69 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N8R5- Family:
-
- Belongs to the UPF0565 family.
No data available for Gene Families for C2orf69 Gene
Function for C2orf69 Gene
Phenotypes for C2orf69 Gene
- GenomeRNAi human phenotypes for C2orf69:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C2orf69
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C2orf69 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C2orf69 gene
- Search ViGene Biosciences for C2orf69
CRISPR Products
-
OriGene CRISPR knockouts for C2orf69
-
Santa Cruz Biotechnology (SCBT) CRISPR for C2orf69
miRNA for C2orf69 Gene
- miRTarBase miRNAs that target C2orf69
miRNA Products
- Search ViGene Biosciences for C2orf69
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C2orf69
- Browse OriGene Inhibitory RNA Products For C2orf69
-
ViGene Biosciences ready-to-package AAV shRNAs for C2orf69 gene
Clone Products
-
OriGene ORF clones in human for C2orf69
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C2orf69
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C2orf69
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C2orf69
-
ViGene Biosciences adenoviral particle packaged cDNA for C2orf69 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C2orf69 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C2orf69 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf69 Gene
Localization for C2orf69 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C2orf69 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| mitochondrion | 2 |
| peroxisome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
Pathways & Interactions for C2orf69 Gene
No Data Available
Interacting Proteins for C2orf69 Gene
No data available for Pathways by source and SIGNOR curated interactions for C2orf69 Gene
Transcripts for C2orf69 Gene
mRNA/cDNA for C2orf69 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (90) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C2orf69 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C2orf69
-
Santa Cruz Biotechnology (SCBT) CRISPR for C2orf69
miRNA Products
- Search ViGene Biosciences for C2orf69
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C2orf69
- Browse OriGene Inhibitory RNA Products For C2orf69
-
ViGene Biosciences ready-to-package AAV shRNAs for C2orf69 gene
Clone Products
-
OriGene ORF clones in human for C2orf69
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C2orf69
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C2orf69
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for C2orf69 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (40.9), Frontal cortex (10.8), and Testis (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C2orf69 Gene
NURSA nuclear receptor signaling pathways regulating expression of C2orf69 Gene:
C2orf69SOURCE GeneReport for Unigene cluster for C2orf69 Gene:
Hs.471040Evidence on tissue expression from TISSUES for C2orf69 Gene
- Nervous system(2.9)
Primer Products
-
OriGene qPCR primer pairs for C2orf69
-
OriGene qPCR primer pairs and template standards for C2orf69
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf69 Gene
Orthologs for C2orf69 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C2BH2orf69 34 |
|
||
| C2orf69 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C2H2orf69 34 |
|
||
| C2orf69 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C37H2orf69 34 |
|
||
| C2orf69 35 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | RGD1306941 34 |
|
||
| mouse (Mus musculus) |
Mammalia | 1700066M21Rik 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | C2orf69 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | C2orf69 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C7H2ORF69 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | C2orf69 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | c2orf69 34 |
|
||
| Str.9332 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:153521 34 |
|
||
| C9H2orf69 35 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG31122 34 35 |
|
- Species where no ortholog for C2orf69 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for C2orf69 Gene
Pseudogenes.org Pseudogenes for C2orf69 Gene
No data available for Paralogs for C2orf69 Gene
Variants for C2orf69 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000199366 | -- | 199,910,523(+) | TGTTG(-/CC)CAGGC | intron-variant, upstream-variant-2KB | |
| rs1000543718 | -- | 199,927,914(+) | AAAAA(C/T)CTAGG | utr-variant-3-prime | |
| rs1001063519 | -- | 199,917,392(+) | AAATG(G/T)GTTTT | intron-variant | |
| rs1001121677 | -- | 199,924,628(+) | AAGAG(A/G)GAGGG | intron-variant | |
| rs1001186372 | -- | 199,920,320(+) | AGTAA(A/T)GATTC | intron-variant |
Residual Variation Intolerance Score:
69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.50;
71.83% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C2orf69 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C2orf69
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf69 Gene
Disorders for C2orf69 Gene
Relevant External Links for C2orf69
No disorders were found for C2orf69 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf69 Gene
Publications for C2orf69 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
- Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3 64
- Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
Products for C2orf69 Gene
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- OriGene Purified Proteins for C2orf69
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C2orf69
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- OriGene qPCR primer pairs and template standards for C2orf69
- OriGene qPCR primer pairs for C2orf69
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- Novus Biologicals Antibodies for C2orf69
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- Novus Biologicals
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- Abcam antibodies for C2orf69
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- Invitrogen Antibodies for C2orf69
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- Search GeneTex for Antibodies for C2orf69
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- ViGene Biosciences adenoviral particle packaged cDNA for C2orf69 gene
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- Horizon Cell Lines for C2orf69
- Cyagen custom Knockout/knockin (KOKI) mouse models for C2orf69
- VectorBuilder custom plasmid, inducible vectors for C2orf69
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C2orf69
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C2orf69 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer