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Aliases for C2orf61 Gene

Aliases for C2orf61 Gene

  • Chromosome 2 Open Reading Frame 61 2 3 5

External Ids for C2orf61 Gene

Previous GeneCards Identifiers for C2orf61 Gene

  • GC02M047209
  • GC02M047314
  • GC02M047273

Summaries for C2orf61 Gene

GeneCards Summary for C2orf61 Gene

C2orf61 (Chromosome 2 Open Reading Frame 61) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf61 Gene

Genomics for C2orf61 Gene

Regulatory Elements for C2orf61 Gene

Enhancers for C2orf61 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C2orf61 on UCSC Golden Path with GeneCards custom track

Genomic Location for C2orf61 Gene

47,045,538 bp from pter
47,155,378 bp from pter
109,841 bases
Minus strand

Genomic View for C2orf61 Gene

Genes around C2orf61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf61 Gene

Proteins for C2orf61 Gene

  • Protein details for C2orf61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C2orf61
    Protein Accession:
    Secondary Accessions:
    • H7C2Z2

    Protein attributes for C2orf61 Gene

    248 amino acids
    Molecular mass:
    27807 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C2orf61 Gene


neXtProt entry for C2orf61 Gene

Post-translational modifications for C2orf61 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf61 Gene

No data available for DME Specific Peptides for C2orf61 Gene

Domains & Families for C2orf61 Gene

Protein Domains for C2orf61 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf61: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf61 Gene

Function for C2orf61 Gene

genes like me logo Genes that share phenotypes with C2orf61: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf61 Gene

Localization for C2orf61 Gene

Subcellular locations from

Jensen Localization Image for C2orf61 Gene COMPARTMENTS Subcellular localization image for C2orf61 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf61 Gene

Pathways & Interactions for C2orf61 Gene

SuperPathways for C2orf61 Gene

No Data Available

Interacting Proteins for C2orf61 Gene

Gene Ontology (GO) - Biological Process for C2orf61 Gene


No data available for Pathways by source and SIGNOR curated interactions for C2orf61 Gene

Drugs & Compounds for C2orf61 Gene

No Compound Related Data Available

Transcripts for C2orf61 Gene

mRNA/cDNA for C2orf61 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2orf61 Gene

Chromosome 2 open reading frame 61:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf61 Gene

No ASD Table

Relevant External Links for C2orf61 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf61 Gene

mRNA expression in normal human tissues for C2orf61 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C2orf61 Gene

This gene is overexpressed in Testis (x44.7).

NURSA nuclear receptor signaling pathways regulating expression of C2orf61 Gene:


SOURCE GeneReport for Unigene cluster for C2orf61 Gene:

genes like me logo Genes that share expression patterns with C2orf61: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C2orf61 Gene

Orthologs for C2orf61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf61 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia C10H2orf61 34
  • 85.7 (n)
  • 84.55 (a)
C2orf61 35
  • 89 (a)
(Mus musculus)
Mammalia 1700011E24Rik 34
  • 77.69 (n)
  • 71.07 (a)
Stpg4 16
1700011E24Rik 35
  • 68 (a)
(Pan troglodytes)
Mammalia C2AH2orf61 34
  • 99.42 (n)
  • 98.84 (a)
C2orf61 35
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC681766 34
  • 76.45 (n)
  • 71.07 (a)
(Monodelphis domestica)
Mammalia C2orf61 35
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia C2orf61 35
  • 58 (a)
(Anolis carolinensis)
Reptilia C2orf61 35
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497472 34
  • 53.27 (n)
  • 43.06 (a)
(Danio rerio)
Actinopterygii LOC100332264 34
  • 45.85 (n)
  • 39.37 (a)
C2orf61 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4094 35
  • 30 (a)
Species where no ortholog for C2orf61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf61 Gene

Gene Tree for C2orf61 (if available)
Gene Tree for C2orf61 (if available)

Paralogs for C2orf61 Gene

No data available for Paralogs for C2orf61 Gene

Variants for C2orf61 Gene

Sequence variations from dbSNP and Humsavar for C2orf61 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs815804 - 47,155,203(-) AAGAC(A/C/G)TGGTG reference, missense
rs17036300 - 47,153,006(+) TCTTT(C/T)GGGCT reference, missense
rs4302259 -- 47,128,137(+) ctgag(A/C)gagtt intron-variant, downstream-variant-500B
rs4322886 -- 47,125,822(+) ccaaa(C/G)tgcta intron-variant
rs4339009 -- 47,095,754(+) ctacc(C/G)agaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf61 Gene

Variant ID Type Subtype PubMed ID
esv2471188 CNV insertion 19546169
esv2669653 CNV deletion 23128226
esv2762549 CNV loss 21179565
esv3590621 CNV loss 21293372
esv3590622 CNV gain 21293372
esv3590623 CNV loss 21293372
esv3892059 CNV loss 25118596
nsv1004828 CNV gain 25217958
nsv2716 CNV deletion 18451855
nsv457352 CNV loss 19166990
nsv498921 CNV loss 21111241
nsv581749 CNV loss 21841781
nsv581754 CNV gain 21841781
nsv963228 CNV duplication 23825009

Variation tolerance for C2orf61 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf61 Gene

Disorders for C2orf61 Gene

Relevant External Links for C2orf61

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C2orf61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf61 Gene

Publications for C2orf61 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 65
  4. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 46 65
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65

Products for C2orf61 Gene

Sources for C2orf61 Gene

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