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Aliases for C2orf68 Gene

Aliases for C2orf68 Gene

  • Chromosome 2 Open Reading Frame 68 2 3 5
  • UPF0561 Protein C2orf68 3
  • HCRCN81 3

External Ids for C2orf68 Gene

Previous GeneCards Identifiers for C2orf68 Gene

  • GC02M085688
  • GC02M085832
  • GC02M085729

Summaries for C2orf68 Gene

GeneCards Summary for C2orf68 Gene

C2orf68 (Chromosome 2 Open Reading Frame 68) is a Protein Coding gene. Diseases associated with C2orf68 include Colorectal Adenocarcinoma.

Additional gene information for C2orf68 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf68 Gene

Genomics for C2orf68 Gene

Regulatory Elements for C2orf68 Gene

Enhancers for C2orf68 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H085536 1.7 FANTOM5 ENCODE dbSUPER 20.4 +72.3 72306 6 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SNORD94 USP39 KDM3A TCF7L1 C2orf68 VAMP8 GGCX SH2D6 CAPG RN7SL251P
GH02H085740 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -131.4 -131435 5 PKNOX1 FOXA2 SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302 ZNF416 DEK SNORD94 KDM3A USP39 PTCD3 POLR1A LOC100996506 C2orf68 LOC105374845 TCF7L1 ELMOD3
GH02H084923 2 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +686.3 686265 3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 USP39 LOC100996506 C2orf68 KCMF1 LOC105374838 RPS2P17
GH02H085701 2 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -92.4 -92373 6 FOXA2 ARNT ZNF2 YY1 ZNF143 ZNF207 FOS DEK SP3 JUNB ATOH8 GNLY LOC100130649 SFTPB C2orf68 USP39 RNU1-38P LOC284950 VAMP8 SH2D6
GH02H085497 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 +112.2 112183 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF766 CBX5 ZNF143 USP39 SNORD94 MAT2A ELMOD3 LOC100996506 RN7SL251P RNU7-64P CAPG KDM3A C2orf68
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C2orf68 on UCSC Golden Path with GeneCards custom track

Promoters for C2orf68 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119601 366 1401 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 PAF1 SP3 SP5

Genomic Location for C2orf68 Gene

Chromosome:
2
Start:
85,605,253 bp from pter
End:
85,612,066 bp from pter
Size:
6,814 bases
Orientation:
Minus strand

Genomic View for C2orf68 Gene

Genes around C2orf68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf68 Gene

Proteins for C2orf68 Gene

  • Protein details for C2orf68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2NKX9-CB068_HUMAN
    Recommended name:
    UPF0561 protein C2orf68
    Protein Accession:
    Q2NKX9
    Secondary Accessions:
    • B4DT10
    • Q4G0J7
    • Q6ZVA6

    Protein attributes for C2orf68 Gene

    Size:
    166 amino acids
    Molecular mass:
    18751 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C2orf68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C2orf68 Gene

Post-translational modifications for C2orf68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf68 Gene

No data available for DME Specific Peptides for C2orf68 Gene

Domains & Families for C2orf68 Gene

Gene Families for C2orf68 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C2orf68 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C2orf68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2NKX9

UniProtKB/Swiss-Prot:

CB068_HUMAN :
  • Belongs to the UPF0561 family.
Family:
  • Belongs to the UPF0561 family.
genes like me logo Genes that share domains with C2orf68: view

Function for C2orf68 Gene

Phenotypes From GWAS Catalog for C2orf68 Gene

genes like me logo Genes that share phenotypes with C2orf68: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C2orf68
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf68 Gene

Localization for C2orf68 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf68 gene
Compartment Confidence
nucleus 4
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear membrane (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf68 Gene

Pathways & Interactions for C2orf68 Gene

SuperPathways for C2orf68 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C2orf68 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf68 Gene

Drugs & Compounds for C2orf68 Gene

No Compound Related Data Available

Transcripts for C2orf68 Gene

Unigene Clusters for C2orf68 Gene

Chromosome 2 open reading frame 68:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C2orf68
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf68 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: -

Relevant External Links for C2orf68 Gene

GeneLoc Exon Structure for
C2orf68
ECgene alternative splicing isoforms for
C2orf68

Expression for C2orf68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf68 Gene

NURSA nuclear receptor signaling pathways regulating expression of C2orf68 Gene:

C2orf68

SOURCE GeneReport for Unigene cluster for C2orf68 Gene:

Hs.516159

Evidence on tissue expression from TISSUES for C2orf68 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with C2orf68: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf68 Gene

Orthologs for C2orf68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf68 33
  • 99.4 (n)
C2orf68 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17H2orf68 33
  • 90.36 (n)
C2orf68 34
  • 61 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H2orf68 33
  • 88.62 (n)
C2orf68 34
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC691113 33
  • 87.55 (n)
mouse
(Mus musculus)
Mammalia 0610030E20Rik 33 16 34
  • 85.34 (n)
oppossum
(Monodelphis domestica)
Mammalia C2orf68 34
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf68 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495513 33
  • 64.01 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19302 33
zebrafish
(Danio rerio)
Actinopterygii si:ch211-283h6.4 33
  • 59.13 (n)
C5H2orf68 34
  • 51 (a)
OneToOne
Species where no ortholog for C2orf68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf68 Gene

ENSEMBL:
Gene Tree for C2orf68 (if available)
TreeFam:
Gene Tree for C2orf68 (if available)

Paralogs for C2orf68 Gene

(1) SIMAP similar genes for C2orf68 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with C2orf68: view

No data available for Paralogs for C2orf68 Gene

Variants for C2orf68 Gene

Sequence variations from dbSNP and Humsavar for C2orf68 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000033559 -- 85,605,076(+) ACTCT(A/G)ATGCT intron-variant
rs1000106784 -- 85,605,460(+) TTTAC(C/T)CAGAA intron-variant, utr-variant-3-prime
rs1000211109 -- 85,612,206(+) GAGGG(C/T)TTTTG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000351466 -- 85,611,292(+) GTAGC(A/T)GAGAA intron-variant, upstream-variant-2KB
rs1000410980 -- 85,612,056(+) CTCCG(C/T)GCCGC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for C2orf68 Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C2orf68 Gene

Disorders for C2orf68 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C2orf68 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal adenocarcinoma
  • adenocarcinoma of large intestine
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C2orf68

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf68
genes like me logo Genes that share disorders with C2orf68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C2orf68 Gene

Publications for C2orf68 Gene

  1. The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. (PMID: 25023051) Wen X … Chen Y (Medical oncology (Northwood, London, England) 2014) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer. (PMID: 26607374) Chen Y … He K (Medical oncology (Northwood, London, England) 2016) 3 60
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 60

Products for C2orf68 Gene

Sources for C2orf68 Gene

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