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Aliases for C2orf49 Gene

Aliases for C2orf49 Gene

  • Chromosome 2 Open Reading Frame 49 2 3
  • Ashwin 2 3
  • Asw 3

External Ids for C2orf49 Gene

Previous GeneCards Identifiers for C2orf49 Gene

  • GC02P105320
  • GC02P105953
  • GC02P099722

Summaries for C2orf49 Gene

GeneCards Summary for C2orf49 Gene

C2orf49 (Chromosome 2 Open Reading Frame 49) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf49 Gene

Genomics for C2orf49 Gene

Regulatory Elements for C2orf49 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C2orf49 Gene

105,337,359 bp from pter
105,360,051 bp from pter
22,693 bases
Plus strand

Genomic View for C2orf49 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C2orf49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf49 Gene

Proteins for C2orf49 Gene

  • Protein details for C2orf49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KXN3
    • B4E2G9

    Protein attributes for C2orf49 Gene

    232 amino acids
    Molecular mass:
    25858 Da
    Quaternary structure:
    • Component of the tRNA-splicing ligase complex.

    Alternative splice isoforms for C2orf49 Gene


neXtProt entry for C2orf49 Gene

Proteomics data for C2orf49 Gene at MOPED

Post-translational modifications for C2orf49 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf49 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for C2orf49 Gene

Domains for C2orf49 Gene

Protein Domains for C2orf49 Gene


Suggested Antigen Peptide Sequences for C2orf49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ashwin family.
  • Belongs to the ashwin family.
genes like me logo Genes that share domains with C2orf49: view

No data available for Gene Families for C2orf49 Gene

Function for C2orf49 Gene

Gene Ontology (GO) - Molecular Function for C2orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C2orf49: view

Animal Model Products

CRISPR Products

miRNA for C2orf49 Gene

miRTarBase miRNAs that target C2orf49

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2orf49

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf49 Gene

Localization for C2orf49 Gene

Subcellular locations from

Jensen Localization Image for C2orf49 Gene COMPARTMENTS Subcellular localization image for C2orf49 gene
Compartment Confidence
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for C2orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072669 tRNA-splicing ligase complex IDA 21311021
genes like me logo Genes that share ontologies with C2orf49: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C2orf49 Gene

Pathways for C2orf49 Gene

SuperPathways for C2orf49 Gene

No Data Available

Interacting Proteins for C2orf49 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000258457 for C2orf49 Gene via STRING

Gene Ontology (GO) - Biological Process for C2orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0048598 embryonic morphogenesis IEA --
genes like me logo Genes that share ontologies with C2orf49: view

No data available for Pathways by source for C2orf49 Gene

Transcripts for C2orf49 Gene

mRNA/cDNA for C2orf49 Gene

Unigene Clusters for C2orf49 Gene

Chromosome 2 open reading frame 49:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2orf49

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf49 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b

Relevant External Links for C2orf49 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf49 Gene

mRNA expression in normal human tissues for C2orf49 Gene

Protein differential expression in normal tissues for C2orf49 Gene

This gene is overexpressed in Breast (34.8) and Peripheral blood mononuclear cells (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C2orf49 Gene

SOURCE GeneReport for Unigene cluster for C2orf49 Gene Hs.549577

genes like me logo Genes that share expressions with C2orf49: view

Expression partners for C2orf49 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C2orf49 Gene

Orthologs for C2orf49 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf49 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C11H2orf49 35
  • 87.21 (n)
  • 89.22 (a)
C2orf49 36
  • 89 (a)
(Canis familiaris)
Mammalia C10H2orf49 35
  • 91.38 (n)
  • 92.24 (a)
C2orf49 36
  • 92 (a)
(Mus musculus)
Mammalia AI597479 35
  • 85.49 (n)
  • 85.34 (a)
AI597479 16
AI597479 36
  • 85 (a)
(Pan troglodytes)
Mammalia C2AH2orf49 35
  • 99.43 (n)
  • 99.57 (a)
C2orf49 36
  • 83 (a)
(Rattus norvegicus)
Mammalia RGD1310553 35
  • 85.92 (n)
  • 86.64 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
-- 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia C2orf49 36
  • 63 (a)
(Gallus gallus)
Aves C1H2ORF49 35
  • 69.59 (n)
  • 65.79 (a)
C1H2ORF49 36
  • 62 (a)
(Anolis carolinensis)
Reptilia C2orf49 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c2orf49 35
  • 58.22 (n)
  • 53.99 (a)
Str.11043 35
African clawed frog
(Xenopus laevis)
Amphibia asw-A-prov 35
(Danio rerio)
Actinopterygii si:dkeyp-118h3.6 35
  • 54.23 (n)
  • 50.78 (a)
C9H2orf49 36
  • 43 (a)
Species with no ortholog for C2orf49:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf49 Gene

Gene Tree for C2orf49 (if available)
Gene Tree for C2orf49 (if available)

Paralogs for C2orf49 Gene

No data available for Paralogs for C2orf49 Gene

Variants for C2orf49 Gene

Sequence variations from dbSNP and Humsavar for C2orf49 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs726286 -- 105,348,227(+) GTCTC(A/G)GGTCC utr-variant-3-prime, intron-variant
rs2460258 -- 105,359,421(-) TGTTA(A/G)AATGT intron-variant
rs2576765 -- 105,341,408(+) GAACT(A/G)CTTAT intron-variant
rs2576766 -- 105,343,590(+) TCACA(C/T)ATTTA intron-variant
rs2576767 -- 105,343,876(+) ATAGG(C/T)GCTTC intron-variant

Relevant External Links for C2orf49 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C2orf49 Gene

Disorders for C2orf49 Gene

No disorders were found for C2orf49 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for C2orf49 Gene

Publications for C2orf49 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Novel gene ashwin functions in Xenopus cell survival and anteroposterior patterning. (PMID: 16680723) Patil S.S. … Sater A.K. (Dev. Dyn. 2006) 2 3
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. HSPC117 is the essential subunit of a human tRNA splicing ligase complex. (PMID: 21311021) Popow J. … Martinez J. (Science 2011) 3 4

Products for C2orf49 Gene

Sources for C2orf49 Gene

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