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Aliases for C2orf16 Gene

Aliases for C2orf16 Gene

  • Chromosome 2 Open Reading Frame 16 2 3 5
  • P-S-E-R-S-H-H-S Repeats Containing 2

External Ids for C2orf16 Gene

Previous GeneCards Identifiers for C2orf16 Gene

  • GC02P027777
  • GC02P027714
  • GC02P027652
  • GC02P027799
  • GC02P027541
  • GC02P027577

Summaries for C2orf16 Gene

GeneCards Summary for C2orf16 Gene

C2orf16 (Chromosome 2 Open Reading Frame 16) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2orf16 Gene

Genomics for C2orf16 Gene

Regulatory Elements for C2orf16 Gene

Enhancers for C2orf16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G027680 1.5 Ensembl ENCODE dbSUPER 9.6 +145.2 145192 3.5 HDGF PKNOX1 FOXA2 ATF1 ARID4B SIN3A ZNF48 TCF12 ZNF143 ZNF207 LINC01460 SLC4A1AP CCDC121 GPN1 ZNF512 C2orf16 SUPT7L LOC105374378
GH02G027953 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.9 +419.8 419847 8.5 PKNOX1 MLX SIN3A YY1 GATA2 FOS REST PPARG SSRP1 PBX2 FOSL2 RBKS FLJ31356 FNDC4 C2orf16 CGREF1 LINC01460 BABAM2 GCKR LOC100422227
GH02G027407 1.4 FANTOM5 ENCODE 5.9 -128.2 -128204 2.7 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A SNX17 ZNF512 KRTCAP3 C2orf16 PPM1G FTH1P3
GH02G027684 0.8 ENCODE dbSUPER 9.6 +148.4 148423 2.7 FOSL1 ZNF316 HINFP ZNF512 FOS MAFK SLC4A1AP SUPT7L LINC01460 GPN1 CCDC121 ZNF512 C2orf16 KRTCAP3 OST4 LOC105374378
GH02G027622 0.7 ENCODE dbSUPER 9.9 +85.4 85371 1.1 JUND SIN3A ZNF24 C2orf16 GPN1 ENSG00000259080
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C2orf16 on UCSC Golden Path with GeneCards custom track

Genomic Location for C2orf16 Gene

Chromosome:
2
Start:
27,537,386 bp from pter
End:
27,582,722 bp from pter
Size:
45,337 bases
Orientation:
Plus strand

Genomic View for C2orf16 Gene

Genes around C2orf16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C2orf16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C2orf16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2orf16 Gene

Proteins for C2orf16 Gene

  • Protein details for C2orf16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DN1-CB016_HUMAN
    Recommended name:
    Uncharacterized protein C2orf16
    Protein Accession:
    Q68DN1
    Secondary Accessions:
    • B9EIQ4
    • Q53S01
    • Q8ND64
    • Q9H088

    Protein attributes for C2orf16 Gene

    Size:
    1984 amino acids
    Molecular mass:
    224321 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX93198.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for C2orf16 Gene

Post-translational modifications for C2orf16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C2orf16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C2orf16 Gene

Domains & Families for C2orf16 Gene

Protein Domains for C2orf16 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C2orf16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68DN1

UniProtKB/Swiss-Prot:

CB016_HUMAN :
  • The P-S-E-R-S-H-H-S repeats give rise to an antiparallel beta-structure.
Domain:
  • The P-S-E-R-S-H-H-S repeats give rise to an antiparallel beta-structure.
genes like me logo Genes that share domains with C2orf16: view

No data available for Gene Families for C2orf16 Gene

Function for C2orf16 Gene

genes like me logo Genes that share phenotypes with C2orf16: view

Animal Model Products

CRISPR Products

miRNA for C2orf16 Gene

miRTarBase miRNAs that target C2orf16

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C2orf16 Gene

Localization for C2orf16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C2orf16 gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for C2orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with C2orf16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C2orf16 Gene

Pathways & Interactions for C2orf16 Gene

SuperPathways for C2orf16 Gene

No Data Available

Interacting Proteins for C2orf16 Gene

Gene Ontology (GO) - Biological Process for C2orf16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C2orf16 Gene

Transcripts for C2orf16 Gene

mRNA/cDNA for C2orf16 Gene

Unigene Clusters for C2orf16 Gene

Chromosome 2 open reading frame 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2orf16 Gene

No ASD Table

Relevant External Links for C2orf16 Gene

GeneLoc Exon Structure for
C2orf16
ECgene alternative splicing isoforms for
C2orf16

Expression for C2orf16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C2orf16 Gene

mRNA differential expression in normal tissues according to GTEx for C2orf16 Gene

This gene is overexpressed in Testis (x33.6).

NURSA nuclear receptor signaling pathways regulating expression of C2orf16 Gene:

C2orf16

SOURCE GeneReport for Unigene cluster for C2orf16 Gene:

Hs.131021
genes like me logo Genes that share expression patterns with C2orf16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C2orf16 Gene

Orthologs for C2orf16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C2orf16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf16 34
  • 98.96 (n)
C2orf16 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102156387 34
  • 80.19 (n)
cfa-mir-1837-2 35 35
  • 62 (a)
OneToMany
cow
(Bos Taurus)
Mammalia C11H2orf16 34
  • 78.38 (n)
C2orf16 35
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia LOC102635990 34
  • 68.68 (n)
4932415D10Rik 35
  • 56 (a)
OneToOne
Gm17695 16
rat
(Rattus norvegicus)
Mammalia LOC100359615 34
  • 68.32 (n)
Species where no ortholog for C2orf16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C2orf16 Gene

ENSEMBL:
Gene Tree for C2orf16 (if available)
TreeFam:
Gene Tree for C2orf16 (if available)

Paralogs for C2orf16 Gene

Pseudogenes.org Pseudogenes for C2orf16 Gene

genes like me logo Genes that share paralogs with C2orf16: view

No data available for Paralogs for C2orf16 Gene

Variants for C2orf16 Gene

Sequence variations from dbSNP and Humsavar for C2orf16 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000435539 -- 27,580,063(+) TCGGT(C/T)GCATC reference, missense
rs1000952218 -- 27,576,659(+) ATGTT(G/T)GTACC reference, missense
rs1001848423 -- 27,575,522(+) AACCC(C/T)GGACC upstream-variant-2KB
rs1002402187 -- 27,575,144(+) TCTGG(C/G)TTGAT upstream-variant-2KB
rs1002901367 -- 27,581,282(+) CCCTC(G/T)GAGAG upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for C2orf16 Gene

Variant ID Type Subtype PubMed ID
nsv471937 CNV novel sequence insertion 20440878
nsv817684 CNV gain 17921354

Variation tolerance for C2orf16 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.74; 91.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C2orf16 Gene

Human Gene Mutation Database (HGMD)
C2orf16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C2orf16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C2orf16 Gene

Disorders for C2orf16 Gene

Relevant External Links for C2orf16

Genetic Association Database (GAD)
C2orf16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C2orf16

No disorders were found for C2orf16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C2orf16 Gene

Publications for C2orf16 Gene

  1. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. (PMID: 21386085) Kraja A.T. … Borecki I.B. (Diabetes 2011) 3 46 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3 64
  5. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D. … Pajukanta P. (J. Med. Genet. 2013) 3 64

Products for C2orf16 Gene

Sources for C2orf16 Gene

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