Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C2orf49 Gene

Aliases for C2orf49 Gene

  • Chromosome 2 Open Reading Frame 49 2 3
  • Ashwin 2 3
  • Asw 3

External Ids for C2orf49 Gene

Summaries for C2orf49 Gene

GeneCards Summary for C2orf49 Gene

C2orf49 (Chromosome 2 Open Reading Frame 49) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf49 Gene

Genomics for C2orf49 Gene

Genomic Location for C2orf49 Gene

Start:
105,337,359 bp from pter
End:
105,360,051 bp from pter
Size:
22,693 bases
Orientation:
Plus strand

Genomic View for C2orf49 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C2orf49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf49 Gene

Regulatory Elements for C2orf49 Gene

Proteins for C2orf49 Gene

  • Protein details for C2orf49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVC5-ASHWN_HUMAN
    Recommended name:
    Ashwin
    Protein Accession:
    Q9BVC5
    Secondary Accessions:
    • B3KXN3
    • B4E2G9

    Protein attributes for C2orf49 Gene

    Size:
    232 amino acids
    Molecular mass:
    25858 Da
    Quaternary structure:
    • Component of the tRNA-splicing ligase complex.

    Alternative splice isoforms for C2orf49 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C2orf49 Gene

Proteomics data for C2orf49 Gene at MOPED

Post-translational modifications for C2orf49 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf49 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2orf49 Gene

Domains for C2orf49 Gene

Protein Domains for C2orf49 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ASHWN_HUMAN
Family:
  • Belongs to the ashwin family.:
    • Q9BVC5
genes like me logo Genes that share domains with C2orf49: view

No data available for Gene Families for C2orf49 Gene

Function for C2orf49 Gene

Gene Ontology (GO) - Molecular Function for C2orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C2orf49: view

miRNA for C2orf49 Gene

miRTarBase miRNAs that target C2orf49

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C2orf49 Gene

Localization for C2orf49 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2orf49 Gene COMPARTMENTS Subcellular localization image for C2orf49 gene
Compartment Confidence
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for C2orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072669 tRNA-splicing ligase complex IDA 21311021
genes like me logo Genes that share ontologies with C2orf49: view

Pathways for C2orf49 Gene

SuperPathways for C2orf49 Gene

No Data Available

Interacting Proteins for C2orf49 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258457%0d%0a9606.ENSP00000380734%0d%0a9606.ENSP00000216038%0d%0a9606.ENSP00000261700%0d%0a9606.ENSP00000233084%0d%0a
Selected Interacting proteins: ENSP00000258457 for C2orf49 Gene via STRING

Gene Ontology (GO) - Biological Process for C2orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0048598 embryonic morphogenesis IEA --
genes like me logo Genes that share ontologies with C2orf49: view

No data available for Pathways by source for C2orf49 Gene

Transcripts for C2orf49 Gene

mRNA/cDNA for C2orf49 Gene

Unigene Clusters for C2orf49 Gene

Chromosome 2 open reading frame 49:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf49 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2:

Relevant External Links for C2orf49 Gene

GeneLoc Exon Structure for
C2orf49
ECgene alternative splicing isoforms for
C2orf49

Expression for C2orf49 Gene

mRNA expression in normal human tissues for C2orf49 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C2orf49 Gene

SOURCE GeneReport for Unigene cluster for C2orf49 Gene Hs.549577

genes like me logo Genes that share expressions with C2orf49: view

Orthologs for C2orf49 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf49 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf49 36
  • 99.43 (n)
  • 99.57 (a)
C2orf49 37
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H2orf49 36
  • 87.21 (n)
  • 89.22 (a)
C2orf49 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C10H2orf49 36
  • 91.38 (n)
  • 92.24 (a)
C2orf49 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI597479 36
  • 85.49 (n)
  • 85.34 (a)
AI597479 16
AI597479 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 72 (a)
OneToMany
-- 37
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia C2orf49 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1310553 36
  • 85.92 (n)
  • 86.64 (a)
chicken
(Gallus gallus)
Aves C1H2ORF49 36
  • 69.59 (n)
  • 65.79 (a)
C1H2ORF49 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf49 37
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia asw-A-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia c2orf49 36
  • 58.22 (n)
  • 53.99 (a)
Str.11043 36
zebrafish
(Danio rerio)
Actinopterygii C9H2orf49 37
  • 43 (a)
OneToOne
si:dkeyp-118h3.6 36
  • 54.23 (n)
  • 50.78 (a)
Species with no ortholog for C2orf49:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf49 Gene

ENSEMBL:
Gene Tree for C2orf49 (if available)
TreeFam:
Gene Tree for C2orf49 (if available)

Paralogs for C2orf49 Gene

No data available for Paralogs for C2orf49 Gene

Variants for C2orf49 Gene

Sequence variations from dbSNP and Humsavar for C2orf49 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs726286 -- 105,348,227(+) GTCTC(A/G)GGTCC utr-variant-3-prime, intron-variant
rs2460258 -- 105,359,421(-) TGTTA(A/G)AATGT intron-variant
rs2576765 -- 105,341,408(+) GAACT(A/G)CTTAT intron-variant
rs2576766 -- 105,343,590(+) TCACA(C/T)ATTTA intron-variant
rs2576767 -- 105,343,876(+) ATAGG(C/T)GCTTC intron-variant

Relevant External Links for C2orf49 Gene

HapMap Linkage Disequilibrium report
C2orf49

No data available for Structural Variations from Database of Genomic Variants (DGV) for C2orf49 Gene

Disorders for C2orf49 Gene

No disorders were found for C2orf49 Gene.

No data available for UniProtKB/Swiss-Prot for C2orf49 Gene

Publications for C2orf49 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Novel gene ashwin functions in Xenopus cell survival and anteroposterior patterning. (PMID: 16680723) Patil S.S. … Sater A.K. (Dev. Dyn. 2006) 2 3
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. HSPC117 is the essential subunit of a human tRNA splicing ligase complex. (PMID: 21311021) Popow J. … Martinez J. (Science 2011) 3 4

Products for C2orf49 Gene

Sources for C2orf49 Gene

Back to Top

Content