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Aliases for C2orf42 Gene

Aliases for C2orf42 Gene

  • Chromosome 2 Open Reading Frame 42 2 3 5

External Ids for C2orf42 Gene

Previous GeneCards Identifiers for C2orf42 Gene

  • GC02M070230
  • GC02M070377
  • GC02M070113

Summaries for C2orf42 Gene

GeneCards Summary for C2orf42 Gene

C2orf42 (Chromosome 2 Open Reading Frame 42) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf42 Gene

Genomics for C2orf42 Gene

Regulatory Elements for C2orf42 Gene

Enhancers for C2orf42 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C2orf42 on UCSC Golden Path with GeneCards custom track

Promoters for C2orf42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C2orf42 on UCSC Golden Path with GeneCards custom track

Genomic Location for C2orf42 Gene

Chromosome:
2
Start:
70,149,880 bp from pter
End:
70,248,615 bp from pter
Size:
98,736 bases
Orientation:
Minus strand

Genomic View for C2orf42 Gene

Genes around C2orf42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf42 Gene

Proteins for C2orf42 Gene

  • Protein details for C2orf42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWW7-CB042_HUMAN
    Recommended name:
    Uncharacterized protein C2orf42
    Protein Accession:
    Q9NWW7
    Secondary Accessions:
    • D6W5G3
    • Q9H629

    Protein attributes for C2orf42 Gene

    Size:
    574 amino acids
    Molecular mass:
    64077 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C2orf42 Gene

Proteomics data for C2orf42 Gene at MOPED

Post-translational modifications for C2orf42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C2orf42 Gene

Domains & Families for C2orf42 Gene

Protein Domains for C2orf42 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf42: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C2orf42 Gene

Function for C2orf42 Gene

Phenotypes for C2orf42 Gene

genes like me logo Genes that share phenotypes with C2orf42: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C2orf42

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf42 Gene

Localization for C2orf42 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C2orf42 Gene COMPARTMENTS Subcellular localization image for C2orf42 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C2orf42 Gene

Pathways & Interactions for C2orf42 Gene

SuperPathways for C2orf42 Gene

No Data Available

Interacting Proteins for C2orf42 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264434%0d%0a9606.ENSP00000309259%0d%0a
Selected Interacting proteins: ENSP00000264434 Q9NWW7-CB042_HUMAN for C2orf42 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for C2orf42 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf42 Gene

Drugs & Compounds for C2orf42 Gene

No Compound Related Data Available

Transcripts for C2orf42 Gene

Unigene Clusters for C2orf42 Gene

Chromosome 2 open reading frame 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf42 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - -
SP7: - - - -
SP8: -
SP9: - - - - - - - - - -
SP10: - - - - - - - -
SP11: -

ExUns: 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for C2orf42 Gene

GeneLoc Exon Structure for
C2orf42
ECgene alternative splicing isoforms for
C2orf42

Expression for C2orf42 Gene

mRNA expression in normal human tissues for C2orf42 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf42 Gene

This gene is overexpressed in Testis (x5.3).

Protein differential expression in normal tissues from HIPED for C2orf42 Gene

This gene is overexpressed in Adrenal (32.7), Colon (19.1), and Testis (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C2orf42 Gene



SOURCE GeneReport for Unigene cluster for C2orf42 Gene Hs.720049

genes like me logo Genes that share expression patterns with C2orf42: view

Protein tissue co-expression partners for C2orf42 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C2orf42 Gene

Orthologs for C2orf42 Gene

This gene was present in the common ancestor of animals.

Orthologs for C2orf42 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C11H2orf42 35
  • 92.86 (n)
  • 97.56 (a)
C2orf42 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C10H2orf42 35
  • 92.16 (n)
  • 96.17 (a)
C2ORF42 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C87436 35
  • 87.22 (n)
  • 91.64 (a)
C87436 16
C87436 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf42 35
  • 99.76 (n)
  • 100 (a)
C2ORF42 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306746 35
  • 88.15 (n)
  • 92.51 (a)
oppossum
(Monodelphis domestica)
Mammalia C2orf42 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves C22H2ORF42 35
  • 74.44 (n)
  • 83.51 (a)
C22H2ORF42 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c2orf42 35
  • 68.02 (n)
  • 70.6 (a)
Str.15817 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-127d4.3 35
  • 57.24 (n)
  • 56.17 (a)
C5H2orf42 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001614 35
  • 39.43 (n)
  • 31.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2321 36
  • 20 (a)
OneToOne
Species with no ortholog for C2orf42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C2orf42 Gene

ENSEMBL:
Gene Tree for C2orf42 (if available)
TreeFam:
Gene Tree for C2orf42 (if available)

Paralogs for C2orf42 Gene

No data available for Paralogs for C2orf42 Gene

Variants for C2orf42 Gene

Sequence variations from dbSNP and Humsavar for C2orf42 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3213941 - 70,175,771(+) TCATC(C/G/T)GTGCA nc-transcript-variant, reference, missense
rs1562295 -- 70,159,326(+) CTCAC(A/G)CCTGT intron-variant
rs4853356 -- 70,154,072(-) acaaa(A/C/G/T)aaaaa intron-variant
rs4853372 -- 70,175,657(+) TTCTA(C/G)GGAAG intron-variant
rs4853373 -- 70,179,784(+) CCCCA(A/T)CTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf42 Gene

Variant ID Type Subtype PubMed ID
nsv518294 CNV Loss 19592680
esv2671105 CNV Deletion 23128226

Variation tolerance for C2orf42 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf42 Gene

Human Gene Mutation Database (HGMD)
C2orf42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf42 Gene

Disorders for C2orf42 Gene

Relevant External Links for C2orf42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf42

No disorders were found for C2orf42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf42 Gene

Publications for C2orf42 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for C2orf42 Gene

Sources for C2orf42 Gene

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