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Aliases for C2orf68 Gene

Aliases for C2orf68 Gene

  • Chromosome 2 Open Reading Frame 68 2 3 5
  • HCRCN81 3

External Ids for C2orf68 Gene

Previous GeneCards Identifiers for C2orf68 Gene

  • GC02M085688
  • GC02M085832
  • GC02M085729

Summaries for C2orf68 Gene

GeneCards Summary for C2orf68 Gene

C2orf68 (Chromosome 2 Open Reading Frame 68) is a Protein Coding gene. Diseases associated with C2orf68 include colorectal adenocarcinoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf68 Gene

Genomics for C2orf68 Gene

Regulatory Elements for C2orf68 Gene

Promoters for C2orf68 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C2orf68 on UCSC Golden Path with GeneCards custom track

Genomic Location for C2orf68 Gene

85,605,253 bp from pter
85,612,066 bp from pter
6,814 bases
Minus strand

Genomic View for C2orf68 Gene

Genes around C2orf68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf68 Gene

Proteins for C2orf68 Gene

  • Protein details for C2orf68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0561 protein C2orf68
    Protein Accession:
    Secondary Accessions:
    • B4DT10
    • Q4G0J7
    • Q6ZVA6

    Protein attributes for C2orf68 Gene

    166 amino acids
    Molecular mass:
    18751 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C2orf68 Gene


neXtProt entry for C2orf68 Gene

Proteomics data for C2orf68 Gene at MOPED

Post-translational modifications for C2orf68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf68 Gene

No data available for DME Specific Peptides for C2orf68 Gene

Domains & Families for C2orf68 Gene

Protein Domains for C2orf68 Gene


Suggested Antigen Peptide Sequences for C2orf68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0561 family.
  • Belongs to the UPF0561 family.
genes like me logo Genes that share domains with C2orf68: view

No data available for Gene Families for C2orf68 Gene

Function for C2orf68 Gene

genes like me logo Genes that share phenotypes with C2orf68: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf68 Gene

Localization for C2orf68 Gene

Subcellular locations from

Jensen Localization Image for C2orf68 Gene COMPARTMENTS Subcellular localization image for C2orf68 gene
Compartment Confidence
nucleus 4
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf68 Gene

Pathways & Interactions for C2orf68 Gene

SuperPathways for C2orf68 Gene

No Data Available

Interacting Proteins for C2orf68 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000304410 for C2orf68 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C2orf68 Gene


No data available for Pathways by source and SIGNOR curated interactions for C2orf68 Gene

Drugs & Compounds for C2orf68 Gene

No Compound Related Data Available

Transcripts for C2orf68 Gene

Unigene Clusters for C2orf68 Gene

Chromosome 2 open reading frame 68:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf68 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: -

Relevant External Links for C2orf68 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf68 Gene

mRNA expression in normal human tissues for C2orf68 Gene

SOURCE GeneReport for Unigene cluster for C2orf68 Gene Hs.516159

genes like me logo Genes that share expression patterns with C2orf68: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C2orf68 Gene

Orthologs for C2orf68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf68 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C11H2orf68 35
  • 88.62 (n)
  • 86.51 (a)
C2orf68 36
  • 86 (a)
(Canis familiaris)
Mammalia C17H2orf68 35
  • 90.36 (n)
  • 89.16 (a)
C2orf68 36
  • 61 (a)
(Mus musculus)
Mammalia 0610030E20Rik 35
  • 85.34 (n)
  • 83.13 (a)
0610030E20Rik 16
0610030E20Rik 36
  • 83 (a)
(Pan troglodytes)
Mammalia C2AH2orf68 35
  • 99.4 (n)
  • 98.19 (a)
C2orf68 36
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC691113 35
  • 87.55 (n)
  • 86.75 (a)
(Monodelphis domestica)
Mammalia C2orf68 36
  • 78 (a)
(Anolis carolinensis)
Reptilia C2orf68 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495513 35
  • 64.01 (n)
  • 64.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19302 35
(Danio rerio)
Actinopterygii si:ch211-283h6.4 35
  • 59.13 (n)
  • 54.79 (a)
C5H2orf68 36
  • 51 (a)
Species with no ortholog for C2orf68:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf68 Gene

Gene Tree for C2orf68 (if available)
Gene Tree for C2orf68 (if available)

Paralogs for C2orf68 Gene

(1) SIMAP similar genes for C2orf68 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with C2orf68: view

No data available for Paralogs for C2orf68 Gene

Variants for C2orf68 Gene

Structural Variations from Database of Genomic Variants (DGV) for C2orf68 Gene

Variant ID Type Subtype PubMed ID
dgv4202n71 CNV Loss 21882294

Variation tolerance for C2orf68 Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf68 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for C2orf68 Gene

Disorders for C2orf68 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C2orf68 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal adenocarcinoma
  • adenocarcinoma of large intestine
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C2orf68

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C2orf68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C2orf68 Gene

Publications for C2orf68 Gene

  1. The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. (PMID: 25023051) Wen X. … Chen Y. (Med. Oncol. 2014) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Hcrcn81 is upregulated by rapamycin treatment in human colorectal adenocarcinoma cells. (PMID: 23404111) Wen X. … Chen Y. (Mol Med Rep 2013) 3
  4. NM_001013649.3 gene is down-regulated in human colorectal adenocarcinoma. (PMID: 21874238) Jiang Q. … Chen Y. (Mol Med Rep 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for C2orf68 Gene

Sources for C2orf68 Gene

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