C2orf44 Gene
protein-coding GIFtS: 40
GCID: GC02M024252
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chromosome 2 open reading frame 44
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Aliases
for C2orf44 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 2 Open Reading Frame 441 2 | | FLJ219451 | | WD Repeat-Containing Protein C2orf442 |
Export aliases for C2orf44 gene to outside databasesPrevious GC identifers: GC02M024105 GC02M023991 |
Summaries
for C2orf44 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C2orf44 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C2orf44 gene promoter:
Sp1 RREB-1 Zic3 YY1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C2orf44
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf44 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3C2orf44 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M024252: view genomic region
(about GC identifiers)
Start:
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24,252,206 bp from pter |
End:
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24,272,445 bp from pter |
Size:
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20,240 bases |
Orientation:
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minus strand |
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Proteins
for C2orf44 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CB044_HUMAN, Q9H6R7 (See
protein sequence)Recommended Name: WD repeat-containing protein C2orf44 Size: 721 amino acids; 79136 Da
Secondary accessions: D6W532 Q8IYK0 Q9HBP5Alternative splicing: 3 isoforms: Q9H6R7-1 Q9H6R7-2 Q9H6R7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C2orf44: NX_Q9H6R7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H6R7
C2orf44 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001135791.1 NP_079479.1
ENSEMBL proteins: ENSP00000295148 ENSP00000385816 ENSP00000413426
Human Recombinant Protein Products:
C2orf44 Antibody Products:
Assay Products for C2orf44: |
Protein
Domains /
Families
for C2orf44 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9H6R7 UniProtKB/Swiss-Prot: CB044_HUMAN, Q9H6R7Similarity: Contains 2 WD repeats |
Function
for C2orf44 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf44 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf44 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): C2orf44 (NM_025203) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf44 |
|
Pathways & Interactions
for C2orf44 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C2orf44
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/16 Interacting proteins for C2orf44 (Q9H6R72, 3 ENSP000002951484) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
|
Drugs & Compounds
for C2orf44 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C2orf44
Search CenterWatch for drugs/clinical trials and news about C2orf44 / CB044
|
Transcripts
for C2orf44 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C2orf44 gene (2 alternative transcripts): NM_001142319.1 NM_025203.2 Unigene Cluster for C2orf44: Chromosome 2 open reading frame 44 Hs.24624 [show with all ESTs]Unigene Representative Sequence: NM_0252033 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000295148(uc002rep.2) ENST00000406895(uc010eya.2) ENST00000443232
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf44 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf44 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C2orf44 (NM_025203) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C2orf44 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf44 |
Additional cDNA sequence: AF218013.1 AK025598.1 BC035698.2 6 DOTS entries: DT.100779852 DT.210067 DT.100779850 DT.100652033 DT.120991903 DT.91806216 24/108 AceView cDNA sequences (see all 108): BM452150 BE733845 BM471894 AA412305 BX102968 CR602012 BU159804 BQ220959 AL709190 Z40630 BE858039 BU507503 BC035698 AA196723 BM728880 AA599090 AA196906 AA236921 BM468804 BE870641 AI510755 BE734536 AK025598 BX374719
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for C2orf44 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 |
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| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | - | | | |
ECgene alternative splicing isoforms for C2orf44
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Expression
for C2orf44 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C2orf44 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTGTCCCTG
About this image
See C2orf44 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C2orf44
SOURCE GeneReport for Unigene cluster: Hs.24624
SABiosciences Custom PCR Arrays for C2orf44
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2orf44
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C2orf44 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf44 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf44 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf44 |
Orthologs
for C2orf44 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C2orf44 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for C2orf44 (if available)
TreeFam Gene Tree for C2orf44 (if available) |
Paralogs
for C2orf44 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C2orf44 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C2orf44 (24252206 - 24272445 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C2orf44: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2orf44 |
|
Disorders
/ Diseases
for C2orf44 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C2orf44 for disorders About GeneDecksing
1  disease for C2orf44: About MalaCardswiskott-aldrich syndrome
Export disorders for C2orf44 gene to outside databases
|
Publications
for C2orf44 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C2orf44 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with C2orf44) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of new ALK and RET gene fusions from co lorectal and lung cancer biopsies. (PubMed id 22327622)1, 3 Lipson D....Stephens P.J. (2012)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Genome-wide association studies in an isolated founde r population from the Pacific Island of Kosrae. (PubMed id 19197348)1 Lowe J.K....Friedman J.M. (2009)
- Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PubMed id 19596235)1 Svendsen J.M.... Harper J.W. (2009)
- Probabilistic assembly of human protein interaction n etworks from label-free quantitative proteomics. (PubMed id 18218781)1 Sardiu M.E....Washburn M.P. (2008)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
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External Searches for C2orf44 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C2orf44 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C2orf44 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C2orf44 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C2orf44 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C2orf44 gene:
Search GeneIP for patents involving C2orf44
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C2orf44 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C2orf44 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C2orf44 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2orf44 | | | OriGene Protein Over-expression Lysate for C2orf44 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C2orf44 | | OriGene 3'-UTR Clone for C2orf44 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf44 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf44 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C2orf44 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2orf44 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf44 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C2orf44 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf44 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf44 |
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| | | | Search Tocris compounds for C2orf44 |
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 | | | C2orf44 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf44 |
|  |  |  | | | | Search ThermoFisher Antibodies for C2orf44 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf44 |
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