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Aliases for C2CD5 Gene

Aliases for C2CD5 Gene

  • C2 Calcium-Dependent Domain Containing 5 2 3
  • KIAA0528 2 3 4
  • 138 KDa C2 Domain-Containing Phosphoprotein 2 3
  • CDP138 3 4
  • C2 Domain-Containing Phosphoprotein Of 138 KDa 4
  • C2 Domain-Containing Protein 5 3

External Ids for C2CD5 Gene

Previous HGNC Symbols for C2CD5 Gene

  • KIAA0528

Previous GeneCards Identifiers for C2CD5 Gene

  • GC12M022602

Summaries for C2CD5 Gene

GeneCards Summary for C2CD5 Gene

C2CD5 (C2 Calcium-Dependent Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding.

UniProtKB/Swiss-Prot for C2CD5 Gene

  • Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C2CD5 Gene

Genomics for C2CD5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C2CD5 Gene

22,448,546 bp from pter
22,544,546 bp from pter
96,001 bases
Minus strand

Genomic View for C2CD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C2CD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C2CD5 Gene

No data available for Regulatory Elements for C2CD5 Gene

Proteins for C2CD5 Gene

  • Protein details for C2CD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C2 domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • B4DJ03
    • B4DRN7
    • B7ZLL0
    • F5H2A1
    • F5H5R1
    • O60280
    • Q17RY7
    • Q7Z619
    • Q86SU3

    Protein attributes for C2CD5 Gene

    1000 amino acids
    Molecular mass:
    110447 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit. The ions are bound to the C2 domains.;
    Quaternary structure:
    No Data Available
    • Sequence=BAA25454.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG58665.1; Type=Frameshift; Positions=33; Evidence={ECO:0000305};

    Alternative splice isoforms for C2CD5 Gene


neXtProt entry for C2CD5 Gene

Proteomics data for C2CD5 Gene at MOPED

Post-translational modifications for C2CD5 Gene

  • Phosphorylated on Ser-197 by active myristoylated kinase AKT2; insulin-stimulated phosphorylation by AKT2 regulates SLC2A4/GLUT4 translocation into the plasma membrane.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C2CD5 Gene

Domains for C2CD5 Gene

Protein Domains for C2CD5 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q86YS7
  • The C2 domain binds to calcium and membrane lipids
  • Contains 1 C2 domain.
genes like me logo Genes that share domains with C2CD5: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C2CD5 Gene

Function for C2CD5 Gene

Molecular function for C2CD5 Gene

UniProtKB/Swiss-Prot Function: Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.

Gene Ontology (GO) - Molecular Function for C2CD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 21907143
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding IDA 21907143
genes like me logo Genes that share ontologies with C2CD5: view

Animal Model Products

CRISPR Products

miRNA for C2CD5 Gene

miRTarBase miRNAs that target C2CD5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C2CD5 Gene

Localization for C2CD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C2CD5 Gene

Cytoplasmic vesicle membrane. Cytoplasm, cell cortex. Cell membrane. Cell projection, ruffle. Note=Dynamically associated with GLUT4-containing glucose storage vesicles (GSV) and plasma membrane in response to insulin stimulation.

Gene Ontology (GO) - Cellular Components for C2CD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005886 plasma membrane IDA 21907143
GO:0005938 cell cortex IDA 21907143
GO:0030659 cytoplasmic vesicle membrane IDA 21907143
genes like me logo Genes that share ontologies with C2CD5: view

No data available for Subcellular locations from COMPARTMENTS for C2CD5 Gene

Pathways for C2CD5 Gene

SuperPathways for C2CD5 Gene

No Data Available

Interacting Proteins for C2CD5 Gene

Gene Ontology (GO) - Biological Process for C2CD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IEA --
GO:0010828 positive regulation of glucose transport ISS --
GO:0031340 positive regulation of vesicle fusion IMP 21907143
GO:0032869 cellular response to insulin stimulus IDA 21907143
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase ISS --
genes like me logo Genes that share ontologies with C2CD5: view

No data available for Pathways by source for C2CD5 Gene

Transcripts for C2CD5 Gene

Unigene Clusters for C2CD5 Gene

C2 calcium-dependent domain containing 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C2CD5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C2CD5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - - - -
SP2: - -
SP3: - -
SP5: -
SP6: -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1: -

Relevant External Links for C2CD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C2CD5 Gene

mRNA expression in normal human tissues for C2CD5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C2CD5 Gene

SOURCE GeneReport for Unigene cluster for C2CD5 Gene Hs.271014

genes like me logo Genes that share expressions with C2CD5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C2CD5 Gene

Orthologs for C2CD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for C2CD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C2CD5 35
  • 99.62 (n)
  • 99.81 (a)
C2CD5 36
  • 100 (a)
(Bos Taurus)
Mammalia C2CD5 35
  • 91.11 (n)
  • 95.01 (a)
C2CD5 36
  • 93 (a)
(Canis familiaris)
Mammalia C2CD5 35
  • 92.36 (n)
  • 95.44 (a)
C2CD5 36
  • 94 (a)
(Mus musculus)
Mammalia C2cd5 35
  • 85.1 (n)
  • 92.95 (a)
C2cd5 16
C2cd5 36
  • 95 (a)
(Monodelphis domestica)
Mammalia C2CD5 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia C2CD5 36
  • 91 (a)
(Rattus norvegicus)
Mammalia C2cd5 35
  • 85.65 (n)
  • 93.24 (a)
(Gallus gallus)
Aves C2CD5 36
  • 81 (a)
KIAA0528 35
  • 80.83 (n)
  • 85.88 (a)
(Anolis carolinensis)
Reptilia C2CD5 36
  • 84 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398515 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c2cd5 35
  • 70.65 (n)
  • 82.95 (a)
Str.17756 35
(Danio rerio)
Actinopterygii C2CD5 (1 of 2) 36
  • 75 (a)
C2CD5 (2 of 2) 36
  • 68 (a)
LOC100333813 35
  • 69.29 (n)
  • 76.85 (a)
zgc63659 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001475 35
  • 51.26 (n)
  • 47.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6454 35
  • 53.76 (n)
  • 48.71 (a)
CG6454 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea F52H2.7 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7205 36
  • 73 (a)
Species with no ortholog for C2CD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C2CD5 Gene

Gene Tree for C2CD5 (if available)
Gene Tree for C2CD5 (if available)

Paralogs for C2CD5 Gene

Selected SIMAP similar genes for C2CD5 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with C2CD5: view

No data available for Paralogs for C2CD5 Gene

Variants for C2CD5 Gene

Sequence variations from dbSNP and Humsavar for C2CD5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs873855 -- 22,457,640(+) GAAAA(C/G)CAACT intron-variant
rs925525 -- 22,488,388(+) AAGCA(A/G)TAATA intron-variant
rs925526 -- 22,492,494(+) TATGG(C/T)TGAAA intron-variant
rs1012839 -- 22,511,924(-) ATGCT(A/C)TTTTT intron-variant
rs1046776 -- 22,449,618(-) CTTTT(G/T)GAGGC utr-variant-3-prime

Relevant External Links for C2CD5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C2CD5 Gene

Disorders for C2CD5 Gene

No disorders were found for C2CD5 Gene.

No data available for UniProtKB/Swiss-Prot for C2CD5 Gene

Publications for C2CD5 Gene

  1. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. (PMID: 21907143) Xie X. … Jiang Z.Y. (Cell Metab. 2011) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. (PMID: 25096995) Xu S. … Chen J. (Mol. Cell Proteomics 2014) 2 3
  5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4

Products for C2CD5 Gene

Sources for C2CD5 Gene

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