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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C2orf62 Gene

protein-coding   GIFtS: 35
GCID: GC02P219221          (predicted)

chromosome 2 open reading frame 62
  Search for C2orf62
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C2orf62    

Aliases
for C2orf62 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 2 Open Reading Frame 621 2
MGC508111
Uncharacterized Protein C2orf622

External Ids:    HGNC: 250621   Entrez Gene: 3753072   Ensembl: ENSG000001584287   UniProtKB: Q7Z7H33   

Export aliases for C2orf62 gene to outside databases

Previous GC identifers: GC02P218930 GC02P211074


Summaries
for C2orf62 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C2orf62 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C2orf62 gene promoter:
         C/EBPbeta   Pbx1a   AML1a   Pax-5   ATF-2   CUTL1   Nkx2-5   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C2orf62

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf62


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

C2orf62 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C2orf62 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219221:  view genomic region     (about GC identifiers)

Start:
 219,221,579 bp from pter      End:
 219,232,822 bp from pter
Size:
 11,244 bases      Orientation:
 plus strand

Proteins
for C2orf62 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CB062_HUMAN, Q7Z7H3 (See protein sequence)
Recommended Name: Uncharacterized protein C2orf62  
Size: 387 amino acids; 43900 Da

Explore the universe of human proteins at neXtProt for C2orf62: NX_Q7Z7H3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z7H3

    • C2orf62 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_940961.1  
    ENSEMBL proteins: 
     ENSP00000289388  

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    Protein Domains /
    Families
    for C2orf62 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q7Z7H3


    Function
    for C2orf62 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for C2orf62 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C2orf62

    Drugs & Compounds
    for C2orf62 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for C2orf62
    Search CenterWatch for drugs/clinical trials and news about C2orf62 / CB062 

    Transcripts
    for C2orf62 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for C2orf62 gene: 
    NM_198559.1  

    Unigene Cluster for C2orf62:

    Chromosome 2 open reading frame 62
    Hs.645453  [show with all ESTs]
    Unigene Representative Sequence: AK098178
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289388(uc002vhr.3) ENST00000480532 ENST00000495773 ENST00000481940
    ENST00000494447

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    Additional cDNA sequence: 

    AK098178.1 BC052750.1 

    6 DOTS entries:

    DT.97787751  DT.99935640  DT.95091736  DT.95133036  DT.101970392  DT.120939824 

    9 AceView cDNA sequences:

    BC052750 CR602769 BM552990 NM_198559 BI918985 BX336005 BM924708 AK098178 
    BX336004 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for C2orf62    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                    -           -                             -                     
    SP2:                                                  -     -     -                     
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for C2orf62

    Expression
    for C2orf62 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C2orf62 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCTGCCAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C2orf62 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C2orf62 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.645453
        SABiosciences Custom PCR Arrays for C2orf62
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    In Situ
    Assay Products:     
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    Orthologs
    for C2orf62 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for C2orf62 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Gm2161 , 5 predicted gene 2161, 5 78.54(n)1
    75.37(a)1    		   1 (38.54 cM)5
    2411121  NM_001033345.21  NP_001028517.11 
     743621085 
    chicken
    (Gallus gallus)    		 Aves C7H2orf621 chromosome unknown open reading frame, human C2orf62 54.06(n)
    43.84(a)    		   426213  XM_423876.3  XP_423876.2 
    lizard
    (Anolis carolinensis)    		 Reptilia C2orf626
    		 --
    		 44(a)
    		 1 ↔ 1
    		 1(88695891-88704236)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1530631 zgc:153063 54.32(n)
    44.75(a)    		   767803  NM_001076770.1  NP_001070238.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG132436
    		 --
    		 17(a)
    		 1 ↔ 1
    		 2L(15852592-15854110)


    ENSEMBL Gene Tree for C2orf62 (if available)
    TreeFam Gene Tree for C2orf62 (if available) 

    Paralogs
    for C2orf62 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C2orf62 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/18 NCBI SNPs in C2orf62 are shown (see all 18)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1497503811,2
    		--219219579(+) GCCCTC/GTGTCA 1 -- us2k10--------
    rs770294581,2
    		C--219219643(+) TTGGGA/CAGACG 1 -- us2k10--------
    rs795735051,2
    		C--219219644(+) TGGGAA/GGACGC 1 -- us2k10--------
    rs758072701,2
    		C--219219645(+) GGGAAG/TACGCC 1 -- us2k10--------
    rs783858901,2
    		C--219219647(+) GAAGAC/TGCCCA 1 -- us2k10--------
    rs1455916831,2
    		--219219648(+) AAGACA/GCCCAT 1 -- us2k10--------
    rs1853610031,2
    		--219219669(+) ACCGCG/TAAAGG 1 -- us2k10--------
    rs1908474331,2
    		--219219812(+) GTCACC/GCTCCT 1 -- us2k10--------
    rs108042681,2
    		C,F,A,H,--219219840(+) CTGCCG/ATACTC 1 -- us2k16Minor allele frequency- A:0.12NA CSA EA 132
    rs46742951,2
    		C,H,--219219875(+) TAGATA/GGCGGT 1 -- us2k17Minor allele frequency- G:0.06NA CSA 17

    HapMap Linkage Disequilibrium report for C2orf62 (219221579 - 219232822 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for C2orf62: --

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    Disorders / Diseases
    for C2orf62 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C2orf62 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C2orf62 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C2orf62)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for C2orf62 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C2orf62 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 375307 HGNC: 25062 AceView: MGC50811 Ensembl:ENSG00000158428 euGenes: HUgn375307
    ECgene: C2orf62 H-InvDB: C2orf62

    Other Databases showing C2orf62 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C2orf62 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C2orf62 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C2orf62 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C2orf62 gene:
    Search GeneIP for patents involving C2orf62

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    for C2orf62 gene

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    About This Section

     
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