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Aliases for C2orf66 Gene

Aliases for C2orf66 Gene

  • Chromosome 2 Open Reading Frame 66 2 3
  • IIDS6411 3
  • UNQ6411 3

External Ids for C2orf66 Gene

Previous GeneCards Identifiers for C2orf66 Gene

  • GC02M197379
  • GC02M197669
  • GC02M189522

Summaries for C2orf66 Gene

GeneCards Summary for C2orf66 Gene

C2orf66 (Chromosome 2 Open Reading Frame 66) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf66 Gene

Genomics for C2orf66 Gene

Regulatory Elements for C2orf66 Gene

Genomic Location for C2orf66 Gene

196,804,415 bp from pter
196,810,276 bp from pter
5,862 bases
Minus strand

Genomic View for C2orf66 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for C2orf66 Gene

Proteins for C2orf66 Gene

  • Protein details for C2orf66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C2orf66
    Protein Accession:
    Secondary Accessions:
    • B2RNW3

    Protein attributes for C2orf66 Gene

    117 amino acids
    Molecular mass:
    13321 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf66 Gene

Proteomics data for C2orf66 Gene at MOPED

Post-translational modifications for C2orf66 Gene

No Post-translational modifications

Other Protein References for C2orf66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2orf66 Gene

Domains & Families for C2orf66 Gene

Protein Domains for C2orf66 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf66: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf66 Gene

Function for C2orf66 Gene

Phenotypes for C2orf66 Gene

genes like me logo Genes that share phenotypes with C2orf66: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2orf66

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf66 Gene

Localization for C2orf66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2orf66 Gene


Subcellular locations from

Jensen Localization Image for C2orf66 Gene COMPARTMENTS Subcellular localization image for C2orf66 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for C2orf66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C2orf66: view

Pathways & Interactions for C2orf66 Gene

SuperPathways for C2orf66 Gene

No Data Available

Interacting Proteins for C2orf66 Gene

Gene Ontology (GO) - Biological Process for C2orf66 Gene


No data available for Pathways by source and SIGNOR curated interactions for C2orf66 Gene

Drugs & Compounds for C2orf66 Gene

No Compound Related Data Available

Transcripts for C2orf66 Gene

mRNA/cDNA for C2orf66 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2orf66 Gene

Chromosome 2 open reading frame 66:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2orf66

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf66 Gene

No ASD Table

Relevant External Links for C2orf66 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf66 Gene

mRNA expression in normal human tissues for C2orf66 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf66 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.9), Pituitary (x6.6), and Brain - Hypothalamus (x4.1).

SOURCE GeneReport for Unigene cluster for C2orf66 Gene Hs.372069

genes like me logo Genes that share expression patterns with C2orf66: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C2orf66 Gene

Orthologs for C2orf66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf66 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100139826 35
  • 79.65 (n)
  • 71.68 (a)
-- 36
  • 72 (a)
-- 36
  • 71 (a)
(Canis familiaris)
Mammalia C37H2orf66 35
  • 79.61 (n)
  • 71.84 (a)
(Mus musculus)
Mammalia LOC102637189 35
  • 77.35 (n)
  • 71.84 (a)
(Pan troglodytes)
Mammalia C2BH2orf66 35
  • 99.72 (n)
  • 99.14 (a)
C2orf66 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC686030 35
  • 77.89 (n)
  • 68.32 (a)
(Monodelphis domestica)
Mammalia C2orf66 36
  • 60 (a)
(Gallus gallus)
Aves C7H2ORF66 35
  • 68.25 (n)
  • 63.1 (a)
Species with no ortholog for C2orf66:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf66 Gene

Gene Tree for C2orf66 (if available)
Gene Tree for C2orf66 (if available)

Paralogs for C2orf66 Gene

No data available for Paralogs for C2orf66 Gene

Variants for C2orf66 Gene

Sequence variations from dbSNP and Humsavar for C2orf66 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1992170 -- 196,810,956(+) CTATG(A/C)AATAG upstream-variant-2KB
rs1992171 -- 196,811,108(+) TCTAA(A/C)AAGGT upstream-variant-2KB
rs2289380 -- 196,804,465(+) ATCCA(C/T)CCAAA utr-variant-3-prime
rs7580839 -- 196,808,311(+) GCAAA(C/T)AGAAG intron-variant
rs11378936 -- 196,807,763(+) ACAAG(-/T)TACAT intron-variant

Variation tolerance for C2orf66 Gene

Residual Variation Intolerance Score: 54.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf66 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C2orf66 Gene

Disorders for C2orf66 Gene

Relevant External Links for C2orf66

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C2orf66: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf66 Gene

Publications for C2orf66 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 67
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for C2orf66 Gene

Sources for C2orf66 Gene

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