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Aliases for C2orf27A Gene

Aliases for C2orf27A Gene

  • Chromosome 2 Open Reading Frame 27A 2 3 5
  • Chromosome 2 Open Reading Frame 27 2
  • Uncharacterized Protein C2orf27 3
  • C2orf27A C2orf27B 4
  • C2orf27B 3
  • C2orf27 3

External Ids for C2orf27A Gene

Previous HGNC Symbols for C2orf27A Gene

  • C2orf27

Previous GeneCards Identifiers for C2orf27A Gene

  • GC02P132197
  • GC02P132479
  • GC02P124473

Summaries for C2orf27A Gene

GeneCards Summary for C2orf27A Gene

C2orf27A (Chromosome 2 Open Reading Frame 27A) is a Protein Coding gene. An important paralog of this gene is C2orf27B.

Additional gene information for C2orf27A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf27A Gene

Genomics for C2orf27A Gene

Regulatory Elements for C2orf27A Gene

Enhancers for C2orf27A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H131681 1.3 Ensembl ENCODE 38.2 -37.6 -37637 6.3 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF416 ZNF143 C2orf27A ENSG00000213222 PIR46456
GH02H131667 1.5 FANTOM5 Ensembl ENCODE 24.4 -53.1 -53090 2.6 PKNOX1 ATF1 ARNT TCF12 ZNF143 ZNF207 FOS ATF7 NCOA1 JUNB C2orf27A PIR46456 PIR51363
GH02H132264 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10 +547.2 547179 9.7 HDGF PKNOX1 ARNT ZFP64 SIN3A YBX1 ZBTB7B YY1 CBX5 ZNF143 LOC150776 ENSG00000272769 ZNF806 FAM201B ENSG00000213222 CCDC74A C2orf27A LOC105373622 GC02P132278
GH02H131672 1.2 Ensembl ENCODE 12.3 -49.1 -49145 2.3 ZFP64 ARID4B SIN3A ZNF2 GLIS2 ZNF143 SP5 YY2 MXD4 REST C2orf27A PIR46456
GH02H131801 0.8 ENCODE 12.3 +79.6 79638 0.2 CTCF MXI1 KLF1 SAP130 RB1 SIN3A RAD21 GLIS2 CTBP1 SMC3 C2orf27A C2orf27B ENSG00000274353
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C2orf27A on UCSC Golden Path with GeneCards custom track

Promoters for C2orf27A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000123184 1926 199

Genomic Locations for C2orf27A Gene

Genomic Locations for C2orf27A Gene
45,030 bases
Plus strand

Genomic View for C2orf27A Gene

Genes around C2orf27A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf27A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf27A Gene

Proteins for C2orf27A Gene

  • Protein details for C2orf27A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C2orf27
    Protein Accession:
    Secondary Accessions:
    • O43575
    • Q2M1X0
    • Q52M10
    • Q86XG2

    Protein attributes for C2orf27A Gene

    203 amino acids
    Molecular mass:
    21517 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C2orf27A Gene


neXtProt entry for C2orf27A Gene

Post-translational modifications for C2orf27A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf27A Gene

No data available for DME Specific Peptides for C2orf27A Gene

Domains & Families for C2orf27A Gene

Protein Domains for C2orf27A Gene


Suggested Antigen Peptide Sequences for C2orf27A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C2orf27A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C2orf27A Gene

Function for C2orf27A Gene

Phenotypes From GWAS Catalog for C2orf27A Gene

genes like me logo Genes that share phenotypes with C2orf27A: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C2orf27A Gene

Localization for C2orf27A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf27A gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C2orf27A Gene

Pathways & Interactions for C2orf27A Gene

SuperPathways for C2orf27A Gene

No Data Available

Interacting Proteins for C2orf27A Gene

Selected Interacting proteins: Q580R0-CB027_HUMAN for C2orf27A Gene via IID

Gene Ontology (GO) - Biological Process for C2orf27A Gene


No data available for Pathways by source and SIGNOR curated interactions for C2orf27A Gene

Drugs & Compounds for C2orf27A Gene

No Compound Related Data Available

Transcripts for C2orf27A Gene

Unigene Clusters for C2orf27A Gene

Chromosome 2 open reading frame 27A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf27A Gene

No ASD Table

Relevant External Links for C2orf27A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2orf27A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf27A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C2orf27A Gene

NURSA nuclear receptor signaling pathways regulating expression of C2orf27A Gene:


SOURCE GeneReport for Unigene cluster for C2orf27A Gene:


Evidence on tissue expression from TISSUES for C2orf27A Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with C2orf27A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf27A Gene

Orthologs for C2orf27A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C2orf27A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100615918 33
  • 97.11 (n)
-- 34
  • 92 (a)
Species where no ortholog for C2orf27A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf27A Gene

Gene Tree for C2orf27A (if available)
Gene Tree for C2orf27A (if available)

Paralogs for C2orf27A Gene

Paralogs for C2orf27A Gene

genes like me logo Genes that share paralogs with C2orf27A: view

Variants for C2orf27A Gene

Sequence variations from dbSNP and Humsavar for C2orf27A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000052761 -- 131,746,991(+) CTGAG(C/T)CCAGC intron-variant
rs1000133308 -- 131,739,778(+) TTGGA(C/G)AACAG intron-variant
rs1000230514 -- 131,740,144(+) ACATT(A/G)TAGTT intron-variant
rs1000417858 -- 131,760,563(+) CGTCC(A/G)CTAGT intron-variant
rs1000751242 -- 131,759,464(+) ATCTG(A/G)TATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C2orf27A Gene

Variant ID Type Subtype PubMed ID
nsv999735 CNV gain 25217958
nsv997248 CNV loss 25217958
nsv963725 CNV duplication 23825009
nsv961889 CNV duplication 23825009
nsv961888 CNV duplication 23825009
nsv961656 CNV duplication 23825009
nsv953176 CNV deletion 24416366
nsv953175 CNV duplication 24416366
nsv953174 CNV duplication 24416366
nsv834377 CNV gain 17160897
nsv820012 CNV loss 19587683
nsv583146 CNV gain 21841781
nsv527590 CNV loss 19592680
nsv514979 CNV gain 21397061
nsv482054 CNV gain 20164927
nsv471420 CNV gain 19718026
nsv428404 CNV loss 18775914
nsv1151957 CNV duplication 26484159
nsv1139737 CNV duplication 24896259
nsv1132513 CNV duplication 24896259
nsv1072033 CNV deletion 25765185
nsv10186 CNV loss 18304495
nsv1011966 CNV loss 25217958
esv3592494 CNV gain 21293372
esv3592493 CNV loss 21293372
esv3592492 CNV gain 21293372
esv2762850 CNV gain 21179565
esv2759092 CNV gain+loss 17122850
esv26126 CNV gain 19812545
esv24587 CNV gain+loss 19812545
dgv2247e59 CNV duplication 20981092

Relevant External Links for C2orf27A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for C2orf27A Gene

Disorders for C2orf27A Gene

Relevant External Links for C2orf27A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C2orf27A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf27A Gene

Publications for C2orf27A Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 60
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for C2orf27A Gene

Sources for C2orf27A Gene

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