C2orf27A Gene
protein-coding GIFtS: 37
GCID: GC02P132479
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chromosome 2 open reading frame 27A(Previous name: chromosome 2 open reading frame 27 )
(Previous symbol: C2orf27)
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Aliases
for C2orf27A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| Chromosome 2 Open Reading Frame 27A1 2 | | C2orf271 2 | | Chromosome 2 Open Reading Frame 271 | | C2orf27B2 | | Uncharacterized Protein C2orf272 |
Export aliases for C2orf27A gene to outside databasesPrevious GC identifers: GC02P132197 GC02P124473 |
Summaries
for C2orf27A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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-- |
Genomic Views
for C2orf27A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C2orf27A gene promoter:
HOXA9B HOXA9 AML1a IRF-1 Meis-1b Meis-1a Pax-4a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C2orf27A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf27A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q21.2 Ensembl cytogenetic band: 2q21.1 HGNC cytogenetic band: 2q21.2C2orf27A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P132479: view genomic region
(about GC identifiers)
Start:
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132,479,948 bp from pter |
End:
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132,524,977 bp from pter |
Size:
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45,030 bases |
Orientation:
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plus strand |
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Proteins
for C2orf27A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CB027_HUMAN, Q580R0 (See
protein sequence)Recommended Name: Uncharacterized protein C2orf27 Size: 203 amino acids; 21517 Da
Secondary accessions: O43575 Q2M1X0 Q52M10 Q86XG2Alternative splicing: 2 isoforms: Q580R0-1 Q580R0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C2orf27A: NX_Q580R0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q580R0
C2orf27A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037442.3
ENSEMBL proteins: ENSP00000347298
Human Recombinant Protein Products for C2orf27A:
C2orf27A Antibody Products:
Assay Products for C2orf27A: |
Protein
Domains /
Families
for C2orf27A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q580R0 |
Function
for C2orf27A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for C2orf27A:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf27A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf27A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C2orf27A (NM_013310) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C2orf27A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf27A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf27A |
|
Pathways & Interactions
for C2orf27A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C2orf27A
|
Drugs & Compounds
for C2orf27A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C2orf27A
Search CenterWatch for drugs/clinical trials and news about C2orf27A / CB027
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Transcripts
for C2orf27A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C2orf27A gene: NM_013310.3 Unigene Cluster for C2orf27A: Chromosome 2 open reading frame 27A Hs.655680 [show with all ESTs]Unigene Representative Sequence: AF0381695 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355171(uc002ttf.1) ENST00000463645 ENST00000466372 ENST00000472358
ENST00000481510
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf27A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf27A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C2orf27A (NM_013310) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C2orf27A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf27A |
Additional cDNA sequence: AF038169.1 AK309649.1 BC071972.1 BC093716.1 BC112189.1 7 DOTS entries: DT.310297 DT.70104636 DT.86857126 DT.103754 DT.120937176 DT.120937156 DT.75116534 24/65 AceView cDNA sequences (see all 65): AF038169 CA411656 AI871567 BF594073 AI469633 AI276139 BU619441 BQ218386 CD103414 AI418663 BQ218082 AA406301 BE140613 AI739520 BI669426 BI670178 BF445094 AI963556 AA608696 AA608697 AA877997 AA431429 AI375033 AI521169
GeneLoc Exon Structure
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Expression
for C2orf27A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C2orf27A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C2orf27A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C2orf27A
SOURCE GeneReport for Unigene cluster: Hs.655680
SABiosciences Custom PCR Arrays for C2orf27A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2orf27A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat C2orf27A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf27A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf27A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf27A |
Orthologs
for C2orf27A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for C2orf27A (if available)
TreeFam Gene Tree for C2orf27A (if available) |
Paralogs
for C2orf27A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C2orf27A gene
- C2orf27B1 2
C2orf27A for paralogs About GeneDecksing
5/11 Pseudogenes.org Pseudogenes for C2orf27A (see all 11)
PGOHUM00000248017 PGOHUM00000238989 PGOHUM00000239120 PGOHUM00000246179 PGOHUM00000246273
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Genomic Variants
for C2orf27A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for C2orf27A (132479948 - 132524977 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for C2orf27A
15/17 CNVs (see all 17): 74266 3393 78776 89994 89999 74267 4307 74264 78777 58918 89997 89998 89993 74268 32376 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2orf27A |
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Disorders
/ Diseases
for C2orf27A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C2orf27A for disorders About GeneDecksing
3  diseases for C2orf27A: About MalaCardsnevoid basal cell carcinoma syndrome basal cell carcinoma carcinoma
1 disease from the University of Copenhagen DISEASES database for C2orf27A:Nevoid basal cell carcinoma syndrome Export disorders for C2orf27A gene to outside databases
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Publications
for C2orf27A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C2orf27A gene integrated from 9 sources:
(articles sorted by number of sources associating them with C2orf27A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for C2orf27A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C2orf27A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing C2orf27A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C2orf27A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C2orf27A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for C2orf27A gene:
Search GeneIP for patents involving C2orf27A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C2orf27A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C2orf27A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C2orf27A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C2orf27A | | | OriGene Protein Over-expression Lysate for C2orf27A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C2orf27A | | OriGene 3'-UTR Clone for C2orf27A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf27A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C2orf27A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C2orf27A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C2orf27A | | OriGene Custom Protein Services for C2orf27A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C2orf27A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C2orf27A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C2orf27A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C2orf27A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C2orf27A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C2orf27A |
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 | | | C2orf27A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C2orf27A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for C2orf27A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C2orf27A |
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