C2orf68 Gene
protein-coding GIFtS: 40
GCID: GC02M085832
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chromosome 2 open reading frame 68
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Aliases
for C2orf68 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 2 Open Reading Frame 681 2 | | UPF0561 Protein C2orf682 |
Export aliases for C2orf68 gene to outside databasesPrevious GC identifers: GC02M085688 GC02M085729 |
Summaries
for C2orf68 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C2orf68 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C2orf68 gene promoter:
c-Fos Elk-1 Pax-5 AP-1 JunB Brachyury Fra-1 FosB JunD c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for C2orf68
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf68 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2C2orf68 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M085832: view genomic region
(about GC identifiers)
Start:
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85,832,376 bp from pter |
End:
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85,839,189 bp from pter |
Size:
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6,814 bases |
Orientation:
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minus strand |
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Proteins
for C2orf68 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CB068_HUMAN, Q2NKX9 (See
protein sequence)Recommended Name: UPF0561 protein C2orf68 Size: 166 amino acids; 18751 Da
Secondary accessions: B4DT10 Q4G0J7 Q6ZVA6Alternative splicing: 2 isoforms: Q2NKX9-1 Q2NKX9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C2orf68: NX_Q2NKX9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2NKX9
C2orf68 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001013671.2
ENSEMBL proteins: ENSP00000304410 ENSP00000401625 ENSP00000395730 ENSP00000386301
Human Recombinant Protein Products for C2orf68:
C2orf68 Antibody Products:
Assay Products for C2orf68: |
Protein
Domains /
Families
for C2orf68 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C2orf68 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q2NKX9ProtoNet protein and cluster: Q2NKX9 UniProtKB/Swiss-Prot: CB068_HUMAN, Q2NKX9Similarity: Belongs to the UPF0561 family |
Function
for C2orf68 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for C2orf68:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf68 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf68
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C2orf68 (NM_001013649) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C2orf68 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf68 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf68 |
|
Pathways & Interactions
for C2orf68 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C2orf68
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for C2orf68 (ENSP000003044104) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C2orf68 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C2orf68
Search CenterWatch for drugs/clinical trials and news about C2orf68 / CB068
|
Transcripts
for C2orf68 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C2orf68 gene: NM_001013649.3 Unigene Cluster for C2orf68: Chromosome 2 open reading frame 68 Hs.516159 [show with all ESTs]Unigene Representative Sequence: NM_0010136495 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000306336(uc002sqc.2) ENST00000420686 ENST00000423181 ENST00000409734(uc002sqd.2)
ENST00000478626
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf68 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf68
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C2orf68 (NM_001013649) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C2orf68 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf68 |
Additional cDNA sequence: AK092972.1 AK300003.1 AK311297.1 BC111483.1 13 DOTS entries: DT.209055 DT.215855 DT.432023 DT.40275136 DT.40316334 DT.405539 DT.120979914 DT.120979887 DT.102842879 DT.120979851 DT.95158384 DT.101964299 DT.40206919 24/186 AceView cDNA sequences (see all 186): BF941107 AA827723 AI197958 CA310867 AW204147 BI063047 AI633815 CB152991 AA233865 AI694971 AK092972 AI123683 AW117727 BU071017 AW770660 AA053779 H27682 AA463249 AW612097 N34888 BU071152 AW770504 AI783832 BX090065
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for C2orf68 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b |
|---|
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| SP1: | | | - | | | | | | - | | - | | - | | - | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | - | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C2orf68
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Expression
for C2orf68 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C2orf68 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATGTTGAC
About this image
See C2orf68 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C2orf68
SOURCE GeneReport for Unigene cluster: Hs.516159
SABiosciences Custom PCR Arrays for C2orf68
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2orf68
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C2orf68 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf68 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf68 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf68 |
Orthologs
for C2orf68 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C2orf68 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for C2orf68 (if available)
TreeFam Gene Tree for C2orf68 (if available) |
Paralogs
for C2orf68 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C2orf68 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2orf68 |
|
Disorders
/ Diseases
for C2orf68 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C2orf68 for disorders About GeneDecksing
1  disease for C2orf68: About MalaCardsadenocarcinoma
Export disorders for C2orf68 gene to outside databases
|
Publications
for C2orf68 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C2orf68 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C2orf68) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- NM_001013649.3 gene is down-regulated in human colore ctal adenocarcinoma. (PubMed id 21874238)1 Jiang Q....Chen Y. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for C2orf68 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C2orf68 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C2orf68 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C2orf68 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C2orf68 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C2orf68 gene:
Search GeneIP for patents involving C2orf68
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C2orf68 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C2orf68 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C2orf68 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2orf68 | | | OriGene Protein Over-expression Lysate for C2orf68 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for C2orf68 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf68 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf68 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C2orf68 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C2orf68 | | OriGene Custom Protein Services for C2orf68 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C2orf68 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2orf68 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf68 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C2orf68 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf68 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf68 |
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 |  |  |  | |
| | | | Search Tocris compounds for C2orf68 |
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 | | | C2orf68 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf68 |
|  |  |  |  | | | | ThermoFisher Antibodies for C2orf68 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf68 |
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