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Aliases for C2orf44 Gene

Aliases for C2orf44 Gene

  • Chromosome 2 Open Reading Frame 44 2 3
  • WDCP 3 4
  • WD Repeat And Coiled-Coil-Containing Protein 4
  • WD Repeat-Containing Protein C2orf44 3
  • PP384 3

External Ids for C2orf44 Gene

Previous GeneCards Identifiers for C2orf44 Gene

  • GC02M024105
  • GC02M024252
  • GC02M023991

Summaries for C2orf44 Gene

GeneCards Summary for C2orf44 Gene

C2orf44 (Chromosome 2 Open Reading Frame 44) is a Protein Coding gene. GO annotations related to this gene include kinase binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf44 Gene

Genomics for C2orf44 Gene

Regulatory Elements for C2orf44 Gene

Transcription factor binding sites by QIAGEN in the C2orf44 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C2orf44 Gene

Chromosome:
2
Start:
24,029,336 bp from pter
End:
24,049,575 bp from pter
Size:
20,240 bases
Orientation:
Minus strand

Genomic View for C2orf44 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C2orf44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf44 Gene

Proteins for C2orf44 Gene

  • Protein details for C2orf44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6R7-CB044_HUMAN
    Recommended name:
    WD repeat and coiled-coil-containing protein C2orf44
    Protein Accession:
    Q9H6R7
    Secondary Accessions:
    • D6W532
    • Q8IYK0
    • Q9HBP5

    Protein attributes for C2orf44 Gene

    Size:
    721 amino acids
    Molecular mass:
    79136 Da
    Quaternary structure:
    • Oligomer. Interacts with HCK (via SH3 domain).

    Alternative splice isoforms for C2orf44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C2orf44 Gene

Proteomics data for C2orf44 Gene at MOPED

Post-translational modifications for C2orf44 Gene

Other Protein References for C2orf44 Gene

No data available for DME Specific Peptides for C2orf44 Gene

Domains & Families for C2orf44 Gene

Protein Domains for C2orf44 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C2orf44 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6R7

UniProtKB/Swiss-Prot:

CB044_HUMAN :
  • Contains 2 WD repeats.
Similarity:
  • Contains 2 WD repeats.
genes like me logo Genes that share domains with C2orf44: view

No data available for Gene Families for C2orf44 Gene

Function for C2orf44 Gene

Gene Ontology (GO) - Molecular Function for C2orf44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019900 kinase binding IPI 25469238
genes like me logo Genes that share ontologies with C2orf44: view

Phenotypes for C2orf44 Gene

GenomeRNAi human phenotypes for C2orf44:
genes like me logo Genes that share phenotypes with C2orf44: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf44 Gene

Localization for C2orf44 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2orf44 Gene COMPARTMENTS Subcellular localization image for C2orf44 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf44 Gene

Pathways & Interactions for C2orf44 Gene

SuperPathways for C2orf44 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C2orf44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051259 protein oligomerization IDA 25469238
genes like me logo Genes that share ontologies with C2orf44: view

No data available for Pathways by source and SIGNOR curated interactions for C2orf44 Gene

Drugs & Compounds for C2orf44 Gene

No Compound Related Data Available

Transcripts for C2orf44 Gene

mRNA/cDNA for C2orf44 Gene

Unigene Clusters for C2orf44 Gene

Chromosome 2 open reading frame 44:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2orf44

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf44 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for C2orf44 Gene

GeneLoc Exon Structure for
C2orf44
ECgene alternative splicing isoforms for
C2orf44

Expression for C2orf44 Gene

mRNA expression in normal human tissues for C2orf44 Gene

Protein differential expression in normal tissues from HIPED for C2orf44 Gene

This gene is overexpressed in Adipocyte (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C2orf44 Gene



SOURCE GeneReport for Unigene cluster for C2orf44 Gene Hs.24624

genes like me logo Genes that share expression patterns with C2orf44: view

Protein tissue co-expression partners for C2orf44 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C2orf44 Gene

Orthologs for C2orf44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C2orf44 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C11H2orf44 35
  • 81.37 (n)
  • 75.71 (a)
C2orf44 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17H2orf44 35
  • 81.85 (n)
  • 74.16 (a)
C2orf44 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC068281 35
  • 74.93 (n)
  • 66.98 (a)
BC068281 16
BC068281 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf44 35
  • 99.4 (n)
  • 98.89 (a)
C2orf44 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563701 35
  • 74.3 (n)
  • 64.04 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia C2orf44 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC421975 35
  • 60.55 (n)
  • 52.87 (a)
C2orf44 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf44 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c2orf44 35
  • 57.55 (n)
  • 53.49 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:103511 35
  • 54.6 (n)
  • 50.54 (a)
C20H2orf44 36
  • 43 (a)
OneToOne
Species with no ortholog for C2orf44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf44 Gene

ENSEMBL:
Gene Tree for C2orf44 (if available)
TreeFam:
Gene Tree for C2orf44 (if available)

Paralogs for C2orf44 Gene

No data available for Paralogs for C2orf44 Gene

Variants for C2orf44 Gene

Sequence variations from dbSNP and Humsavar for C2orf44 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3203 -- 24,029,547(+) GTCAC(C/G/T)GCTCT utr-variant-3-prime
rs3204 -- 24,029,566(+) TGATT(A/G)CAGAC utr-variant-3-prime
rs872169 -- 24,036,318(-) ATGTT(C/G)CCTAG intron-variant
rs2339939 -- 24,029,079(-) GGAGA(A/G)AAGAG downstream-variant-500B
rs2339940 -- 24,028,917(-) TTGGA(A/C)AAACA downstream-variant-500B

Variation tolerance for C2orf44 Gene

Residual Variation Intolerance Score: 44.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf44 Gene

HapMap Linkage Disequilibrium report
C2orf44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C2orf44 Gene

Disorders for C2orf44 Gene

Relevant External Links for C2orf44

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf44
genes like me logo Genes that share disorders with C2orf44: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf44 Gene

Publications for C2orf44 Gene

  1. Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK. (PMID: 25469238) Yokoyama N. … Miller W.T. (Biomed. Rep. 2015) 2 67
  2. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. (PMID: 22327622) Lipson D. … Stephens P.J. (Nat. Med. 2012) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 67

Products for C2orf44 Gene

Sources for C2orf44 Gene

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