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Aliases for C2orf57 Gene

Aliases for C2orf57 Gene

  • Chromosome 2 Open Reading Frame 57 2 3 5

External Ids for C2orf57 Gene

Previous GeneCards Identifiers for C2orf57 Gene

  • GC02P232166
  • GC02P232457
  • GC02P224299

Summaries for C2orf57 Gene

GeneCards Summary for C2orf57 Gene

C2orf57 (Chromosome 2 Open Reading Frame 57) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf57 Gene

Genomics for C2orf57 Gene

Regulatory Elements for C2orf57 Gene

Enhancers for C2orf57 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C2orf57 on UCSC Golden Path with GeneCards custom track

Genomic Location for C2orf57 Gene

Chromosome:
2
Start:
231,592,864 bp from pter
End:
231,594,283 bp from pter
Size:
1,420 bases
Orientation:
Plus strand

Genomic View for C2orf57 Gene

Genes around C2orf57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf57 Gene

Proteins for C2orf57 Gene

  • Protein details for C2orf57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53QW1-CB057_HUMAN
    Recommended name:
    Uncharacterized protein C2orf57
    Protein Accession:
    Q53QW1
    Secondary Accessions:
    • Q8N4F2

    Protein attributes for C2orf57 Gene

    Size:
    395 amino acids
    Molecular mass:
    41589 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf57 Gene

Proteomics data for C2orf57 Gene at MOPED

Post-translational modifications for C2orf57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf57 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2orf57 Gene

Domains & Families for C2orf57 Gene

Protein Domains for C2orf57 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf57: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf57 Gene

Function for C2orf57 Gene

genes like me logo Genes that share phenotypes with C2orf57: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf57 Gene

Localization for C2orf57 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2orf57 Gene COMPARTMENTS Subcellular localization image for C2orf57 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf57 Gene

Pathways & Interactions for C2orf57 Gene

SuperPathways for C2orf57 Gene

No Data Available

Interacting Proteins for C2orf57 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315557%0d%0a9606.ENSP00000312189%0d%0a
Selected Interacting proteins: ENSP00000315557 Q53QW1-CB057_HUMAN for C2orf57 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for C2orf57 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf57 Gene

Drugs & Compounds for C2orf57 Gene

No Compound Related Data Available

Transcripts for C2orf57 Gene

mRNA/cDNA for C2orf57 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C2orf57 Gene

Chromosome 2 open reading frame 57:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf57 Gene

No ASD Table

Relevant External Links for C2orf57 Gene

GeneLoc Exon Structure for
C2orf57
ECgene alternative splicing isoforms for
C2orf57

Expression for C2orf57 Gene

mRNA expression in normal human tissues for C2orf57 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf57 Gene

This gene is overexpressed in Testis (x52.3).

Protein differential expression in normal tissues from HIPED for C2orf57 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf57 Gene



SOURCE GeneReport for Unigene cluster for C2orf57 Gene Hs.98104

genes like me logo Genes that share expression patterns with C2orf57: view

Protein tissue co-expression partners for C2orf57 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C2orf57 Gene

Orthologs for C2orf57 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf57 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C2H2orf57 35
  • 70.58 (n)
  • 54.22 (a)
C2orf57 36
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C25H2orf57 35
  • 69.31 (n)
  • 54.39 (a)
C2orf57 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700019O17Rik 35
  • 64.26 (n)
  • 48.74 (a)
1700019O17Rik 16
1700019O17Rik 36
  • 31 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C2BH2orf57 35
  • 98.42 (n)
  • 96.95 (a)
C2orf57 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC501180 35
  • 61.75 (n)
  • 44.74 (a)
oppossum
(Monodelphis domestica)
Mammalia C2orf57 36
  • 27 (a)
OneToOne
Species with no ortholog for C2orf57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf57 Gene

ENSEMBL:
Gene Tree for C2orf57 (if available)
TreeFam:
Gene Tree for C2orf57 (if available)

Paralogs for C2orf57 Gene

No data available for Paralogs for C2orf57 Gene

Variants for C2orf57 Gene

Sequence variations from dbSNP and Humsavar for C2orf57 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs16828251 - 231,592,982(+) GCAAC(A/C/G)TGGAT reference, missense
rs16828254 - 231,593,187(+) CGGCC(A/G)GAAGA reference, missense
rs16828257 - 231,593,453(+) CCGTC(A/G)AGAGT reference, missense
rs10933378 - 231,593,732(+) TGGAC(A/C/T)CCAGC reference, missense
rs1865373 -- 231,591,302(+) TCAAC(A/G)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C2orf57 Gene

Variant ID Type Subtype PubMed ID
nsv875967 CNV Loss 21882294
nsv875968 CNV Gain 21882294

Variation tolerance for C2orf57 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C2orf57 Gene

Disorders for C2orf57 Gene

Relevant External Links for C2orf57

Genetic Association Database (GAD)
C2orf57
Human Genome Epidemiology (HuGE) Navigator
C2orf57
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf57

No disorders were found for C2orf57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf57 Gene

Publications for C2orf57 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for C2orf57 Gene

Sources for C2orf57 Gene

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